G:3558

Official Symbol IL2 Aliases IL-2, TCGF, lymphokine EntrezGene 3558 UniProt Coming Soon

Unique Molecular Interactions 113 Total Molecular Interactions 138 Total Single Events 1682 Unique Interaction Partners 82

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to IL2. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to IL2. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to IL2. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT329956	Binding of IL2 and IL23R	1	0.33	4.58	1.21
2	INT88193	Binding of IL2 and IL4	1	0.13	1.7	1.2
3	INT21415	POMC Positive_regulation of Gene_expression of IL2	1	0.00	0.27	1
4	INT161306	POMC Negative_regulation of Transcription of IL2	1	0.24	0.27	0.85
5	INT161307	JUN Positive_regulation of IL2	1	0.14	0.25	0.84
6	INT161305	NFKB1 Positive_regulation of IL2	1	0.25	0.25	0.83
7	INT12883	Binding of IL2 and POMC	1	0.01	0	0.81
8	INT8411	IL2 Regulation of Gene_expression of Vip	1	0.00	0.27	0.8
9	INT266769	IL2 Positive_regulation of Localization of IL4	1	0.00	1.03	0.72
10	INT266765	IL2 Positive_regulation of Localization of IL10	1	0.01	1.03	0.72
11	INT27034	HERPUD1 Regulation of Gene_expression of IL2	1	0.38	0	0.71
12	INT13238	POMC Regulation of Gene_expression of IL2	1	0.09	0.26	0.59
13	INT74656	YY1 Positive_regulation of Localization of IL2	1	0.07	0.09	0.58
14	INT39210	TF Positive_regulation of Gene_expression of IL2	1	0.17	0.07	0.57
15	INT141362	EP300 Negative_regulation of Transcription of IL2	1	0.17	0	0.56
16	INT144598	Hrh2 Positive_regulation of IL2	1	0.01	0.08	0.56
17	INT95206	Binding of CSF2 and IL2	1	0.40	1.81	0.4
18	INT292891	IL2 Regulation of IL5	1	0.02	0.25	0.39
19	INT292889	IL2 Regulation of IL12A	1	0.01	0.25	0.39
20	INT292886	IL2 Regulation of IL8	1	0.03	0.25	0.39
21	INT172148	Binding of IL2 and TNF	2	0.05	0.67	0.37
22	INT172135	Binding of IL2 and IL6	1	0.01	0.57	0.37
23	INT27036	HERPUD1 Positive_regulation of Gene_expression of IL2	1	0.31	0	0.37
24	INT68119	Binding of IL2 and Oprd1	1	0.02	0	0.37
25	INT27032	ASNA1 Regulation of Gene_expression of IL2	1	0.03	0	0.36
26	INT320699	Gene_expression of Ptger2 Negative_regulation of Gene_expression of IL2	1	0.00	1.1	0.35
27	INT267589	IL2 Positive_regulation of Gene_expression of IL12A	1	0.01	0.69	0.34
28	INT39208	ALOX5 Regulation of Gene_expression of IL2	1	0.04	0.06	0.34
29	INT285565	Positive_regulation of Zeb1 Negative_regulation of IL2	1	0.02	0.62	0.33
30	INT285566	F8 Negative_regulation of IL2	1	0.00	0.62	0.33
31	INT285563	Zeb1 Negative_regulation of IL2	1	0.01	0.62	0.33
32	INT303993	Lep Positive_regulation of Gene_expression of IL2	1	0.15	0.24	0.33
33	INT34727	TNF Positive_regulation of Gene_expression of IL2	1	0.56	0.81	0.31
34	INT94076	ARSA Negative_regulation of Gene_expression of IL2	1	0.13	0.09	0.3
35	INT94072	ARSA Regulation of Gene_expression of IL2	1	0.07	0.09	0.29
36	INT62753	IL2 Regulation of POMC	1	0.27	0	0.28
37	INT19513	Prl Positive_regulation of IL2	1	0.41	0.8	0.27
38	INT68118	Binding of IL2 and OPRD1	1	0.35	0	0.26
39	INT189145	MTNR1B Positive_regulation of Gene_expression of IL2	1	0.02	0.3	0.26
40	INT351007	Binding of IL2 and IL2RA	1	0.33	1.33	0.26
41	INT307011	MT1JP Regulation of IL2	1	0.01	0	0.24
42	INT63196	INS Positive_regulation of IL2	1	0.10	0.3	0.23
43	INT63197	POMC Positive_regulation of IL2	1	0.16	0.3	0.23
44	INT164517	CABIN1 Positive_regulation of Transcription of IL2	1	0.13	0.35	0.22
45	INT63200	PTH Positive_regulation of IL2	1	0.24	0.29	0.22
46	INT318303	Negative_regulation of Myoz1 Negative_regulation of Transcription of IL2	1	0.00	0.75	0.21
47	INT141043	ZNF404 Negative_regulation of Transcription of IL2	1	0.01	0	0.21
48	INT299787	Binding of IL2 and ISG20	1	0.04	0.82	0.21
49	INT39209	TMSB4XP5 Positive_regulation of Gene_expression of IL2	1	0.07	0	0.21
50	INT34903	CALM1 Negative_regulation of Gene_expression of IL2	1	0.18	0	0.2
51	INT226528	BTPs Negative_regulation of Gene_expression of IL2	1	0.04	0.22	0.19
52	INT292625	IL2 Positive_regulation of Gene_expression of IL9	1	0.11	0.29	0.19
53	INT353037	IL4 Positive_regulation of IL2	1	0.02	0.99	0.16
54	INT303980	Lep Positive_regulation of Transcription of IL2	1	0.10	0.24	0.16
55	INT353038	IL4 Positive_regulation of Localization of IL2	1	0.02	0.99	0.16
56	INT49608	IL2 Positive_regulation of Alpk1	1	0.01	1.47	0.14
57	INT289958	Binding of IL2 and IL2RB	1	0.02	0.59	0.12
58	INT39207	LBR Positive_regulation of Gene_expression of IL2	1	0.23	0	0.11
59	INT352030	Binding of NR3C1 and IL2	1	0.15	0.5	0.11
60	INT286969	IL2 Regulation of Gene_expression of FOXP3	1	0.04	1.05	0.1
61	INT333095	Localization of IL2 Negative_regulation of Negative_regulation of CD8A	1	0.10	0.8	0.09
62	INT194730	Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL2	1	0.06	0	0.09
63	INT33809	IL2 Regulation of Regulation of LIPE	1	0.23	0.09	0.09
64	INT333099	Localization of IL2 Negative_regulation of Negative_regulation of CD4	1	0.14	0.8	0.09
65	INT33806	IL2 Regulation of ADRB3	1	0.28	0.08	0.09
66	INT159852	Gene_expression of IL2 Regulation of Gene_expression of ACTN1	1	0.03	0.16	0.07
67	INT278059	XRCC1 Positive_regulation of Gene_expression of IL2	1	0.01	1.06	0.07
68	INT159854	Gene_expression of IL2 Regulation of Gene_expression of CDC42EP5	1	0.01	0.16	0.07
69	INT33807	IL2 Negative_regulation of Negative_regulation of LIPE	1	0.16	0.06	0.07
70	INT333092	Binding of CD4 and IL2	1	0.01	0.17	0.07
71	INT159853	Gene_expression of IL2 Regulation of Gene_expression of RHO	1	0.17	0.16	0.07
72	INT333098	Binding of CD8A and IL2	1	0.01	0.17	0.07
73	INT286955	IL2 Positive_regulation of Binding of STAT3 and FOXP3	1	0.03	0.63	0.06
74	INT159851	Positive_regulation of RHOA Positive_regulation of Gene_expression of IL2	1	0.15	0.15	0.06
75	INT286966	IL2 Positive_regulation of Binding of STAT3	1	0.04	0.5	0.06
76	INT194678	IL2 Positive_regulation of Positive_regulation of MAPK1	1	0.05	0	0.06
77	INT194664	Negative_regulation of MAPK1 Negative_regulation of IL2	1	0.06	0	0.05
78	INT60089	IL2 Regulation of IFNA2	1	0.25	0.09	0.05
79	INT351010	ISG20 Positive_regulation of Transcription of IL2	1	0.31	0.46	0.05
80	INT336388	Binding of IL2 and ALPK1	1	0.06	0.73	0.05
81	INT351009	IL2RG Positive_regulation of Transcription of IL2	1	0.27	0.44	0.05
82	INT351008	IL2RB Positive_regulation of Gene_expression of IL2	1	0.18	0.42	0.05
83	INT268674	IL2 Positive_regulation of XRCC1	1	0.08	0.75	0.05
84	INT194694	MAPK1 Negative_regulation of Gene_expression of IL2	1	0.04	0	0.04
85	INT331172	Binding of IFNA1 and IL2	1	0.00	0.46	0.04
86	INT35172	IL2 Positive_regulation of Gene_expression of IFNG	1	0.01	0.27	0.04
87	INT176326	IL2 Positive_regulation of Gene_expression of MUC1	1	0.08	0.71	0.04
88	INT286962	IL2 Regulation of Gene_expression of CD4	1	0.01	0.45	0.04
89	INT270206	Hdl1 Positive_regulation of Gene_expression of IL2	1	0.01	0.35	0.03
90	INT60088	IFNA2 Positive_regulation of IL2	1	0.12	0.07	0.03
91	INT211191	CD28 Positive_regulation of Gene_expression of IL2	1	0.15	0.15	0.03
92	INT235493	SFTPA1 Positive_regulation of Gene_expression of IL2	1	0.04	0	0.03
93	INT104864	IL2 Positive_regulation of NXT1	1	0.08	0	0
94	INT130222	IL2 Positive_regulation of Il2rb	1	0.00	0	0
95	INT210707	Binding of IFNA2 and IL2	1	0.06	0.91	0
96	INT340515	HIVEP1 Regulation of IL2	1	0.01	0.32	0
97	INT235491	SFTPA1 Regulation of Gene_expression of IL2	1	0.02	0.23	0
98	INT294521	Binding of IL2 and p53	1	0.40	0.1	0
99	INT111768	IL2 Positive_regulation of Localization of CRH	1	0.02	0	0
100	INT235492	SFTPA1 Positive_regulation of Localization of IL2	1	0.04	0	0
101	INT202599	Binding of IL2 and PTPN5	1	0.03	0.12	0
102	INT272775	IL2 Positive_regulation of Gene_expression of IGHG3	1	0.01	0.16	0
103	INT321788	IL2 Negative_regulation of Localization of IFN1@	1	0.23	0.09	0
104	INT202600	IL2 Regulation of HIVEP1	1	0.01	0.5	0
105	INT270145	TNF Positive_regulation of IL2	1	0.01	0.53	0
106	INT181216	IL2 Positive_regulation of Gpi1	1	0.00	0.15	0
107	INT340516	CD4 Regulation of IL2	1	0.04	0.32	0
108	INT293362	CSH1 Negative_regulation of Gene_expression of IL2	1	0.01	0.12	0
109	INT235495	PLAT Positive_regulation of Gene_expression of IL2	1	0.05	0	0
110	INT104865	IL2 Positive_regulation of TH1L	1	0.38	0	0
111	INT104863	IL2 Positive_regulation of ZAK	1	0.19	0	0
112	INT294522	Binding of IL2 and MDM2	1	0.40	0.2	0
113	INT294525	Binding of IL2 and PDB1	1	0.40	0.1	0
114	INT283461	Binding of IL2 and SLC4A2	1	0.01	0.98	0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 3558. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 3558. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT5116	Gene_expression of IL2	670	0.78	291.13	146.69
2	INT6105	Positive_regulation of IL2	133	0.69	82.76	34.67
3	INT10763	Localization of IL2	157	0.80	81.11	33.21
4	INT7538	Negative_regulation of IL2	95	0.57	47.31	31.7
5	INT9993	Positive_regulation of Gene_expression of IL2	131	0.69	46.27	30.04
6	INT5117	Negative_regulation of Gene_expression of IL2	118	0.59	52.33	29.96
7	INT15796	Regulation of IL2	66	0.61	25.43	20.62
8	INT10000	Regulation of Gene_expression of IL2	56	0.45	15.33	16.2
9	INT51014	Transcription of IL2	42	0.71	21.56	12.7
10	INT22383	Binding of IL2	59	0.48	39.06	8.56
11	INT58459	Negative_regulation of Localization of IL2	13	0.41	6.46	4.88
12	INT29138	Positive_regulation of Localization of IL2	25	0.50	10.06	3.89
13	INT22831	Negative_regulation of Positive_regulation of IL2	7	0.55	1.7	2.62
14	INT141367	Negative_regulation of Transcription of IL2	9	0.32	2.07	2.43
15	INT20289	Regulation of Localization of IL2	7	0.26	1.23	2.24
16	INT199591	Protein_catabolism of IL2	2	0.05	1.2	1.81
17	INT97108	Phosphorylation of IL2	5	0.73	2.47	1.7
18	INT88746	Positive_regulation of Transcription of IL2	7	0.51	2.14	1.6
19	INT152190	Positive_regulation of Phosphorylation of IL2	1	0.23	0.2	1.41
20	INT87029	Positive_regulation of Positive_regulation of IL2	8	0.50	8.17	1.36
21	INT97261	Negative_regulation of Regulation of IL2	2	0.26	1.04	1.17
22	INT112004	Positive_regulation of Negative_regulation of IL2	3	0.50	1.56	1.08
23	INT22830	Negative_regulation of Binding of IL2	4	0.55	4.8	1.06
24	INT19279	Negative_regulation of Negative_regulation of IL2	3	0.43	1.62	0.79
25	INT61623	Regulation of Positive_regulation of IL2	1	0.21	0.33	0.65
26	INT298430	Positive_regulation of Protein_catabolism of IL2	1	0.03	0.85	0.26
27	INT293350	Regulation of Binding of IL2	2	0.22	0.87	0.23
28	INT57480	Regulation of Negative_regulation of IL2	1	0.45	0.37	0.07
29	INT244650	Positive_regulation of Binding of IL2	1	0.20	1.39	0.05
30	INT235499	Regulation of Regulation of IL2	1	0.27	0	0.03
31	INT337565	Regulation of Transcription of IL2	1	0.45	0.51	0.03