D:Reperfusion Injury

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pChart

Disease Term
Synonyms DAMAGE REPERFUSION, Damages Reperfusion, Injuries Ischemia Reperfusion, Injuries Reperfusion, Injury Ischemia Reperfusion, Injury Reperfusion, Ischaemia Reperfusion Injuries, Ischaemia Reperfusion Injury, Ischemia Reperfusion Injuries, ISCHEMIA REPERFUSION INJURY, Reperfusion Damage
Documents 851
Hot Single Events 200
Hot Interactions 82

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Reperfusion Injury. They are ordered first by their relevance to Reperfusion Injury and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT230532 LILRB1 Positive_regulation of Gene_expression of Mmp2 1 0.14 1.04 0.5 100.00
2 INT230533 LILRB1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.5 100.00
3 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35 100.00
4 INT343916 Hspa1a Positive_regulation of Gene_expression of TNF 1 0.16 1.17 0.41 100.00
5 INT343919 Hspa1a Positive_regulation of Gene_expression of IL6 1 0.02 1.17 0.4 100.00
6 INT343907 Hspa1a Positive_regulation of Gene_expression of Cxcl2 1 0.01 1.17 0.4 100.00
7 INT297316 Negative_regulation of Rock2 Positive_regulation of Cdh1 1 0.01 1.92 0.43 100.00
8 INT242400 Binding of Bdkrb2 and Ros1 1 0.02 0.84 0.15 99.84
9 INT231764 TLR4 Negative_regulation of HMOX1 1 0.27 1.54 0.11 99.16
10 INT302731 Binding of Gfm1 and Hk 1 0.01 1 0.2 98.76
11 INT302732 Positive_regulation of Binding of Gfm1 and Hk 1 0.01 1 0.2 98.76
12 INT274080 Binding of ARHGAP4 and Map3k5 1 0.41 1.92 0.2 98.72
13 INT263975 NR4A3 Negative_regulation of Positive_regulation of TBK1 1 0.02 1.2 0.57 98.44
14 INT332013 Hc Regulation of Binding of C3ar1 1 0.12 1.11 0.21 98.20
15 INT332016 C3ar1 Regulation of Binding of Hc 1 0.12 1.11 0.21 98.20
16 INT352943 Pik3cb Positive_regulation of Pdk1 1 0.09 0.21 0.06 98.00
17 INT324829 ROS1 Positive_regulation of Gene_expression of Ecm1 1 0.00 0.66 0.09 97.80
18 INT343910 TLR4 Regulation of Gene_expression of Icam1 1 0.04 1.3 0.22 97.76
19 INT310595 Ros1 Positive_regulation of Npr1 1 0.03 0.84 0.16 96.36
20 INT231767 Positive_regulation of CD14 Positive_regulation of Binding of IRF6 1 0.04 1.6 0.11 95.88
21 INT352942 Pik3cb Positive_regulation of Phosphorylation of Akt1 1 0.33 0.21 0.06 95.84
22 INT352941 Pik3cb Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.21 0.06 95.52
23 INT231770 CD14 Positive_regulation of Binding of IRF6 1 0.04 1.59 0.11 95.20
24 INT231755 CD14 Positive_regulation of Binding of IRF6 and TLR4 1 0.03 1.6 0.11 95.20
25 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6 94.08
26 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27 93.60
27 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47 93.60
28 INT297307 Negative_regulation of Binding of Ccr1 and Ccl3 1 0.27 0.73 0.67 93.60
29 INT297313 Negative_regulation of Binding of Ccr1 and Ccl5 1 0.28 0.74 0.67 93.60
30 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65 93.08
31 INT175986 Ros1 Positive_regulation of Gtf3a 2 0.01 4.75 1.71 92.28
32 INT175988 Ros1 Positive_regulation of Transcription of Gtf3a 1 0.01 1.56 0.34 92.28
33 INT175990 Ros1 Positive_regulation of Gene_expression of Gtf3a 1 0.01 1.56 0.34 92.28
34 INT221234 Gja3 Regulation of Binding of Ptpn2 1 0.08 0.58 0.18 92.24
35 INT242399 Cyp19a1 Negative_regulation of Gene_expression of Bad 1 0.00 1.32 0.31 91.84
36 INT242398 Cyp19a1 Positive_regulation of Bcl2 1 0.00 1.28 0.3 91.84
37 INT329369 Jun Regulation of Gene_expression of Il12a 1 0.00 1.48 0.27 91.84
38 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73 91.16
39 INT190824 Binding of Cl and Bcl2 1 0.02 1.4 0.05 88.88
40 INT328501 Sumo1 Negative_regulation of Gene_expression of Pglyrp1 1 0.00 1.54 0.83 88.72
41 INT205228 Cldn5 Regulation of Gene_expression of Cldn1 1 0.03 0.29 0.07 88.16
42 INT205235 Cldn2 Regulation of Gene_expression of Cldn1 1 0.06 0.29 0.07 88.16
43 INT205227 Cldn3 Regulation of Gene_expression of Cldn1 1 0.03 0.29 0.07 88.16
44 INT205237 Cldn2 Regulation of Gene_expression of Cldn5 1 0.03 0.29 0.07 87.72
45 INT205238 Cldn3 Regulation of Gene_expression of Cldn2 1 0.03 0.29 0.07 87.72
46 INT205229 Cldn2 Regulation of Gene_expression of Ocln 1 0.07 0.29 0.07 87.72
47 INT205231 Cldn2 Regulation of Tjp1 1 0.07 0.29 0.07 87.72
48 INT205248 Cldn2 Regulation of Gene_expression of Tjp1 1 0.07 0.29 0.07 87.72
49 INT205232 Cldn5 Regulation of Gene_expression of Cldn2 1 0.03 0.29 0.07 87.72
50 INT205234 Cldn2 Regulation of Gene_expression of Cldn3 1 0.03 0.29 0.07 87.72
51 INT205244 Cldn3 Regulation of Gene_expression of Ocln 1 0.04 0.29 0.07 87.28
52 INT205245 Cldn5 Regulation of Gene_expression of Cldn3 1 0.02 0.29 0.07 87.28
53 INT205239 Cldn3 Regulation of Gene_expression of Cldn5 1 0.02 0.29 0.07 87.28
54 INT205240 Cldn3 Regulation of Tjp1 1 0.04 0.29 0.07 87.28
55 INT205247 Cldn3 Regulation of Gene_expression of Tjp1 1 0.04 0.29 0.07 87.28
56 INT175985 Igf1 Positive_regulation of Gene_expression of Serpina1c 1 0.14 0.55 0.11 86.92
57 INT175987 Igf1 Positive_regulation of Serpina1c 1 0.13 0.54 0.11 86.92
58 INT205236 Cldn5 Regulation of Tjp1 1 0.03 0.28 0.07 86.84
59 INT205233 Cldn5 Regulation of Gene_expression of Ocln 1 0.03 0.28 0.07 86.84
60 INT205246 Cldn5 Regulation of Gene_expression of Tjp1 1 0.03 0.28 0.07 86.84
61 INT190525 Acot1 Positive_regulation of Localization of S100a8 1 0.00 0.86 0.63 86.56
62 INT190526 Acot1 Positive_regulation of Il1 1 0.01 0.87 0.63 86.56
63 INT239396 Atp7b Negative_regulation of Gene_expression of Icam1 1 0.07 1.69 0.26 86.32
64 INT239346 Olfr642 Positive_regulation of Lcat 1 0.00 1.06 0.07 86.00
65 INT350862 Hist1h1t Regulation of Kcnj5 1 0.02 1.35 1.22 85.64
66 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75 85.60
67 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91 85.20
68 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69 85.04
69 INT218499 Cfb Negative_regulation of ap 1 0.00 0.74 0.13 84.88
70 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03 84.08
71 INT343834 Binding of CD14 and IRF6 1 0.02 2.08 0.9 84.08
72 INT343844 Binding of IRF6 and LY96 1 0.01 1.03 0.4 84.08
73 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39 84.08
74 INT175984 Igf1 Regulation of Localization of Serpina1c 1 0.14 0.54 0.08 83.92
75 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6 83.44
76 INT242875 INS Negative_regulation of Gene_expression of TLR4 1 0.11 1.41 0.24 83.44
77 INT242878 INS Negative_regulation of Gene_expression of SPI1 1 0.04 1.81 0.27 82.84
78 INT331600 Il18 Regulation of IFN1@ 1 0.00 1.05 0.16 82.68
79 INT329223 Prkag1 Regulation of Rps6kb1 1 0.14 0.35 0.04 82.48
80 INT331601 Il10 Regulation of IFN1@ 1 0.00 1.05 0.16 82.28
81 INT329216 Prkag1 Regulation of Mtor 1 0.01 0.35 0.04 82.08
82 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91 81.12
83 INT285981 Ros1 Regulation of Positive_regulation of Trib3 1 0.01 0.95 0.12 79.52
84 INT242401 Negative_regulation of Bdkrb1 Negative_regulation of Gene_expression of Mcpt1 1 0.16 1.45 0.46 79.40
85 INT242402 Negative_regulation of Bdkrb1 Positive_regulation of Hmox1 1 0.17 1.44 0.45 79.40
86 INT330105 Rac1 Positive_regulation of Mapk8 1 0.15 1.47 0.34 77.44
87 INT285979 Ros1 Positive_regulation of Trib3 2 0.02 2.18 0.2 77.44
88 INT285982 Ros1 Positive_regulation of Binding of Trib3 1 0.02 1.41 0.08 77.44
89 INT328499 Binding of Cebpz and Sumo1 1 0.08 0.84 0.27 75.76
90 INT350860 Hist1h1t Positive_regulation of Kcnj5 1 0.02 0.54 0.5 75.28
91 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42 75.00
92 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4 75.00
93 INT87391 Negative_regulation of Pars2 Positive_regulation of Gfra1 1 0.08 0.58 0.15 75.00
94 INT151424 Tfrc Negative_regulation of Positive_regulation of Tnni3 1 0.21 0.98 0.2 75.00
95 INT134761 Ghrl Regulation of Localization of Tnf 1 0.20 0.76 0.4 75.00
96 INT137386 Ghrl Regulation of Gene_expression of Pigm 1 0.00 0.36 0.3 75.00
97 INT143688 Binding of Dlc1 and Trpv1 1 0.01 0.45 0.3 75.00
98 INT137385 Ghrl Negative_regulation of Gene_expression of Pigm 1 0.01 0.36 0.3 75.00
99 INT96801 Nxnl1 Negative_regulation of Mpo 1 0.01 0.62 0.13 75.00
100 INT151423 Tfrc Positive_regulation of Gene_expression of Nos2 1 0.24 0.49 0.1 75.00
101 INT96045 Capn1 Regulation of Rasgrp1 1 0.01 0.44 0.09 75.00
102 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76 74.92
103 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55 74.72
104 INT301907 Binding of THBD and VWF 1 0.02 1.71 0.16 74.04
105 INT329226 Negative_regulation of ATIC Positive_regulation of Psmd9 1 0.01 0.58 0.04 74.00
106 INT329229 ATIC Positive_regulation of Tpt1 1 0.01 0.58 0.04 74.00
107 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04 74.00
108 INT329231 ATIC Positive_regulation of Psmd9 1 0.01 0.58 0.04 74.00
109 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04 74.00
110 INT329227 Negative_regulation of ATIC Positive_regulation of Tpt1 1 0.01 0.58 0.04 74.00
111 INT323352 Binding of F8 and VWF 5 0.08 2.22 0.33 73.84
112 INT323351 Positive_regulation of Binding of F8 and VWF 1 0.03 0.8 0.13 73.84
113 INT171162 Negative_regulation of Ace Negative_regulation of Gene_expression of Ccl2 1 0.02 1.18 0.1 73.68
114 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46 73.56
115 INT127301 Crp Regulation of Crp 1 0.08 0.37 0.07 73.36
116 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34 72.96
117 INT350859 Hist1h1t Regulation of Gene_expression of Kcnj5 1 0.02 0.37 0.59 71.56
118 INT279507 Serping1 Negative_regulation of Gene_expression of C3 1 0.03 1.12 0.19 71.52
119 INT279500 Serping1 Negative_regulation of Transcription of C3 1 0.03 1.12 0.19 71.52
120 INT263977 PROC Negative_regulation of JAK2 1 0.00 0.93 0.47 71.16
121 INT324828 ELANE Positive_regulation of Localization of Ecm1 1 0.00 0.61 0.09 70.56
122 INT260495 VEGFA Positive_regulation of Grin1 1 0.08 1.08 0.12 69.96
123 INT260497 VEGFA Positive_regulation of Gria2 1 0.03 1.08 0.12 69.96
124 INT186243 IL36RN Positive_regulation of B4GALNT1 1 0.00 0.43 0.12 68.88
125 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15 67.72
126 INT231761 TNF Negative_regulation of HMOX1 1 0.19 1.2 0.12 67.72
127 INT350861 Hist1h1t Positive_regulation of Gene_expression of Kcnj5 1 0.02 0.35 0.56 67.16
128 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2 66.88
129 INT195769 MIF Regulation of Gene_expression of TP53I11 1 0.19 1.24 0.47 66.44
130 INT277012 Binding of PAPPA and ACE2 1 0.02 1.26 0.15 66.12
131 INT330106 Racgap1 Positive_regulation of Positive_regulation of Mapk8 1 0.01 1.32 0.35 65.04
132 INT330103 Rac1 Positive_regulation of Positive_regulation of Mapk8 1 0.14 1.24 0.32 65.04
133 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 64.76
134 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 64.76
135 INT293361 Binding of CD80 and KLRD1 1 0.00 0.38 0.16 64.76
136 INT293359 Binding of CD86 and KLRD1 1 0.00 0.38 0.16 64.76
137 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73 64.48
138 INT202620 Binding of Ppara and Rxra 15 0.09 2.63 1.11 63.76
139 INT190527 TNF Positive_regulation of Gene_expression of Ros1 1 0.01 1.02 0.68 63.64
140 INT266383 Binding of Ager and S100b 1 0.01 3.48 0.33 63.32
141 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62 62.32
142 INT330100 Binding of Sh3rf1 and Map3k11 1 0.08 1.21 0.31 62.32
143 INT330104 Binding of Sh3rf1 and Rac1 1 0.13 2.41 0.62 61.60
144 INT308815 Got1 Positive_regulation of Ldha 1 0.09 0.71 0.24 61.60
145 INT308817 Ldha Positive_regulation of Tnf 1 0.06 0.71 0.24 61.60
146 INT308818 Got1 Positive_regulation of Tnf 1 0.08 0.71 0.24 61.60
147 INT308816 Gpt Positive_regulation of Tnf 1 0.08 0.72 0.24 61.60
148 INT292571 Positive_regulation of F2RL1 Positive_regulation of Localization of IL6 1 0.07 0.8 0.27 60.80
149 INT329552 Binding of PPARA and SNRNP70 1 0.01 1.3 0.07 60.72
150 INT330109 Binding of Racgap1 and Rac1 1 0.03 1.22 0.32 59.20
151 INT331602 Binding of SSRP1 and Tlr4 1 0.03 0.9 0.21 57.68
152 INT266375 S100b Positive_regulation of Ager 1 0.02 1.8 0.31 57.36
153 INT266405 S100b Positive_regulation of Gene_expression of TFAM 1 0.00 1.02 0.21 57.36
154 INT266401 S100b Positive_regulation of S100b Positive_regulation of Ager 1 0.01 0.96 0.21 57.36
155 INT195708 SERPINC1 Negative_regulation of TNF 1 0.17 0.66 0.15 56.64
156 INT293312 CTLA4 Negative_regulation of Binding of CD28 and CD80 1 0.01 0.29 0.12 55.88
157 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32 54.72
158 INT343847 IRF6 Positive_regulation of TBCE 1 0.01 1.11 0.87 54.72
159 INT329219 Ins1 Positive_regulation of Gene_expression of Slc2a4 1 0.04 0.93 0.05 53.60
160 INT231763 Binding of HSPD1 and TLR2 1 0.12 2 0.19 52.56
161 INT231765 Binding of HSPD1 and TLR4 1 0.13 1.94 0.16 52.56
162 INT317394 Binding of Stk11 and Amp1 1 0.04 0.89 0.21 51.68
163 INT317399 Binding of Acc and Amp1 1 0.05 0.55 0.11 51.68
164 INT319718 Binding of Crebbp and Creb1 1 0.10 1.68 0.48 51.52
165 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06 50.00
166 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06 50.00
167 INT313223 Binding of Cx3cr1 and Mcpt1 1 0.06 0.99 0.56 50.00
168 INT313224 Negative_regulation of Binding of Cx3cr1 and Mcpt1 1 0.07 0.99 0.56 50.00
169 INT355153 Gpt Positive_regulation of Positive_regulation of Ldha 1 0.02 1.33 0.3 50.00
170 INT355152 Gpt Positive_regulation of Gene_expression of Ldha 1 0.02 1.26 0.29 50.00
171 INT352001 Binding of Casz1 and RGD735065 1 0.00 0.46 0.15 50.00
172 INT313225 Binding of Tec and Gopc 1 0.05 1.21 0.06 50.00
173 INT96044 Rasgrp1 Positive_regulation of Gene_expression of Nos2 1 0.14 0.05 0 50.00
174 INT161438 Penk Positive_regulation of Localization of ICA1 1 0.00 0 0 50.00
175 INT155996 OPA1 Positive_regulation of Transcription of Calcb 1 0.02 0 0 50.00
176 INT96046 Rasgrp1 Negative_regulation of Mpo 1 0.23 0.06 0 50.00
177 INT155997 OPA1 Positive_regulation of Gene_expression of Calca 1 0.12 0 0 50.00
178 INT96043 Rasgrp1 Negative_regulation of Sdcbp 1 0.02 0.06 0 50.00
179 INT155998 OPA1 Positive_regulation of Transcription of Calca 1 0.13 0 0 50.00
180 INT343829 TLR1 Positive_regulation of TBCE 1 0.03 0.96 0.85 49.24
181 INT292556 Binding of F2RL1 and TLR4 1 0.05 0.52 0.22 48.56
182 INT292557 Binding of F2RL1 and MYD88 1 0.08 0.52 0.22 48.56
183 INT350006 Tlr4 Regulation of Positive_regulation of Tlr3 1 0.41 0.17 0.21 48.24
184 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13 47.84
185 INT341375 Sod2 Regulation of Bcl2 1 0.08 1.96 0.05 47.44
186 INT341376 Sod2 Regulation of Bax 1 0.09 0.99 0.03 47.44
187 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44 47.24
188 INT317833 Nlrp3 Positive_regulation of Localization of Il1 1 0.06 1.38 0.26 47.12
189 INT264950 Binding of FPR1 and BOC 1 0.11 0.67 1.55 46.08
190 INT264944 Binding of POMC and BOC 1 0.07 0.44 0.89 46.08
191 INT277010 Binding of PAPPA and TNNT1 1 0.24 0.99 0.07 45.92
192 INT277016 Binding of MB and PAPPA 1 0.10 1 0.07 45.92
193 INT221258 Negative_regulation of Binding of VDAC1 and Crk 1 0.00 0.22 0.08 44.60
194 INT221255 Binding of VDAC1 and Crk 1 0.00 0.22 0.08 44.12
195 INT210933 Tlr4 Regulation of Il6 1 0.19 0.33 0.18 42.60
196 INT231772 TNF Positive_regulation of Gene_expression of HMOX1 1 0.21 0.96 0.1 42.20
197 INT181618 NOS3 Positive_regulation of INS 1 0.02 0.59 0.03 41.76
198 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95 41.28
199 INT310321 DLD Negative_regulation of COQ10A 1 0.01 0.06 0.05 41.28
200 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 41.16

Single Events

The table below shows the top 200 pain related interactions that have been reported for Reperfusion Injury. They are ordered first by their pain relevance and then by number of times they were reported in Reperfusion Injury. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT78044 Regulation of Tnnc1 9 0.52 12.3 1.76 100.00
2 INT202035 Gene_expression of LILRB1 5 0.75 4.78 1.41 100.00
3 INT230527 Regulation of Gene_expression of LILRB1 1 0.44 1.73 0.3 100.00
4 INT134418 Regulation of LILRB1 3 0.44 2.7 0.5 100.00
5 INT230521 Regulation of Gene_expression of Klk1c7 1 0.03 1.66 0.29 100.00
6 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57 100.00
7 INT230526 Positive_regulation of Positive_regulation of LILRB1 1 0.49 0.67 0.04 100.00
8 INT48970 Positive_regulation of LILRB1 7 0.67 11.38 0.67 100.00
9 INT230524 Binding of LILRB1 2 0.35 2.14 0.15 100.00
10 INT230522 Regulation of Regulation of LILRB1 1 0.44 0.87 0.15 100.00
11 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77 100.00
12 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86 100.00
13 INT4460 Regulation of Mpo 44 0.62 31.16 12.11 100.00
14 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 100.00
15 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73 100.00
16 INT86671 Negative_regulation of Positive_regulation of Bcl2 6 0.57 3.83 2.03 100.00
17 INT12945 Negative_regulation of Positive_regulation of Cat 3 0.41 2.61 0.97 100.00
18 INT114965 Negative_regulation of Gpx1 13 0.53 6.82 0.14 100.00
19 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.98
20 INT93789 Gene_expression of Tnnc1 28 0.76 17.3 1.99 99.98
21 INT227781 Positive_regulation of GON4L 4 0.13 7.56 0.54 99.98
22 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 99.98
23 INT110568 Positive_regulation of Gene_expression of XDH 7 0.49 5.14 0.09 99.98
24 INT161107 Gene_expression of Ptpn2 58 0.58 49.92 7.4 99.96
25 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 99.96
26 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 99.96
27 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 99.92
28 INT70286 Negative_regulation of Positive_regulation of Racgap1 2 0.43 3.78 2.42 99.92
29 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 99.92
30 INT74447 Gene_expression of Vwf 39 0.76 21.96 4.66 99.92
31 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 99.90
32 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 99.90
33 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 99.86
34 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 99.86
35 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04 99.84
36 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 99.84
37 INT67975 Gene_expression of Bdkrb2 38 0.68 21.69 17.94 99.84
38 INT170106 Binding of Nnat 3 0.31 1.65 0.98 99.84
39 INT78827 Gene_expression of Bdkrb1 34 0.78 18.48 15.81 99.82
40 INT71442 Negative_regulation of Pars2 9 0.58 6.53 2.78 99.80
41 INT58438 Positive_regulation of Hspa1a 8 0.68 6.24 1.91 99.80
42 INT186299 Negative_regulation of Stat6 6 0.42 3.61 0.62 99.80
43 INT242391 Negative_regulation of Ncoa2 1 0.02 1.21 0.16 99.80
44 INT90792 Localization of Il10 144 0.80 87.88 30.03 99.80
45 INT99003 Regulation of Vcam1 7 0.41 6.91 1.04 99.80
46 INT105289 Gene_expression of Tjp1 28 0.76 11.72 4.67 99.76
47 INT105284 Gene_expression of Ocln 39 0.78 14.98 5.08 99.76
48 INT93468 Gene_expression of Cldn1 15 0.27 10.12 3.51 99.76
49 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 99.76
50 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 99.76
51 INT195527 Binding of Rela 17 0.25 4.42 3.56 99.76
52 INT230517 Localization of Myo1f 2 0.15 1.38 0.44 99.72
53 INT103094 Binding of PPARA 308 0.47 177.26 34.75 99.70
54 INT205216 Gene_expression of Cldn4 47 0.53 9.47 2.08 99.68
55 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 99.68
56 INT205206 Gene_expression of Cldn2 17 0.27 3.4 0.66 99.68
57 INT205221 Negative_regulation of Gene_expression of Cldn2 1 0.15 0.86 0.2 99.68
58 INT23344 Gene_expression of Alox5 60 0.75 28.2 13.82 99.66
59 INT43901 Negative_regulation of Ptpn2 65 0.37 56.32 7.48 99.62
60 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74 99.62
61 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 99.60
62 INT110569 Gene_expression of XDH 31 0.75 18.35 1.34 99.60
63 INT199789 Negative_regulation of Gene_expression of CYP2J2 3 0.41 2.15 0.08 99.60
64 INT186261 Gene_expression of ME1 3 0.10 2.87 0 99.60
65 INT36221 Positive_regulation of Nlrp3 25 0.68 19.7 4.5 99.56
66 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.54
67 INT205214 Transcription of Cldn5 1 0.11 0.44 0.11 99.52
68 INT205210 Transcription of Ocln 2 0.32 0.58 0.11 99.52
69 INT205219 Transcription of Cldn3 1 0.13 0.44 0.11 99.52
70 INT205224 Transcription of Cldn1 1 0.23 0.44 0.11 99.52
71 INT205220 Transcription of Tjp1 1 0.26 0.44 0.11 99.52
72 INT205207 Transcription of Cldn2 1 0.24 0.44 0.11 99.52
73 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 99.50
74 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 99.48
75 INT133789 Regulation of Gene_expression of Bdkrb1 5 0.39 3 2.38 99.48
76 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15 99.44
77 INT5647 Positive_regulation of Mptp1 5 0.30 3.6 2.01 99.42
78 INT160124 Localization of Mptp1 1 0.10 0.36 0.13 99.42
79 INT93787 Negative_regulation of Tnnc1 6 0.26 5.81 0.67 99.40
80 INT136850 Positive_regulation of Arg1 10 0.50 6.96 2.47 99.40
81 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 99.36
82 INT39448 Gene_expression of Scr 13 0.67 5.18 2.96 99.36
83 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.36
84 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 99.36
85 INT242388 Regulation of Gene_expression of Scr 1 0.17 0.87 0.25 99.36
86 INT205213 Positive_regulation of Gene_expression of Cldn4 12 0.47 3.37 0.8 99.34
87 INT105285 Regulation of Gene_expression of Tjp1 6 0.26 2.73 1.08 99.32
88 INT205205 Regulation of Gene_expression of Cldn4 1 0.42 1.27 0.36 99.32
89 INT271376 Localization of Hspa1a 2 0.53 1.49 0.39 99.32
90 INT107133 Regulation of KCNJ5 6 0.05 1.26 1.1 99.32
91 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 99.28
92 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 99.28
93 INT49768 Positive_regulation of Kcnj5 58 0.41 11.89 16.02 99.28
94 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 99.28
95 INT5793 Binding of CTS 110 0.48 63.91 40.62 99.26
96 INT309176 Negative_regulation of Gene_expression of Proc 4 0.01 3.12 0.35 99.24
97 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 99.24
98 INT160828 Regulation of Gene_expression of Ros1 29 0.21 13.97 3.75 99.24
99 INT90752 Positive_regulation of Gene_expression of Nr4a1 13 0.70 2.83 5.53 99.24
100 INT106649 Positive_regulation of Gene_expression of Socs3 3 0.62 2.04 0.95 99.24
101 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 99.20
102 INT230520 Positive_regulation of Cd5 4 0.38 1.71 0.22 99.20
103 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 99.20
104 INT166644 Positive_regulation of Cd8a 6 0.14 3.04 0.59 99.20
105 INT56292 Negative_regulation of Gene_expression of Ros1 70 0.38 36.14 9.17 99.18
106 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 99.16
107 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25 99.16
108 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74 99.16
109 INT71441 Positive_regulation of Pars2 12 0.69 5.75 4.13 99.12
110 INT221210 Negative_regulation of Gene_expression of Ptpn2 9 0.37 8.3 0.84 99.12
111 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 99.12
112 INT63338 Regulation of Gene_expression of ICAM1 42 0.62 28.26 9.06 99.12
113 INT9210 Regulation of IL6 166 0.62 125.61 49.95 99.12
114 INT10835 Regulation of IL8 79 0.49 53.04 24.14 99.12
115 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 99.12
116 INT16188 Positive_regulation of Pls1 4 0.19 3.07 2.85 99.12
117 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.08
118 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15 99.08
119 INT117465 Positive_regulation of Localization of S100a8 8 0.42 10.04 3.89 99.06
120 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 99.04
121 INT124825 Transcription of Plat 8 0.70 3.15 5.68 99.04
122 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95 99.04
123 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 99.04
124 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34 99.04
125 INT124583 Negative_regulation of Elane 8 0.29 5.26 2.14 99.00
126 INT55342 Negative_regulation of Gene_expression of Ros1 49 0.37 31.62 8.93 99.00
127 INT205211 Localization of Cldn4 1 0.54 0.69 0.19 99.00
128 INT91159 Negative_regulation of Ros1 35 0.44 26.12 5.97 99.00
129 INT110165 Negative_regulation of Arg1 8 0.38 3.21 0.48 99.00
130 INT96861 Binding of Ang 11 0.32 4.46 1.1 99.00
131 INT250169 Localization of Itprip 1 0.23 0.87 0.17 98.98
132 INT185691 Positive_regulation of WDTC1 24 0.48 12.57 6.49 98.96
133 INT185684 Positive_regulation of Positive_regulation of WDTC1 2 0.32 1.32 0.47 98.96
134 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 98.92
135 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 98.92
136 INT135773 Negative_regulation of Gene_expression of HMOX1 31 0.53 28.31 3.32 98.92
137 INT16722 Negative_regulation of MPO 25 0.59 18.55 6.99 98.88
138 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18 98.88
139 INT47708 Gene_expression of Nr4a1 30 0.78 5.12 13.59 98.84
140 INT106646 Gene_expression of Socs3 15 0.69 6.19 4.31 98.84
141 INT97596 Localization of S100a8 94 0.78 90.69 40.41 98.80
142 INT79458 Localization of Prkca 30 0.81 11.13 15.78 98.80
143 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 98.80
144 INT65536 Negative_regulation of Positive_regulation of Nfkb1 77 0.59 38.86 33.33 98.76
145 INT65055 Negative_regulation of Nfkb1 83 0.58 44.85 34.94 98.76
146 INT171446 Positive_regulation of Gene_expression of Emp1 1 0.37 0.93 0.47 98.76
147 INT162706 Gene_expression of Emp1 2 0.49 0.91 0.43 98.76
148 INT77490 Positive_regulation of Tnnc1 85 0.68 43.54 9.07 98.74
149 INT74286 Regulation of Il10 42 0.44 28.06 19.44 98.72
150 INT615 Regulation of Alb 66 0.62 33.43 15.33 98.72
151 INT154134 Regulation of Tymp 4 0.09 1.19 0.17 98.72
152 INT248410 Negative_regulation of Regulation of Il10 1 0.27 0.38 0.11 98.72
153 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98 98.68
154 INT60285 Negative_regulation of Racgap1 27 0.56 21.71 8.14 98.68
155 INT65459 Binding of Racgap1 9 0.07 4.57 2.28 98.68
156 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 98.68
157 INT27627 Binding of Rac1 41 0.41 22.88 13.68 98.68
158 INT8652 Protein_catabolism of Ace 10 0.94 4.7 2.74 98.68
159 INT17821 Gene_expression of Pls1 4 0.32 2.19 1.96 98.68
160 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 98.60
161 INT151421 Negative_regulation of Positive_regulation of Sdcbp 11 0.30 6.61 3.32 98.60
162 INT24069 Negative_regulation of Localization of Hspb1 3 0.14 3.93 1.3 98.60
163 INT330074 Negative_regulation of Binding of Racgap1 1 0.03 1.47 0.35 98.60
164 INT121987 Phosphorylation of Grin1 11 0.80 4.73 8.88 98.60
165 INT135113 Localization of Grin1 18 0.73 3.73 7.69 98.60
166 INT132888 Negative_regulation of Phosphorylation of Grin1 3 0.57 1.18 3.43 98.60
167 INT135114 Negative_regulation of Localization of Grin1 1 0.41 0.17 1 98.60
168 INT199793 Gene_expression of CYP2J2 18 0.68 19.6 0.67 98.60
169 INT339566 Positive_regulation of Gene_expression of CYP2J2 3 0.61 2.22 0.08 98.60
170 INT9433 Negative_regulation of Pfn2 1 0.29 2.38 1.19 98.58
171 INT274069 Binding of Map3k5 1 0.29 2.68 0.49 98.52
172 INT21569 Binding of Mapk8 8 0.48 5.55 3.44 98.52
173 INT274074 Binding of Map2k4 1 0.08 1.98 0.36 98.52
174 INT105608 Positive_regulation of Mc3r 9 0.68 8.53 4.83 98.52
175 INT355682 Negative_regulation of Positive_regulation of Mc3r 1 0.41 1.04 0.47 98.52
176 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 98.48
177 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 98.48
178 INT18922 Gene_expression of Klk1c7 5 0.18 1.44 1.18 98.46
179 INT169203 Positive_regulation of Gdf15 2 0.55 14.27 3.47 98.44
180 INT291767 Positive_regulation of Gene_expression of ALDOA 2 0.07 1.5 0.04 98.44
181 INT291770 Gene_expression of ALDOA 6 0.10 1.49 0.04 98.44
182 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75 98.40
183 INT28923 Negative_regulation of Ldha 8 0.58 4.94 3.11 98.38
184 INT237390 Localization of Casz1 2 0.55 1.39 0.66 98.36
185 INT54573 Positive_regulation of NFYB 6 0.33 2.02 0.87 98.36
186 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 98.32
187 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 98.32
188 INT239050 Negative_regulation of Mbl1 1 0.45 15 4.24 98.32
189 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 98.32
190 INT101497 Phosphorylation of Prkce 9 0.81 2.55 5.59 98.32
191 INT207892 Binding of Tlr9 35 0.46 26.66 6.61 98.24
192 INT170381 Transcription of Gopc 59 0.60 15.96 6.82 98.24
193 INT35998 Positive_regulation of Gene_expression of Calca 31 0.70 16.16 16.98 98.24
194 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19 98.24
195 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 98.20
196 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 98.20
197 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 98.20
198 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01 98.20
199 INT196392 Negative_regulation of Positive_regulation of Ros1 7 0.17 4.94 0.88 98.20
200 INT332001 Binding of C3ar1 1 0.28 2.15 0.39 98.20
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