GO:0001106

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Name RNA polymerase II transcription corepressor activity
Categary Function
Go Slim No
Go Link GO:0001106
Unique Molecular Interactions 85
Total Molecular Interactions 94
Total Single Events 365
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for RNA polymerase II transcription corepressor activity. They are ordered first by their pain relevance and then by number of times they were reported for RNA polymerase II transcription corepressor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT144547 Binding of Mecp2 and Sin3a 1 0.40 0.87 0.76
2 INT127585 Binding of CNR2 and Ctbp1 1 0.00 0.6 0.76
3 INT127584 Binding of CNR1 and Ctbp1 1 0.00 0.6 0.75
4 INT306263 Binding of NFIB and TFAM 1 0.00 1.74 0.7
5 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
6 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
7 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
8 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
9 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
10 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
11 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
12 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
13 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
14 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
15 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
16 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
17 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
18 INT244060 Binding of Cacnb3 and Tfap2a 1 0.00 0.24 0.49
19 INT280479 Binding of Mecp2 and Sin3a 1 0.00 1.54 0.35
20 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
21 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
22 INT100946 TNF Positive_regulation of Localization of NFIB 1 0.01 1.3 0.29
23 INT245554 Tbx15 Positive_regulation of Gene_expression of Ntrk1 1 0.02 0.65 0.29
24 INT100945 TNF Positive_regulation of NFIB 1 0.00 1.29 0.29
25 INT180570 Binding of HEYL and Positive_regulation of DMD 1 0.00 1.08 0.28
26 INT180564 HEYL Regulation of Regulation of DMD 1 0.00 0.88 0.28
27 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
28 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
29 INT245557 Runx1 Positive_regulation of Gene_expression of Tbx15 1 0.02 0.75 0.25
30 INT317771 GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
31 INT245561 Gene_expression of Runx1 Positive_regulation of Gene_expression of Tbx15 1 0.02 0.8 0.25
32 INT317776 Positive_regulation of GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
33 INT245567 Tbx15 Positive_regulation of Ntrk1 1 0.02 0.9 0.24
34 INT333892 TNF Positive_regulation of Gene_expression of HDAC1 1 0.09 0.46 0.23
35 INT280487 Negative_regulation of Binding of Mecp2 and Sin3a 1 0.00 0.77 0.18
36 INT180562 Binding of CYP27A1 and HEYL 1 0.02 0.29 0.16
37 INT339392 Binding of Nfib and Gtf3a 1 0.00 0.53 0.14
38 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
39 INT180567 HEYL Regulation of Positive_regulation of IBSP 1 0.01 0.18 0.12
40 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
41 INT200306 Hdac1 Negative_regulation of Rorb 1 0.00 0 0.12
42 INT200332 Binding of Rcor2 and Hdac1 1 0.15 0.3 0.12
43 INT302380 Tnf Positive_regulation of Nfib 1 0.00 1.41 0.09
44 INT302383 Il1b Positive_regulation of Nfib 1 0.00 1.42 0.09
45 INT180561 HEYL Negative_regulation of IBSP 1 0.01 0.19 0.09
46 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07
47 INT268675 Binding of NCOR2 and SIN3A 1 0.27 2.54 0.07
48 INT268676 Binding of HDAC1 and BCOR 1 0.01 1.31 0.04
49 INT235365 Binding of Mid1 and Nfib 1 0.02 0.09 0.04
50 INT180565 HEYL Positive_regulation of Negative_regulation of COL1A1 1 0.01 0 0.03
51 INT180571 HEYL Positive_regulation of Protein_catabolism of COL1A1 1 0.01 0 0.03
52 INT348592 Binding of HDAC1 and PPARG 1 0.23 0 0.03
53 INT319171 Binding of Cgn and Hdac1 1 0.00 0 0
54 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
55 INT183412 Dnmt3a Positive_regulation of Tbx15 1 0.05 0.27 0
56 INT283341 Binding of Ctbp1 and Fig4 1 0.06 0 0
57 INT333685 Binding of Trp53 and Hdac1 1 0.26 0.55 0
58 INT284920 Binding of HDAC1 and NCOR1 1 0.03 0.13 0
59 INT245820 Binding of Sp1 and Tfap2a 1 0.03 0.64 0
60 INT259095 Binding of RBBP8 and LMO4 1 0.15 0.73 0
61 INT230762 Binding of DAG1 and Tbx15 1 0.00 0.21 0
62 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0
63 INT311398 Positive_regulation of Celf1 Positive_regulation of Hdac1 1 0.12 0.19 0
64 INT277928 WIF1 Negative_regulation of TLE1 1 0.26 0.37 0
65 INT196946 Binding of E2f1 and Hdac1 1 0.26 0.65 0
66 INT301469 Negative_regulation of Binding of Sin3a and Smyd2 1 0.28 0.31 0
67 INT337401 Binding of E2F1 and HDAC1 1 0.07 0 0
68 INT245828 Binding of VEGFA and Tfap2a 1 0.01 0.64 0
69 INT299462 Binding of Mxd1 and Sin3a 1 0.08 0.62 0
70 INT183410 Dnmt3b Positive_regulation of Tbx15 1 0.05 0.27 0
71 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
72 INT301475 Binding of Sin3a and Smyd2 1 0.32 0.31 0
73 INT196941 Hdac1 Negative_regulation of Rb1 1 0.27 0.44 0
74 INT299463 Binding of Sin3a and SIDT1 1 0.39 0.31 0
75 INT196944 Binding of Rb1 and Hdac1 1 0.24 0.4 0
76 INT301470 Binding of Smyd2 and Hdac1 1 0.35 0.31 0
77 INT319170 Casp3 Regulation of Hdac1 1 0.01 0.27 0
78 INT208139 Binding of PITX1 and URI1 1 0.01 0.62 0
79 INT283347 Binding of Srr and Ctbp1 1 0.13 0 0
80 INT284995 Binding of HDAC1 and Sin3a 1 0.00 0.13 0
81 INT177783 Binding of HDAC1 and PCNA 1 0.09 0.5 0
82 INT333684 Binding of Hr and Hdac1 1 0.19 0.56 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for RNA polymerase II transcription corepressor activity. They are ordered first by their pain relevance and then by number of times they were reported in RNA polymerase II transcription corepressor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19
2 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37
3 INT333909 Positive_regulation of Gene_expression of HDAC1 1 0.44 14.15 5.9
4 INT125439 Positive_regulation of NFIB 4 0.67 6.71 2.52
5 INT183402 Positive_regulation of Gene_expression of Tbx15 7 0.49 4.87 1.62
6 INT139546 Gene_expression of URI1 3 0.75 3 1.49
7 INT219259 Binding of Nfib 1 0.36 1.46 1.46
8 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45
9 INT333914 Transcription of HDAC1 1 0.34 3.04 1.37
10 INT180588 Gene_expression of HEYL 13 0.52 8.37 1.19
11 INT180580 Binding of HEYL 7 0.17 4.49 1.15
12 INT247615 Binding of URI1 2 0.20 1.17 1.13
13 INT260447 Binding of HDAC1 8 0.23 4.47 1.12
14 INT151261 Negative_regulation of Nfib 2 0.47 2.12 1.11
15 INT151260 Gene_expression of Nfib 5 0.75 1.83 1.06
16 INT13263 Binding of Ctbp1 2 0.41 0.57 1.06
17 INT84511 Positive_regulation of Tfap2a 3 0.27 0.72 1.04
18 INT333907 Positive_regulation of HDAC1 4 0.32 3.07 1.03
19 INT151262 Binding of Nfib 1 0.36 1.02 1.03
20 INT245514 Regulation of Gene_expression of Tbx15 3 0.01 2.83 0.98
21 INT306295 Regulation of NFIB 1 0.13 2.43 0.97
22 INT243974 Binding of Tfap2a 7 0.18 1.36 0.93
23 INT221796 Positive_regulation of Gene_expression of Tfap2a 2 0.10 1.19 0.83
24 INT306276 Binding of NFIB 1 0.14 1.73 0.77
25 INT144540 Negative_regulation of Gene_expression of Sin3a 1 0.57 0.85 0.75
26 INT207535 Transcription of Tfap2a 3 0.31 0.98 0.74
27 INT284955 Localization of HDAC1 2 0.47 1.71 0.74
28 INT144544 Gene_expression of Sin3a 1 0.75 0.84 0.74
29 INT120239 Gene_expression of NFIB 3 0.65 1.01 0.72
30 INT135197 Gene_expression of Tfap2a 1 0.45 0.48 0.69
31 INT174537 Positive_regulation of HEYL 7 0.39 3.07 0.68
32 INT100948 Localization of NFIB 2 0.12 1.8 0.62
33 INT207529 Localization of Tfap2a 2 0.34 0.13 0.6
34 INT243970 Phosphorylation of Tfap2a 2 0.25 0.56 0.56
35 INT177842 Negative_regulation of HDAC1 6 0.31 4.65 0.49
36 INT180578 Regulation of HEYL 3 0.06 3.15 0.49
37 INT249457 Positive_regulation of URI1 3 0.27 0.8 0.45
38 INT287488 Negative_regulation of NFIB 2 0.13 1.39 0.4
39 INT310250 Regulation of TLE1 1 0.00 0.68 0.37
40 INT196927 Binding of Hdac1 9 0.36 2.31 0.36
41 INT306297 Negative_regulation of Binding of NFIB 1 0.13 0.79 0.36
42 INT125438 Negative_regulation of Positive_regulation of NFIB 1 0.41 1.25 0.34
43 INT100947 Negative_regulation of Localization of NFIB 1 0.01 1.3 0.29
44 INT196917 Gene_expression of Hdac1 15 0.71 3.66 0.28
45 INT168232 Positive_regulation of Transcription of Nfib 1 0.45 0.22 0.2
46 INT168235 Transcription of Nfib 1 0.52 0.22 0.2
47 INT168231 Negative_regulation of Transcription of Nfib 1 0.42 0.23 0.2
48 INT315759 Regulation of URI1 1 0.01 0.12 0.19
49 INT13262 Regulation of Ctbp1 1 0.01 0.25 0.18
50 INT280465 Negative_regulation of Sin3a 2 0.41 1.07 0.17
51 INT162939 Binding of Tfap2a 1 0.26 0.34 0.17
52 INT162940 Negative_regulation of Tfap2a 1 0.32 0.34 0.17
53 INT162941 Negative_regulation of Binding of Tfap2a 1 0.32 0.34 0.17
54 INT180592 Negative_regulation of Gene_expression of HEYL 1 0.03 0.3 0.15
55 INT180593 Positive_regulation of Gene_expression of HEYL 1 0.03 0.18 0.12
56 INT196934 Negative_regulation of Hdac1 4 0.39 1.41 0.11
57 INT331783 Regulation of Negative_regulation of Hdac1 1 0.04 0.98 0.11
58 INT259802 Positive_regulation of Tbx15 2 0.45 1.87 0.09
59 INT318400 Localization of Nfib 1 0.73 0 0.09
60 INT251976 Positive_regulation of TLE1 3 0.52 0.95 0.07
61 INT302964 Protein_catabolism of Tbx15 1 0.02 0.86 0.07
62 INT293405 Transcription of URI1 1 0.03 0.74 0.07
63 INT16799 Positive_regulation of Phosphorylation of Ctbp1 1 0.10 0 0.05
64 INT325191 Positive_regulation of Nfib 1 0.12 1.08 0.05
65 INT346683 Protein_catabolism of URI1 1 0.19 0.15 0.05
66 INT16801 Phosphorylation of Ctbp1 1 0.16 0 0.05
67 INT299425 Binding of Sin3a 2 0.36 0.92 0.04
68 INT284973 Negative_regulation of Negative_regulation of HDAC1 1 0.20 1.59 0.04
69 INT328554 Regulation of HDAC1 1 0.26 1.12 0.03
70 INT283318 Localization of Ctbp1 1 0.54 0 0.03
71 INT287486 Phosphorylation of NFIB 1 0.03 0.5 0.03
72 INT250504 Negative_regulation of URI1 1 0.10 0.71 0.03
73 INT277595 Localization of Hdac1 4 0.73 0.81 0
74 INT251978 Gene_expression of TLE1 3 0.51 0.45 0
75 INT196207 Negative_regulation of Tbx15 2 0.42 0.86 0
76 INT261751 Regulation of Hdac1 2 0.41 0 0
77 INT350509 Phosphorylation of HDAC1 1 0.25 0.62 0
78 INT180583 Negative_regulation of HEYL 1 0.03 0 0
79 INT319154 Transcription of Hdac1 1 0.66 0 0
80 INT319156 Negative_regulation of Gene_expression of Hdac1 1 0.39 0.22 0
81 INT158347 Positive_regulation of Positive_regulation of Nfib 1 0.46 0 0
82 INT277940 Binding of TLE1 1 0.28 0.3 0
83 INT277596 Phosphorylation of Hdac1 1 0.61 0.59 0
84 INT277933 Negative_regulation of Gene_expression of TLE1 1 0.32 0.66 0
85 INT235345 Regulation of Nfib 1 0.10 0.46 0
86 INT210818 Phosphorylation of HEYL 1 0.04 0.08 0
87 INT319169 Negative_regulation of Transcription of Hdac1 1 0.54 0 0
88 INT283324 Gene_expression of Ctbp1 1 0.18 0 0
89 INT231996 Negative_regulation of Gene_expression of Tbx15 1 0.01 0.81 0
90 INT355198 Positive_regulation of Localization of Hdac1 1 0.19 0.48 0
91 INT158345 Negative_regulation of Positive_regulation of Nfib 1 0.43 0 0
92 INT158346 Positive_regulation of Nfib 1 0.46 0 0
93 INT319162 Regulation of Gene_expression of Hdac1 1 0.56 0 0
94 INT319152 Positive_regulation of Gene_expression of Hdac1 1 0.46 0 0
95 INT311329 Positive_regulation of Hdac1 1 0.19 0.14 0
96 INT311630 Negative_regulation of Tfap2a 1 0.34 0.23 0
97 INT346682 Positive_regulation of Gene_expression of URI1 1 0.14 0.27 0
98 INT319128 Positive_regulation of Binding of Tfap2a 1 0.23 0.5 0
99 INT311626 Negative_regulation of Gene_expression of Tfap2a 1 0.34 0.29 0
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