D:Vascular Disease

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Disease Term
Synonyms ANGIOGENESIS DISEASE, ANGIOGENESIS DISEASES, Angiogenesis Disorder, Angiogenesis Disorders, ANGIOGENESIS DYSFUNCTION, Angiogenesis Dysfunctions, Angiogenesis Syndrome, Angiogenesis Syndromes, ANGIOPATHY, Arteriovenous Fistula, Artery Disease
Documents 774
Hot Single Events 124
Hot Interactions 13

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Vascular Disease. They are ordered first by their relevance to Vascular Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT308648 Binding of sps and Gopc 1 0.01 2.71 0 100.00
2 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05 95.96
3 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39 95.88
4 INT217396 Binding of Abca1 and App 1 0.26 0.83 0 93.76
5 INT161086 NOTCH3 Regulation of Notch3 1 0.51 1.06 0.14 91.44
6 INT291625 Binding of CSTA and RAPGEF5 1 0.03 4.81 0.37 86.84
7 INT332287 LEP Positive_regulation of Phosphorylation of IRS1 1 0.20 1.48 0.08 84.76
8 INT31008 Crh Positive_regulation of Pomc 3 0.49 2.31 1.28 84.28
9 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0 82.40
10 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0 82.40
11 INT217402 Binding of Bace1 and PSENEN 1 0.02 0.72 0 82.40
12 INT217399 Binding of Bace1 and Ncstn 1 0.05 0.72 0 82.40
13 INT217397 Binding of Bace1 and Alph1 1 0.02 0.73 0 82.40
14 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 43.00
15 INT182775 Binding of PTH and ROS1 1 0.04 1.73 0.04 34.00
16 INT187796 Binding of Tnf and Il1 1 0.09 1.85 0.48 32.24
17 INT187795 Positive_regulation of Binding of Tnf and Il1 1 0.13 1.87 0.48 32.24
18 INT286476 Binding of App and Itm2b 1 0.47 5.24 0.14 30.92
19 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55 29.20
20 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31 29.20
21 INT332288 Positive_regulation of IRS1 Regulation of PIK3CD 1 0.07 0.73 0.03 15.48
22 INT332284 IRS1 Regulation of PIK3CD 1 0.15 0.72 0.03 15.08
23 INT332286 PIK3CD Positive_regulation of MTOR 1 0.14 0.73 0.03 13.20
24 INT291623 Binding of CRP and CSTA 1 0.03 0.38 0 11.04
25 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
26 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
27 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
28 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93 5.00
29 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87 5.00
30 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82 5.00
31 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
32 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 5.00
33 INT294708 CRP Positive_regulation of Gene_expression of VCAM1 2 0.31 1.92 0.56 5.00
34 INT194595 Binding of TNFSF10 and TNFRSF10B 4 0.15 9.3 0.53 5.00
35 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 5.00
36 INT22674 Binding of SERPINE1 and PLAT 7 0.04 0.65 0.45 5.00
37 INT194596 Binding of HLA-DRB4 and TNFSF10 3 0.08 6 0.38 5.00
38 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36 5.00
39 INT99015 Binding of Selp and Vcam1 2 0.27 1.76 0.35 5.00
40 INT174266 TNF Regulation of Gene_expression of F3 1 0.00 3.2 0.33 5.00
41 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33 5.00
42 INT230855 KNG1 Regulation of NOS1 2 0.03 0.94 0.33 5.00
43 INT174265 IL18 Regulation of Gene_expression of F3 1 0.00 3.21 0.33 5.00
44 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32 5.00
45 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32 5.00
46 INT277011 CRP Positive_regulation of Gene_expression of F3 1 0.06 1.03 0.32 5.00
47 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31 5.00
48 INT182771 ROS1 Positive_regulation of NFKB1 Positive_regulation of CRP 1 0.00 3.83 0.28 5.00
49 INT256063 Myd88 Positive_regulation of Gene_expression of Mcpt1 1 0.13 0.56 0.27 5.00
50 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25 5.00
51 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25 5.00
52 INT123462 Binding of TNF and Tnfrsf11b 3 0.21 3.52 0.24 5.00
53 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23 5.00
54 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22 5.00
55 INT308650 Binding of nt and Ntrk2 1 0.01 0.41 0.21 5.00
56 INT336946 Binding of ITGA4 and VCAM1 1 0.03 2.02 0.21 5.00
57 INT308654 Binding of Ngfr and Nts 1 0.06 0.39 0.21 5.00
58 INT236362 Binding of Gfap and Itgam 1 0.23 2.31 0.2 5.00
59 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2 5.00
60 INT308646 Car2 Regulation of Gene_expression of Ins1 1 0.00 0 0.19 5.00
61 INT308669 CREB1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
62 INT308657 Creb1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
63 INT192333 PDGFA Positive_regulation of Gene_expression of FN1 2 0.11 1.26 0.18 5.00
64 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18 5.00
65 INT277013 PLAT Positive_regulation of Gene_expression of F13A1 1 0.02 0.31 0.17 5.00
66 INT353861 Binding of Mgp and Phdlc1 1 0.01 5.09 0.16 5.00
67 INT277012 Binding of PAPPA and ACE2 1 0.02 1.26 0.15 5.00
68 INT182772 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL1B 1 0.00 1.89 0.14 5.00
69 INT332285 Binding of KLRD1 and CRLF1 1 0.00 1.71 0.14 5.00
70 INT182773 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL6 1 0.00 1.9 0.14 5.00
71 INT182780 NFKB1 Positive_regulation of IL1B 1 0.00 1.8 0.14 5.00
72 INT182782 NFKB1 Positive_regulation of IL6 1 0.00 1.8 0.14 5.00
73 INT321408 INS Positive_regulation of EGR1 1 0.03 2.36 0.13 5.00
74 INT321414 INS Positive_regulation of Transcription of EGR1 1 0.03 2.36 0.13 5.00
75 INT308659 Binding of Ager and ecs 1 0.01 1.14 0.12 5.00
76 INT321404 Positive_regulation of MAP3K5 Positive_regulation of Gene_expression of SERPINE1 1 0.02 2.2 0.12 5.00
77 INT321410 EGR1 Negative_regulation of Gene_expression of TNFSF10 1 0.10 2.07 0.12 5.00
78 INT308647 Ager Positive_regulation of Gene_expression of Bace1 1 0.09 1.01 0.12 5.00
79 INT308660 Binding of Ager and App 1 0.08 1.22 0.12 5.00
80 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11 5.00
81 INT291622 HSD11B1 Regulation of CSTA 1 0.00 0.6 0.11 5.00
82 INT256061 Gopc Positive_regulation of Gene_expression of Vcam1 1 0.18 0.29 0.1 5.00
83 INT256060 Gopc Positive_regulation of Vcam1 1 0.13 0.29 0.1 5.00
84 INT264085 CYP2C19 Regulation of CYP3A4 1 0.02 0 0.09 5.00
85 INT264103 Cyp2e1 Regulation of CYP2C9 1 0.04 0 0.09 5.00
86 INT230857 Negative_regulation of Binding of HSP90AA1 and NOS1 1 0.05 1.18 0.09 5.00
87 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09 5.00
88 INT308662 Binding of Esr1 and Fdft1 1 0.00 0.05 0.09 5.00
89 INT264104 Cyp1a2 Regulation of CYP2C9 1 0.04 0 0.09 5.00
90 INT264083 CYP2C19 Regulation of CYP2D6 1 0.05 0 0.09 5.00
91 INT291624 SERPINH1 Regulation of CSTA 1 0.00 0.39 0.09 5.00
92 INT230856 Binding of HSP90AA1 and NOS1 1 0.04 1.17 0.09 5.00
93 INT264084 CYP2C19 Regulation of CYP2C9 1 0.03 0 0.09 5.00
94 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09 5.00
95 INT308666 Binding of Lrp1 and Chol1 1 0.10 0.69 0.09 5.00
96 INT264107 Cyp2e1 Regulation of CYP2D6 1 0.05 0 0.09 5.00
97 INT264105 Cyp2e1 Regulation of CYP3A4 1 0.02 0 0.09 5.00
98 INT308652 Binding of Renbp and Nps 1 0.01 1.38 0.09 5.00
99 INT230245 Binding of CBFA2T2 and Cd2bp2 1 0.00 0.36 0.08 5.00
100 INT277010 Binding of PAPPA and TNNT1 1 0.24 0.99 0.07 5.00
101 INT308655 Binding of Lrp1 and Gopc 1 0.01 0.49 0.07 5.00
102 INT231440 PDGFA Positive_regulation of Gene_expression of HGF 1 0.16 0.83 0.07 5.00
103 INT230853 Binding of SELE and VWF 1 0.06 1.3 0.07 5.00
104 INT231434 FN1 Positive_regulation of Gene_expression of PDGFA 1 0.04 0.83 0.07 5.00
105 INT231436 FN1 Positive_regulation of Gene_expression of VEGFA 1 0.06 0.83 0.07 5.00
106 INT308665 Binding of Apoe and Gopc 1 0.02 0.49 0.07 5.00
107 INT308663 Apoe Regulation of Car2 1 0.02 0.44 0.07 5.00
108 INT277016 Binding of MB and PAPPA 1 0.10 1 0.07 5.00
109 INT231442 FN1 Positive_regulation of Gene_expression of HGF 1 0.05 0.83 0.07 5.00
110 INT231441 PDGFA Positive_regulation of Gene_expression of VEGFA 1 0.17 0.83 0.07 5.00
111 INT236363 Regulation of Binding of Ptprc and Tlr4 1 0.25 1.23 0.06 5.00
112 INT231507 Binding of Ptprc and Tlr4 2 0.21 1.22 0.06 5.00
113 INT321399 Positive_regulation of SETD7 Positive_regulation of SETDB1 1 0.00 1.25 0.06 5.00
114 INT345245 Adam9 Regulation of Adam10 1 0.09 0.18 0.05 5.00
115 INT321401 Gene_expression of ROS1 Negative_regulation of Positive_regulation of AKR1B1 1 0.01 0.8 0.05 5.00
116 INT308649 Binding of Ppp1r13b and Iars 1 0.01 0.29 0.04 5.00
117 INT89384 Negative_regulation of INS Positive_regulation of AKT1 2 0.36 1.37 0.04 5.00
118 INT230854 INS Regulation of Positive_regulation of SNAP47 1 0.09 1.03 0.03 5.00
119 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03 5.00
120 INT230851 INS Regulation of VCAM1 1 0.07 1.02 0.03 5.00
121 INT321407 EDN1 Positive_regulation of Phosphorylation of IRS1 1 0.06 1.07 0.03 5.00
122 INT353865 Binding of CHI3L1 and Lepr 1 0.00 1.88 0.03 5.00
123 INT256228 EDNRB Positive_regulation of EDN1 1 0.26 0.62 0.03 5.00
124 INT321402 Binding of NPHS1 and PIK3CD 1 0.02 0.73 0.03 5.00
125 INT321412 ABCC8 Positive_regulation of Gene_expression of SELE 1 0.00 1.18 0.03 5.00
126 INT231439 LEP Positive_regulation of Negative_regulation of AKT1 1 0.06 0.32 0.03 5.00
127 INT321405 AGT Positive_regulation of MAPK8 1 0.00 0.94 0.03 5.00
128 INT291621 RAPGEF5 Regulation of CSTA 1 0.04 0.43 0.03 5.00
129 INT308658 Binding of Apoa2 and Apoe 1 0.17 0.15 0.03 5.00
130 INT321398 SETD7 Positive_regulation of SETDB1 1 0.00 0.62 0.03 5.00
131 INT321406 VEGFA Regulation of BCL2 1 0.01 0.75 0 5.00
132 INT182784 IGF1 Positive_regulation of Gene_expression of INS 1 0.02 1.87 0 5.00
133 INT321400 VEGFA Negative_regulation of Gene_expression of BAX 1 0.03 0.75 0 5.00
134 INT278293 Binding of DBP and SHBG 2 0.02 1.34 0 5.00
135 INT182804 Binding of ETV3 and T2DM 1 0.10 2.62 0 5.00
136 INT308643 Binding of Proc and Renbp 1 0.00 1.61 0 5.00
137 INT308664 Akt1 Positive_regulation of Phosphorylation of Insr 1 0.02 0.43 0 5.00
138 INT182778 IGF1 Positive_regulation of Gene_expression of ETV3 1 0.03 1.89 0 5.00
139 INT232574 ROS1 Positive_regulation of PRKCA 1 0.13 0.69 0 5.00
140 INT232575 SNRNP70 Regulation of SOD1 1 0.12 0.65 0 5.00
141 INT182774 Binding of ETV3 and SAE1 1 0.00 1.17 0 5.00
142 INT182783 INS Positive_regulation of Gene_expression of ETV3 1 0.01 1.89 0 5.00
143 INT182777 IAPP Positive_regulation of Gene_expression of ETV3 1 0.06 1.88 0 5.00
144 INT182776 IAPP Positive_regulation of Gene_expression of INS 1 0.03 1.87 0 5.00
145 INT232576 ROS1 Positive_regulation of Localization of OLR1 1 0.04 0.7 0 5.00
146 INT121225 Positive_regulation of Ngf Positive_regulation of Ntrk1 2 0.49 0 0 5.00
147 INT242858 Binding of HFE and INS 1 0.06 1.64 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Vascular Disease. They are ordered first by their pain relevance and then by number of times they were reported in Vascular Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1704 Positive_regulation of PCa 68 0.59 34.92 23.36 100.00
2 INT5137 Binding of PCa 45 0.47 16.91 18.47 100.00
3 INT39948 Binding of FLNA 45 0.42 58.05 4.27 100.00
4 INT277030 Negative_regulation of Binding of NPPB 1 0.26 1.29 0.21 100.00
5 INT242865 Binding of HFE 7 0.42 6.01 0.12 99.80
6 INT68216 Binding of NF1 40 0.48 51.24 4.59 99.76
7 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87 99.48
8 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 99.34
9 INT213923 Positive_regulation of MTOR 16 0.65 9.28 0.7 98.92
10 INT74109 Positive_regulation of Sele 26 0.48 22.32 5.84 98.72
11 INT103853 Positive_regulation of Thbd 3 0.18 3.97 0.23 98.72
12 INT71510 Positive_regulation of Selp 47 0.68 30.43 12.8 98.56
13 INT67424 Positive_regulation of Gene_expression of Selp 36 0.68 17.08 7.95 98.56
14 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 98.44
15 INT286475 Positive_regulation of ITM2B 1 0.03 1.83 0.1 98.44
16 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 98.20
17 INT2541 Binding of Calca 200 0.48 67.14 134.62 98.12
18 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03 98.00
19 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65 97.72
20 INT186686 Regulation of Positive_regulation of EDNRA 5 0.22 2.35 0.51 97.72
21 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 97.64
22 INT210527 Positive_regulation of Gene_expression of Tenc1 14 0.38 6.37 2.45 97.04
23 INT63042 Binding of Apoe 59 0.48 31.23 5.88 97.00
24 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71 97.00
25 INT101726 Gene_expression of Notch3 4 0.77 4.87 0.64 96.84
26 INT178198 Gene_expression of C3 62 0.78 39.5 7.69 96.76
27 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94 96.64
28 INT15490 Negative_regulation of Gene_expression of COL7A1 40 0.58 25.97 7.18 96.44
29 INT133846 Binding of NPPB 14 0.42 11.52 0.98 96.40
30 INT65500 Gene_expression of App 605 0.78 429.94 98.31 96.20
31 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 96.18
32 INT262109 Positive_regulation of Mgp 2 0.63 42.44 0.9 96.16
33 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 96.16
34 INT353857 Positive_regulation of Positive_regulation of Mgp 1 0.40 2.61 0.04 96.16
35 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12 95.96
36 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79 95.88
37 INT46646 Localization of FLNA 19 0.73 18.83 2.53 95.76
38 INT106038 Regulation of PEPD 3 0.43 3.93 1.01 95.66
39 INT353854 Positive_regulation of Gene_expression of Mgp 1 0.63 13.92 0.73 95.52
40 INT353859 Positive_regulation of Binding of Mgp 1 0.37 2.89 0.04 95.52
41 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 95.44
42 INT180497 Binding of MRI1 45 0.42 28.35 14.77 95.28
43 INT337100 Gene_expression of Mgp 3 0.71 45.04 1.64 94.56
44 INT103246 Positive_regulation of Protein_catabolism of COL7A1 8 0.34 8.67 3.03 94.32
45 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 94.28
46 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 94.20
47 INT217379 Phosphorylation of Hras1 1 0.01 1.43 0.33 94.20
48 INT1308 Localization of Pomc 457 0.81 66.83 217.5 93.96
49 INT84573 Regulation of Mavs 1 0.01 1.37 0.49 93.68
50 INT217383 Regulation of Regulation of Mavs 1 0.01 0.79 0.08 93.68
51 INT31989 Binding of SOD1 43 0.47 19.38 2.55 93.44
52 INT178615 Binding of SOD2 12 0.48 6.93 1.51 93.44
53 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66 93.20
54 INT163544 Binding of Psen1 40 0.36 15.28 2.42 92.84
55 INT305390 Negative_regulation of NKX2-5 2 0.37 2.24 0.49 92.76
56 INT70622 Binding of Hypism 9 0.04 14.9 0.59 92.48
57 INT136931 Negative_regulation of NOTCH3 1 0.42 1.08 0.13 92.40
58 INT210522 Protein_catabolism of Ide 16 0.79 7.73 0.55 92.32
59 INT16794 Binding of App 103 0.48 64.87 19.79 92.20
60 INT18412 Binding of PLEK 49 0.47 17.82 10.72 92.04
61 INT49599 Binding of CD177 3 0.15 2.34 0.45 92.04
62 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49 91.96
63 INT353858 Binding of Mgp 1 0.38 7.16 0.11 91.76
64 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 91.68
65 INT182800 Positive_regulation of ETV3 5 0.46 10.01 0.14 91.60
66 INT4207 Regulation of Avp 267 0.62 63.72 115.33 91.56
67 INT186511 Gene_expression of ABRA 1 0.19 1.92 0.42 91.36
68 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48 91.20
69 INT61316 Gene_expression of Coq10a 59 0.73 32.81 3.95 91.20
70 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 90.96
71 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 90.80
72 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 90.52
73 INT73673 Negative_regulation of Mtap2 9 0.32 8.25 1.4 90.32
74 INT119076 Positive_regulation of PEPD 3 0.63 1.15 0.52 90.24
75 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 90.20
76 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 90.16
77 INT329021 Regulation of Gene_expression of Notch3 1 0.09 2.04 0 89.76
78 INT329022 Gene_expression of Notch3 1 0.27 2.04 0 89.76
79 INT243382 Positive_regulation of CSTA 4 0.05 14.65 0.12 89.56
80 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65 88.92
81 INT286472 Protein_catabolism of Itm2b 1 0.62 1.67 0.2 88.88
82 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 88.88
83 INT204989 Gene_expression of Mavs 3 0.02 0.86 0.15 88.56
84 INT64252 Negative_regulation of Localization of NOTCH3 1 0.41 0.97 0.16 88.24
85 INT287448 Gene_expression of Tagln 6 0.65 3.73 0.16 88.12
86 INT242866 Regulation of HFE 2 0.39 1.84 0 88.08
87 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 87.92
88 INT187050 Localization of RENBP 8 0.35 6.92 0.61 87.84
89 INT64253 Localization of NOTCH3 1 0.78 0.97 0.16 87.76
90 INT287445 Regulation of Tagln 2 0.29 2.59 0.08 87.72
91 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52 87.48
92 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 87.36
93 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 87.12
94 INT144490 Regulation of Gene_expression of Tnfsf11 14 0.58 14.09 2.39 86.88
95 INT6970 Gene_expression of St8sia1 13 0.52 4.94 9.27 86.48
96 INT179535 Negative_regulation of C1qa 10 0.57 4.7 1.03 86.48
97 INT226829 Gene_expression of Adra1b 2 0.01 0.56 0 86.48
98 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 85.92
99 INT120752 Positive_regulation of Gene_expression of NPPB 17 0.67 16.4 2.21 85.68
100 INT208421 Negative_regulation of LOC100361836 1 0.03 0.99 0 85.52
101 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 84.96
102 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 84.96
103 INT181639 Positive_regulation of Positive_regulation of NOS3 8 0.41 3.72 1.41 84.96
104 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04 84.96
105 INT48270 Negative_regulation of RNF130 44 0.57 21.31 6.14 84.72
106 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 84.44
107 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 84.12
108 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42 83.64
109 INT8713 Regulation of Tac1 56 0.60 25.29 45.94 83.16
110 INT6969 Negative_regulation of St8sia1 12 0.42 6.36 12.96 83.12
111 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 83.08
112 INT37590 Regulation of COL7A1 15 0.54 9.4 3.12 82.56
113 INT2649 Regulation of Calca 433 0.62 146.05 330.95 82.52
114 INT217390 Negative_regulation of Positive_regulation of Apoe 3 0.37 1.95 1.05 82.28
115 INT161085 Positive_regulation of Notch3 4 0.41 4.36 0.27 82.04
116 INT46305 Negative_regulation of GAA 2 0.57 1.17 0.07 82.00
117 INT156489 Positive_regulation of Gene_expression of Bace1 67 0.69 41.07 7.02 81.88
118 INT11625 Localization of App 98 0.78 55.46 20.86 81.44
119 INT61613 Regulation of DLD 6 0.34 2.96 0.92 81.20
120 INT197494 Gene_expression of Apoa4 9 0.05 7.33 0.78 81.04
121 INT115087 Negative_regulation of Gdnf 10 0.51 5.78 5.73 80.88
122 INT10888 Binding of Vwf 32 0.46 22.87 5.21 80.36
123 INT181922 Binding of RENBP 16 0.36 13.92 3.71 80.16
124 INT321420 Binding of MOK 1 0.09 1.13 0 80.16
125 INT332296 Negative_regulation of Gene_expression of ETV3 1 0.25 0.65 0.04 79.84
126 INT332299 Negative_regulation of Gene_expression of IRS1 1 0.31 0.65 0.04 79.84
127 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81 78.84
128 INT284334 Gene_expression of IRS1 10 0.49 5.81 0.59 78.84
129 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53 78.72
130 INT182788 Gene_expression of ETV3 8 0.40 11.33 0.36 78.60
131 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 78.48
132 INT217393 Negative_regulation of Gene_expression of Mme 3 0.43 5.98 0.46 78.44
133 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 78.12
134 INT332297 Negative_regulation of Binding of MTOR 2 0.40 1.6 0.18 77.04
135 INT6971 Regulation of St8sia1 9 0.44 3.25 10.04 76.96
136 INT84769 Positive_regulation of St8sia1 10 0.41 7.56 9.86 76.96
137 INT334930 Regulation of Positive_regulation of St8sia1 1 0.12 0.59 0 76.96
138 INT188122 Negative_regulation of Hras1 12 0.02 8.38 0.21 76.32
139 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 76.20
140 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 75.92
141 INT28692 Positive_regulation of CIC 3 0.49 2.92 0.43 75.84
142 INT45075 Gene_expression of Sugt1 24 0.27 8.5 1.33 75.76
143 INT204122 Gene_expression of GJA8 13 0.47 22.98 3.04 75.36
144 INT95414 Positive_regulation of Alms1 40 0.41 20.3 8.1 75.36
145 INT190883 Gene_expression of Apoc3 16 0.38 14.18 1.93 75.20
146 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 75.20
147 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 75.00
148 INT109102 Binding of Tcm 13 0.39 3.67 0.58 75.00
149 INT42942 Gene_expression of Clstn2 3 0.67 1.05 0.31 75.00
150 INT143179 Positive_regulation of Arid3a 1 0.39 0.64 0.08 75.00
151 INT136180 Binding of MTOR 9 0.35 5.01 0.38 74.92
152 INT17032 Positive_regulation of Ttr 7 0.50 3.87 1.2 74.84
153 INT79938 Regulation of Gene_expression of VCAM1 12 0.61 11.22 2.64 74.24
154 INT321422 Regulation of Gene_expression of THBD 1 0.10 0.59 0 74.24
155 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 74.20
156 INT178772 Transcription of App 17 0.70 10.79 2.79 74.08
157 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 74.08
158 INT11118 Gene_expression of RAPGEF5 13 0.65 9.35 0.43 74.08
159 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 73.80
160 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 73.80
161 INT155992 Gene_expression of THBD 16 0.66 17 1.24 73.80
162 INT74924 Positive_regulation of LOC100362295 3 0.36 1.39 2.4 73.40
163 INT44955 Negative_regulation of Eln 8 0.42 3.79 0.83 73.36
164 INT129058 Binding of Arid3a 2 0.34 0.95 0.09 73.12
165 INT203508 Gene_expression of Eno2 12 0.65 4.98 1.55 72.84
166 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 72.84
167 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 72.56
168 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 71.80
169 INT217380 Negative_regulation of Negative_regulation of Mtap2 2 0.27 1.18 0.31 71.80
170 INT217371 Negative_regulation of Negative_regulation of Syp 2 0.11 1.16 0.29 71.80
171 INT185973 Negative_regulation of Syp 16 0.54 2.83 0.87 71.28
172 INT91594 Localization of NOS3 12 0.78 5.39 2.02 71.12
173 INT192238 Positive_regulation of Localization of NOS3 2 0.21 0.76 0.09 71.12
174 INT129454 Negative_regulation of Adamts13 6 0.30 7.78 0.31 70.40
175 INT8476 Binding of Bche 10 0.37 4.38 1.29 69.52
176 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 68.68
177 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 68.64
178 INT240451 Positive_regulation of Localization of DSE 1 0.42 2.03 0.08 68.04
179 INT1114 Localization of Ins1 748 0.80 192.95 165.48 67.96
180 INT130387 Binding of CAT 4 0.36 2.39 0.55 67.84
181 INT78182 Positive_regulation of ACCS 43 0.43 46.39 6.78 67.76
182 INT277033 Positive_regulation of Positive_regulation of ACCS 2 0.15 1.69 0.21 67.76
183 INT18681 Gene_expression of Thy1 80 0.71 38.8 5.23 67.60
184 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83 67.56
185 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19 67.56
186 INT286473 Positive_regulation of Gene_expression of Itm2b 1 0.66 1.74 0.18 67.56
187 INT177992 Positive_regulation of SNRNP70 28 0.49 16.14 4.28 67.36
188 INT198873 Regulation of Lrp1 3 0.35 1.45 0.24 67.28
189 INT217387 Regulation of Abca1 3 0.27 2.01 0.15 67.28
190 INT217395 Regulation of NR1H3 2 0.04 0.68 0.11 67.28
191 INT233453 Gene_expression of Itm2b 8 0.74 8.45 0.99 66.72
192 INT217382 Regulation of Gene_expression of Bace1 26 0.61 17 1.76 65.88
193 INT217370 Phosphorylation of Apoe 2 0.63 1.8 0.49 65.80
194 INT217375 Phosphorylation of Eno2 1 0.79 0.41 0.13 65.80
195 INT217389 Negative_regulation of Gene_expression of Bace1 43 0.59 18.57 3.27 65.60
196 INT185969 Regulation of Syp 5 0.57 2.58 0.92 65.12
197 INT55537 Positive_regulation of Coq10a 22 0.58 8.17 8.33 64.08
198 INT131296 Positive_regulation of Bace1 208 0.70 170.1 15.79 64.00
199 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 62.76
200 INT240450 Localization of DSE 2 0.62 1.88 0.08 62.64
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