Evaluation:1

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These are evaluation pages designed to aid in the manual curation process.

These are ints 1-500 ordered by relevance to pain.

Molecular Interactions

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4
3 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
4 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
5 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49
6 INT2161 Gnrh1 Positive_regulation of Localization of LH 33 0.73 0.87 14.34
7 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2
8 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
9 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
10 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36
11 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18
12 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25
13 INT10161 Binding of Cck and Penk 6 0.53 0.97 11.15
14 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
15 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
16 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57
17 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46
18 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
19 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21
20 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82
21 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
22 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18
23 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
24 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8
25 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73
26 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
27 INT11250 Cck Positive_regulation of Gene_expression of Fos 14 0.78 0.08 7.29
28 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
29 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
30 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
31 INT69229 Ngf Positive_regulation of Gene_expression of Bdnf 6 0.76 8.19 6.66
32 INT140015 Avp Positive_regulation of Localization of Penk 3 0.63 3.48 6.63
33 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62
34 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
35 INT26824 Crh Positive_regulation of Localization of Penk 7 0.54 0.42 6.49
36 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
37 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25
38 INT31439 Penk Positive_regulation of Localization of Prl 8 0.55 0.23 6.24
39 INT91538 Pomc Positive_regulation of P9Ehs1 6 0.11 1.47 6.23
40 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
41 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 8 0.74 4.31 6.1
42 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09
43 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87
44 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
45 INT269444 Binding of RAB5A and HHIP 1 0.04 0 5.79
46 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
47 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
48 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
49 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
50 INT140935 Binding of Cd40lg and Cd40 1 0.30 6.34 5.61
51 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
52 INT296275 Binding of Dlg4 and Kcnip3 1 0.39 3.58 5.6
53 INT92466 Pomc Positive_regulation of Binding of Crygs 8 0.06 0 5.56
54 INT227157 Binding of PEBP1 and Gpm6a 1 0.00 1.28 5.52
55 INT20133 Trh Positive_regulation of Localization of Prl 23 0.78 2.04 5.44
56 INT33314 Binding of Ap1m1 and Ap1m2 1 0.07 0.97 5.42
57 INT170447 Binding of Pax3 and Spr 1 0.01 0.1 5.37
58 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27
59 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
60 INT9546 Binding of Adarb1 and Penk 5 0.03 0 5.1
61 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
62 INT1310 Pomc Regulation of Localization of Prl 9 0.40 0.61 4.96
63 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
64 INT102122 Binding of Calca and RT1-M4 7 0.29 5.83 4.94
65 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
66 INT166590 Binding of RAMP1 and DCLK3 2 0.37 0.39 4.8
67 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
68 INT44716 Binding of ABL2 and PDYN 2 0.40 0.66 4.77
69 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71
70 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
71 INT24742 Binding of Calca and Vip 1 0.37 0.18 4.68
72 INT164362 Binding of NLRP1 and VTA1 1 0.15 2.37 4.67
73 INT125407 Binding of OPRL1 and PTPRM 1 0.03 0.72 4.67
74 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
75 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
76 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
77 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59
78 INT34444 Binding of Oprl1 and Ptprg 4 0.03 0.18 4.58
79 INT14095 Binding of Vsig2 and Coq10a 2 0.33 1.98 4.55
80 INT51497 Cck Negative_regulation of Localization of Trim13 1 0.34 0 4.53
81 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
82 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
83 INT186566 Hpcl1 Positive_regulation of Fos 1 0.17 0.38 4.49
84 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
85 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
86 INT38217 Penk Regulation of Localization of Avp 2 0.38 0.56 4.45
87 INT30423 Penk Regulation of Localization of Ins1 4 0.26 0.77 4.42
88 INT1390 Trh Positive_regulation of Prl 14 0.67 4.42 4.39
89 INT36536 PRSS1 Positive_regulation of PENK 1 0.24 0.86 4.39
90 INT64480 Binding of OPRL1 and PNOC 2 0.33 0.23 4.38
91 INT180774 Gdnf Positive_regulation of Trpv1 1 0.33 2.43 4.37
92 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
93 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
94 INT1392 Trh Regulation of Prl 15 0.29 2.47 4.29
95 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
96 INT122567 Mog Positive_regulation of Eae1 8 0.31 10.18 4.26
97 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
98 INT240653 Ngf Positive_regulation of Positive_regulation of Bdnf 1 0.55 2.97 4.23
99 INT259209 Binding of Glul and Flna 1 0.03 0 4.2
100 INT1313 Pomc Positive_regulation of Prl 7 0.35 0 4.19
101 INT161109 Avp Positive_regulation of Chkb 1 0.12 0.18 4.19
102 INT143270 Binding of Cnr1 and Gprasp1 4 0.54 0.64 4.18
103 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
104 INT11613 Cck Positive_regulation of Localization of Oxt 3 0.53 0 4.17
105 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
106 INT128998 Cxcl1 Positive_regulation of Localization of Calca 1 0.66 2.96 4.15
107 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
108 INT31440 Penk Positive_regulation of Prl 7 0.76 0 4.1
109 INT64756 oh Negative_regulation of Gpi1 1 0.03 0 4.09
110 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08
111 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
112 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
113 INT11248 Gh Positive_regulation of Ghrh 2 0.26 0.09 4.04
114 INT2169 Penk Regulation of Localization of Prl 6 0.48 0 4.03
115 INT13969 Binding of Calca and Sst 3 0.32 0.6 4.02
116 INT95730 Binding of CP and SPINK1 2 0.19 5.65 4.02
117 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
118 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4
119 INT138961 Dbi Positive_regulation of Chkb 1 0.00 3.05 3.99
120 INT138959 Dbi Positive_regulation of Penk 1 0.01 3.05 3.99
121 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
122 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97
123 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
124 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93
125 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92
126 INT13966 Calca Positive_regulation of Localization of Sst 5 0.49 0.75 3.91
127 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
128 INT107801 Ugt1a5 Positive_regulation of Localization of Prl 3 0.76 1 3.9
129 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
130 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
131 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
132 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
133 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
134 INT69032 IL18 Positive_regulation of IFNA1 12 0.23 7.87 3.83
135 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
136 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
137 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
138 INT11252 Cck Positive_regulation of Fos 6 0.78 0 3.79
139 INT122349 Ngf Regulation of Trpv1 3 0.64 1.55 3.79
140 INT180813 Ngf Positive_regulation of Sorbs1 1 0.04 2.09 3.79
141 INT69938 Cck Positive_regulation of Localization of Abat 2 0.29 0 3.78
142 INT136525 Binding of Prokr1 and Trpv1 1 0.39 2.9 3.76
143 INT141254 Ngf Regulation of Transcription of Trpv1 1 0.53 1.37 3.74
144 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
145 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
146 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
147 INT107331 Binding of PPBP and Adarb1 1 0.01 0 3.67
148 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
149 INT132862 Ngf Positive_regulation of Bdnf 4 0.46 4.05 3.65
150 INT15984 Binding of Avp and Oxt 11 0.32 1.33 3.64
151 INT34534 Binding of Penk and Oprl1 4 0.37 0 3.64
152 INT71069 Oprl1 Regulation of Gene_expression of Tac4 1 0.03 0.13 3.64
153 INT64883 Ptger2 Positive_regulation of Ina 1 0.03 1.26 3.64
154 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
155 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 0.47 0.72 3.63
156 INT140011 Avp Positive_regulation of Dbi 2 0.07 0.93 3.61
157 INT132228 Negative_regulation of Binding of Pik3cg and Sh2d6 1 0.07 1.96 3.6
158 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
159 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
160 INT29837 Gnrh1 Positive_regulation of LH 6 0.67 0 3.53
161 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
162 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
163 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
164 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52
165 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
166 INT17317 Binding of Jun and Fos 7 0.42 1.03 3.5
167 INT158770 Binding of Trpv1 and Trpa1 5 0.34 2.07 3.5
168 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
169 INT24710 Binding of Calca and SUB1P1 1 0.01 2.09 3.48
170 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47
171 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
172 INT340118 Binding of Sugt1 and Pain1 1 0.00 3.53 3.44
173 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
174 INT108473 Binding of ADCYAP1 and PNOC 1 0.32 0.64 3.41
175 INT152035 Binding of HLA-A and MRAP 2 0.31 6.95 3.4
176 INT69770 Penk Negative_regulation of Pscs 1 0.11 0.22 3.39
177 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
178 INT334928 Binding of pr and Aes 1 0.00 1.49 3.38
179 INT212658 KCNA1 Positive_regulation of Cort 1 0.00 2.58 3.36
180 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
181 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
182 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
183 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
184 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
185 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
186 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
187 INT56458 Binding of GPM6A and IGHG3 4 0.02 0 3.31
188 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
189 INT276678 Nkx1-1 Regulation of Nav1 1 0.15 0.88 3.31
190 INT276676 Prkcg Regulation of Nav1 1 0.30 0.82 3.29
191 INT17300 Prss12 Positive_regulation of Localization of Acot1 4 0.11 0 3.28
192 INT182704 Binding of NPFF and TP53INP2 1 0.01 0.73 3.28
193 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
194 INT108472 Binding of NOS1 and PNOC 1 0.32 0.64 3.27
195 INT48162 RIMS3 Regulation of Localization of LTC4S 1 0.10 2.14 3.25
196 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
197 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
198 INT354207 Igfbp7 Positive_regulation of Accn3 1 0.52 6.55 3.24
199 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
200 INT7190 Syt17 Positive_regulation of Ctsb 1 0.16 0 3.23
201 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
202 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
203 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
204 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
205 INT3434 Vip Positive_regulation of Localization of Prl 6 0.76 0.16 3.21
206 INT7193 Abl2 Positive_regulation of Ctsb 1 0.21 0 3.21
207 INT13729 GHRH Positive_regulation of Localization of GH1 13 0.62 0.59 3.2
208 INT18793 Crh Regulation of Localization of Penk 1 0.59 0 3.2
209 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
210 INT34294 Penk Positive_regulation of Localization of Crh 1 0.16 0.43 3.19
211 INT166134 Binding of Cxcl12 and Cxcr4 3 0.49 5.69 3.17
212 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
213 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
214 INT29657 Binding of Calca and Calcb 1 0.26 0 3.16
215 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16
216 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16
217 INT17456 Binding of CSF2 and POMC 3 0.32 4.06 3.15
218 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
219 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
220 INT128513 Pnoc Regulation of Adarb1 1 0.01 0.92 3.14
221 INT202959 Binding of BAG3 and MCRS1 1 0.11 7.46 3.14
222 INT289979 Binding of Helt and Negative_regulation of Maoa 1 0.00 0.17 3.14
223 INT211694 Binding of Cntnap1 and Nav1 1 0.04 0 3.14
224 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
225 INT85042 Binding of CCT6A and MAX 1 0.00 0 3.13
226 INT91539 Pomc Positive_regulation of Pomc Positive_regulation of P9Ehs1 1 0.03 0.84 3.13
227 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12
228 INT94204 NCOR2 Regulation of Gene_expression of SP5 1 0.02 2.15 3.12
229 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
230 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11
231 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
232 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1
233 INT30424 Penk Regulation of Localization of Sst 1 0.20 0 3.1
234 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
235 INT158752 Binding of TRPV1 and Rvm 1 0.05 1.6 3.1
236 INT101408 Binding of Grin1 and Olr1469 1 0.03 0.86 3.1
237 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
238 INT309150 Edc4 Positive_regulation of Creb1 1 0.03 3.46 3.09
239 INT1151 Binding of CCK and GAST 7 0.49 0.73 3.08
240 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08
241 INT158751 Binding of TRPV1 and Pag1 1 0.03 1.59 3.08
242 INT276679 Prkcg Positive_regulation of Positive_regulation of Nkx1-1 1 0.07 0.94 3.08
243 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 0.67 2.13 3.06
244 INT36535 PRSS1 Positive_regulation of Regulation of PENK 1 0.23 0.54 3.06
245 INT26677 Penk Regulation of Localization of Trh 5 0.50 0 3.05
246 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
247 INT106338 Positive_regulation of Tacr1 Positive_regulation of Localization of Abat 5 0.34 0 3.01
248 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
249 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
250 INT40660 Pdyn Positive_regulation of Localization of Prl 1 0.27 0 3.01
251 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
252 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
253 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
254 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
255 INT28235 Binding of Cck and Gast 5 0.38 0.73 2.96
256 INT202965 Binding of STC2 and BAG3 1 0.02 7.86 2.96
257 INT324927 Syt17 Positive_regulation of Bdkrb1 1 0.04 4.29 2.96
258 INT152699 Bdnf Positive_regulation of Ltp 5 0.05 1.22 2.95
259 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
260 INT312686 CP Positive_regulation of CP Positive_regulation of CCL20 1 0.03 10.97 2.94
261 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
262 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
263 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
264 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
265 INT41152 Binding of Penk and Slc3a1 3 0.12 0.11 2.91
266 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
267 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
268 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
269 INT150632 Ea1 Negative_regulation of Mpo 1 0.17 1.55 2.9
270 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
271 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
272 INT156381 Binding of Grin1 and Dlg4 1 0.39 0.86 2.9
273 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
274 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
275 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
276 INT69937 Cck Positive_regulation of Abat 2 0.31 0 2.88
277 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
278 INT140014 Avp Negative_regulation of Chkb 1 0.04 1.58 2.86
279 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
280 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
281 INT114126 Binding of APLNR and OPRL1 1 0.01 0.47 2.85
282 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
283 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84
284 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
285 INT194409 Binding of CALCA and IGKV1D-8 1 0.15 0 2.84
286 INT32656 Pomc Positive_regulation of Rbm39 1 0.08 0.42 2.84
287 INT130085 Crp Positive_regulation of Gene_expression of Vcam1 1 0.23 4.34 2.84
288 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
289 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
290 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81
291 INT229497 Binding of Vim and Ndel1 1 0.33 3.5 2.81
292 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
293 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
294 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
295 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
296 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
297 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
298 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
299 INT91649 Binding of Lbp and SPECC1 1 0.12 2.88 2.78
300 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76
301 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
302 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
303 INT23280 PRSS1 Positive_regulation of Penk 1 0.05 1.53 2.74
304 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
305 INT202974 Binding of BAG3 and CPP 1 0.25 6.22 2.73
306 INT127621 Bst1 Regulation of Positive_regulation of Fos 1 0.26 0 2.73
307 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
308 INT69030 IL18 Positive_regulation of IL12A 3 0.31 5.57 2.72
309 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72
310 INT69059 Klkb1 Regulation of H2-M3 Regulation of Klkb1 1 0.00 0.42 2.71
311 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
312 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
313 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
314 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
315 INT30133 Binding of Cck and Penk 1 0.27 2.49 2.71
316 INT69057 H2-M3 Regulation of Klkb1 1 0.00 0.42 2.71
317 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
318 INT103669 Hps4 Positive_regulation of Mors1 1 0.01 0 2.7
319 INT151381 St8sia1 Positive_regulation of Cck 1 0.19 0.45 2.7
320 INT134294 Binding of Pdyn and Penk 1 0.23 0 2.69
321 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
322 INT87267 Binding of BMP8B and KRIT1 1 0.06 0.16 2.69
323 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69
324 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
325 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
326 INT182564 Binding of Ptger2 and Trpv1 1 0.18 1.77 2.67
327 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
328 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
329 INT150455 Binding of Prss12 and Nts 3 0.24 1.42 2.66
330 INT91350 Binding of Pla2g4a and RYBP 1 0.00 1.15 2.65
331 INT70946 Penk Positive_regulation of Hpse 1 0.34 0 2.65
332 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
333 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
334 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64
335 INT259198 Oprm1 Negative_regulation of Binding of Oprm1 and Flna 1 0.00 0 2.64
336 INT259214 Oprm1 Negative_regulation of Binding of Flna and Flna 1 0.01 0 2.64
337 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64
338 INT62450 Il2 Positive_regulation of Localization of Crh 1 0.43 0.59 2.64
339 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63
340 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
341 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
342 INT152113 Binding of NTSR1 and Ngf 3 0.33 2.09 2.62
343 INT212505 Binding of pr and Lbp 1 0.01 4.26 2.62
344 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
345 INT30345 Pomc Regulation of Localization of Penk 3 0.31 0 2.61
346 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
347 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
348 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
349 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
350 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
351 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
352 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
353 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
354 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
355 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
356 INT210696 Trpv1 Regulation of Slc12a2 1 0.25 1.97 2.58
357 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
358 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
359 INT111789 Cck Regulation of Gene_expression of Penk 1 0.49 1.68 2.57
360 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55
361 INT111786 Penk Regulation of Gene_expression of Cck 1 0.49 1.66 2.55
362 INT340117 Binding of Bdnf and Pain1 1 0.01 2.48 2.55
363 INT67905 Binding of Spn and Fosl1 1 0.24 2.1 2.54
364 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54
365 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
366 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54
367 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
368 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 1 0.78 0.16 2.53
369 INT26892 OGG1 Negative_regulation of Gene_expression of Gh1 1 0.12 0 2.53
370 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
371 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
372 INT107812 Nppa Positive_regulation of Localization of Sst 1 0.48 0.54 2.51
373 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
374 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
375 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
376 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
377 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
378 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
379 INT113714 Em Positive_regulation of tf 1 0.32 0 2.5
380 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
381 INT299783 Binding of Cd28 and Cd80 7 0.14 6.49 2.49
382 INT317528 Ppp1r9b Regulation of Grin1 1 0.18 0.2 2.48
383 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48
384 INT20411 Ghrh Positive_regulation of Gh1 6 0.56 0.62 2.47
385 INT130284 Ins1 Negative_regulation of Gene_expression of Npy 1 0.32 0.1 2.47
386 INT92182 Mir702 Negative_regulation of Adk 1 0.07 1.29 2.47
387 INT113715 Msh3 Positive_regulation of tf 1 0.11 0 2.47
388 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
389 INT170038 Gtf3a Regulation of Gene_expression of DRGX 1 0.00 1.36 2.46
390 INT14687 Binding of Penk and Ppt1 1 0.41 0 2.46
391 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
392 INT170037 Ngf Regulation of Gene_expression of DRGX 1 0.01 1.37 2.46
393 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
394 INT103330 Ngf Positive_regulation of Gdnf 2 0.28 1.27 2.45
395 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
396 INT231968 Binding of Cpn1 and Rvm 1 0.11 1.57 2.45
397 INT96462 Pnoc Positive_regulation of Pag1 1 0.01 0.74 2.45
398 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
399 INT231970 Binding of Cpn1 and Pag1 1 0.07 1.56 2.44
400 INT135867 Zfp821 Positive_regulation of Positive_regulation of Chrne 1 0.01 0 2.44
401 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
402 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43
403 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42
404 INT255317 Binding of Dpep1 and Nav1 1 0.01 0 2.42
405 INT143272 Binding of CNR1 and Gprasp1 1 0.01 0.17 2.42
406 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
407 INT37873 Pag1 Regulation of Nrm 2 0.04 1.1 2.41
408 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
409 INT103332 Ngf Regulation of Gene_expression of TRPV1 3 0.09 2.6 2.4
410 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
411 INT318998 IFNA1 Positive_regulation of Localization of CXCL10 1 0.15 2.09 2.39
412 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39
413 INT96465 Pnoc Positive_regulation of GEM 1 0.01 0.74 2.39
414 INT317526 Binding of Hint1 and Gipc1 1 0.00 0.25 2.38
415 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37
416 INT284088 Binding of BDNF and NTRK2 5 0.41 3.4 2.37
417 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
418 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
419 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
420 INT153728 RYBP Positive_regulation of Gpt 3 0.03 2.01 2.36
421 INT107578 Kitl Negative_regulation of Grin2b 1 0.12 2.05 2.36
422 INT29716 Crh Negative_regulation of Localization of Gnrh1 5 0.44 0 2.35
423 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
424 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
425 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
426 INT284860 Binding of Pdzd2 and Nav1 9 0.29 2.33 2.34
427 INT107165 Binding of Gabrg1 and Trpv1 2 0.01 0.16 2.34
428 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
429 INT214159 Cck Positive_regulation of Nts 1 0.03 0.93 2.34
430 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
431 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
432 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
433 INT158809 Pag1 Regulation of Rvm 1 0.02 1.28 2.33
434 INT108987 Ngf Regulation of Gene_expression of Sit1 1 0.00 1.46 2.32
435 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
436 INT249013 Gabrg1 Negative_regulation of Per2 1 0.34 0.07 2.31
437 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
438 INT54489 Binding of Jun and Rabep2 4 0.16 1.48 2.3
439 INT14781 Cck Regulation of Gast 3 0.38 0.28 2.3
440 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
441 INT13967 Calca Positive_regulation of Sst 1 0.45 0 2.3
442 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
443 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
444 INT76776 Binding of Pnoc and Ptprg 2 0.02 0 2.29
445 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
446 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
447 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28
448 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
449 INT128778 Binding of Mcam and Nav1 1 0.03 0.51 2.28
450 INT128777 Binding of Cntn1 and Nav1 1 0.48 0.51 2.28
451 INT247601 Binding of PEPD and SCN9A 1 0.15 2.26 2.27
452 INT321474 Binding of Slc6a2 and Ubqln1 1 0.00 0.8 2.27
453 INT156622 Umod Regulation of Phosphorylation of Creb1 1 0.05 0.33 2.27
454 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27
455 INT211748 Binding of Pag1 and Mors1 2 0.07 0.2 2.26
456 INT321477 Binding of Ubqln1 and Flvcr2 1 0.00 0.81 2.26
457 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
458 INT350148 Binding of IL12A and ERAL1 1 0.21 8.23 2.26
459 INT231971 Binding of Cpn1 and Shbdp1 1 0.04 1.39 2.26
460 INT134872 Binding of Calm3 and IQCJ 1 0.00 0.82 2.26
461 INT228454 Ngf Positive_regulation of Phosphorylation of Trpv1 1 0.39 2.97 2.26
462 INT7367 Ghrh Regulation of Localization of Gh1 5 0.49 1.55 2.25
463 INT7195 Negative_regulation of Syt17 Positive_regulation of Ctsb 1 0.10 0 2.25
464 INT231967 Binding of Psmd1 and Cpn1 1 0.06 1.39 2.25
465 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
466 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
467 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
468 INT231969 Binding of Cfp and Cpn1 1 0.05 1.38 2.25
469 INT91860 Npy Regulation of Npy1r 2 0.28 1.13 2.24
470 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24
471 INT275398 Binding of ITIH4 and Htatsf1 1 0.02 5.05 2.24
472 INT18197 Ghrh Positive_regulation of Localization of Ggh 4 0.46 0 2.23
473 INT38161 Binding of Caf and Ack 1 0.21 0.52 2.23
474 INT51317 Binding of POMC and OR5D2P 1 0.00 0.6 2.23
475 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
476 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
477 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
478 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
479 INT197379 Tbs1 Positive_regulation of Ltp 6 0.07 1.87 2.21
480 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
481 INT40408 Positive_regulation of Gnrh1 Positive_regulation of LH 2 0.58 0 2.21
482 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
483 INT312690 CP Positive_regulation of CCL20 1 0.11 8.23 2.2
484 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
485 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
486 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
487 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
488 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
489 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
490 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
491 INT146930 CAP1 Regulation of ABCB1 1 0.29 0.3 2.19
492 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
493 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
494 INT334136 Binding of IFNA1 and Acsm3 1 0.01 4.52 2.19
495 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
496 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18
497 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18
498 INT146520 Tmem132a Regulation of Gene_expression of Fos 1 0.69 0.5 2.18
499 INT113451 Ngf Regulation of Gene_expression of ASIC3 1 0.07 1.35 2.18
500 INT12140 Ngf Regulation of Chat 1 0.44 1.67 2.18
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