D:Refractory Anemia

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pChart

Disease Term
Synonyms ANEMIAS REFRACTORY, Refractory Anemias
Documents 32
Hot Single Events 9
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Refractory Anemia. They are ordered first by their relevance to Refractory Anemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
2 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
3 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
4 INT312305 Binding of HIF1A and Positive_regulation of Transcription of VEGFA 1 0.17 2.8 0.1 5.00
5 INT279286 Binding of TXK and VEGFA 3 0.05 2.35 0.07 5.00
6 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04 5.00
7 INT312303 Positive_regulation of FLT1 Positive_regulation of VEGFA 1 0.38 0.73 0.03 5.00
8 INT297614 ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.56 0 5.00
9 INT297613 Negative_regulation of ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.66 0 5.00
10 INT297615 Binding of TSC1 and HDAC9 1 0.01 0.4 0 5.00
11 INT312304 Binding of JAK2 and VEGFA 1 0.30 0.82 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Refractory Anemia. They are ordered first by their pain relevance and then by number of times they were reported in Refractory Anemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 97.36
2 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 95.52
3 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 95.00
4 INT174100 Gene_expression of YWHAE 14 0.31 12.42 0.08 93.88
5 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 93.20
6 INT124061 Binding of YWHAE 3 0.30 3.43 0.4 89.60
7 INT175035 Gene_expression of Mecom 11 0.65 10.1 0.19 88.40
8 INT312299 Positive_regulation of Gene_expression of Mecom 1 0.03 1.9 0 88.40
9 INT101612 Protein_catabolism of HTT 3 0.86 1.44 0.05 84.12
10 INT597 Positive_regulation of PON1 26 0.62 19.14 2.87 79.76
11 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 77.40
12 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 77.40
13 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 77.40
14 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 77.00
15 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 77.00
16 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 76.64
17 INT68576 Positive_regulation of Positive_regulation of CSF2 8 0.40 8.1 2.83 76.64
18 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 74.16
19 INT55114 Gene_expression of CRS 42 0.58 26.86 4.69 73.84
20 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 60.00
21 INT51646 Binding of IL3 3 0.37 3.26 0.56 56.00
22 INT234422 Gene_expression of PML 14 0.75 15.93 1.14 54.96
23 INT97062 Binding of PML 10 0.41 11.63 1.65 42.20
24 INT289317 Positive_regulation of Localization of PML 1 0.23 1.09 0.26 34.52
25 INT262726 Localization of PML 6 0.57 7.13 0.72 34.36
26 INT31572 Negative_regulation of FLT1 21 0.48 16.49 1.18 32.08
27 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 13.16
28 INT86805 Localization of HGF 49 0.71 28.48 6.35 13.16
29 INT168003 Localization of Fgf2 24 0.80 12.52 3.31 13.16
30 INT148797 Phosphorylation of KDR 7 0.80 5.15 0.36 13.04
31 INT224335 Negative_regulation of Phosphorylation of KDR 5 0.35 5.24 0.09 13.04
32 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 10.96
33 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
34 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
35 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
36 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
37 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
38 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
39 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
40 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
41 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
42 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
43 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
44 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
45 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
46 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
47 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
48 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
49 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
50 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
51 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
52 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 5.00
53 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
54 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 5.00
55 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
56 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 5.00
57 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
58 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51 5.00
59 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 5.00
60 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 5.00
61 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
62 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 5.00
63 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
64 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
65 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22 5.00
66 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 5.00
67 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88 5.00
68 INT31450 Binding of HIST1H1B 20 0.37 10.21 2.84 5.00
69 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 5.00
70 INT83236 Localization of PGR 14 0.73 8.26 2.23 5.00
71 INT133648 Regulation of HDAC9 14 0.60 10.01 2.18 5.00
72 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16 5.00
73 INT130364 Positive_regulation of Thbs1 7 0.62 7.73 1.97 5.00
74 INT143127 Positive_regulation of FLT1 44 0.66 21.7 1.92 5.00
75 INT191154 Binding of HDAC9 20 0.36 14.12 1.83 5.00
76 INT183753 Regulation of HBM 24 0.39 13.13 1.79 5.00
77 INT62712 Negative_regulation of HGF 19 0.58 7.21 1.67 5.00
78 INT143443 Localization of HIF1A 14 0.78 10.93 1.49 5.00
79 INT119520 Gene_expression of TXK 19 0.19 17.54 1.45 5.00
80 INT133898 Binding of HSP90AA1 17 0.30 8.83 1.12 5.00
81 INT116512 Gene_expression of MVD 4 0.75 1.61 1.06 5.00
82 INT102249 Binding of HIF1A 39 0.36 30.47 1.04 5.00
83 INT112717 Negative_regulation of Binding of VEGFA 21 0.56 11.07 0.99 5.00
84 INT200738 Gene_expression of HIST2H4A 7 0.18 4.65 0.91 5.00
85 INT173100 Binding of KDR 39 0.39 22.48 0.81 5.00
86 INT117145 Negative_regulation of Gene_expression of Thbs1 11 0.43 5.67 0.57 5.00
87 INT143125 Binding of FLT1 48 0.40 13.6 0.51 5.00
88 INT45111 Gene_expression of PRB1 15 0.58 4.16 0.47 5.00
89 INT64977 Gene_expression of TFF3 9 0.75 3.54 0.39 5.00
90 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 5.00
91 INT283244 Gene_expression of Pgf 7 0.52 2.41 0.32 5.00
92 INT179687 Negative_regulation of Gene_expression of KDR 6 0.22 5.37 0.31 5.00
93 INT173097 Localization of KDR 20 0.73 12.73 0.31 5.00
94 INT297626 Gene_expression of RLN3 3 0.11 5.07 0.3 5.00
95 INT256540 Regulation of Gene_expression of TSC1 4 0.07 4.74 0.3 5.00
96 INT265661 Positive_regulation of Gene_expression of HIST2H4A 2 0.09 2.69 0.28 5.00
97 INT312302 Gene_expression of Prss27 2 0.02 3.95 0.19 5.00
98 INT197103 Binding of FLT4 2 0.29 3.08 0.14 5.00
99 INT120615 Negative_regulation of TFF3 2 0.42 1.5 0.13 5.00
100 INT265803 Positive_regulation of Positive_regulation of FLT1 5 0.41 2.85 0.1 5.00
101 INT151948 Positive_regulation of Gene_expression of MVD 2 0.49 1.35 0.09 5.00
102 INT154423 Regulation of CDAN1 2 0.60 1.55 0.09 5.00
103 INT297627 Positive_regulation of Gene_expression of RLN3 3 0.08 3.06 0.08 5.00
104 INT198034 Positive_regulation of Localization of KDR 3 0.29 2.17 0.05 5.00
105 INT189580 Positive_regulation of Gene_expression of KDR 9 0.49 5.9 0.05 5.00
106 INT284979 Binding of HIST2H4A 2 0.05 2 0.04 5.00
107 INT312307 Positive_regulation of Regulation of HBM 2 0.01 1.94 0.03 5.00
108 INT275245 Positive_regulation of HIST2H2BE 2 0.15 1.94 0 5.00
109 INT297621 Positive_regulation of RLN3 1 0.05 2.79 0 5.00
110 INT274683 Localization of HIST2H4A 5 0.12 1.54 0 5.00
111 INT297623 Localization of HDAC11 1 0.29 0.26 0 5.00
112 INT297619 Binding of RLN3 1 0.02 1.4 0 5.00
113 INT297620 Negative_regulation of Positive_regulation of RLN3 1 0.03 1.04 0 5.00
114 INT297625 Positive_regulation of Binding of RLN3 1 0.03 1.42 0 5.00
115 INT297628 Negative_regulation of ZNF275 1 0.00 3.2 0 5.00
116 INT297622 Positive_regulation of Binding of HIST2H4A 1 0.06 1.42 0 5.00
117 INT297624 Localization of RLN3 1 0.05 1 0 5.00
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