D:Rotator Cuff Tears

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Disease Term
Synonyms ROTATOR CUFF INJURIES, ROTATOR CUFF INJURY, Rotator Cuff Repair, Rotator Cuff Repairs, Rotator Cuff Tear
Documents 674
Hot Single Events 61
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Rotator Cuff Tears. They are ordered first by their relevance to Rotator Cuff Tears and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT330514 Vegfa Positive_regulation of VEGFA 1 0.18 0.5 0.18 86.44
2 INT339260 EPAS1 Positive_regulation of VEGFA 1 0.19 3.67 0 82.96
3 INT348924 Mmp1 Regulation of Gene_expression of Renbp 1 0.03 0.95 0.26 73.60
4 INT339262 EPAS1 Positive_regulation of Gene_expression of VEGFA 1 0.14 0.23 0 60.56
5 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4 5.00
6 INT266006 Binding of COL5A2 and SGCG 1 0.00 0.89 0.23 5.00
7 INT242094 Binding of ACLY and Pts 1 0.01 0 0.22 5.00
8 INT266005 Binding of DIO3 and SGCG 1 0.00 0.86 0.22 5.00
9 INT266003 Binding of COL5A2 and DIO3 1 0.01 0.43 0.11 5.00
10 INT332588 Binding of RAPH1 and MND1 1 0.01 3.88 0.07 5.00
11 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 0.00 2.21 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Rotator Cuff Tears. They are ordered first by their pain relevance and then by number of times they were reported in Rotator Cuff Tears. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT149259 Gene_expression of RCT 38 0.67 15.73 3.87 100.00
2 INT168418 Positive_regulation of RCT 32 0.55 20.2 4.07 100.00
3 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 100.00
4 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.96
5 INT110809 Gene_expression of Mmp1 20 0.75 18 14.49 99.82
6 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89 99.48
7 INT140503 Negative_regulation of Gene_expression of Mmp3 7 0.44 5.93 6.08 99.48
8 INT118217 Regulation of Cuzd1 2 0.30 2.36 0.91 99.40
9 INT183672 Gene_expression of EPAS1 37 0.35 28.68 0.72 99.32
10 INT266250 Gene_expression of Lhb 28 0.64 10.75 4.66 99.32
11 INT200223 Positive_regulation of EPAS1 21 0.17 21.95 1.7 99.32
12 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 99.26
13 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 99.24
14 INT110810 Positive_regulation of Gene_expression of Mmp1 9 0.52 4.2 5.11 99.20
15 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 99.04
16 INT266251 Positive_regulation of Gene_expression of Lhb 4 0.42 3.26 2.13 98.44
17 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 98.44
18 INT330513 Protein_catabolism of Lhb 1 0.60 0.65 0.06 98.36
19 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 98.36
20 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48 98.04
21 INT110811 Positive_regulation of Mmp1 5 0.60 2.96 2.83 97.84
22 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 97.68
23 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28 97.68
24 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 97.44
25 INT111199 Gene_expression of Acly 11 0.16 5.65 0.78 97.44
26 INT329391 Positive_regulation of Gene_expression of Acly 1 0.12 0.68 0.06 97.44
27 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 97.20
28 INT56406 Regulation of Gene_expression of PROC 4 0.05 1.52 0.79 96.88
29 INT95636 Gene_expression of ACTG2 23 0.44 19.87 1.75 96.40
30 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 96.40
31 INT193015 Positive_regulation of Gene_expression of EPAS1 6 0.32 8.77 0.21 94.84
32 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 94.32
33 INT339266 Regulation of Gene_expression of EPAS1 3 0.11 2.92 0.14 94.20
34 INT173592 Binding of COL5A2 32 0.33 9.14 2.48 94.10
35 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 93.68
36 INT60860 Gene_expression of Slmap 32 0.66 8.55 1.34 93.44
37 INT99896 Positive_regulation of Gene_expression of Mmp23 5 0.38 4.52 1.8 93.08
38 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81 93.04
39 INT63822 Gene_expression of Mmp23 23 0.43 14.15 5.96 92.68
40 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 92.56
41 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 91.88
42 INT162803 Regulation of F5 3 0.44 3.68 0.81 91.24
43 INT110428 Negative_regulation of Gene_expression of Mmp23 6 0.17 4.88 1.33 90.80
44 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 89.52
45 INT177459 Negative_regulation of RCT 13 0.25 7.9 2.7 89.40
46 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 89.28
47 INT180684 Regulation of Gene_expression of Mmp1 2 0.44 0.88 1.06 88.52
48 INT118267 Negative_regulation of ARSD 14 0.36 8.27 1.44 88.04
49 INT22354 Positive_regulation of Lhb 13 0.63 2.15 3.74 87.84
50 INT293883 Positive_regulation of SLA 1 0.25 0.34 0.07 87.12
51 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 86.96
52 INT193016 Regulation of EPAS1 9 0.15 7.38 0.06 86.92
53 INT187616 Negative_regulation of Gene_expression of Mmp1 3 0.44 2.37 1.73 85.64
54 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 85.36
55 INT128717 Regulation of Tgfb1 6 0.61 1.94 0.94 84.64
56 INT50295 Regulation of Mtpn 13 0.26 7.54 3.77 84.64
57 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 84.64
58 INT118459 Regulation of Bmp7 3 0.43 0.25 0.15 84.64
59 INT197143 Positive_regulation of Renbp 15 0.33 9.41 1.31 82.12
60 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04 81.92
61 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 80.80
62 INT154018 Binding of Lhb 5 0.31 1.39 1.13 79.32
63 INT121106 Binding of Slmap 10 0.37 5.19 3.71 77.96
64 INT51757 Gene_expression of COBRA1 4 0.51 2.71 0.75 77.80
65 INT120860 Positive_regulation of Gene_expression of Col1a1 12 0.44 4.84 1.34 77.00
66 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77 76.60
67 INT37380 Negative_regulation of Sis 31 0.55 19.89 3.92 75.92
68 INT266254 Regulation of Lhb 4 0.31 0.43 0.76 75.84
69 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 75.32
70 INT1648 Regulation of LHB 21 0.61 3.32 9.6 75.00
71 INT37215 Positive_regulation of SMN1 18 0.45 8.99 4.87 74.12
72 INT224327 Negative_regulation of EPAS1 5 0.09 4.29 0.08 74.00
73 INT205618 Gene_expression of Renbp 15 0.26 9.26 1.04 73.60
74 INT123883 Positive_regulation of Gene_expression of Mmp3 16 0.60 4.42 3.74 72.88
75 INT339265 Negative_regulation of Gene_expression of EPAS1 2 0.15 2.67 0 66.32
76 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 64.16
77 INT348920 Negative_regulation of Positive_regulation of Mmp1 1 0.32 0.35 0.49 62.96
78 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85 58.32
79 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 56.24
80 INT207734 Negative_regulation of SRY 2 0.28 0.77 0 55.92
81 INT329390 Negative_regulation of Gene_expression of Acly 1 0.10 0.83 0.09 54.80
82 INT9095 Regulation of Gene_expression of COL7A1 24 0.57 10.55 4.88 54.16
83 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 53.28
84 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 53.28
85 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 50.08
86 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 50.00
87 INT113671 Negative_regulation of Mmp3 26 0.49 6.33 7.88 50.00
88 INT89791 Transcription of Mmp3 7 0.33 2.28 4.64 50.00
89 INT125710 Negative_regulation of Mmp1 3 0.42 0.92 1.04 50.00
90 INT354994 Positive_regulation of Transcription of CEBPB 1 0.01 0.68 0.12 47.72
91 INT354993 Transcription of CEBPB 1 0.01 0.63 0.12 47.00
92 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 44.16
93 INT114164 Negative_regulation of Slmap 2 0.32 0.92 0.32 43.56
94 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45 40.76
95 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 37.88
96 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 28.40
97 INT170472 Negative_regulation of Gene_expression of THY1 4 0.41 0.26 0.1 28.40
98 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 10.80
99 INT14448 Localization of COL5A2 34 0.67 17.35 2.85 10.56
100 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 5.00
101 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
102 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
103 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
104 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
105 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
106 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
107 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 5.00
108 INT5298 Negative_regulation of MTHFS 70 0.57 27.07 28.11 5.00
109 INT3167 Binding of KNG1 48 0.48 23.26 26.77 5.00
110 INT5511 Negative_regulation of Gene_expression of Pomc 47 0.59 12.08 23.02 5.00
111 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 5.00
112 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
113 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
114 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 5.00
115 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
116 INT8794 Negative_regulation of Ppt1 35 0.57 6.44 14.52 5.00
117 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
118 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
119 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96 5.00
120 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
121 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
122 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 5.00
123 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 5.00
124 INT144689 Regulation of RCT 49 0.53 25.91 9.6 5.00
125 INT35269 Localization of SGCG 38 0.78 14.68 9.01 5.00
126 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 5.00
127 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 5.00
128 INT112183 Gene_expression of CRCP 10 0.67 3.34 7.47 5.00
129 INT35584 Binding of ACLY 22 0.35 31.78 7.17 5.00
130 INT65480 Gene_expression of Pts 15 0.66 7.53 6.46 5.00
131 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
132 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 5.00
133 INT10138 Negative_regulation of Gene_expression of KNG1 13 0.57 9.57 4.9 5.00
134 INT20981 Binding of HRAS 42 0.48 24.49 4.23 5.00
135 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18 5.00
136 INT38066 Binding of MSC 14 0.41 5.28 4.12 5.00
137 INT82871 Protein_catabolism of MMP1 13 0.96 10.71 4.09 5.00
138 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97 5.00
139 INT169475 Localization of HRAS 14 0.73 9.02 3.9 5.00
140 INT38561 Regulation of SEMG1 19 0.51 3.75 3.66 5.00
141 INT122051 Negative_regulation of ROM1 17 0.48 9.11 3.38 5.00
142 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 5.00
143 INT75500 Negative_regulation of Gene_expression of CCND1 21 0.57 11.59 3.24 5.00
144 INT43907 Binding of CD79A 28 0.48 28.11 3.04 5.00
145 INT133144 Localization of Mtpn 18 0.24 7.88 2.77 5.00
146 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65 5.00
147 INT120124 Transcription of MMP3 9 0.69 2.15 2.38 5.00
148 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 5.00
149 INT120109 Negative_regulation of Timp2 8 0.33 3.28 2.23 5.00
150 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 5.00
151 INT39453 Negative_regulation of TCN2 12 0.59 3.98 2.13 5.00
152 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12 5.00
153 INT120106 Negative_regulation of Mmp13 8 0.51 2.25 2.08 5.00
154 INT15580 Gene_expression of TCN2 16 0.44 7.59 1.97 5.00
155 INT67604 Gene_expression of SERPINC1 14 0.67 11.47 1.72 5.00
156 INT73927 Gene_expression of FBL 10 0.48 3.55 1.72 5.00
157 INT74586 Negative_regulation of MMP8 6 0.27 1.68 1.64 5.00
158 INT243799 Gene_expression of PIK3CD 15 0.45 6.63 1.5 5.00
159 INT57785 Positive_regulation of SGCB 25 0.69 5.01 1.49 5.00
160 INT120111 Regulation of Mmp13 4 0.29 2.65 1.48 5.00
161 INT184206 Protein_catabolism of HRAS 22 0.66 7.86 1.46 5.00
162 INT181868 Localization of ACLY 5 0.62 6.36 1.4 5.00
163 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 5.00
164 INT272613 Gene_expression of Sis 7 0.58 3.48 1.36 5.00
165 INT37076 Negative_regulation of Binding of KNG1 3 0.14 1.77 1.32 5.00
166 INT120108 Transcription of Mmp13 3 0.51 0.22 1.22 5.00
167 INT188396 Positive_regulation of Positive_regulation of GOPC 13 0.42 1.78 1.21 5.00
168 INT118196 Gene_expression of ROM1 18 0.66 4.81 1.19 5.00
169 INT87988 Gene_expression of ASAH1 9 0.77 9.75 1.18 5.00
170 INT182285 Positive_regulation of Positive_regulation of COL5A2 2 0.13 0.37 1.07 5.00
171 INT165387 Regulation of ROM1 6 0.37 0.87 1.06 5.00
172 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 5.00
173 INT69132 Negative_regulation of ACLY 5 0.42 2.95 0.92 5.00
174 INT195616 Binding of ROM1 4 0.23 1.61 0.9 5.00
175 INT87344 Gene_expression of PTK2 90 0.78 59.03 0.87 5.00
176 INT160799 Regulation of IGFALS 11 0.29 9.09 0.7 5.00
177 INT120112 Negative_regulation of Timp3 2 0.05 1.15 0.64 5.00
178 INT120113 Positive_regulation of Mmp13 5 0.70 2.02 0.64 5.00
179 INT230410 Negative_regulation of Gene_expression of TNFAIP1 3 0.16 3.67 0.63 5.00
180 INT240281 Positive_regulation of IGFALS 11 0.31 10.44 0.56 5.00
181 INT44408 Positive_regulation of Sis 6 0.40 1.61 0.55 5.00
182 INT242093 Negative_regulation of Positive_regulation of COL5A2 1 0.08 0 0.53 5.00
183 INT73731 Binding of RAPH1 9 0.33 14.58 0.5 5.00
184 INT142550 Binding of Sis 3 0.31 1.98 0.47 5.00
185 INT120121 Transcription of NPEPPS 2 0.23 0.1 0.46 5.00
186 INT37381 Regulation of Sis 7 0.25 0.73 0.46 5.00
187 INT264689 Negative_regulation of IGFALS 10 0.33 12.58 0.45 5.00
188 INT266786 Binding of ASAH1 2 0.11 3.87 0.44 5.00
189 INT146917 Localization of Slmap 4 0.80 1.56 0.42 5.00
190 INT119001 Regulation of ACLY 5 0.44 4.83 0.36 5.00
191 INT257288 Regulation of Gene_expression of COL5A2 7 0.21 2.52 0.36 5.00
192 INT22665 Negative_regulation of MMP10 2 0.31 0.15 0.31 5.00
193 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 5.00
194 INT87338 Regulation of PTK2 10 0.62 4.75 0.21 5.00
195 INT168929 Gene_expression of PPR 3 0.48 0.17 0.21 5.00
196 INT36479 Binding of NR0B2 2 0.36 3.5 0.21 5.00
197 INT332592 Binding of MND1 1 0.08 9.21 0.16 5.00
198 INT229301 Gene_expression of NR0B2 3 0.18 3.49 0.16 5.00
199 INT175556 Regulation of Positive_regulation of PTH 3 0.39 2.34 0.12 5.00
200 INT120123 Negative_regulation of Transcription of MMP3 3 0.41 0.31 0.12 5.00
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