G:23411

Official Symbol SIRT1 Aliases SIR2L1 EntrezGene 23411 UniProt Coming Soon

Unique Molecular Interactions 10 Total Molecular Interactions 11 Total Single Events 62 Unique Interaction Partners 5

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to SIRT1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to SIRT1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to SIRT1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT204318	NOS3 Regulation of NOS3 Regulation of SIRT1	1	0.20	0.1	0
2	INT204325	Binding of PPARGC1A and SIRT1	1	0.39	0.19	0
3	INT318218	SIRT1 Positive_regulation of Binding of FOXO3	1	0.44	0.51	0
4	INT318219	SIRT1 Regulation of TBK1	1	0.03	0.43	0
5	INT204326	SIRT1 Positive_regulation of PPARGC1A	1	0.51	0.19	0
6	INT318221	SIRT1 Positive_regulation of FOXO3	1	0.41	0.63	0
7	INT337637	SIRT1 Negative_regulation of TP53	1	0.23	1.49	0
8	INT204321	NOS3 Regulation of SIRT1	1	0.23	0.1	0
9	INT318216	SIRT1 Positive_regulation of Gene_expression of FOXO3	1	0.36	0.52	0
10	INT318217	SIRT1 Regulation of TP53	1	0.07	0.43	0
11	INT204319	SIRT1 Regulation of Gene_expression of PPARGC1A	1	0.50	0.12	0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 23411. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 23411. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT204368	Gene_expression of SIRT1	17	0.76	4.48	0.3
2	INT204365	Positive_regulation of Gene_expression of SIRT1	8	0.68	2.9	0.13
3	INT339991	Localization of SIRT1	1	0.34	0.3	0.06
4	INT318236	Negative_regulation of Gene_expression of SIRT1	1	0.42	0.59	0.05
5	INT204367	Positive_regulation of SIRT1	13	0.68	4.17	0
6	INT204349	Regulation of SIRT1	8	0.61	1.99	0
7	INT204353	Transcription of SIRT1	3	0.68	0.67	0
8	INT204361	Negative_regulation of SIRT1	1	0.42	0.18	0
9	INT204371	Positive_regulation of Transcription of SIRT1	1	0.49	0.13	0
10	INT318239	Regulation of Transcription of SIRT1	1	0.26	0.45	0
11	INT350520	Phosphorylation of SIRT1	1	0.25	0.72	0
12	INT204356	Regulation of Gene_expression of SIRT1	1	0.61	0.29	0
13	INT204331	Binding of SIRT1	1	0.47	0.39	0