D:Symphalangism

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pChart

Disease Term
Synonyms Congenital Webbing Of Digits, Mule Foot, SYMPHALANGY, Syndactylia, Syndactylism, Syndactylus, Syndactyly, Webbed Digits
Documents 53
Hot Single Events 9
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Symphalangism. They are ordered first by their relevance to Symphalangism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT227399 Binding of D5Mit424 and Alms1 1 0.01 0.71 0 18.32
2 INT227398 Binding of H2afy and Alms1 1 0.01 1.42 0 18.32
3 INT177396 Npy1r Positive_regulation of Negative_regulation of Npy 1 0.27 0.38 0.37 5.00
4 INT177400 RNY1 Positive_regulation of Negative_regulation of Npy 1 0.03 0.38 0.37 5.00
5 INT177398 Binding of Npy1r and Npy 1 0.18 0.73 0.24 5.00
6 INT177397 Binding of Npy5r and Npy 1 0.16 0.73 0.24 5.00
7 INT231206 Binding of KCNH2 and KCNQ1 2 0.22 1.04 0.24 5.00
8 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
9 INT231223 Binding of KCNQ1 and Nav1 1 0.03 0.59 0.11 5.00
10 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 5.00
11 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00
12 INT210285 Ccrs1 Regulation of RAI1 1 0.00 0.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Symphalangism. They are ordered first by their pain relevance and then by number of times they were reported in Symphalangism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT85462 Binding of KTWS 3 0.31 2.91 0.54 97.68
2 INT239610 Localization of KCNQ1 4 0.62 1.47 0.2 96.72
3 INT130556 Binding of CACNA1C 3 0.22 1.84 0.4 85.60
4 INT136267 Binding of KCNQ1 3 0.36 3.28 0.28 85.60
5 INT333531 Regulation of CACNA1C 1 0.60 0.69 0 84.72
6 INT51584 Regulation of KCNQ1 10 0.44 3.21 1.84 84.24
7 INT123795 Positive_regulation of KCNQ1 13 0.49 3.53 2.65 82.72
8 INT86600 Gene_expression of KCNH2 37 0.78 14.88 6.14 82.24
9 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 80.88
10 INT230194 Negative_regulation of Gene_expression of PISRT1 1 0.30 0.81 0 78.72
11 INT84375 Regulation of COL1A2 6 0.44 8.75 1.72 77.64
12 INT230200 Gene_expression of PISRT1 1 0.53 0.8 0 77.60
13 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 75.28
14 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 71.44
15 INT23598 Binding of SCN5A 32 0.40 16 5.35 69.28
16 INT86602 Binding of KCNH2 14 0.36 4.65 2.58 68.64
17 INT183820 Regulation of BCAR1 4 0.39 3.27 1.06 54.84
18 INT68216 Binding of NF1 40 0.48 51.24 4.59 54.52
19 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 52.00
20 INT4360 Gene_expression of Hypism 29 0.22 38.1 4.07 51.68
21 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26 49.04
22 INT86601 Positive_regulation of KCNH2 7 0.49 1.56 0.52 39.68
23 INT256627 Regulation of Negative_regulation of Ptch2 1 0.32 1.33 0 20.24
24 INT256625 Negative_regulation of Ptch2 1 0.42 1.27 0 18.80
25 INT125391 Gene_expression of Rim5 2 0.01 1.94 0.11 10.32
26 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
27 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
28 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
29 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
30 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
31 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 5.00
32 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67 5.00
33 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
34 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
35 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
36 INT95930 Negative_regulation of Gria2 63 0.56 18.37 17.04 5.00
37 INT62861 Regulation of Gria2 45 0.60 13.35 16.07 5.00
38 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
39 INT6163 Negative_regulation of INA 39 0.43 2.9 14.8 5.00
40 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
41 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85 5.00
42 INT3535 Regulation of CA2 61 0.32 16.48 10.8 5.00
43 INT115614 Binding of Gria2 25 0.43 8.97 9.91 5.00
44 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 5.00
45 INT15189 Localization of Npy 26 0.79 9.09 8.28 5.00
46 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 5.00
47 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94 5.00
48 INT13042 Gene_expression of INA 26 0.78 4.65 6.44 5.00
49 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33 5.00
50 INT112102 Regulation of Gene_expression of Gria2 14 0.55 5.4 5.55 5.00
51 INT6164 Positive_regulation of INA 16 0.67 2.19 5.45 5.00
52 INT113112 Negative_regulation of CXCR4 39 0.58 28.28 5.36 5.00
53 INT142162 Binding of IL10 30 0.37 21.9 4.84 5.00
54 INT111739 Negative_regulation of Npy 15 0.43 4.9 4.65 5.00
55 INT44249 Negative_regulation of ELK3 8 0.51 1.99 4.45 5.00
56 INT30031 Gene_expression of Hba-a1 7 0.60 7.46 4.41 5.00
57 INT4711 Regulation of ELK3 17 0.62 2.36 4.26 5.00
58 INT81213 Binding of Gpm6a 6 0.35 0.72 3.87 5.00
59 INT108761 Localization of Alms1 24 0.70 13.92 3.74 5.00
60 INT78203 Gene_expression of PMP22 12 0.63 7.49 3.58 5.00
61 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47 5.00
62 INT136266 Gene_expression of KCNQ1 23 0.64 8.34 3.11 5.00
63 INT14872 Gene_expression of TGFB3 15 0.55 12.45 2.96 5.00
64 INT221097 Negative_regulation of Atp8a1 15 0.57 10.52 2.65 5.00
65 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63 5.00
66 INT14282 Regulation of INA 5 0.23 0.87 2.42 5.00
67 INT96762 Gene_expression of RAI1 9 0.56 5.77 2.17 5.00
68 INT17688 Positive_regulation of IKZF1 5 0.50 0.48 2.11 5.00
69 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02 5.00
70 INT173512 Positive_regulation of Gene_expression of Alms1 12 0.44 8.66 1.95 5.00
71 INT48787 Regulation of GRIA1 5 0.27 1.28 1.88 5.00
72 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 5.00
73 INT42311 Regulation of HMI 9 0.43 0 1.64 5.00
74 INT87571 Negative_regulation of KCNQ1 6 0.41 1.69 1.51 5.00
75 INT140245 Binding of Gli3 3 0.36 2.65 1.46 5.00
76 INT113111 Regulation of CXCR4 14 0.61 12.81 1.39 5.00
77 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36 5.00
78 INT52589 Positive_regulation of Gene_expression of SCN5A 14 0.49 3.84 1.33 5.00
79 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 5.00
80 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29 5.00
81 INT147909 Gene_expression of Lpl 21 0.58 9.35 1.14 5.00
82 INT122474 Negative_regulation of Npy1r 3 0.42 1.71 1.1 5.00
83 INT177392 Binding of Npy1r 2 0.47 1.14 0.98 5.00
84 INT210571 Gene_expression of KCNE2 7 0.61 2.7 0.97 5.00
85 INT21660 Regulation of CHM 14 0.61 8.51 0.93 5.00
86 INT210276 Positive_regulation of Gene_expression of PMP22 3 0.46 1.58 0.88 5.00
87 INT232561 Positive_regulation of ELK3 4 0.46 0.55 0.86 5.00
88 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 5.00
89 INT69744 Gene_expression of CDT1 3 0.65 1.6 0.75 5.00
90 INT142416 Binding of Ptch1 6 0.34 4.92 0.74 5.00
91 INT132662 Binding of Hcm 11 0.31 14.41 0.73 5.00
92 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67 5.00
93 INT52590 Transcription of SCN5A 4 0.55 0.91 0.65 5.00
94 INT52347 Negative_regulation of CHM 17 0.58 13.03 0.59 5.00
95 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56 5.00
96 INT163993 Gene_expression of Hnf1a 2 0.65 1.38 0.49 5.00
97 INT200401 Gene_expression of KCNE1 14 0.57 6.42 0.45 5.00
98 INT192006 Gene_expression of RYR2 5 0.23 7.69 0.44 5.00
99 INT256628 Regulation of Nsdhl 2 0.11 4.12 0.43 5.00
100 INT177395 Negative_regulation of Binding of Npy1r 1 0.37 0.62 0.41 5.00
101 INT117096 Gene_expression of Wnt4 2 0.67 4.68 0.38 5.00
102 INT177394 Positive_regulation of Binding of Gria2 2 0.45 1.18 0.36 5.00
103 INT32509 Positive_regulation of Npc1 6 0.50 2.24 0.33 5.00
104 INT249273 Regulation of Regulation of CA2 3 0.23 0.26 0.31 5.00
105 INT230722 Regulation of Hcm 4 0.37 3 0.21 5.00
106 INT177393 Binding of Glra1 4 0.28 0.21 0.19 5.00
107 INT208539 Positive_regulation of Gene_expression of Gnas 4 0.08 2.76 0.18 5.00
108 INT231220 Localization of ANK2 1 0.40 0.91 0.17 5.00
109 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16 5.00
110 INT239609 Positive_regulation of KCNE2 1 0.40 1.29 0.15 5.00
111 INT333530 Negative_regulation of Positive_regulation of ELK3 1 0.06 0.3 0.14 5.00
112 INT166325 Negative_regulation of RAI1 2 0.36 2.74 0.13 5.00
113 INT231217 Positive_regulation of ANK2 1 0.26 0.67 0.12 5.00
114 INT193632 Positive_regulation of ARVD4 2 0.01 2.73 0.11 5.00
115 INT213515 Binding of Shh 8 0.37 1.92 0.08 5.00
116 INT51444 Regulation of PMP22 2 0.44 1.39 0.07 5.00
117 INT205973 Binding of SHH 3 0.35 1.03 0.07 5.00
118 INT183819 Negative_regulation of Positive_regulation of BCAR1 1 0.38 2.04 0.05 5.00
119 INT183818 Positive_regulation of MKKS 1 0.01 1.82 0.05 5.00
120 INT192016 Localization of RYR2 5 0.25 4.18 0.05 5.00
121 INT201155 Regulation of Jph2 2 0.37 1.13 0.05 5.00
122 INT221865 Positive_regulation of Localization of RYR2 2 0.15 4.56 0.05 5.00
123 INT231205 Negative_regulation of Binding of Hcm 1 0.03 0.87 0.04 5.00
124 INT230181 Binding of Aurka 2 0.35 0.63 0.03 5.00
125 INT210569 Negative_regulation of Gene_expression of KCNH2 2 0.41 0 0.03 5.00
126 INT231221 Gene_expression of Prkag2 1 0.07 0.94 0.03 5.00
127 INT231222 Gene_expression of Lamp2 1 0.07 0.93 0.03 5.00
128 INT230198 Gene_expression of LDLRAP1 1 0.06 0.87 0 5.00
129 INT192611 Negative_regulation of Gene_expression of Hba-a1 1 0.07 0.86 0 5.00
130 INT239612 Negative_regulation of TDP1 1 0.41 0.8 0 5.00
131 INT192615 Localization of Atrx 1 0.74 0.1 0 5.00
132 INT192609 Negative_regulation of Gene_expression of Atrx 1 0.37 0.28 0 5.00
133 INT210275 Positive_regulation of PMP22 1 0.55 0.52 0 5.00
134 INT210279 Negative_regulation of Gene_expression of PMP22 1 0.34 0.3 0 5.00
135 INT227397 Localization of Rim5 1 0.02 0.49 0 5.00
136 INT192616 Negative_regulation of Atrx 1 0.43 1.04 0 5.00
137 INT205576 Positive_regulation of Hnf1a 2 0.49 1.1 0 5.00
138 INT192608 Regulation of Atrx 1 0.39 0.67 0 5.00
139 INT230195 Negative_regulation of LDLRAP1 1 0.04 0.88 0 5.00
140 INT205587 Negative_regulation of Cyp17a1 1 0.28 0.24 0 5.00
141 INT210280 Negative_regulation of Gene_expression of RAI1 1 0.35 1.01 0 5.00
142 INT205583 Gene_expression of Hnf1b 1 0.59 2.09 0 5.00
143 INT192610 Positive_regulation of Atrx 1 0.50 0.78 0 5.00
144 INT192613 Positive_regulation of Binding of Atrx 1 0.69 0.09 0 5.00
145 INT210278 Positive_regulation of RAI1 2 0.42 1.64 0 5.00
146 INT230196 Positive_regulation of Transcription of PISRT1 1 0.34 0.4 0 5.00
147 INT205579 Positive_regulation of Gene_expression of Hnf1b 1 0.44 2.1 0 5.00
148 INT192619 Regulation of SMARCA2 1 0.06 0.3 0 5.00
149 INT230193 Transcription of PISRT1 1 0.49 0.4 0 5.00
150 INT205582 Positive_regulation of Hnf1b 1 0.44 1.05 0 5.00
151 INT239613 Positive_regulation of TDP1 1 0.45 0.8 0 5.00
152 INT205585 Regulation of Wnt4 1 0.45 0.7 0 5.00
153 INT192617 Binding of Atrx 1 0.48 0.58 0 5.00
154 INT192620 Regulation of BTAF1 1 0.06 0.3 0 5.00
155 INT205578 Negative_regulation of Wnt4 1 0.43 1.69 0 5.00
156 INT210277 Regulation of RAI1 3 0.37 1.49 0 5.00
157 INT256626 Regulation of Ptch2 1 0.28 1.11 0 5.00
158 INT230199 Regulation of Transcription of PISRT1 1 0.19 0.4 0 5.00
159 INT192612 Regulation of Gene_expression of Hba-a1 1 0.07 0.99 0 5.00
160 INT210272 Binding of Ccrs1 1 0.01 1.13 0 5.00
161 INT205581 Regulation of Negative_regulation of Wnt4 1 0.27 0.7 0 5.00
162 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0 5.00
163 INT205577 Positive_regulation of Gene_expression of Hnf1a 1 0.49 1.1 0 5.00
164 INT230197 Binding of LDLRAP1 1 0.03 0.63 0 5.00
165 INT210271 Positive_regulation of Ccrs1 1 0.01 0.4 0 5.00
166 INT192614 Gene_expression of Atrx 1 0.77 1.75 0 5.00
167 INT192607 Transcription of Atrx 1 0.68 0.4 0 5.00
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