D:Retroperitoneal Fibrosis

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pChart

Disease Term
Synonyms Chronic Periaortitides, Chronic Periaortitis, Disease Ormond, DISEASE ORMOND S, Fibroses Retroperitoneal, Fibrosis Inflammatory Perianeurysmal, FIBROSIS PERIANEURYSMAL INFLAMMATORY, Fibrosis Retroperitoneal, Inflammatory Fibrosis Perianeurysmal, Inflammatory Perianeurysmal Fibrosis, Ormond Disease
Documents 206
Hot Single Events 35
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Retroperitoneal Fibrosis. They are ordered first by their relevance to Retroperitoneal Fibrosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT287794 Binding of IGHG3 and AIP 1 0.05 2.8 0.24 99.72
2 INT320492 KRT7 Positive_regulation of Pip 1 0.00 1.02 0.2 72.80
3 INT83422 Binding of FANCB and IGHG3 3 0.12 5.09 1.22 5.00
4 INT225067 Binding of ETF1 and IGHG3 1 0.03 4.52 1.17 5.00
5 INT185997 Binding of FANCB and fc 2 0.01 2.51 0.63 5.00
6 INT225065 Binding of ETF1 and FANCB 1 0.01 2.07 0.59 5.00
7 INT225083 Binding of ETF1 and fc 1 0.00 2.13 0.57 5.00
8 INT225082 Binding of IGHG3 and fc 6 0.01 3.6 0.55 5.00
9 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4 5.00
10 INT236955 Binding of Cxcr5 and Cxcl13 1 0.28 2.26 0.34 5.00
11 INT273024 Binding of FXYD1 and RLS 1 0.04 1.24 0.21 5.00
12 INT198307 IL10 Positive_regulation of Gene_expression of IGHG3 2 0.01 1.21 0.15 5.00
13 INT199031 Binding of ALB and F2 1 0.05 1.78 0.08 5.00
14 INT225068 Binding of FCAR and IGHG3 1 0.02 0.27 0.07 5.00
15 INT225081 Binding of FCAR and fc 1 0.00 0.27 0.07 5.00
16 INT225064 Binding of IGHA1 and IGHG3 1 0.01 1.54 0.07 5.00
17 INT225084 IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00
18 INT225080 Positive_regulation of IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Retroperitoneal Fibrosis. They are ordered first by their pain relevance and then by number of times they were reported in Retroperitoneal Fibrosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT112989 Gene_expression of AIP 3 0.56 25.4 4.23 100.00
2 INT287799 Positive_regulation of Gene_expression of AIP 1 0.42 7.39 1.19 100.00
3 INT120062 Binding of AIP 4 0.42 28.86 3.91 99.98
4 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 99.66
5 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 99.60
6 INT121801 Binding of Aip 18 0.36 24.1 5.26 99.36
7 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 98.08
8 INT105114 Gene_expression of Arigg4 16 0.52 21.88 4.56 97.20
9 INT121800 Positive_regulation of Gene_expression of Arigg4 7 0.31 10.86 2.02 97.20
10 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 97.08
11 INT49266 Positive_regulation of Arigg4 37 0.47 53.79 11.2 96.20
12 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 95.12
13 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 95.12
14 INT287800 Positive_regulation of Positive_regulation of AIP 1 0.42 2.15 0.3 95.12
15 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15 94.72
16 INT287797 Phosphorylation of AIP 1 0.78 2.04 0.16 94.56
17 INT274238 Positive_regulation of AIP 2 0.42 8.14 0.97 93.60
18 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 93.28
19 INT2065 Binding of BTG3 15 0.36 10.9 4.65 91.76
20 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 91.72
21 INT3353 Localization of HLA-B 25 0.75 16.05 8.62 90.92
22 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 90.20
23 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 87.80
24 INT144179 Localization of Aip 4 0.61 2.59 0.33 87.60
25 INT3512 Gene_expression of Igha 9 0.60 7.71 1.13 87.32
26 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 86.96
27 INT287795 Localization of FAM190B 1 0.05 2.71 0.33 86.84
28 INT62386 Negative_regulation of Gene_expression of IGHG3 12 0.20 7.94 3.62 86.72
29 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 86.56
30 INT296947 Binding of ISM1 1 0.15 4.54 0.46 84.84
31 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 83.76
32 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03 82.96
33 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 82.80
34 INT133102 Negative_regulation of Gene_expression of COL1A2 8 0.08 2.56 1.02 80.96
35 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 80.52
36 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 80.00
37 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 78.88
38 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 78.88
39 INT228977 Binding of SERPINA2 1 0.25 5.42 0.35 78.36
40 INT154613 Regulation of Aip 5 0.21 3.86 0.55 77.76
41 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 77.68
42 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 77.68
43 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 76.64
44 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 73.32
45 INT179524 Negative_regulation of Pip 7 0.38 4.49 0.29 72.24
46 INT272794 Positive_regulation of Positive_regulation of IGHG3 3 0.04 2.84 0.17 67.44
47 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 64.16
48 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46 60.56
49 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 58.80
50 INT287798 Localization of AIP 1 0.63 5.96 1.31 55.68
51 INT3564 Positive_regulation of Aip 11 0.58 15.38 3.62 55.12
52 INT130760 Localization of Pcd4ts3 1 0.01 1.53 0.27 52.40
53 INT52021 Regulation of IGHG3 34 0.39 22.43 3.3 52.24
54 INT21999 Regulation of Gene_expression of IGHG3 8 0.30 3.26 1.84 52.24
55 INT287796 Regulation of Positive_regulation of IGHG3 1 0.02 1.19 0.03 52.24
56 INT211272 Positive_regulation of Igh-VS107 8 0.37 5.79 0.7 49.68
57 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 49.12
58 INT129454 Negative_regulation of Adamts13 6 0.30 7.78 0.31 42.40
59 INT195758 Negative_regulation of Transcription of Adamts13 1 0.03 2.23 0 42.40
60 INT195759 Transcription of Adamts13 1 0.05 2.22 0 42.00
61 INT273025 Phosphorylation of RLS 1 0.67 4.2 0.38 37.60
62 INT83734 Negative_regulation of RLS 24 0.50 35.75 5.66 33.12
63 INT236956 Gene_expression of PDZD2 6 0.53 6.13 1.8 32.16
64 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38 30.00
65 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91 25.60
66 INT142735 Regulation of RLS 33 0.53 45.83 11.35 22.00
67 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 18.80
68 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 10.24
69 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 8.24
70 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 7.48
71 INT75742 Binding of RLS 86 0.42 95.27 19.04 6.28
72 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
73 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
74 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
75 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
76 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
77 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
78 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
79 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
80 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
81 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
82 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
83 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
84 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
85 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49 5.00
86 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
87 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
88 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
89 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
90 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
91 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
92 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
93 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
94 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 5.00
95 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05 5.00
96 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
97 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
98 INT135629 Binding of COMT 33 0.48 16.68 19.37 5.00
99 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
100 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
101 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
102 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
103 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
104 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
105 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
106 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 5.00
107 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
108 INT58841 Gene_expression of HTR2A 33 0.75 9.01 9.07 5.00
109 INT59165 Binding of fc 67 0.36 37.51 8.68 5.00
110 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
111 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 5.00
112 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 5.00
113 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 5.00
114 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 5.00
115 INT67112 Positive_regulation of fc 27 0.58 21.17 7.2 5.00
116 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 5.00
117 INT22450 Gene_expression of GPI 31 0.58 18.77 6.71 5.00
118 INT17618 Gene_expression of B2M 36 0.66 16.39 6.68 5.00
119 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
120 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 5.00
121 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 5.00
122 INT102836 Binding of LRP2 12 0.38 11.27 5.58 5.00
123 INT76884 Positive_regulation of Cp 22 0.69 12.84 4.6 5.00
124 INT14502 Gene_expression of BCHE 40 0.67 18.52 4.6 5.00
125 INT19449 Binding of FANCB 22 0.47 7.4 4.27 5.00
126 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09 5.00
127 INT149623 Negative_regulation of fc 17 0.12 10.56 4.05 5.00
128 INT156137 Gene_expression of Col1a2 28 0.73 13.3 3.99 5.00
129 INT181347 Gene_expression of Cxcl13 9 0.63 9.08 3.75 5.00
130 INT9223 Localization of Ighg1 22 0.78 11.03 3.67 5.00
131 INT232667 Binding of Pd 17 0.16 20.76 3.58 5.00
132 INT58756 Binding of GPI 10 0.48 7.17 3 5.00
133 INT78190 Gene_expression of Tnc 10 0.75 21.23 2.91 5.00
134 INT162957 Positive_regulation of STON1 5 0.35 4.83 2.77 5.00
135 INT124862 Gene_expression of Col5a1 4 0.17 2.05 2.32 5.00
136 INT220178 Positive_regulation of Cxcl13 5 0.42 5.98 2.21 5.00
137 INT112784 Positive_regulation of Positive_regulation of IFNG 11 0.49 7.84 2.18 5.00
138 INT236959 Localization of PDZD2 7 0.16 5.77 2.1 5.00
139 INT236951 Gene_expression of Cxcr5 5 0.66 6.2 2.04 5.00
140 INT186134 Binding of IGHA1 5 0.01 4.71 1.99 5.00
141 INT119018 Gene_expression of TREH 22 0.65 12.44 1.95 5.00
142 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 5.00
143 INT246089 Negative_regulation of Negative_regulation of MAOA 2 0.41 2.42 1.92 5.00
144 INT22448 Regulation of GPI 4 0.33 1.95 1.85 5.00
145 INT126457 Gene_expression of BCL6 34 0.66 22.45 1.75 5.00
146 INT99234 Binding of FCGR2A 1 0.01 1.77 1.68 5.00
147 INT92386 Gene_expression of Tnfrsf8 14 0.54 13.55 1.67 5.00
148 INT107641 Negative_regulation of Ighg1 19 0.39 11.44 1.54 5.00
149 INT114091 Negative_regulation of Aip 6 0.48 4.16 1.3 5.00
150 INT66852 Gene_expression of Fcer2 15 0.14 9.74 1.27 5.00
151 INT15896 Gene_expression of FANCB 18 0.65 6.44 1.18 5.00
152 INT83592 Gene_expression of Col6a3 6 0.70 4.27 1.17 5.00
153 INT236958 Positive_regulation of PDZD2 1 0.07 4.24 1.17 5.00
154 INT37679 Positive_regulation of HLA-DRB4 12 0.34 11.93 1.16 5.00
155 INT173916 Regulation of LRP2 6 0.44 7.96 1.14 5.00
156 INT22962 Gene_expression of FXYD1 2 0.58 3.32 1.12 5.00
157 INT236945 Positive_regulation of Gene_expression of Cxcl13 3 0.38 3.98 1.11 5.00
158 INT85831 Positive_regulation of CA9 5 0.60 8.29 1.02 5.00
159 INT246088 Negative_regulation of Negative_regulation of COMT 2 0.37 2.01 1 5.00
160 INT267808 Positive_regulation of Gene_expression of RLS 4 0.41 5.96 0.94 5.00
161 INT151682 Regulation of STON1 3 0.24 1.98 0.88 5.00
162 INT236947 Transcription of Cxcl13 2 0.43 1.74 0.84 5.00
163 INT236953 Gene_expression of Sparcl1 2 0.14 1.73 0.83 5.00
164 INT236949 Gene_expression of Dazap2 1 0.04 1.97 0.77 5.00
165 INT114700 Positive_regulation of Sdc1 2 0.45 1.67 0.64 5.00
166 INT225072 Binding of ETF1 1 0.02 2.55 0.63 5.00
167 INT49770 Binding of FCAR 7 0.26 0.86 0.62 5.00
168 INT236952 Positive_regulation of Gene_expression of Sparcl1 2 0.13 1.28 0.58 5.00
169 INT236960 Positive_regulation of Gene_expression of PDZD2 2 0.11 1.37 0.53 5.00
170 INT154449 Positive_regulation of Gene_expression of Aip 2 0.43 2.88 0.52 5.00
171 INT236943 Positive_regulation of Cxcr5 1 0.39 1.09 0.5 5.00
172 INT236950 Transcription of Cxcr5 1 0.45 1.07 0.49 5.00
173 INT236944 Positive_regulation of Transcription of Cxcl13 1 0.38 1.13 0.49 5.00
174 INT236957 Transcription of PDZD2 1 0.06 1.11 0.49 5.00
175 INT170736 Gene_expression of Ccl27a 3 0.48 2.05 0.47 5.00
176 INT160663 Positive_regulation of Dazap2 3 0.27 1.92 0.47 5.00
177 INT35699 Binding of Umod 3 0.41 2.3 0.46 5.00
178 INT236948 Positive_regulation of Gene_expression of Col5a1 1 0.10 1.15 0.41 5.00
179 INT129302 Positive_regulation of Gene_expression of TREH 4 0.49 1.28 0.37 5.00
180 INT296949 Transcription of ISM1 1 0.21 1.92 0.36 5.00
181 INT273027 Regulation of Negative_regulation of FXYD1 1 0.05 1.19 0.35 5.00
182 INT247999 Negative_regulation of FXYD1 2 0.06 1.75 0.35 5.00
183 INT225076 Positive_regulation of Binding of IGHG3 2 0.50 0.92 0.26 5.00
184 INT107643 Positive_regulation of Positive_regulation of Arigg4 2 0.02 1.72 0.25 5.00
185 INT356135 Positive_regulation of Binding of Aip 1 0.09 0.81 0.24 5.00
186 INT356136 Negative_regulation of Localization of Aip 1 0.08 0.88 0.23 5.00
187 INT246083 Positive_regulation of Cacna1d 1 0.02 0.89 0.22 5.00
188 INT225077 Positive_regulation of Binding of ETF1 1 0.03 0.82 0.21 5.00
189 INT167038 Binding of Aip 2 0.21 2.13 0.19 5.00
190 INT236954 Binding of Cxcl13 1 0.29 1.13 0.17 5.00
191 INT228976 Binding of MCAT 3 0.06 3.45 0.17 5.00
192 INT236946 Binding of Cxcr5 1 0.41 1.13 0.17 5.00
193 INT19706 Binding of Arigg4 2 0.02 1.76 0.16 5.00
194 INT296948 Negative_regulation of ISM1 1 0.16 1.04 0.14 5.00
195 INT168503 Binding of FUS 5 0.29 5.12 0.12 5.00
196 INT225075 Positive_regulation of Gene_expression of NKRF 1 0.18 0.26 0.04 5.00
197 INT225074 Gene_expression of NKRF 1 0.24 0.26 0.04 5.00
198 INT273026 Localization of FXYD1 1 0.08 1.53 0 5.00
199 INT225069 Localization of NKRF 1 0.31 0.66 0 5.00
200 INT228975 Gene_expression of SERPINA2 1 0.31 1.61 0 5.00
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