G:93759

Official Symbol Sirt1 Aliases Sir2, Sir2a, SIR2L1, AA673258, MGC150273, Sir2alpha EntrezGene 93759 UniProt Coming Soon

Unique Molecular Interactions 18 Total Molecular Interactions 28 Total Single Events 146 Unique Interaction Partners 11

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Sirt1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Sirt1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Sirt1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT340300	Ea1 Positive_regulation of Gene_expression of Sirt1	1	0.08	1.68	1.49
2	INT340294	Ea1 Positive_regulation of Sirt1	1	0.06	0.53	0.83
3	INT340296	Ea1 Regulation of Gene_expression of Sirt1	1	0.08	0.15	0.46
4	INT190628	Negative_regulation of Binding of Rab7 and Sirt1	1	0.33	0.62	0.17
5	INT190638	Binding of Rab7 and Sirt1	1	0.29	0.62	0.17
6	INT246625	Sirt1 Positive_regulation of Negative_regulation of Trp53	1	0.10	0.96	0.08
7	INT256160	Positive_regulation of Binding of Pgc and Sirt1	1	0.55	0.21	0.07
8	INT256161	Binding of Pgc and Sirt1	1	0.38	0.21	0.07
9	INT340293	Binding of Ins1 and Sirt1	1	0.25	1.25	0.05
10	INT180040	Binding of D7Cwr3P and Sirt1	1	0.00	0	0
11	INT300696	Sirt1 Regulation of Cyb5r3	1	0.03	0	0
12	INT299444	Foxl2 Positive_regulation of Sirt1	1	0.24	0.31	0
13	INT289600	Negative_regulation of Binding of Sirt1 and Sirt1	1	0.47	1.17	0
14	INT299458	Gene_expression of Sirt1 Negative_regulation of Foxl2	1	0.25	0.32	0
15	INT256165	Binding of Sirt6 and Sirt1	1	0.13	0.58	0
16	INT289598	Binding of Sirt1 and Sirt1	1	0.41	1.15	0
17	INT314132	Sirt1 Positive_regulation of Ppargc1a	1	0.50	2.3	0
18	INT299451	Foxl2 Negative_regulation of Gene_expression of Sirt1	1	0.25	0.32	0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 93759. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 93759. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT4613	Positive_regulation of Sirt1	32	0.67	18.19	5.53
2	INT240934	Gene_expression of Sirt1	24	0.75	18.77	4.68
3	INT221409	Regulation of Sirt1	8	0.58	5.53	2.1
4	INT255787	Positive_regulation of Gene_expression of Sirt1	9	0.67	7.61	1.5
5	INT168065	Binding of Sirt1	13	0.47	4.55	1.02
6	INT240935	Transcription of Sirt1	2	0.68	0.42	0.42
7	INT340290	Regulation of Transcription of Sirt1	1	0.43	0.13	0.42
8	INT240914	Negative_regulation of Sirt1	9	0.46	3.16	0.34
9	INT246620	Negative_regulation of Positive_regulation of Sirt1	2	0.39	1.9	0.17
10	INT256111	Regulation of Gene_expression of Sirt1	1	0.32	0.73	0.14
11	INT256136	Negative_regulation of Binding of Sirt1	1	0.30	0.5	0.07
12	INT256137	Positive_regulation of Regulation of Sirt1	1	0.36	0.32	0.05
13	INT256129	Negative_regulation of Gene_expression of Sirt1	1	0.31	0.4	0.05
14	INT270038	Positive_regulation of Positive_regulation of Sirt1	2	0.43	0.44	0.03
15	INT246622	Phosphorylation of Sirt1	2	0.74	0.56	0.03
16	INT256134	Localization of Sirt1	5	0.50	2.99	0
17	INT300686	Regulation of Binding of Sirt1	1	0.44	0.06	0
18	INT300683	Positive_regulation of Negative_regulation of Sirt1	1	0.45	0	0
19	INT240932	Negative_regulation of Transcription of Sirt1	1	0.34	0.29	0
20	INT300685	Positive_regulation of Binding of Sirt1	1	0.67	0	0