D:Rickets

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pChart

Disease Term
Synonyms Hypophosphataemic Rickets, HYPOPHOSPHATAEMIC RICKETTS, Hypophosphatemic Rickets, Hypophosphatemic Ricketts, Hypovitaminosis D, INFANTILE OSTEOMALACIA, OSTEOMALACIA, Rachitides, Rachitis, Ricketts, Vitamin D Deficiency Disease
Documents 569
Hot Single Events 200
Hot Interactions 11

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Rickets. They are ordered first by their relevance to Rickets and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT266837 Dmp1 Negative_regulation of Gene_expression of Fgf23 1 0.48 2.41 0 98.32
2 INT266839 Fgf23 Negative_regulation of Slc34a1 1 0.21 0.88 0 98.20
3 INT262170 Nr1i2 Positive_regulation of Gene_expression of Cyp24a1 1 0.29 0.4 0 97.56
4 INT262216 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Vdr 1 0.29 0.44 0.08 95.76
5 INT262145 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp24a1 1 0.29 0.45 0.06 94.00
6 INT239081 Binding of GH1 and MAS1 1 0.03 1.41 0.15 93.48
7 INT266833 Phex Regulation of Gene_expression of Fgf23 1 0.23 0.46 0 89.00
8 INT239080 Binding of PPY and KAT2B 1 0.02 2.38 0 86.88
9 INT266834 Pth Negative_regulation of Positive_regulation of Grxcr1 1 0.04 0.51 0 85.56
10 INT262219 Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07 82.48
11 INT262143 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07 82.48
12 INT75355 Negative_regulation of GCG Regulation of Gh 1 0.01 1.26 0.18 78.08
13 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 77.24
14 INT75356 GCG Regulation of Gh 1 0.01 1.25 0.18 76.96
15 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08 73.24
16 INT295006 Binding of TNFRSF11A and Tnfrsf11b 2 0.10 1.6 0.04 73.24
17 INT262163 Positive_regulation of Binding of Nr1i2 and Plec 1 0.04 0.31 0.09 63.28
18 INT262157 Binding of Nr1i2 and Plec 1 0.03 0.3 0.09 60.72
19 INT262196 Nr1i2 Negative_regulation of Vdr 1 0.27 0.14 0.04 60.32
20 INT262221 Nr1i2 Negative_regulation of Cyp24a1 1 0.27 0.15 0.04 60.32
21 INT262166 Binding of Nr1i2 and Vdr 1 0.23 0.14 0.04 60.32
22 INT262151 Vdr Regulation of Cyp24a1 1 0.24 0.24 0.23 60.08
23 INT335019 Fgf23 Positive_regulation of Phosphorylation of Mapk1 1 0.08 0.45 0 58.88
24 INT262154 Vdr Negative_regulation of Cyp24a1 1 0.16 0.14 0.04 58.60
25 INT262194 Rhof Positive_regulation of Nr1i2 1 0.15 0.64 0.27 52.64
26 INT262164 Positive_regulation of Rhof Positive_regulation of Nr1i2 1 0.11 0.65 0.27 52.64
27 INT335021 Fgf23 Negative_regulation of Gene_expression of Cyp27b1 1 0.53 1.49 0.21 52.24
28 INT266835 Pth Regulation of Slc34a3 1 0.19 0.07 0 50.00
29 INT266836 Pth Regulation of Slc34a1 1 0.09 0.07 0 50.00
30 INT266838 Fgf23 Regulation of Slc34a1 1 0.13 0.3 0 50.00
31 INT352547 Binding of CFTR and DMD 1 0.01 1.42 0.35 45.56
32 INT335017 Fgf23 Positive_regulation of Fgfr1 1 0.23 0.59 0.04 43.52
33 INT335016 Fgf23 Negative_regulation of Gene_expression of Slc34a3 1 0.03 0.63 0.03 40.48
34 INT339272 VDR Positive_regulation of Gene_expression of KRT20 1 0.00 0.07 0.05 36.72
35 INT354923 Binding of VDR and Uvbs1 1 0.00 0.83 0 17.44
36 INT197647 DPH1 Negative_regulation of VDR 1 0.02 0.58 0.18 9.36
37 INT262165 Nr0b2 Negative_regulation of Nr5a2 1 0.02 0.5 0.92 5.00
38 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
39 INT186672 IL8 Positive_regulation of Transcription of PTH 1 0.01 1.83 0.85 5.00
40 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 5.00
41 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71 5.00
42 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67 5.00
43 INT339275 Il6 Regulation of KRT20 1 0.00 3.11 0.49 5.00
44 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45 5.00
45 INT262220 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Abcc2 1 0.14 0.25 0.44 5.00
46 INT186673 IL8 Positive_regulation of Positive_regulation of PTH 1 0.01 0.92 0.42 5.00
47 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4 5.00
48 INT171990 Binding of DMD and VDR 5 0.05 2.58 0.39 5.00
49 INT262205 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.33 0.11 0.38 5.00
50 INT262153 Binding of Clta and Nr1i2 1 0.05 0.65 0.38 5.00
51 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36 5.00
52 INT262189 Binding of Nr1i2 and Nr1h4 1 0.14 0.18 0.36 5.00
53 INT262218 Nr1h4 Regulation of Nr1i2 1 0.10 0.15 0.34 5.00
54 INT335027 Binding of Vdr and Fgf23 1 0.24 0.34 0.29 5.00
55 INT262208 Clta Positive_regulation of Nr1i2 1 0.09 0.59 0.29 5.00
56 INT262144 Nr1h4 Positive_regulation of Positive_regulation of Nr1i2 1 0.19 0.19 0.27 5.00
57 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 5.00
58 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26 5.00
59 INT262202 Nr1i2 Regulation of Abcc2 1 0.19 0.12 0.25 5.00
60 INT262180 Nr1h4 Regulation of Sult2a1 1 0.11 0.11 0.25 5.00
61 INT262152 Nr1h4 Regulation of Abcc2 1 0.07 0.12 0.25 5.00
62 INT262200 Nr1i2 Regulation of Sult2a1 1 0.31 0.12 0.25 5.00
63 INT262167 Binding of Nr1i2 and Nr0b2 1 0.15 0.11 0.25 5.00
64 INT335028 Fgf15 Positive_regulation of Fgfr4 1 0.40 0.31 0.25 5.00
65 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24 5.00
66 INT262179 Nr1i2 Regulation of Gene_expression of Nr0b2 1 0.09 0.07 0.24 5.00
67 INT335015 Fgf15 Negative_regulation of Gene_expression of Cyp7a1 1 0.57 0.2 0.24 5.00
68 INT262211 Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23 5.00
69 INT262159 Positive_regulation of Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23 5.00
70 INT283520 Binding of DLAT and Pain1 1 0.27 0.65 0.22 5.00
71 INT335025 Gm7647 Positive_regulation of Gene_expression of Fgf21 1 0.01 0.29 0.21 5.00
72 INT262178 Binding of Nr1i2 and Abcb1b 1 0.07 1.68 0.21 5.00
73 INT262210 Negative_regulation of Nr1i2 Negative_regulation of Positive_regulation of Cyp3a11 1 0.31 0.4 0.2 5.00
74 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2 5.00
75 INT335020 Fgf23 Positive_regulation of Gene_expression of Cyp24a1 1 0.62 0.82 0.18 5.00
76 INT335018 Vdr Positive_regulation of Gene_expression of Fgf23 1 0.44 0.36 0.17 5.00
77 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14 5.00
78 INT197645 DPH1 Positive_regulation of SHBG 1 0.02 0.06 0.14 5.00
79 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14 5.00
80 INT334541 Binding of HIVEP1 and TNF 1 0.01 1.32 0.13 5.00
81 INT335026 Positive_regulation of Fgf23 Positive_regulation of Gene_expression of Cyp24a1 1 0.45 0.2 0.13 5.00
82 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13 5.00
83 INT305287 Renbp Regulation of FRTS 1 0.02 0.06 0.13 5.00
84 INT262193 Binding of Nr1i2 and Sfn 1 0.15 0.26 0.13 5.00
85 INT335024 Positive_regulation of Fgf23 Negative_regulation of Gene_expression of Cyp27b1 1 0.39 0.19 0.13 5.00
86 INT262185 Positive_regulation of Binding of Ncoa1 and Nr1i2 1 0.04 0.56 0.12 5.00
87 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12 5.00
88 INT238036 Binding of ENPP1 and OPLL 1 0.27 0.66 0.12 5.00
89 INT262148 Positive_regulation of Nr1i2 Positive_regulation of Abcb1b 1 0.09 0.69 0.12 5.00
90 INT262197 Nr1i2 Positive_regulation of Insig1 2 0.23 0 0.12 5.00
91 INT262206 Sfn Negative_regulation of Nr1i2 1 0.17 0.28 0.12 5.00
92 INT262146 Binding of Ncoa1 and Nr1i2 1 0.03 0.56 0.11 5.00
93 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11 5.00
94 INT262141 Edcs1 Positive_regulation of Nr1i2 1 0.02 0 0.1 5.00
95 INT352555 DKK1 Positive_regulation of Wnt2 1 0.01 0.25 0.1 5.00
96 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09 5.00
97 INT283460 Binding of CTLA4 and DLAT 1 0.06 3.14 0.09 5.00
98 INT308225 Alb Positive_regulation of Binding of EIF4G2 1 0.02 0.33 0.09 5.00
99 INT262142 Edcs1 Regulation of Nr1i2 1 0.01 0 0.09 5.00
100 INT270777 Binding of DMD and BPs 1 0.01 0.33 0.09 5.00
101 INT197644 NR1I2 Negative_regulation of Positive_regulation of CYP3A 1 0.02 0.47 0.08 5.00
102 INT197650 NR1I2 Negative_regulation of Positive_regulation of CYP2A 1 0.02 0.47 0.08 5.00
103 INT197652 NR1I2 Positive_regulation of Positive_regulation of CYP2A 1 0.02 0.47 0.08 5.00
104 INT262176 Nr1i2 Regulation of Regulation of Casr 1 0.11 0.17 0.07 5.00
105 INT262161 Nr1i2 Positive_regulation of Gene_expression of Cyp27a1 1 0.29 0.24 0.07 5.00
106 INT262168 Nr1i2 Regulation of Casr 1 0.07 0.17 0.07 5.00
107 INT197649 NR1I2 Positive_regulation of VDR 1 0.15 0.54 0.07 5.00
108 INT262147 Nr1i2 Regulation of Gene_expression of Cyp2j8 1 0.00 0.07 0.07 5.00
109 INT283521 PREB Regulation of Fam89b 1 0.00 1.08 0.07 5.00
110 INT197648 ESRRB Positive_regulation of VDR 1 0.03 0.54 0.07 5.00
111 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06 5.00
112 INT262190 Foxo1 Positive_regulation of Pck1 1 0.04 0.15 0.06 5.00
113 INT262175 Nr1i2 Positive_regulation of Gene_expression of Abca1 1 0.24 0.21 0.06 5.00
114 INT262187 Nr1i2 Positive_regulation of Gene_expression of Abcg1 1 0.24 0.21 0.06 5.00
115 INT305288 Gtf3a Regulation of Binding of Renbp and Renbp 1 0.00 0 0.06 5.00
116 INT262209 Positive_regulation of Nr1i2 Positive_regulation of Transcription of Ppig 1 0.03 0 0.06 5.00
117 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06 5.00
118 INT262233 Nr1i2 Negative_regulation of SOD1 1 0.03 0.23 0.05 5.00
119 INT335023 Fgf21 Positive_regulation of Gene_expression of Igf1 1 0.49 0.65 0.05 5.00
120 INT262230 SOD1 Regulation of Nr1i2 1 0.02 0.3 0.05 5.00
121 INT238034 Binding of DMD and SNRNP70 1 0.00 1.18 0.04 5.00
122 INT241536 Binding of Abcb1b and Abcg2 1 0.10 0.17 0.04 5.00
123 INT326625 Binding of ALB and Trf 1 0.01 0.64 0.04 5.00
124 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04 5.00
125 INT197646 DPH1 Negative_regulation of Localization of BGLAP 1 0.01 0.26 0.04 5.00
126 INT199526 Ceacam1 Negative_regulation of Col1a1 1 0.01 0.06 0.03 5.00
127 INT269759 PTH Positive_regulation of DMD 2 0.06 0.37 0.03 5.00
128 INT262162 Nr1i2 Regulation of Cyp2b9 1 0.14 0.14 0.03 5.00
129 INT262195 Nr1i2 Positive_regulation of Srebf1 1 0.08 0.18 0.03 5.00
130 INT262198 Foxo1 Positive_regulation of Igfbp1 1 0.11 0.08 0.03 5.00
131 INT238035 Binding of LEPR and OPLL 1 0.01 0.43 0.03 5.00
132 INT262177 Nr1i2 Positive_regulation of Cd36 1 0.16 0.18 0.03 5.00
133 INT262171 Binding of Cyp3a11 and Rare1 1 0.02 0.15 0.03 5.00
134 INT262217 Casr Regulation of Cyp3a11 1 0.05 0.13 0.03 5.00
135 INT238033 Binding of COL6A1 and OPLL 1 0.13 0.13 0.03 5.00
136 INT262149 Binding of Nfe2l2 and Rare1 1 0.03 0.32 0.03 5.00
137 INT283463 Binding of DLAT and GAGE4 1 0.00 1.1 0.03 5.00
138 INT270775 PTH Regulation of DMD 1 0.09 0.64 0.03 5.00
139 INT238032 Binding of SNRNP70 and OPLL 1 0.00 0.13 0.03 5.00
140 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03 5.00
141 INT270776 PTH Regulation of Negative_regulation of DMD 1 0.09 0.3 0.03 5.00
142 INT262150 Binding of Rare1 and Sfn 1 0.01 0.33 0.03 5.00
143 INT199527 Ceacam1 Negative_regulation of CYP27A1 1 0.02 0.06 0.03 5.00
144 INT262184 Binding of Nr1i2 and Rare1 1 0.03 0.15 0.03 5.00
145 INT262169 Binding of Foxa2 and Nr1i2 1 0.17 0.33 0 5.00
146 INT262203 Nr1i2 Positive_regulation of Gene_expression of Hmgcs2 1 0.23 0.22 0 5.00
147 INT280162 Twist1 Negative_regulation of Binding of MAPK8 and Twist1 1 0.18 0.78 0 5.00
148 INT262183 Foxa2 Positive_regulation of Gene_expression of Hmgcs2 1 0.10 0.22 0 5.00
149 INT335013 Fgf21 Positive_regulation of Localization of Ins1 1 0.06 0.58 0 5.00
150 INT280164 Twist1 Negative_regulation of Mod2 1 0.06 1.76 0 5.00
151 INT354919 Uvbs1 Positive_regulation of Binding of VDR and Uvbs1 1 0.00 0.13 0 5.00
152 INT262172 Nr1i2 Regulation of Msx2 1 0.12 0.53 0 5.00
153 INT262212 Positive_regulation of Nr1i2 Positive_regulation of Insig1 1 0.12 0 0 5.00
154 INT218973 Gen1 Regulation of Gene_expression of Pgr 1 0.06 0.09 0 5.00
155 INT262204 Nr1i2 Positive_regulation of Cyp3a11 1 0.33 0.08 0 5.00
156 INT262225 Binding of CYP3A4 and Nr1i2 1 0.13 0 0 5.00
157 INT218976 Dlst Positive_regulation of Gene_expression of PCNA 1 0.05 0.06 0 5.00
158 INT270780 BPs Positive_regulation of DMD 1 0.02 0 0 5.00
159 INT342265 Binding of VDR and HHIP 1 0.00 0.93 0 5.00
160 INT257589 Negative_regulation of Pth Positive_regulation of DMD 1 0.01 0 0 5.00
161 INT262213 Plec Positive_regulation of Cyp3a11 1 0.02 0 0 5.00
162 INT295007 Binding of DMD and Pth 1 0.00 0.07 0 5.00
163 INT340379 Binding of Rabep1 and Ocrl 1 0.08 0.62 0 5.00
164 INT335012 Fgf21 Positive_regulation of Gene_expression of Ins1 1 0.06 0.57 0 5.00
165 INT340380 Binding of Cfl1 and Clcn4-2 1 0.13 0.82 0 5.00
166 INT295004 Binding of Pth and Tnfrsf11b 1 0.07 0.06 0 5.00
167 INT257590 Pth Positive_regulation of DMD 2 0.02 0.44 0 5.00
168 INT197651 TNF Regulation of PTH 1 0.05 1.67 0 5.00
169 INT270778 Binding of TNFSF11 and CALCRL 1 0.00 0.44 0 5.00
170 INT354106 Binding of BCAT1 and PTH 1 0.04 0 0 5.00
171 INT280166 Binding of MAPK8 and Twist1 1 0.19 0.78 0 5.00
172 INT262215 Binding of Nr1i2 and Dnajc7 1 0.08 0.26 0 5.00
173 INT255385 Binding of COL1A2 and DSPP 1 0.40 0.12 0 5.00
174 INT255384 Binding of AKR1C2 and DSG1 1 0.01 1.54 0 5.00
175 INT335022 Fgf15 Regulation of Pbx1 1 0.15 0.17 0 5.00
176 INT262191 Binding of Nr1i2 and Foxo1 1 0.22 0.09 0 5.00
177 INT262223 Negative_regulation of Nr1i2 Negative_regulation of Gene_expression of CYP3A4 1 0.21 0.48 0 5.00
178 INT354105 BCAT1 Regulation of PTH 1 0.07 0.48 0 5.00
179 INT340378 Binding of Cfl1 and Clcn5 1 0.15 0.82 0 5.00
180 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0 5.00
181 INT241537 Negative_regulation of Binding of Abl1 and Src 1 0.04 0.14 0 5.00
182 INT262156 Nr1i2 Negative_regulation of Gene_expression of Hmgcs2 1 0.22 0.22 0 5.00
183 INT262174 Binding of Casr and Foxo1 1 0.05 0.09 0 5.00
184 INT262192 Nr1i2 Regulation of Positive_regulation of Cyp3a11 1 0.32 0 0 5.00
185 INT241539 Binding of Abl1 and Lyn 1 0.09 0.14 0 5.00
186 INT280167 Twist1 Positive_regulation of MAPK8 1 0.29 0.94 0 5.00
187 INT262199 Binding of Cyp2b9 and Rare1 1 0.01 0.15 0 5.00
188 INT280163 Twist1 Positive_regulation of Mod2 1 0.07 1.67 0 5.00
189 INT218974 Gen1 Negative_regulation of Gnrh1 1 0.13 0.16 0 5.00
190 INT241534 Binding of Abl1 and Src 1 0.04 0.14 0 5.00
191 INT218975 Dlst Negative_regulation of Gnrh1 1 0.16 0.16 0 5.00
192 INT197643 TNF Regulation of VDR 1 0.04 1.67 0 5.00
193 INT340377 Binding of Clcn4-2 and Clcn5 1 0.35 0.82 0 5.00
194 INT283461 Binding of IL2 and SLC4A2 1 0.01 0.98 0 5.00
195 INT238031 Binding of COL11A2 and OPLL 1 0.10 0.3 0 5.00
196 INT241538 Negative_regulation of Binding of Abl1 and Lyn 1 0.11 0.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Rickets. They are ordered first by their pain relevance and then by number of times they were reported in Rickets. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT118373 Gene_expression of Fgf23 16 0.77 29.62 1.04 100.00
2 INT16003 Gene_expression of Phex 3 0.65 4.68 0.77 100.00
3 INT136964 Gene_expression of Dmp1 10 0.75 3.69 2.83 100.00
4 INT117827 Positive_regulation of PHEX 3 0.41 1.59 0.08 100.00
5 INT120540 Negative_regulation of FGF23 1 0.38 2.16 0.11 100.00
6 INT130802 Localization of FGF23 2 0.17 1.78 0.2 100.00
7 INT130799 Localization of Fgf23 2 0.63 1.94 0.28 100.00
8 INT145009 Positive_regulation of Negative_regulation of VDR 2 0.41 1.18 0.25 100.00
9 INT1893 Localization of Gh 1041 0.79 340.23 256.58 99.98
10 INT98642 Binding of FGF23 1 0.22 1.46 0.09 99.98
11 INT98640 Binding of Phex 1 0.13 1.44 0.09 99.98
12 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 99.92
13 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 99.92
14 INT156850 Binding of VDR 40 0.47 24.86 4.87 99.92
15 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 99.92
16 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.92
17 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 99.92
18 INT59083 Positive_regulation of Gene_expression of IL1A 11 0.70 9.09 4.48 99.92
19 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.92
20 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 99.92
21 INT266832 Positive_regulation of Grxcr1 9 0.12 7.91 0.19 99.90
22 INT169072 Gene_expression of Nr1h4 7 0.60 6.23 2.18 99.88
23 INT118371 Positive_regulation of Fgf23 15 0.69 25.34 0.85 99.84
24 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 99.84
25 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69 99.80
26 INT334993 Negative_regulation of Gene_expression of Fgf23 1 0.38 4.1 0 99.78
27 INT57326 Regulation of Positive_regulation of CYP2B6 4 0.44 2.08 0.43 99.78
28 INT125727 Positive_regulation of FGF23 5 0.69 4.04 0.53 99.74
29 INT121943 Positive_regulation of Nr1i2 64 0.68 19.22 8.39 99.74
30 INT125729 Positive_regulation of MAMLD1 1 0.49 0.72 0.14 99.74
31 INT39265 Positive_regulation of Tapbp 2 0.17 2.28 0.08 99.70
32 INT98645 Gene_expression of FGF23 9 0.78 10.07 0.8 99.68
33 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 99.66
34 INT67624 Gene_expression of Phex 3 0.26 4.15 1.67 99.62
35 INT266822 Negative_regulation of Grxcr1 10 0.10 8.12 0.17 99.58
36 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 99.56
37 INT287118 Negative_regulation of Gene_expression of VDR 3 0.36 3.53 0.66 99.48
38 INT130798 Positive_regulation of Gene_expression of Fgf23 2 0.59 1.12 0.2 99.46
39 INT98643 Positive_regulation of Gene_expression of FGF23 2 0.47 2.16 0.13 99.42
40 INT69282 Binding of PHEX 4 0.15 1.43 0.41 99.40
41 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 99.32
42 INT130797 Gene_expression of Fgf23 6 0.66 4.73 0.77 99.24
43 INT135880 Positive_regulation of Gene_expression of Fgf23 4 0.46 7.52 0.29 99.08
44 INT238041 Binding of OPLL 7 0.27 2.95 0.54 99.08
45 INT320989 Phosphorylation of Gc 1 0.07 0.83 0.05 99.08
46 INT102638 Regulation of VDR 21 0.44 9.92 2.54 99.04
47 INT162061 Regulation of Gene_expression of FGF23 1 0.45 1.02 0.07 98.92
48 INT262095 Positive_regulation of Gene_expression of Cyp24a1 1 0.40 2.58 0.44 98.86
49 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 98.84
50 INT335007 Protein_catabolism of Fgf23 1 0.59 1.28 0.03 98.84
51 INT262048 Positive_regulation of Gene_expression of Cyp27a1 1 0.18 0.68 0.08 98.84
52 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 98.76
53 INT33097 Negative_regulation of PHEX 3 0.14 0.41 0.82 98.72
54 INT266818 Localization of Grxcr1 7 0.12 3.9 0 98.68
55 INT129901 Gene_expression of Nr1i2 60 0.73 22.44 6.04 98.68
56 INT118372 Regulation of Fgf23 4 0.55 3.31 0.15 98.64
57 INT135133 Binding of NR1I2 7 0.42 1.7 0.29 98.60
58 INT55964 Localization of PHB2 1 0.39 0.79 0.07 98.60
59 INT262123 Gene_expression of Cyp24a1 17 0.67 6.67 1.38 98.58
60 INT262099 Negative_regulation of Gene_expression of Cyp27a1 1 0.17 0.68 0.08 98.56
61 INT262061 Negative_regulation of Gene_expression of Abca1 1 0.19 0.68 0.08 98.56
62 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 98.54
63 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 98.52
64 INT70263 Negative_regulation of Cyp39a1 2 0.05 0.96 0 98.44
65 INT29582 Negative_regulation of BBS9 8 0.57 8.3 1.48 98.40
66 INT262130 Negative_regulation of Gene_expression of Cyp24a1 1 0.33 1.37 0.37 98.32
67 INT69283 Gene_expression of PHEX 25 0.75 7.81 0.64 98.32
68 INT43907 Binding of CD79A 28 0.48 28.11 3.04 98.32
69 INT266828 Negative_regulation of Fgf23 3 0.42 5.63 0.04 98.28
70 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 98.28
71 INT262096 Gene_expression of Cyp27a1 1 0.30 1.21 0.32 98.12
72 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 98.08
73 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 98.00
74 INT9500 Negative_regulation of Ceacam1 26 0.58 6.89 3.91 97.96
75 INT134901 Negative_regulation of Fah 1 0.20 0.87 0.1 97.92
76 INT107731 Negative_regulation of Cyp2d9 2 0.02 0.49 0.16 97.64
77 INT190081 Gene_expression of Abca1 21 0.65 18.18 2.45 97.64
78 INT136981 Positive_regulation of Gene_expression of Nr1i2 2 0.65 3.63 1.34 97.56
79 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 97.52
80 INT262087 Gene_expression of Cyp2d9 1 0.01 1.64 0.44 97.48
81 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 97.36
82 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 97.36
83 INT15588 Regulation of PHEX 4 0.26 1.48 0.39 97.32
84 INT166755 Localization of PHEX 2 0.73 1.16 0.28 97.32
85 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 97.20
86 INT9118 Gene_expression of Ceacam1 37 0.75 17.19 6.12 97.20
87 INT30381 Localization of CLPP 2 0.54 0.19 0.32 97.12
88 INT98639 Positive_regulation of Gene_expression of Phex 1 0.24 1.26 0.06 97.04
89 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 96.96
90 INT159112 Transcription of MT1F 2 0.60 0.71 0.23 96.40
91 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 96.24
92 INT266825 Positive_regulation of Regulation of Fgf23 1 0.46 0.25 0 96.16
93 INT39500 Positive_regulation of Positive_regulation of Pth 14 0.48 9.75 1.28 96.12
94 INT36770 Positive_regulation of Localization of Pth 14 0.70 10.42 0.46 96.12
95 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 95.96
96 INT160642 Positive_regulation of Gene_expression of Vdr 5 0.62 1.61 0.42 95.76
97 INT160633 Gene_expression of Vdr 21 0.77 10.01 2.73 95.76
98 INT98641 Transcription of Phex 1 0.23 2.89 0.17 95.44
99 INT98644 Transcription of FGF23 1 0.41 2.83 0.17 95.44
100 INT159113 Binding of MT1F 5 0.42 1.85 0.23 95.44
101 INT334975 Gene_expression of Fgf15 1 0.74 7.12 2.02 95.12
102 INT4097 Localization of Pth 66 0.81 47.17 4.36 95.08
103 INT34358 Binding of MME 13 0.37 7.25 5.14 94.88
104 INT320985 Positive_regulation of Localization of Pth 1 0.37 1.26 0.08 94.80
105 INT136982 Positive_regulation of Positive_regulation of Nr1i2 3 0.65 4.66 2.89 94.72
106 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 94.64
107 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 94.64
108 INT169756 Binding of CFTR 9 0.35 9.65 4.55 94.64
109 INT266819 Regulation of Localization of Grxcr1 2 0.06 1.28 0 94.48
110 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 94.44
111 INT98018 Protein_catabolism of FGF23 2 0.65 1.58 0.17 94.28
112 INT266829 Regulation of Cyp39a1 1 0.02 0.44 0 94.24
113 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 94.16
114 INT30040 Negative_regulation of TYRP1 11 0.51 2.72 2.54 94.12
115 INT23030 Positive_regulation of Pth 13 0.61 9.24 0.97 94.00
116 INT125804 Localization of Pth 9 0.69 3.93 0.29 94.00
117 INT266830 Regulation of Slc34a3 1 0.42 1.85 0 93.84
118 INT545 Binding of GC 15 0.45 10.74 3.47 93.68
119 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 93.64
120 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 93.64
121 INT167957 Gene_expression of Grxcr1 8 0.10 3.43 0.14 93.60
122 INT9683 Binding of GH1 57 0.47 21.14 5.99 93.48
123 INT45894 Negative_regulation of PTRH1 1 0.37 1.11 0.07 93.40
124 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 93.36
125 INT125726 Localization of CANT1 1 0.68 0.72 0.14 93.36
126 INT266821 Positive_regulation of Negative_regulation of Grxcr1 1 0.06 1.51 0.06 93.20
127 INT152395 Binding of SLC34A3 1 0.09 1.27 0.08 92.88
128 INT2649 Regulation of Calca 433 0.62 146.05 330.95 92.84
129 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03 92.84
130 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 92.72
131 INT12598 Binding of DBP 20 0.48 13.11 3.62 92.60
132 INT266831 Positive_regulation of Slc34a3 1 0.47 1.79 0 92.56
133 INT266820 Positive_regulation of Positive_regulation of Grxcr1 1 0.06 1.58 0.06 92.40
134 INT2336 Negative_regulation of Lct 51 0.58 33.79 13.73 92.28
135 INT125728 Localization of MAMLD1 1 0.68 1.44 0.28 92.08
136 INT22413 Positive_regulation of Cyp39a1 2 0.08 2.49 0.09 91.96
137 INT266823 Regulation of Grxcr1 3 0.06 1.4 0.03 91.92
138 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98 91.88
139 INT3343 Regulation of PTH 24 0.62 11.18 1.62 91.76
140 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 91.60
141 INT38886 Positive_regulation of Regulation of ICT1 1 0.34 0.91 0.1 91.52
142 INT38883 Regulation of Positive_regulation of ICT1 1 0.20 0.91 0.1 91.52
143 INT38884 Regulation of PTRH1 1 0.14 0.91 0.1 91.52
144 INT38885 Regulation of ICT1 3 0.20 2.02 0.26 91.52
145 INT334991 Positive_regulation of Positive_regulation of Fgf23 1 0.39 1.5 0 91.48
146 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02 91.16
147 INT8841 Positive_regulation of ICT1 3 0.34 2.27 0.17 90.96
148 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 90.92
149 INT112215 Binding of Vdr 4 0.31 2.43 0.44 90.84
150 INT70602 Regulation of Phex 3 0.13 1.51 1.06 90.60
151 INT334997 Localization of Fgf23 1 0.72 3.56 0 90.56
152 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 90.48
153 INT70262 Gene_expression of Pth 8 0.66 5.64 0.12 90.40
154 INT146805 Positive_regulation of Gene_expression of Pth 4 0.49 4.2 0.07 90.40
155 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3 90.40
156 INT22812 Positive_regulation of PTRH1 4 0.49 3.06 0.43 90.32
157 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04 90.32
158 INT67169 Negative_regulation of GOT2 2 0.36 0.94 0.25 90.32
159 INT334546 Negative_regulation of SNORD32A 1 0.36 0.46 0 90.32
160 INT101550 Negative_regulation of Negative_regulation of EMP1 1 0.42 0.98 0.09 90.28
161 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 90.16
162 INT144019 Negative_regulation of Pdgfrb 21 0.58 14.93 1.26 89.84
163 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 89.68
164 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05 89.68
165 INT320988 Regulation of Gc 3 0.13 2.52 0.62 89.52
166 INT177337 Localization of VDR 6 0.73 3.44 0.59 89.40
167 INT258430 Localization of MRPL49 2 0.11 1.52 0.03 89.32
168 INT266826 Binding of Fgf23 1 0.32 1.26 0.07 88.96
169 INT130800 Localization of Mepe 1 0.30 0.46 0 88.96
170 INT5852 Gene_expression of Penk 167 0.78 44.44 71.13 88.88
171 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 88.88
172 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 88.76
173 INT101549 Negative_regulation of EMP1 8 0.57 1.82 1.01 88.76
174 INT130801 Localization of SFRP4 4 0.28 2.41 0.49 88.56
175 INT149237 Gene_expression of Slc34a3 2 0.42 2.22 0.39 88.48
176 INT340368 Binding of Ocrl 1 0.37 2.61 0 88.16
177 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 87.76
178 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 87.60
179 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 87.48
180 INT177312 Negative_regulation of Gene_expression of GNAS 2 0.05 0.46 0 87.28
181 INT743 Negative_regulation of Salpa1 16 0.57 8.75 3.1 87.20
182 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 87.08
183 INT218315 Gene_expression of RBP4 25 0.76 18.19 0.85 87.08
184 INT233570 Gene_expression of Rbp4 4 0.66 3.4 0.17 87.08
185 INT266827 Positive_regulation of Mepe 1 0.67 1.25 0 86.88
186 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 86.88
187 INT37758 Gene_expression of GC 10 0.75 7.09 1.75 86.80
188 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 86.56
189 INT70781 Positive_regulation of Dpyd 6 0.54 2.51 1.26 86.48
190 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9 86.36
191 INT6513 Positive_regulation of Gene_expression of BGLAP 24 0.67 11.69 3.96 86.36
192 INT112214 Gene_expression of Vdr 4 0.33 3.59 1.11 86.28
193 INT104906 Negative_regulation of Alpl 5 0.31 1.72 0.21 86.24
194 INT266824 Regulation of Positive_regulation of Fgf23 1 0.27 1.22 0 86.16
195 INT56918 Negative_regulation of TAT 11 0.57 5.92 2.44 86.04
196 INT97149 Binding of Dpyd 3 0.14 1.73 0.25 85.84
197 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 85.80
198 INT186541 Positive_regulation of ADRA1A 3 0.45 2.29 0.86 85.36
199 INT62067 Negative_regulation of Gene_expression of Pth 13 0.41 8.24 0.61 85.16
200 INT2723 Gene_expression of Salpa1 16 0.64 11.78 3.5 84.88
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