G:351

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Official Symbol APP
Aliases AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma
EntrezGene 351
UniProt Coming Soon
Unique Molecular Interactions 43
Total Molecular Interactions 62
Total Single Events 564
Unique Interaction Partners 27

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to APP. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to APP. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to APP. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
2 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
3 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
4 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
5 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
6 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
7 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
8 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
9 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4
10 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37
11 INT147434 Psenen Positive_regulation of APP 1 0.01 0.58 0.32
12 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
13 INT319220 FSIP1 Regulation of APP 1 0.29 1.46 0.29
14 INT79592 Binding of APP and Reg1 1 0.01 0.16 0.27
15 INT139980 Negative_regulation of CTSB Negative_regulation of Gene_expression of APP 1 0.15 0.7 0.26
16 INT139981 CTSB Negative_regulation of Gene_expression of APP 1 0.11 0.7 0.26
17 INT114244 Cpox Negative_regulation of Gene_expression of APP 1 0.00 0.7 0.25
18 INT70082 Binding of APP and TGM1 1 0.00 1.22 0.22
19 INT70084 Negative_regulation of Binding of APP and TGM1 1 0.00 0.61 0.11
20 INT70083 TGM1 Positive_regulation of Binding of APP 1 0.00 0.61 0.11
21 INT123101 Binding of APP and Ache 1 0.07 0.32 0.11
22 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08
23 INT288099 Binding of APP and App 1 0.01 1.04 0.05
24 INT236009 HIST2H2AA3 Positive_regulation of Protein_catabolism of APP 1 0.02 0.19 0.04
25 INT236015 HIST2H2AA3 Positive_regulation of Gene_expression of APP 1 0.02 0.95 0.04
26 INT162753 Binding of APP and Slc30a2 1 0.00 1.25 0.04
27 INT162754 Negative_regulation of Binding of APP and Slc30a2 1 0.00 1.26 0.04
28 INT230137 OSBP Regulation of APP 1 0.59 0.15 0.03
29 INT270432 Lhb Positive_regulation of APP 1 0.03 0.51 0.03
30 INT270431 Gnrh1 Positive_regulation of APP 1 0.06 0.51 0.03
31 INT236013 HIST2H2AA3 Regulation of Gene_expression of APP 1 0.01 0 0
32 INT230140 Gene_expression of OSBP Regulation of Localization of APP 1 0.30 0.06 0
33 INT334643 Binding of APP and HM13 1 0.02 0 0
34 INT230146 Binding of APP and SORL1 1 0.20 0.17 0
35 INT225629 APP Positive_regulation of Positive_regulation of nr 1 0.01 0.08 0
36 INT230139 OSBP Regulation of Phosphorylation of APP 1 0.50 0 0
37 INT142955 Positive_regulation of Binding of APP and BACE1 1 0.48 0.5 0
38 INT230143 OSBP Regulation of Gene_expression of APP 1 0.50 0.1 0
39 INT142954 Binding of APP and BACE1 1 0.37 0.5 0
40 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
41 INT230151 OSBP Regulation of Localization of APP 1 0.50 0 0
42 INT225627 APP Positive_regulation of nr 1 0.02 0.08 0
43 INT230149 Binding of APP and NOTCH2 1 0.32 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 351. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 351. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
2 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
3 INT29745 Binding of APP 47 0.48 26.49 12.4
4 INT41569 Regulation of APP 32 0.62 17.15 9.4
5 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
6 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
7 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
8 INT58003 Localization of APP 32 0.80 13.75 4.2
9 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
10 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
11 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
12 INT162513 Regulation of Protein_catabolism of APP 5 0.51 1.79 2.36
13 INT58004 Positive_regulation of Localization of APP 5 0.46 2.1 1.5
14 INT125796 Regulation of Gene_expression of APP 8 0.59 5.95 1.41
15 INT141529 Regulation of Positive_regulation of APP 3 0.44 0.31 1.34
16 INT135899 Regulation of Binding of APP 3 0.45 1.22 1.14
17 INT162514 Positive_regulation of Regulation of APP 1 0.41 0.37 0.86
18 INT99375 Positive_regulation of Binding of APP 3 0.61 1.63 0.83
19 INT118078 Phosphorylation of APP 10 0.79 2.5 0.76
20 INT99820 Negative_regulation of Localization of APP 2 0.37 0.75 0.76
21 INT141528 Regulation of Localization of APP 2 0.52 0.4 0.67
22 INT118077 Negative_regulation of Phosphorylation of APP 1 0.07 0.74 0.61
23 INT225462 Positive_regulation of Positive_regulation of APP 3 0.44 1.41 0.55
24 INT142958 Positive_regulation of Protein_catabolism of APP 3 0.55 2.04 0.1
25 INT182830 Negative_regulation of Protein_catabolism of APP 2 0.35 2.09 0.03
26 INT234255 Transcription of APP 2 0.49 0.98 0
27 INT236037 Positive_regulation of Phosphorylation of APP 1 0.48 0.14 0
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