D:Varicose Veins

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pChart

Disease Term
Synonyms Phlebectasia, Uneven Venous Ectasia, Varices, Varices Disorder, Varicose Vein, Varix, VEIN VARICOSE, Veins Varicose, Venous Ectasia, Venous Varices
Documents 405
Hot Single Events 32
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Varicose Veins. They are ordered first by their relevance to Varicose Veins and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT227400 Binding of DLAT and HCC 1 0.01 2.82 0.11 84.52
2 INT158110 Negative_regulation of Del(7)Tyr<c-23DVT>-p Negative_regulation of Pts 1 0.00 1.92 0.08 84.40
3 INT312794 Hdl1 Regulation of Pon1 1 0.02 1.63 0.15 20.96
4 INT312768 Pon1 Negative_regulation of Gene_expression of Ccl2 1 0.06 1.42 0.26 5.00
5 INT350363 Gatm Negative_regulation of NOS1 1 0.00 0.31 0.17 5.00
6 INT312793 Binding of Hdl1 and Pon3 1 0.00 0.84 0.14 5.00
7 INT312792 Binding of Pon1 and Hdl1 1 0.04 1.85 0.11 5.00
8 INT227418 Binding of DLAT and Pdc 1 0.05 1.01 0.07 5.00
9 INT277765 Binding of BCR and Abl1 1 0.18 1.55 0.03 5.00
10 INT186502 Binding of AMELX and HLA-A 1 0.00 0.71 0 5.00
11 INT312769 Binding of Apoe and Pon1 1 0.04 0.86 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Varicose Veins. They are ordered first by their pain relevance and then by number of times they were reported in Varicose Veins. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT34808 Binding of Ec 14 0.24 17.27 2.65 100.00
2 INT176089 Regulation of EcV 2 0.09 3.93 0.03 100.00
3 INT27555 Positive_regulation of Ec 12 0.14 7.38 2.3 100.00
4 INT354484 Negative_regulation of Evl 1 0.31 3.86 0 100.00
5 INT34809 Gene_expression of Ec 36 0.15 15.7 3.24 100.00
6 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 100.00
7 INT354486 Negative_regulation of Positive_regulation of Evl 1 0.31 1.95 0 100.00
8 INT152353 Binding of Evl 3 0.42 2.01 0.33 99.64
9 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 99.52
10 INT354485 Positive_regulation of Evl 1 0.36 1.72 0 99.32
11 INT477 Localization of Avp 813 0.81 131.58 300.4 97.70
12 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 97.52
13 INT354483 Gene_expression of Evl 1 0.49 1.92 0.1 97.52
14 INT24029 Regulation of AFP 7 0.44 6.45 0.51 96.60
15 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 96.12
16 INT10140 Negative_regulation of ANXA3 4 0.07 6.07 0.62 95.80
17 INT309915 Negative_regulation of F2RL3 2 0.01 2.06 0.27 95.80
18 INT345973 Binding of EVL 1 0.07 1.4 0.14 94.32
19 INT277080 Phosphorylation of Ectopic 1 0.09 1.74 0.14 94.24
20 INT170960 Protein_catabolism of MYO3A 1 0.17 0.87 0 92.32
21 INT47909 Binding of CPP 32 0.48 24.9 13.79 92.24
22 INT213965 Gene_expression of rsm1 7 0.54 4.18 1.29 89.24
23 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 87.64
24 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 86.68
25 INT60498 Negative_regulation of Positive_regulation of B2M 1 0.09 0.54 0.1 86.68
26 INT9842 Binding of F2 36 0.47 22.79 4.42 86.28
27 INT894 Binding of Avp 84 0.48 29.16 29.63 85.68
28 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 84.80
29 INT89159 Negative_regulation of Del(7)Tyr<c-23DVT>-p 5 0.34 6.8 0.68 84.40
30 INT48635 Negative_regulation of Pts 15 0.49 15.38 2.43 83.04
31 INT96542 Negative_regulation of SMN1 14 0.51 10.72 3.11 82.88
32 INT176618 Gene_expression of HEY1 29 0.59 36 4.37 82.36
33 INT7351 Gene_expression of NPS 5 0.58 1.87 0.88 79.36
34 INT1038 Negative_regulation of F2 26 0.58 15.12 6.75 75.08
35 INT39444 Negative_regulation of Positive_regulation of F2 7 0.59 5.82 1.42 75.08
36 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 74.52
37 INT48636 Positive_regulation of Pts 8 0.42 7.14 1.01 73.04
38 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77 72.36
39 INT70242 Localization of HCC 18 0.66 23.95 2.35 71.96
40 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 68.68
41 INT124218 Gene_expression of Pon1 9 0.75 19.55 1.19 64.44
42 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 59.56
43 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 59.04
44 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 57.12
45 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 57.12
46 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57 57.12
47 INT4636 Positive_regulation of Regulation of Agt 4 0.50 1.3 0.3 57.12
48 INT14916 Binding of RASA1 15 0.37 13.64 1.44 56.60
49 INT1158 Regulation of Agt 106 0.61 29.4 30.29 56.20
50 INT5806 Regulation of Edn1 63 0.62 23.46 13.88 56.20
51 INT287307 Binding of ENO1 9 0.48 11.24 2.51 56.12
52 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 55.68
53 INT180029 Regulation of rsm1 3 0.02 2.38 0.55 54.48
54 INT334041 Gene_expression of Cdt1 5 0.29 2.69 0.32 53.84
55 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 52.08
56 INT1153 Negative_regulation of FUT3 17 0.38 8.61 2.21 50.48
57 INT64224 Localization of FUT3 3 0.06 3.16 0.2 50.48
58 INT79140 Binding of HCC 36 0.31 46.96 1.87 49.32
59 INT78210 Gene_expression of MCC 7 0.65 1.8 0.98 48.32
60 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 46.00
61 INT227417 Protein_catabolism of DLAT 1 0.44 1.51 0.27 43.88
62 INT38856 Positive_regulation of Ccl4 24 0.69 9.55 1.62 43.44
63 INT240765 Positive_regulation of Pon1 16 0.67 12.06 0.48 41.04
64 INT5499 Transcription of Avp 52 0.72 7.98 19.87 40.64
65 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 39.40
66 INT303837 Negative_regulation of Pon1 4 0.57 11.08 0.71 38.80
67 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 37.28
68 INT227414 Localization of DLAT 2 0.49 5.14 0.26 34.92
69 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 33.36
70 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 32.20
71 INT187286 Binding of HEY1 17 0.32 31.21 4.52 31.56
72 INT154057 Gene_expression of Ear1 14 0.41 9.72 1.12 29.88
73 INT182667 Binding of DLAT 11 0.31 40.75 2.8 28.76
74 INT250645 Gene_expression of Samsn1 6 0.33 9.95 0.86 28.32
75 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 22.04
76 INT12035 Regulation of F2 21 0.45 12.66 1.47 21.84
77 INT10173 Binding of Tnf 45 0.48 35.6 14.32 20.96
78 INT21756 Regulation of Alb 15 0.43 8.21 1.19 20.56
79 INT103094 Binding of PPARA 308 0.47 177.26 34.75 18.40
80 INT2364 Localization of Sct 134 0.80 26.21 41.47 16.60
81 INT211271 Regulation of Igh-VS107 1 0.01 1.96 0.44 10.88
82 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 10.84
83 INT5743 Localization of NA 104 0.59 14.35 35.29 10.40
84 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 9.60
85 INT227413 Gene_expression of DLAT 12 0.44 13.21 1.36 6.88
86 INT179883 Transcription of HCC 2 0.31 1.7 0.03 6.36
87 INT76581 Regulation of Negative_regulation of NOS1 14 0.45 7.49 4.4 5.20
88 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 5.00
89 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 5.00
90 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
91 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
92 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
93 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
94 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
95 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
96 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
97 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
98 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 5.00
99 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 5.00
100 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
101 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7 5.00
102 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
103 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
104 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
105 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
106 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 5.00
107 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
108 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14 5.00
109 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27 5.00
110 INT5793 Binding of CTS 110 0.48 63.91 40.62 5.00
111 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
112 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43 5.00
113 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
114 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77 5.00
115 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 5.00
116 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
117 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
118 INT84171 Negative_regulation of Gene_expression of Ccl2 30 0.58 26.37 18.28 5.00
119 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71 5.00
120 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 5.00
121 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
122 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
123 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 5.00
124 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 5.00
125 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
126 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 5.00
127 INT113317 Regulation of Cnr2 17 0.52 10.27 10.68 5.00
128 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 5.00
129 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
130 INT132938 Phosphorylation of Insrr 21 0.03 10.55 8.88 5.00
131 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 5.00
132 INT48908 Transcription of NOS1 27 0.55 13.46 8.39 5.00
133 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 5.00
134 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
135 INT165036 Gene_expression of S100a9 38 0.77 38.33 7.84 5.00
136 INT17686 Negative_regulation of Hdl1 72 0.36 81.85 7.74 5.00
137 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
138 INT25022 Binding of PAEP 66 0.42 22.83 6.59 5.00
139 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
140 INT3041 Positive_regulation of MIA3 34 0.56 21.11 6.49 5.00
141 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 5.00
142 INT31582 Gene_expression of Hdl1 103 0.66 118.95 6.42 5.00
143 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 5.00
144 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
145 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06 5.00
146 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 5.00
147 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 5.00
148 INT115370 Gene_expression of PSIP1 22 0.65 9.45 5.68 5.00
149 INT22839 Gene_expression of F2 31 0.74 15.53 5.56 5.00
150 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 5.00
151 INT187295 Gene_expression of Serpinb1a 6 0.58 13.73 5.05 5.00
152 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76 5.00
153 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69 5.00
154 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 5.00
155 INT8743 Positive_regulation of Gcg 19 0.65 10.63 4.43 5.00
156 INT24332 Regulation of Hdl1 28 0.45 45.45 4.26 5.00
157 INT1149 Binding of ecs 19 0.37 13.67 3.9 5.00
158 INT39945 Binding of Dlat 27 0.32 14.95 3.88 5.00
159 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79 5.00
160 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75 5.00
161 INT192951 Negative_regulation of AES 15 0.38 6.38 3.5 5.00
162 INT81280 Binding of Atp9a 20 0.47 11.14 3.24 5.00
163 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 5.00
164 INT110445 Phosphorylation of Gtf3a 15 0.09 5.58 3.07 5.00
165 INT1631 Binding of Hdl1 42 0.36 49.22 2.92 5.00
166 INT54331 Positive_regulation of Glul 8 0.67 3.55 2.74 5.00
167 INT39469 Negative_regulation of Alb 21 0.41 13.33 2.68 5.00
168 INT49759 Negative_regulation of CETP 43 0.58 52 2.68 5.00
169 INT100144 Negative_regulation of Positive_regulation of PPARA 17 0.49 12.71 2.68 5.00
170 INT71794 Binding of SERPINC1 17 0.39 10.5 2.64 5.00
171 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57 5.00
172 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 5.00
173 INT223080 Binding of Pdgfa 8 0.18 7.21 2.44 5.00
174 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37 5.00
175 INT63505 Negative_regulation of F2 18 0.57 7.4 2.2 5.00
176 INT67332 Negative_regulation of ITGA4 8 0.51 7.95 2.14 5.00
177 INT152174 Negative_regulation of Samsn1 5 0.14 6.46 2.1 5.00
178 INT156064 Gene_expression of LMNA 50 0.65 13.38 2.01 5.00
179 INT17274 Gene_expression of Got1 11 0.58 3.98 2 5.00
180 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92 5.00
181 INT100689 Negative_regulation of JAK1 8 0.57 5.36 1.87 5.00
182 INT102839 Gene_expression of Pdc 15 0.52 6.3 1.87 5.00
183 INT37216 Binding of SMN1 11 0.36 6.66 1.86 5.00
184 INT91550 Gene_expression of PPM1D 7 0.10 0.68 1.81 5.00
185 INT79691 Regulation of Gene_expression of PPARG 10 0.50 10.44 1.62 5.00
186 INT82866 Localization of Atp9a 13 0.78 6.95 1.56 5.00
187 INT287309 Positive_regulation of ENO1 5 0.59 5.67 1.52 5.00
188 INT12429 Negative_regulation of Spdya 5 0.20 1.07 1.49 5.00
189 INT173717 Gene_expression of Ccl4 22 0.65 13.98 1.47 5.00
190 INT11710 Positive_regulation of SERPINC1 6 0.59 6.15 1.47 5.00
191 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 5.00
192 INT83891 Gene_expression of FUT3 20 0.61 10.49 1.41 5.00
193 INT287308 Negative_regulation of ENO1 5 0.59 4.07 1.24 5.00
194 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22 5.00
195 INT140288 Localization of Pon1 4 0.78 6.15 1.15 5.00
196 INT227416 Positive_regulation of DLAT 4 0.45 17.02 1.11 5.00
197 INT15527 Gene_expression of FFAR1 19 0.61 11.15 1.08 5.00
198 INT50444 Negative_regulation of Gene_expression of Alb 11 0.39 7.63 1.06 5.00
199 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04 5.00
200 INT52113 Gene_expression of CETP 25 0.69 25.71 0.99 5.00
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