GO:0000209

Name protein polyubiquitination Categary Process Go Slim No Go Link GO:0000209

Unique Molecular Interactions 442 Total Molecular Interactions 614 Total Single Events 5553 Pain Genes Associated 51

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein polyubiquitination. They are ordered first by their pain relevance and then by number of times they were reported for protein polyubiquitination. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT338167	Binding of CDKN2A and MC1R	1	0.42	6.14	5.76
2	INT60867	Binding of G2e3 and Gpm6a	2	0.01	0.1	1.93
3	INT68272	Binding of Oprd1 and G2e3	1	0.00	0.11	1.93
4	INT156008	Bcl2 Regulation of Localization of Aifm1	1	0.17	1.92	1.47
5	INT145930	ecs Positive_regulation of Gene_expression of Bcl2	1	0.01	2.06	1.34
6	INT162163	CDKN2A Positive_regulation of PLD2	1	0.24	0	1.24
7	INT59203	ecs Positive_regulation of Negative_regulation of Ube2d3	1	0.00	1.93	1.15
8	INT79602	Binding of PSMA5 and Oprd1	2	0.19	1.05	1.01
9	INT153039	Binding of G2e3 and LOC100360318	1	0.00	0	1.01
10	INT142202	FL Positive_regulation of Bcl2	1	0.05	0.39	0.99
11	INT112765	Binding of Nfkb1 and Bcl2	1	0.00	1.37	0.91
12	INT61698	G2e3 Regulation of Localization of Abat	1	0.05	0	0.88
13	INT277832	Binding of TNFRSF1B and NPEPPS	1	0.01	1.1	0.88
14	INT277831	Binding of TNFRSF1A and NPEPPS	1	0.01	1.1	0.87
15	INT166634	Binding of Bcl2 and Becn1	1	0.20	0.5	0.86
16	INT150864	RYBP Positive_regulation of Positive_regulation of Bcl2	1	0.01	0.66	0.86
17	INT124427	NPEPPS Positive_regulation of Protein_catabolism of COL7A1	1	0.00	0.56	0.84
18	INT144286	ACP1 Negative_regulation of Phosphorylation of PSMC6	1	0.45	0.39	0.78
19	INT104749	Ugt1a1 Regulation of Positive_regulation of G2e3	1	0.00	0.07	0.77
20	INT141911	Arih2 Regulation of Positive_regulation of Cpox	1	0.01	1.19	0.76
21	INT141910	Arih2 Regulation of Cpox	1	0.01	1.19	0.76
22	INT218935	Cyp3a23/3a1 Regulation of Bcl2	1	0.00	1.08	0.74
23	INT72229	Binding of NFKBIL1 and BTRC	1	0.00	0	0.73
24	INT320633	Positive_regulation of MAPK1 Regulation of BCL2	1	0.04	1.21	0.7
25	INT296785	Tlr9 Regulation of Bcl2	1	0.19	0.76	0.65
26	INT59202	ecs Positive_regulation of Ube2d3	1	0.00	0.98	0.59
27	INT72230	Binding of BTRC and EMID1	1	0.00	0	0.49
28	INT72227	Binding of BTRC and AP1M2	1	0.00	0	0.49
29	INT302839	MIR15A Negative_regulation of Bcl2	1	0.15	1.41	0.47
30	INT95404	Map3k1 Positive_regulation of Phosphorylation of Ephb1	1	0.12	0.16	0.46
31	INT95408	Map3k1 Positive_regulation of Ephb1	1	0.12	0.16	0.46
32	INT238639	Cd86 Negative_regulation of Negative_regulation of Bcl2	1	0.01	0.97	0.46
33	INT112772	Binding of Bcl2 and SGSM3	1	0.02	0.69	0.45
34	INT116609	Lnpep Negative_regulation of Bcl2	1	0.05	0.62	0.43
35	INT116606	Lnpep Regulation of Gene_expression of Bcl2	1	0.07	0.62	0.43
36	INT116607	Lnpep Negative_regulation of Gene_expression of Bcl2	1	0.10	0.62	0.43
37	INT60063	IL1B Regulation of NPEPPS	1	0.00	0.29	0.42
38	INT299041	SPARC Regulation of Gene_expression of NPEPPS	1	0.01	0.83	0.42
39	INT309143	Dlat Positive_regulation of Bcl2	1	0.06	1.04	0.42
40	INT148548	Cd44 Positive_regulation of Regulation of NPEPPS	1	0.00	0.29	0.42
41	INT309152	Dlat Positive_regulation of Gene_expression of Bcl2	1	0.04	1.05	0.42
42	INT13879	Binding of PSMB9 and KCNAB2	1	0.03	0.19	0.41
43	INT354704	Binding of MAP3K1 and Pick1	1	0.00	0.76	0.41
44	INT148547	Cd44 Positive_regulation of NPEPPS	1	0.00	0.29	0.41
45	INT158032	Binding of CDKN2A and KRT20	1	0.28	0.59	0.4
46	INT339511	Binding of Tlr4 and Traf6	1	0.05	0.12	0.38
47	INT339512	Negative_regulation of Binding of Tlr4 and Traf6	1	0.05	0.17	0.38
48	INT235878	Creb1 Positive_regulation of Gene_expression of Bcl2	1	0.05	0.17	0.38
49	INT339506	Binding of Irak1 and Traf6	1	0.03	0.12	0.37
50	INT299790	IL4 Negative_regulation of Gene_expression of NPEPPS	1	0.00	0.86	0.37
51	INT299788	INCENP Negative_regulation of Gene_expression of NPEPPS	1	0.00	0.86	0.37
52	INT97043	Binding of G2e3 and Hist1h3g	1	0.01	0.5	0.36
53	INT155062	Csf2 Positive_regulation of Transcription of Bcl2	1	0.31	2.91	0.36
54	INT107726	BIRC2 Regulation of ASIP	1	0.03	0.24	0.35
55	INT95644	PROC Negative_regulation of NPEPPS	1	0.00	1.24	0.35
56	INT264555	IL15 Positive_regulation of Gene_expression of BCL2	1	0.02	0.92	0.35
57	INT204071	HP Positive_regulation of Gene_expression of CDKN2A	1	0.00	3.48	0.34
58	INT269962	Bcl2 Negative_regulation of Bcl2l11	1	0.15	2.14	0.34
59	INT130803	MC1R Regulation of Positive_regulation of Cdkn2a	1	0.17	0.82	0.34
60	INT324690	Binding of Traf6 and Ticam1	2	0.07	0.23	0.33
61	INT155060	Stat3 Negative_regulation of Bcl2	1	0.21	3.7	0.33
62	INT312803	F2 Positive_regulation of NPEPPS	1	0.01	1.32	0.32
63	INT203089	Binding of Il1a and Traf6	1	0.04	0.66	0.32
64	INT255934	Tauph Positive_regulation of Map3k1	1	0.00	0.1	0.32
65	INT255946	MAPK14 Positive_regulation of Map3k1	1	0.04	0.1	0.32
66	INT203086	Positive_regulation of Binding of Il1a and Traf6	1	0.06	0.67	0.32
67	INT312802	F2 Positive_regulation of Binding of NPEPPS	1	0.01	1.33	0.32
68	INT198566	Ddit4l Regulation of Axin1	1	0.03	1	0.31
69	INT222690	TNF Positive_regulation of Gene_expression of NPEPPS	1	0.01	1.03	0.3
70	INT242398	Cyp19a1 Positive_regulation of Bcl2	1	0.00	1.28	0.3
71	INT303995	Lep Positive_regulation of PSME1	1	0.09	0.32	0.29
72	INT218928	Cyp3a23/3a1 Regulation of Transcription of Bcl2	1	0.00	0.56	0.28
73	INT260837	NRP2 Negative_regulation of Negative_regulation of Bcl2	1	0.00	0.9	0.28
74	INT323710	TRAF6 Regulation of MIR146A	1	0.06	0.55	0.28
75	INT274932	Binding of Insrr and Map3k1	1	0.00	0	0.28
76	INT172905	Binding of Bad and Bcl2	3	0.08	6.46	0.27
77	INT312894	Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6	1	0.08	1.3	0.27
78	INT274947	Binding of Map3k1 and Grip1	1	0.00	0	0.27
79	INT237927	BCL2 Positive_regulation of BAX	2	0.24	2.22	0.26
80	INT237928	BCL2 Positive_regulation of FAS	1	0.02	1.41	0.26
81	INT272157	Gh1 Negative_regulation of Bcl2	1	0.23	1.2	0.26
82	INT272158	Gh1 Regulation of Bcl2	1	0.15	1.2	0.26
83	INT237925	BCL2 Positive_regulation of Protein_catabolism of PARP1	1	0.02	1.42	0.26
84	INT147593	Binding of CDK4 and CDKN2A	1	0.42	0.23	0.26
85	INT147592	Positive_regulation of Binding of CDK4 and CDKN2A	1	0.44	0.23	0.26
86	INT35178	Binding of STT3A and PSME3	1	0.01	0.38	0.25
87	INT260840	NRP2 Positive_regulation of Gene_expression of Bcl2	1	0.00	0.85	0.24
88	INT243640	Binding of Twist1 and Stub1	1	0.08	0.34	0.24
89	INT72231	Negative_regulation of Binding of NFKBIL1 and BTRC	1	0.00	0	0.24
90	INT302170	PTGER2 Positive_regulation of Gene_expression of BCL2	1	0.04	3.76	0.23
91	INT116469	VEGFA Positive_regulation of Amfr	1	0.01	1.39	0.21
92	INT116466	Vegfa Positive_regulation of Amfr	1	0.07	1.41	0.21
93	INT301282	Tnfsf11 Positive_regulation of Traf6	1	0.10	0.65	0.2
94	INT42467	PTGER1 Negative_regulation of LNPEP	1	0.02	0	0.18
95	INT176133	AKT1 Regulation of BCL2	2	0.12	1.84	0.17
96	INT285026	Bak1 Regulation of Bcl2	1	0.09	0.71	0.17
97	INT285022	Regulation of Bak1 Regulation of Bcl2	1	0.09	0.71	0.17
98	INT349475	Regulation of Bax Regulation of Bcl2	1	0.07	1.35	0.17
99	INT217074	Binding of Acsm3 and Axin1	1	0.00	5.37	0.17
100	INT155233	TXNIP Regulation of BCL2	1	0.23	0.15	0.17
101	INT285024	Bcl2 Regulation of Bak1	1	0.09	0.71	0.17
102	INT229203	Binding of Bcl2 and Cyp2c11	1	0.36	1.2	0.17
103	INT155068	Csf2 Negative_regulation of Bcl2	1	0.12	1.88	0.17
104	INT217478	Binding of Tnfrsf11a and Traf6	1	0.39	1.22	0.17
105	INT316132	IL10 Regulation of MARCH1	1	0.11	2.12	0.17
106	INT316122	IL10 Regulation of Gene_expression of MARCH1	1	0.19	2.12	0.17
107	INT111863	Negative_regulation of Binding of AGT and LNPEP	1	0.09	0	0.16
108	INT347445	CD99 Positive_regulation of BCL2	1	0.17	0.95	0.16
109	INT180503	Binding of SARS and PSMD6	1	0.22	2.44	0.16
110	INT111861	Binding of AGT and LNPEP	1	0.07	0	0.16
111	INT136855	Arf5 Positive_regulation of Cdkn2a	1	0.07	1.8	0.15
112	INT292750	Akt1 Positive_regulation of Bcl2	1	0.01	1.67	0.15
113	INT349476	Bax Regulation of Bcl2	1	0.07	1.33	0.15
114	INT188694	Traf6 Positive_regulation of Positive_regulation of Irf3	1	0.08	0.2	0.15
115	INT314856	Binding of Cdc7 and Cdkn2a	1	0.28	1.34	0.14
116	INT302146	CDKN2A Regulation of CDKN1B	1	0.11	0.51	0.14
117	INT311666	Binding of BCL2 and TP53	1	0.19	1.26	0.14
118	INT302144	CDKN2A Regulation of CDKN1A	1	0.11	0.51	0.14
119	INT95104	TGFBR2 Positive_regulation of BCL2	1	0.08	0.61	0.14
120	INT180960	Protein_catabolism of COL5A2 Positive_regulation of Positive_regulation of NPEPPS	1	0.00	0.59	0.14
121	INT180963	COL5A2 Positive_regulation of Positive_regulation of NPEPPS	1	0.00	0.59	0.14
122	INT117913	CREM Positive_regulation of Negative_regulation of BIRC2	1	0.15	0.81	0.14
123	INT177916	PRKG1 Positive_regulation of Positive_regulation of MAP3K1	1	0.05	1.07	0.14
124	INT314852	Binding of Cdkn2a and Tgfbr3	1	0.28	1.15	0.14
125	INT309139	Edc4 Positive_regulation of Bcl2	1	0.03	0.12	0.13
126	INT148594	Binding of BCL2 and CD34	1	0.39	1.17	0.13
127	INT312893	Gsk3b Positive_regulation of Hdac6	1	0.07	0.65	0.13
128	INT209645	AR Regulation of STUB1	1	0.04	0.93	0.13
129	INT309142	Edc4 Regulation of Bcl2	1	0.02	0.12	0.13
130	INT246016	Negative_regulation of Timp1 Negative_regulation of Gene_expression of Bcl2	1	0.03	1.07	0.13
131	INT342311	Binding of Tp53 and Positive_regulation of Gene_expression of BCL2	1	0.08	1.25	0.13
132	INT348542	BCL2 Negative_regulation of NLRP1	1	0.07	2.02	0.13
133	INT246017	Timp1 Negative_regulation of Gene_expression of Bcl2	1	0.03	1.07	0.13
134	INT172899	Binding of Bcl2 and Bcl2l1	3	0.02	5.54	0.12
135	INT117136	NPEPPS Positive_regulation of Hbegf	1	0.00	0	0.12
136	INT178101	EDN1 Negative_regulation of Phosphorylation of BCL2	1	0.03	1	0.12
137	INT305194	Bcl2 Positive_regulation of Epo	1	0.06	0.29	0.12
138	INT117911	MAPK1 Regulation of Positive_regulation of BIRC2	1	0.04	0.9	0.12
139	INT334254	Binding of Traf6 and Gtf3a	1	0.00	0.18	0.11
140	INT280488	Bdnf Positive_regulation of Gene_expression of Map3k1	1	0.01	1.49	0.11
141	INT273063	Negative_regulation of Fas Negative_regulation of Positive_regulation of Bcl2	1	0.01	0.72	0.11
142	INT221684	Binding of Bcl2 and FRTS	1	0.01	1.19	0.11
143	INT265888	BCL2 Regulation of Gene_expression of BAD	1	0.04	1.08	0.1
144	INT265890	BCL2 Regulation of Gene_expression of BAX	1	0.04	1.08	0.1
145	INT217470	Traf6 Positive_regulation of Ngf	1	0.36	0.52	0.1
146	INT57014	PSMB1 Regulation of SCN5A	1	0.02	0	0.1
147	INT239643	Binding of BCL2 and BCL2L11	3	0.16	2.26	0.09
148	INT217477	Traf6 Positive_regulation of Binding of Nup62	1	0.32	0.47	0.09
149	INT111866	Binding of LNPEP and CNOT4	1	0.02	0	0.09
150	INT282094	Apoa2 Negative_regulation of BCL2	1	0.06	1.15	0.09
151	INT275183	Bad Positive_regulation of Gene_expression of Bcl2	1	0.08	0.63	0.09
152	INT265887	IGF1 Negative_regulation of BCL2	1	0.09	1.02	0.09
153	INT92389	ALK Positive_regulation of Gene_expression of Map3k1	1	0.01	1.14	0.09
154	INT111865	Binding of LNPEP and ANGPT4	1	0.06	0	0.09
155	INT294637	Bcl2a1a Positive_regulation of Gene_expression of Bcl2	1	0.15	0.97	0.09
156	INT232559	Map3k1 Positive_regulation of Esr1	1	0.19	0.26	0.09
157	INT204300	Bcl2 Negative_regulation of Positive_regulation of Bak1	1	0.02	1.13	0.09
158	INT294289	IL11 Positive_regulation of Gene_expression of NPEPPS	1	0.01	0.06	0.09
159	INT298351	PSMD1 Regulation of Gene_expression of HLA-DRA	1	0.01	0.42	0.08
160	INT302178	CDKN1C Regulation of CDKN2A	1	0.09	0.26	0.08
161	INT302158	CDKN1A Regulation of CDKN2A	1	0.04	0.26	0.08
162	INT136856	Cdkn2a Positive_regulation of Arf5	1	0.01	0.9	0.08
163	INT302139	LAMTOR1 Regulation of CDKN2A	1	0.08	0.26	0.08
164	INT302157	MRPL28 Regulation of CDKN2A	1	0.09	0.26	0.08
165	INT298356	PSMD1 Regulation of Gene_expression of Cd14	1	0.04	0.42	0.08
166	INT350908	Binding of Bcl2 and Twist1	1	0.04	1.9	0.08
167	INT166784	Binding of PSMD1 and Nkx6-2	1	0.21	0.5	0.08
168	INT201456	Hmox1 Positive_regulation of Gene_expression of Bcl2	1	0.06	0.74	0.08
169	INT302148	IFI27 Regulation of CDKN2A	1	0.11	0.26	0.08
170	INT204299	Bcl2 Negative_regulation of Localization of Aifm1	1	0.06	1.22	0.07
171	INT297733	Cbr1 Regulation of Gene_expression of Bcl2	1	0.05	0.94	0.07
172	INT302177	PTGER2 Positive_regulation of BCL2	1	0.04	2.08	0.06
173	INT352299	Regulation of Binding of BCL2 and VIM	1	0.10	1.07	0.06
174	INT352298	Binding of BCL2 and VIM	1	0.09	1.06	0.06
175	INT298258	Binding of Runx3 and Stub1	1	0.11	0.18	0.06
176	INT217471	Binding of Nup62 and Traf6	1	0.26	0	0.05
177	INT334265	Binding of Traf6 and Irak4	1	0.19	0.24	0.05
178	INT204073	Binding of Cdkn2a and Cdk4	1	0.02	0.78	0.05
179	INT204072	Binding of Cdkn2a and Cdk6	1	0.02	0.78	0.05
180	INT341375	Sod2 Regulation of Bcl2	1	0.08	1.96	0.05
181	INT190824	Binding of Cl and Bcl2	1	0.02	1.4	0.05
182	INT333252	Positive_regulation of Binding of Bcl2 and Mcl1	1	0.03	0.88	0.04
183	INT201729	Traf6 Positive_regulation of Phosphorylation of Nfkb1	1	0.00	0.45	0.04
184	INT201733	Traf6 Positive_regulation of Protein_catabolism of Nfkbib	1	0.00	0.44	0.04
185	INT268664	Ptger2 Positive_regulation of Bcl2	1	0.02	0.9	0.04
186	INT333245	Binding of Bcl2 and Bcl2l11	1	0.03	0.87	0.04
187	INT268666	Ptger2 Positive_regulation of Gene_expression of Bcl2	1	0.02	0.9	0.04
188	INT201750	Traf6 Positive_regulation of Cib1	1	0.00	0.37	0.04
189	INT231605	Binding of PSMD1 and SGCG	1	0.02	0.34	0.04
190	INT342726	Binding of Laptm5 and Park2	1	0.03	0.64	0.04
191	INT350905	Binding of Bcl2 and Pcsk4	1	0.03	0.96	0.04
192	INT201746	Traf6 Positive_regulation of Map4k4	1	0.00	0.37	0.04
193	INT213815	Binding of Tfeb and Stub1	1	0.13	0.09	0.04
194	INT333253	Binding of Bcl2 and Mcl1	1	0.02	2.14	0.04
195	INT201739	Traf6 Positive_regulation of Localization of Nfkb1	1	0.00	0.45	0.04
196	INT288369	Binding of Laptm5 and Mgrn1	1	0.05	0	0.04
197	INT250025	Map3k1 Positive_regulation of Regulation of Bcl2	1	0.01	1.1	0.04
198	INT172902	Binding of Bax and Bcl2	5	0.30	3.19	0.03
199	INT192164	Binding of BAK1 and BCL2	3	0.04	2.8	0.03
200	INT192167	Negative_regulation of Binding of BAK1 and BCL2	2	0.05	1.89	0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein polyubiquitination. They are ordered first by their pain relevance and then by number of times they were reported in protein polyubiquitination. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT82650	Gene_expression of Bcl2	312	0.78	211.71	55.03
2	INT77307	Gene_expression of Bcl2	399	0.77	319.77	38
3	INT65960	Gene_expression of BCL2	352	0.78	312.03	30.73
4	INT48235	Negative_regulation of NPEPPS	72	0.46	44.54	25.03
5	INT69592	Positive_regulation of PSMD1	27	0.70	17.83	18.98
6	INT93734	Positive_regulation of Gene_expression of Bcl2	76	0.70	61.95	18.46
7	INT151747	Positive_regulation of PSMD2	26	0.68	17.48	17.89
8	INT86673	Positive_regulation of Bcl2	77	0.70	57.74	17.37
9	INT5333	Gene_expression of NPEPPS	45	0.65	26.34	15.25
10	INT94774	Regulation of CDKN2A	43	0.60	44.41	13.99
11	INT78472	Gene_expression of CDKN2A	223	0.78	173.76	13.61
12	INT80222	Negative_regulation of Bcl2	82	0.58	69.16	13.18
13	INT60865	Gene_expression of G2e3	20	0.73	2.1	12.76
14	INT81640	Positive_regulation of Gene_expression of Bcl2	106	0.69	84.58	11.63
15	INT58775	Binding of G2e3	10	0.33	0.19	11.52
16	INT70017	Positive_regulation of BCL2	87	0.67	66.62	8.68
17	INT86672	Negative_regulation of Bcl2	50	0.53	34.16	8.37
18	INT65959	Positive_regulation of Gene_expression of BCL2	75	0.70	77.3	8.27
19	INT80220	Positive_regulation of Bcl2	71	0.58	57.73	7.86
20	INT58774	Negative_regulation of G2e3	8	0.38	0.22	7.75
21	INT77306	Negative_regulation of Gene_expression of Bcl2	46	0.58	38.05	7.71
22	INT92138	Binding of CDKN2A	28	0.37	25.64	7.47
23	INT91445	Regulation of Bcl2	50	0.56	38.8	7.41
24	INT93101	Regulation of Gene_expression of Bcl2	26	0.62	18.45	6.71
25	INT84685	Regulation of BCL2	67	0.60	72.96	6.65
26	INT141151	Regulation of PSMD1	16	0.40	8.19	5.86
27	INT100422	Negative_regulation of Gene_expression of Bcl2	46	0.58	28.86	5.7
28	INT125467	Positive_regulation of Gene_expression of CDKN2A	35	0.63	39.07	5.56
29	INT13295	Positive_regulation of Cdkn2a	18	0.68	13.02	5.47
30	INT89794	Positive_regulation of CDKN2A	58	0.67	50.18	5.38
31	INT151748	Positive_regulation of Positive_regulation of PSMD2	4	0.49	4.45	5.35
32	INT70613	Negative_regulation of Gene_expression of BCL2	48	0.59	38.91	5.22
33	INT73262	Negative_regulation of BCL2	67	0.57	61.01	5.07
34	INT60066	Positive_regulation of NPEPPS	17	0.22	11.99	4.83
35	INT17110	Gene_expression of PSMD1	60	0.65	19.57	4.69
36	INT101957	Transcription of Bcl2	30	0.69	16.57	4.3
37	INT5332	Negative_regulation of Gene_expression of NPEPPS	11	0.04	7.79	4.29
38	INT60067	Localization of NPEPPS	9	0.26	3.36	4.15
39	INT69591	Positive_regulation of Positive_regulation of PSMD1	2	0.50	3.06	3.99
40	INT60415	Regulation of NPEPPS	13	0.27	5.81	3.78
41	INT105882	Phosphorylation of Bcl2	11	0.59	8.15	3.73
42	INT50022	Positive_regulation of G2e3	10	0.42	0.47	3.72
43	INT109403	Regulation of Gene_expression of BCL2	31	0.60	31.22	3.4
44	INT69593	Negative_regulation of PSMD1	11	0.57	4.06	3.33
45	INT78471	Regulation of Gene_expression of CDKN2A	13	0.45	12.52	3.28
46	INT81642	Regulation of Gene_expression of Bcl2	20	0.44	16.93	3.19
47	INT64234	Regulation of Bcl2	41	0.54	31.88	3.16
48	INT101034	Protein_catabolism of NPEPPS	8	0.65	2.08	3.12
49	INT105884	Binding of Bcl2	19	0.35	15.67	3
50	INT51993	Gene_expression of PSMA5	5	0.75	2.59	2.92
51	INT140547	Negative_regulation of PSMB10	3	0.02	2.33	2.92
52	INT54749	Binding of BTRC	7	0.09	0.88	2.9
53	INT78248	Negative_regulation of Cdkn2a	17	0.59	15.15	2.8
54	INT24443	Gene_expression of PSMD2	20	0.54	7.29	2.77
55	INT209889	Gene_expression of TRAF6	13	0.63	6.85	2.67
56	INT159121	Positive_regulation of Map3k1	10	0.45	8.79	2.6
57	INT60440	Localization of PSMD1	10	0.74	3.94	2.57
58	INT60864	Regulation of G2e3	4	0.21	0.64	2.54
59	INT92141	Negative_regulation of CDKN2A	53	0.57	44.23	2.48
60	INT338170	Regulation of Regulation of CDKN2A	1	0.44	0.96	2.46
61	INT147349	Localization of Bcl2	13	0.65	7.83	2.31
62	INT106616	Gene_expression of PSMB9	35	0.72	28.4	2.29
63	INT52785	Localization of G2e3	5	0.66	0.33	2.26
64	INT142677	Negative_regulation of Positive_regulation of Bcl2	4	0.36	3.09	2.24
65	INT12061	Negative_regulation of LNPEP	19	0.58	5.52	2.14
66	INT94772	Gene_expression of Cdkn2a	14	0.75	8.25	2.04
67	INT86671	Negative_regulation of Positive_regulation of Bcl2	6	0.57	3.83	2.03
68	INT69027	Binding of PSMA5	4	0.47	1.08	1.93
69	INT95400	Negative_regulation of Map3k1	3	0.15	0.78	1.92
70	INT101108	Localization of Bcl2	16	0.72	11.68	1.86
71	INT105883	Positive_regulation of Phosphorylation of Bcl2	8	0.32	5.67	1.86
72	INT5331	Positive_regulation of Gene_expression of NPEPPS	6	0.49	3.74	1.81
73	INT100563	Regulation of Binding of G2e3	1	0.24	0	1.79
74	INT104745	Positive_regulation of Binding of G2e3	1	0.05	0.07	1.77
75	INT148721	Binding of PSMD1	13	0.31	4.78	1.76
76	INT71788	Gene_expression of MAP3K1	13	0.70	4.9	1.66
77	INT101958	Positive_regulation of Transcription of Bcl2	4	0.50	2.22	1.65
78	INT159185	Positive_regulation of Gene_expression of PSMD2	3	0.40	1.4	1.63
79	INT85955	Negative_regulation of Localization of G2e3	2	0.48	0.05	1.63
80	INT137513	Negative_regulation of Positive_regulation of BCL2	6	0.35	5.3	1.62
81	INT79141	Regulation of Gene_expression of NPEPPS	3	0.01	2.95	1.61
82	INT117915	Gene_expression of BIRC2	8	0.63	6.74	1.59
83	INT164152	Negative_regulation of PSMD2	9	0.37	3.41	1.56
84	INT54750	Gene_expression of BTRC	4	0.14	0.99	1.55
85	INT96137	Gene_expression of LNPEP	8	0.68	5.27	1.43
86	INT69513	Regulation of PSMA5	2	0.60	1.04	1.43
87	INT108587	Negative_regulation of PSMA5	1	0.57	1.73	1.42
88	INT60065	Positive_regulation of Localization of NPEPPS	3	0.22	1.07	1.41
89	INT163354	Negative_regulation of Protein_catabolism of NPEPPS	1	0.25	0	1.4
90	INT78470	Negative_regulation of Gene_expression of CDKN2A	14	0.59	14.44	1.38
91	INT6018	Positive_regulation of PSMB9	7	0.60	4.36	1.33
92	INT50785	Gene_expression of Map3k1	6	0.44	4.22	1.32
93	INT101107	Positive_regulation of Localization of Bcl2	3	0.48	3.13	1.28
94	INT79660	Phosphorylation of PSMC6	3	0.80	0.45	1.28
95	INT60064	Negative_regulation of Localization of NPEPPS	3	0.05	0.68	1.27
96	INT59200	Negative_regulation of Ube2d3	3	0.13	2.37	1.23
97	INT298979	Gene_expression of Traf6	5	0.31	1.75	1.21
98	INT172855	Binding of Bcl2	37	0.32	23.41	1.09
99	INT70021	Localization of BCL2	23	0.74	21.6	1.09
100	INT46734	Positive_regulation of Stub1	6	0.16	1.44	1.09
101	INT96138	Positive_regulation of LNPEP	6	0.45	3.81	1.07
102	INT42104	Regulation of Cdkn2a	4	0.44	5.67	1.06
103	INT67638	Positive_regulation of PSMA5	1	0.21	1.15	1.05
104	INT13882	Binding of PSMB9	3	0.15	2.84	1
105	INT78322	Positive_regulation of PSME1	2	0.44	1.8	0.95
106	INT70248	Positive_regulation of Positive_regulation of G2e3	1	0.13	0.17	0.94
107	INT338168	Positive_regulation of Binding of CDKN2A	1	0.49	0.52	0.94
108	INT144289	Negative_regulation of Positive_regulation of PSMC6	1	0.41	0.56	0.92
109	INT144287	Positive_regulation of PSMC6	1	0.49	0.56	0.92
110	INT151115	Regulation of Regulation of Bcl2	4	0.21	4.12	0.88
111	INT113121	Negative_regulation of Binding of G2e3	1	0.07	0	0.88
112	INT92117	Phosphorylation of BCL2	26	0.80	9.93	0.86
113	INT42469	Regulation of LNPEP	9	0.60	0.46	0.83
114	INT71784	Positive_regulation of Gene_expression of MAP3K1	4	0.34	4.8	0.82
115	INT128143	Negative_regulation of Gene_expression of G2e3	4	0.09	0	0.82
116	INT50784	Positive_regulation of Gene_expression of Map3k1	2	0.06	0.94	0.8
117	INT70019	Binding of BCL2	25	0.47	17.55	0.79
118	INT144429	Positive_regulation of Cdkn2a	7	0.58	4.05	0.78
119	INT78323	Negative_regulation of PSME1	1	0.37	0.5	0.78
120	INT316151	Gene_expression of MARCH1	1	0.55	2.32	0.78
121	INT109404	Transcription of BCL2	6	0.69	4.49	0.77
122	INT129115	Negative_regulation of Cdkn2a	16	0.50	17.03	0.76
123	INT177933	Positive_regulation of MAP3K1	6	0.42	4.13	0.76
124	INT124844	Regulation of Positive_regulation of Bcl2	3	0.43	2.55	0.75
125	INT108590	Negative_regulation of Negative_regulation of PSMA5	1	0.57	0.92	0.75
126	INT155392	Negative_regulation of Negative_regulation of Bcl2	3	0.21	1.64	0.74
127	INT105483	Protein_catabolism of LNPEP	3	0.42	3.26	0.74
128	INT134444	Positive_regulation of Binding of Bcl2	3	0.47	2.67	0.72
129	INT50855	Gene_expression of TRIM21	4	0.65	3.07	0.71
130	INT92348	Binding of NPEPPS	3	0.04	2.94	0.71
131	INT108586	Positive_regulation of Negative_regulation of PSMA5	1	0.49	0.82	0.67
132	INT60228	Negative_regulation of Negative_regulation of NPEPPS	2	0.34	0.62	0.63
133	INT312882	Negative_regulation of Hdac6	1	0.52	1.86	0.63
134	INT106608	Regulation of Gene_expression of SKP2	1	0.50	0.26	0.63
135	INT106603	Gene_expression of SKP2	5	0.63	6.99	0.62
136	INT251026	Negative_regulation of Phosphorylation of CDKN2A	5	0.42	5.02	0.62
137	INT177886	Positive_regulation of Gene_expression of Cdkn2a	3	0.67	3.42	0.62
138	INT188799	Positive_regulation of Protein_catabolism of Traf6	2	0.19	1.98	0.62
139	INT196939	Gene_expression of Stub1	10	0.18	1.67	0.59
140	INT147598	Negative_regulation of Positive_regulation of CDKN2A	3	0.41	1.47	0.59
141	INT17109	Regulation of Gene_expression of PSMD1	3	0.44	0.86	0.58
142	INT70025	Positive_regulation of Positive_regulation of BCL2	3	0.27	0.96	0.58
143	INT288354	Gene_expression of Mgrn1	1	0.60	0	0.58
144	INT111602	Negative_regulation of Gene_expression of MAP3K1	1	0.06	0.58	0.58
145	INT178128	Negative_regulation of Phosphorylation of BCL2	7	0.27	3.94	0.56
146	INT242011	Localization of Cdkn2a	4	0.73	2.49	0.54
147	INT155090	Regulation of Positive_regulation of BCL2	3	0.26	1.78	0.54
148	INT16681	Positive_regulation of PSMC2	1	0.07	0	0.54
149	INT144701	Gene_expression of Cdkn2a	15	0.75	8.42	0.53
150	INT117926	Positive_regulation of Gene_expression of BIRC2	1	0.48	3.25	0.52
151	INT288355	Localization of Mgrn1	1	0.67	0	0.52
152	INT144696	Regulation of Transcription of Bcl2	5	0.44	2.96	0.51
153	INT144431	Positive_regulation of Transcription of Cdkn2a	1	0.41	1.11	0.51
154	INT144426	Transcription of Cdkn2a	1	0.42	1.11	0.51
155	INT134445	Positive_regulation of Positive_regulation of Bcl2	3	0.47	2.43	0.49
156	INT89258	Localization of STUB1	3	0.14	0.67	0.49
157	INT221676	Protein_catabolism of Bcl2	4	0.24	2.77	0.48
158	INT120121	Transcription of NPEPPS	2	0.23	0.1	0.46
159	INT95401	Phosphorylation of Map3k1	1	0.21	0.16	0.46
160	INT209013	Regulation of Stub1	1	0.06	0.29	0.46
161	INT210125	Regulation of Axin1	1	0.02	2.45	0.46
162	INT204052	Transcription of Bcl2	5	0.51	3.25	0.45
163	INT117919	Negative_regulation of BIRC2	4	0.30	3.72	0.45
164	INT188800	Protein_catabolism of Traf6	2	0.40	1.6	0.45
165	INT306885	Positive_regulation of SKP2	1	0.21	0.6	0.45
166	INT220088	Positive_regulation of Positive_regulation of CDKN2A	4	0.49	4.04	0.44
167	INT140295	Protein_catabolism of BCL2	4	0.64	5.7	0.44
168	INT220424	Positive_regulation of Negative_regulation of Bcl2	2	0.14	1.81	0.44
169	INT350879	Negative_regulation of Localization of PSMD1	1	0.05	0.43	0.43
170	INT202762	Gene_expression of PSMD3	8	0.47	1.44	0.42
171	INT252657	Positive_regulation of Phosphorylation of CDKN2A	2	0.45	3.09	0.42
172	INT42105	Regulation of Positive_regulation of Cdkn2a	1	0.44	0.33	0.42
173	INT148546	Regulation of Positive_regulation of NPEPPS	1	0.02	0.29	0.42
174	INT280564	Negative_regulation of Gene_expression of PSMB9	5	0.54	5.99	0.41
175	INT209891	Regulation of Gene_expression of TRAF6	2	0.22	1.4	0.41
176	INT78324	Regulation of PSME1	1	0.61	0.49	0.41
177	INT155857	Regulation of Negative_regulation of NPEPPS	1	0.04	0.54	0.39
178	INT203568	Regulation of SKP2	3	0.26	1.61	0.38
179	INT117923	Positive_regulation of BIRC2	1	0.48	2.5	0.38
180	INT155724	Negative_regulation of Transcription of Bcl2	6	0.53	2.35	0.37
181	INT280560	Positive_regulation of Gene_expression of PSMB9	7	0.64	6.44	0.36
182	INT217464	Binding of Traf6	5	0.29	1.28	0.35
183	INT335718	Regulation of Gene_expression of PSMD2	1	0.09	0.07	0.35
184	INT11689	Binding of PSMD2	16	0.36	2.77	0.34
185	INT57019	Gene_expression of PSMB1	1	0.38	0	0.34
186	INT316165	Positive_regulation of Gene_expression of MARCH1	1	0.33	0.12	0.33
187	INT196323	Localization of Cdkn2a	8	0.73	9.1	0.32
188	INT251025	Phosphorylation of CDKN2A	4	0.61	3.19	0.32
189	INT203075	Positive_regulation of Traf6	1	0.16	0.67	0.32
190	INT203074	Positive_regulation of Positive_regulation of Traf6	1	0.16	0.67	0.32
191	INT144854	Gene_expression of STUB1	10	0.13	2.03	0.31
192	INT102721	Negative_regulation of MAP3K1	2	0.53	8.03	0.3
193	INT228477	Positive_regulation of Gene_expression of Cdkn2a	2	0.11	1.3	0.29
194	INT312879	Regulation of Hdac6	1	0.55	0.76	0.29
195	INT288356	Positive_regulation of Mgrn1	1	0.45	0.07	0.29
196	INT178114	Positive_regulation of Phosphorylation of BCL2	11	0.49	4.44	0.28
197	INT11688	Binding of PSMD3	5	0.36	1.17	0.28
198	INT209886	Positive_regulation of TRAF6	2	0.39	1.27	0.28
199	INT336997	Negative_regulation of Gene_expression of LNPEP	2	0.16	0.93	0.27
200	INT144855	Positive_regulation of STUB1	3	0.08	0.59	0.26