GO:0001515

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Name opioid peptide activity
Categary Function
Go Slim No
Go Link GO:0001515
Unique Molecular Interactions 709
Total Molecular Interactions 1147
Total Single Events 13621
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for opioid peptide activity. They are ordered first by their pain relevance and then by number of times they were reported for opioid peptide activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4
2 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49
3 INT10161 Binding of Cck and Penk 6 0.53 0.97 11.15
4 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
5 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57
6 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46
7 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82
8 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
9 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8
10 INT140015 Avp Positive_regulation of Localization of Penk 3 0.63 3.48 6.63
11 INT26824 Crh Positive_regulation of Localization of Penk 7 0.54 0.42 6.49
12 INT31439 Penk Positive_regulation of Localization of Prl 8 0.55 0.23 6.24
13 INT9546 Binding of Adarb1 and Penk 5 0.03 0 5.1
14 INT44716 Binding of ABL2 and PDYN 2 0.40 0.66 4.77
15 INT38217 Penk Regulation of Localization of Avp 2 0.38 0.56 4.45
16 INT30423 Penk Regulation of Localization of Ins1 4 0.26 0.77 4.42
17 INT36536 PRSS1 Positive_regulation of PENK 1 0.24 0.86 4.39
18 INT64480 Binding of OPRL1 and PNOC 2 0.33 0.23 4.38
19 INT31440 Penk Positive_regulation of Prl 7 0.76 0 4.1
20 INT2169 Penk Regulation of Localization of Prl 6 0.48 0 4.03
21 INT138959 Dbi Positive_regulation of Penk 1 0.01 3.05 3.99
22 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93
23 INT34534 Binding of Penk and Oprl1 4 0.37 0 3.64
24 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52
25 INT108473 Binding of ADCYAP1 and PNOC 1 0.32 0.64 3.41
26 INT69770 Penk Negative_regulation of Pscs 1 0.11 0.22 3.39
27 INT108472 Binding of NOS1 and PNOC 1 0.32 0.64 3.27
28 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
29 INT18793 Crh Regulation of Localization of Penk 1 0.59 0 3.2
30 INT34294 Penk Positive_regulation of Localization of Crh 1 0.16 0.43 3.19
31 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
32 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
33 INT128513 Pnoc Regulation of Adarb1 1 0.01 0.92 3.14
34 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1
35 INT30424 Penk Regulation of Localization of Sst 1 0.20 0 3.1
36 INT36535 PRSS1 Positive_regulation of Regulation of PENK 1 0.23 0.54 3.06
37 INT26677 Penk Regulation of Localization of Trh 5 0.50 0 3.05
38 INT40660 Pdyn Positive_regulation of Localization of Prl 1 0.27 0 3.01
39 INT41152 Binding of Penk and Slc3a1 3 0.12 0.11 2.91
40 INT23280 PRSS1 Positive_regulation of Penk 1 0.05 1.53 2.74
41 INT30133 Binding of Cck and Penk 1 0.27 2.49 2.71
42 INT134294 Binding of Pdyn and Penk 1 0.23 0 2.69
43 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
44 INT70946 Penk Positive_regulation of Hpse 1 0.34 0 2.65
45 INT30345 Pomc Regulation of Localization of Penk 3 0.31 0 2.61
46 INT111789 Cck Regulation of Gene_expression of Penk 1 0.49 1.68 2.57
47 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55
48 INT111786 Penk Regulation of Gene_expression of Cck 1 0.49 1.66 2.55
49 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
50 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
51 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
52 INT14687 Binding of Penk and Ppt1 1 0.41 0 2.46
53 INT96462 Pnoc Positive_regulation of Pag1 1 0.01 0.74 2.45
54 INT96465 Pnoc Positive_regulation of GEM 1 0.01 0.74 2.39
55 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
56 INT76776 Binding of Pnoc and Ptprg 2 0.02 0 2.29
57 INT18791 Crh Regulation of Penk 2 0.49 0 2.15
58 INT39108 Binding of PDYN and YY1 2 0.50 0.44 2.14
59 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
60 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
61 INT18355 Penk Positive_regulation of Localization of Sst 1 0.31 0 2.04
62 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
63 INT23755 Mptp1 Regulation of PDYN 1 0.01 2.27 1.98
64 INT58678 Binding of Penk and Abat 2 0.40 1.39 1.97
65 INT2653 Slc3a1 Regulation of Penk 3 0.04 0.37 1.96
66 INT122381 Positive_regulation of Pnoc Positive_regulation of Oprl1 1 0.36 1.11 1.96
67 INT37882 Penk Positive_regulation of LOC100366054 1 0.08 0.35 1.93
68 INT6931 Binding of Oprk1 and Pdyn 2 0.24 0.92 1.92
69 INT30146 Binding of Adarb1 and Pdyn 1 0.01 0.17 1.91
70 INT31438 Penk Positive_regulation of Localization of Pomc 1 0.18 0 1.9
71 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
72 INT75069 Penk Regulation of Gene_expression of Pkhd1l1 1 0.09 0 1.85
73 INT40239 Penk Regulation of Avp 1 0.07 0 1.84
74 INT40238 Penk Regulation of Oxt 1 0.04 0 1.83
75 INT72468 Negative_regulation of Binding of OPRL1 and PNOC 1 0.40 0 1.83
76 INT115048 Kcnip3 Regulation of Gene_expression of Pdyn 2 0.27 0.71 1.78
77 INT14576 Tac4 Regulation of Penk 1 0.07 0 1.77
78 INT149491 PNOC Negative_regulation of Gene_expression of CD14 1 0.40 0.37 1.76
79 INT140892 Penk Negative_regulation of Mnp 1 0.13 0.55 1.75
80 INT34472 Penk Regulation of Slc3a1 2 0.03 0.42 1.74
81 INT79365 Pnoc Negative_regulation of Oprl1 2 0.41 0.16 1.72
82 INT80787 Negative_regulation of Binding of Pnoc and Oprl1 2 0.39 0.39 1.72
83 INT62065 Binding of YY1 and Penk 3 0.14 0 1.69
84 INT199497 Pdyn Negative_regulation of Il1 1 0.00 0.14 1.67
85 INT69666 Binding of OPRL1 and Pnoc 2 0.45 0.06 1.66
86 INT140009 Avp Positive_regulation of Gene_expression of Penk 1 0.40 0.77 1.64
87 INT199490 Penk Positive_regulation of Oprk1 1 0.03 0.87 1.64
88 INT147258 Binding of Tac1 and Penk 1 0.35 0 1.64
89 INT32839 Binding of Trh and Penk 2 0.42 0 1.63
90 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
91 INT32412 Penk Regulation of Pomc 3 0.21 0.36 1.62
92 INT151020 Binding of Pdyn and Crh 1 0.14 0.42 1.59
93 INT128512 Regulation of Pnoc Regulation of Adarb1 1 0.01 0.46 1.58
94 INT42928 Penk Negative_regulation of Localization of Oxt 2 0.03 0 1.57
95 INT54844 Negative_regulation of Penk Positive_regulation of Vip 1 0.26 0 1.54
96 INT33815 Vta1 Negative_regulation of Penk 1 0.25 0 1.54
97 INT73016 PDYN Regulation of TAC1 1 0.29 0.34 1.54
98 INT40887 Penk Regulation of Th 1 0.04 0 1.53
99 INT245347 Binding of Penk and Vta1 1 0.05 0.14 1.53
100 INT140016 Avp Positive_regulation of Gene_expression of Pdyn 1 0.21 0.85 1.52
101 INT62481 Penk Negative_regulation of Slc6a7 2 0.60 0 1.5
102 INT30463 Binding of PDYN and Penk 2 0.01 0 1.5
103 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
104 INT48101 RT1-DMb Positive_regulation of Penk 1 0.10 0 1.5
105 INT69788 Binding of Gpr1 and Pnoc 2 0.09 0 1.49
106 INT39109 Binding of INSRR and PDYN 1 0.15 0.45 1.46
107 INT158282 Binding of Penk and Csf2 1 0.33 0.87 1.44
108 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
109 INT137958 Asprv1 Positive_regulation of Localization of Pdyn 1 0.21 0 1.43
110 INT158283 Binding of Penk and Accn4 1 0.07 0.87 1.43
111 INT154114 PENK Positive_regulation of YY1 1 0.50 0.06 1.41
112 INT154111 POMC Positive_regulation of Localization of PENK 1 0.34 0.05 1.41
113 INT41591 Binding of PDYN and FAIM3 1 0.00 0 1.41
114 INT128913 Binding of COMT and PENK 1 0.30 0.07 1.41
115 INT154110 PENK Positive_regulation of Localization of POMC 1 0.34 0.05 1.41
116 INT199494 Crh Positive_regulation of Localization of Pdyn 1 0.02 0.43 1.4
117 INT93388 Rbm39 Positive_regulation of Positive_regulation of Pdyn 1 0.03 0.32 1.4
118 INT2170 Penk Regulation of Localization of LH 2 0.44 0 1.38
119 INT75807 Gpm6a Positive_regulation of Localization of Penk 1 0.04 0 1.35
120 INT54490 Npepo Positive_regulation of Gene_expression of Pdyn 1 0.06 0 1.35
121 INT87812 Penk Regulation of Prl 1 0.16 0 1.34
122 INT86172 Pdyn Positive_regulation of Gene_expression of Il2 1 0.20 0 1.33
123 INT143999 IK Regulation of Gene_expression of Penk 1 0.04 0 1.33
124 INT38453 Binding of Pomc and Penk 1 0.17 0 1.33
125 INT116102 Cck Positive_regulation of Negative_regulation of Pnoc 1 0.51 0.41 1.33
126 INT76508 Pnoc Regulation of Oprl1 1 0.47 0.25 1.32
127 INT39950 Binding of ALB and PDYN 1 0.31 0 1.32
128 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
129 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
130 INT49231 TAC1 Negative_regulation of Penk 1 0.00 0 1.3
131 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 0.35 0 1.29
132 INT85742 Pdyn Positive_regulation of Rbm39 1 0.01 0.17 1.29
133 INT89873 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.23 0 1.29
134 INT24378 Penk Regulation of Oprl1 1 0.10 0 1.29
135 INT31771 Penk Positive_regulation of Nppa 1 0.22 0.13 1.28
136 INT136200 Binding of Penk and NUP37 1 0.04 0 1.28
137 INT89876 Pdyn Positive_regulation of Gata4 1 0.23 0 1.28
138 INT73398 Binding of Pnoc and Nr1d2 1 0.10 0 1.27
139 INT31773 Pdyn Positive_regulation of Nppa 1 0.12 0.13 1.27
140 INT19819 Penk Regulation of Gene_expression of Ins1 1 0.05 0 1.27
141 INT88449 Uncx Positive_regulation of Penk 1 0.12 0 1.27
142 INT71989 Binding of Pdyn and Insrr 1 0.01 0 1.27
143 INT71990 Negative_regulation of Binding of Pdyn and Insrr 1 0.01 0 1.27
144 INT67383 Binding of OPRK1 and Pdyn 2 0.00 0 1.25
145 INT52205 Prl Positive_regulation of Gene_expression of Penk 1 0.52 0.15 1.25
146 INT126801 Regulation of Binding of Oprm1 and Penk 1 0.34 0.4 1.25
147 INT45269 POMC Negative_regulation of Penk 1 0.01 0 1.24
148 INT104348 Pnoc Negative_regulation of Localization of Gnrh1 1 0.45 0 1.24
149 INT123453 Binding of POMC and Penk 1 0.01 0.31 1.23
150 INT42806 Binding of CCT6A and PENK 1 0.02 0 1.23
151 INT40900 PDYN Regulation of Localization of POMC 2 0.07 0.56 1.22
152 INT240095 Binding of PDYN and Oprk1 1 0.52 1.3 1.22
153 INT21424 Binding of Penk and Gtpbp4 1 0.02 0.16 1.2
154 INT3302 Penk Positive_regulation of Slc43a3 1 0.01 0.09 1.19
155 INT25660 Binding of Penk and Pag1 1 0.01 0.67 1.19
156 INT140010 Avp Regulation of Gene_expression of Penk 1 0.25 0.58 1.19
157 INT94091 Binding of Pnoc and Tbce 1 0.03 0.19 1.19
158 INT75126 Pnoc Regulation of Localization of Avp 2 0.26 0.24 1.18
159 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14
160 INT128515 Binding of PNOC and Pnoc 1 0.12 0.38 1.14
161 INT102570 Abat Regulation of Gene_expression of Penk 3 0.13 0 1.12
162 INT85744 Binding of Pdyn and Rbm39 1 0.01 0.16 1.12
163 INT59606 Binding of Tspo and Penk 1 0.04 0 1.12
164 INT70603 Penk Positive_regulation of Pdyn 1 0.13 0 1.11
165 INT7927 Penk Regulation of Trh 2 0.26 0.66 1.09
166 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
167 INT105423 Jun Positive_regulation of Gene_expression of Penk 1 0.43 0 1.09
168 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
169 INT70270 Binding of ADRA2B and Pnoc 2 0.02 0.15 1.08
170 INT79322 Penk Regulation of Vmn2r1 1 0.00 0 1.08
171 INT88614 Penk Negative_regulation of Il2 1 0.23 0 1.08
172 INT87805 Pnoc Negative_regulation of Gene_expression of Fosl1 1 0.33 0 1.08
173 INT77737 Pnoc Positive_regulation of Localization of Prl 3 0.55 0 1.07
174 INT79372 Calca Regulation of Pnoc 1 0.34 0 1.07
175 INT79094 PDYN Positive_regulation of PRL 1 0.35 0.09 1.07
176 INT83936 Binding of Mtap2 and Penk 1 0.22 0.19 1.07
177 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
178 INT90050 Binding of GRP and Penk 1 0.06 0 1.06
179 INT107566 Penk Regulation of Hps4 1 0.00 0.1 1.04
180 INT107563 Penk Regulation of Mtr 1 0.00 0.1 1.04
181 INT101443 Penk Positive_regulation of Localization of Gcg 1 0.50 1.21 1.04
182 INT10552 Penk Positive_regulation of Regulation of Cebpz 1 0.44 0.25 1.03
183 INT105101 Pdyn Regulation of Samd10 1 0.00 0 1.02
184 INT40715 Binding of SST and Penk 1 0.10 0 1.02
185 INT34535 Regulation of Binding of Penk and Oprl1 1 0.05 0 1.02
186 INT83903 Penk Positive_regulation of Npff 1 0.49 0 1.02
187 INT13502 Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
188 INT13503 Regulation of Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
189 INT30378 Binding of Sst and Penk 1 0.28 0.52 1.01
190 INT53843 Penk Regulation of Pag1 1 0.07 0.9 1.01
191 INT53846 Positive_regulation of Penk Regulation of Pag1 1 0.07 0.9 1.01
192 INT47163 Penk Regulation of Rtcd1 1 0.00 0 1.01
193 INT53844 Penk Regulation of Kitl 1 0.00 0.9 1
194 INT40950 Binding of Penk and Srms 1 0.05 0 1
195 INT63803 RGD1560349 Positive_regulation of Penk 1 0.04 0 1
196 INT53845 Positive_regulation of Penk Regulation of Kitl 1 0.00 0.9 1
197 INT71319 Binding of Penk and Fos 3 0.40 0.15 0.99
198 INT127738 Binding of Crygb and Pnoc 2 0.49 0.1 0.99
199 INT44143 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Penk 1 0.46 0 0.99
200 INT18139 Binding of Penk and Stmn1 1 0.08 0 0.99

Single Events

The table below shows the top 100 pain related interactions that have been reported for opioid peptide activity. They are ordered first by their pain relevance and then by number of times they were reported in opioid peptide activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59
2 INT292 Localization of Penk 876 0.81 88.44 669.14
3 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87
4 INT797 Regulation of Penk 812 0.62 111.13 542.24
5 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81
6 INT1396 Binding of Penk 355 0.48 22.79 269.65
7 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47
8 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07
9 INT4803 Transcription of Penk 435 0.72 59.09 182.4
10 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65
11 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88
12 INT5595 Positive_regulation of Pdyn 223 0.70 48.37 130.14
13 INT6822 Gene_expression of Pdyn 215 0.78 35.99 125.76
14 INT2555 Positive_regulation of Localization of Penk 116 0.70 24.35 119.73
15 INT293 Protein_catabolism of Penk 161 1.00 11.71 98.45
16 INT5594 Regulation of Pdyn 137 0.62 27.04 86.63
17 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49
18 INT5593 Positive_regulation of Gene_expression of Pdyn 114 0.70 29.1 74.46
19 INT7028 Localization of Pdyn 90 0.81 8.89 73.54
20 INT442 Localization of PDYN 99 0.81 11.87 72.75
21 INT5852 Gene_expression of Penk 167 0.78 44.44 71.13
22 INT66416 Regulation of Pnoc 66 0.61 17.32 68.91
23 INT6824 Regulation of Gene_expression of Pdyn 114 0.62 9.48 66.73
24 INT66531 Gene_expression of Pnoc 88 0.78 22.9 65.11
25 INT5573 Negative_regulation of Gene_expression of Penk 113 0.59 21.83 64.66
26 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04
27 INT66779 Binding of Pnoc 79 0.48 6.43 60.46
28 INT1430 Regulation of PDYN 88 0.60 16.99 60.32
29 INT65078 Negative_regulation of Pnoc 64 0.59 15.48 59.81
30 INT7032 Positive_regulation of Pdyn 94 0.66 26.51 58.83
31 INT7491 Localization of Pdyn 80 0.81 3.94 58.77
32 INT5819 Regulation of Localization of Penk 64 0.62 6.69 57.68
33 INT1510 Binding of PDYN 94 0.48 4.68 56.44
34 INT5598 Negative_regulation of Pdyn 95 0.59 14.4 55.43
35 INT2421 Positive_regulation of Positive_regulation of Penk 97 0.69 13.38 55.32
36 INT6826 Transcription of Pdyn 130 0.71 22.19 54.88
37 INT6073 Negative_regulation of Localization of Penk 63 0.59 8.67 53.95
38 INT5136 Negative_regulation of PDYN 71 0.59 11.22 51.14
39 INT7287 Positive_regulation of Transcription of Penk 103 0.70 19.81 50.37
40 INT6823 Negative_regulation of Pdyn 68 0.58 13.95 46.12
41 INT64440 Gene_expression of Pnoc 66 0.78 13.61 41.76
42 INT66532 Positive_regulation of Pnoc 46 0.70 14.99 41.39
43 INT7029 Regulation of Pdyn 51 0.61 12.89 40.34
44 INT4862 Localization of PENK 62 0.81 11.57 40.28
45 INT1457 Negative_regulation of Binding of Penk 40 0.57 0.25 34.24
46 INT7286 Regulation of Transcription of Penk 81 0.62 9.25 33.45
47 INT7692 Positive_regulation of PENK 71 0.70 20.34 32.54
48 INT1711 Negative_regulation of Positive_regulation of Penk 54 0.59 6.55 32.42
49 INT610 Regulation of PENK 47 0.62 14.17 31.55
50 INT8531 Transcription of PDYN 56 0.72 19.51 30.99
51 INT11279 Positive_regulation of Penk 65 0.70 18.72 30.29
52 INT10684 Negative_regulation of Protein_catabolism of Penk 41 0.59 2.33 28.63
53 INT5851 Positive_regulation of Gene_expression of Penk 52 0.70 14.57 25.05
54 INT30276 Positive_regulation of Gene_expression of Pdyn 39 0.67 11.28 24.89
55 INT66417 Localization of Pnoc 34 0.80 1.61 24.48
56 INT5596 Negative_regulation of Gene_expression of Pdyn 41 0.59 5.34 24.36
57 INT5592 Regulation of Regulation of Penk 36 0.62 4.37 24.02
58 INT21344 Negative_regulation of Penk 34 0.57 8.83 23.32
59 INT47876 Binding of Pnoc 20 0.47 4.99 20.01
60 INT10118 Positive_regulation of Localization of Pdyn 15 0.70 0.77 19.5
61 INT68970 Positive_regulation of Pnoc 33 0.67 9.29 19.08
62 INT30312 Binding of Pdyn 30 0.37 4.2 18.23
63 INT7056 Positive_regulation of Gene_expression of PENK 35 0.70 14.31 18.21
64 INT6666 Negative_regulation of PENK 30 0.58 9.16 17.91
65 INT8056 Regulation of Positive_regulation of Penk 34 0.59 4.71 17.66
66 INT7644 Positive_regulation of Gene_expression of PDYN 27 0.69 10.19 17.47
67 INT68640 Regulation of Pnoc 18 0.54 7.6 17.27
68 INT9780 Regulation of Penk 30 0.60 6.78 17.19
69 INT30245 Binding of Pdyn 26 0.37 2.31 17
70 INT7290 Negative_regulation of Transcription of Penk 33 0.59 7.28 16.5
71 INT8530 Transcription of Penk 48 0.70 11.67 16.34
72 INT9663 Protein_catabolism of PDYN 43 0.99 0.67 16.15
73 INT8223 Transcription of PENK 53 0.69 6.84 14.7
74 INT7030 Regulation of Gene_expression of Pdyn 23 0.61 5.77 14.18
75 INT73351 Negative_regulation of Pnoc 13 0.42 5.71 14.17
76 INT7031 Transcription of Pdyn 43 0.71 5.82 13.58
77 INT20495 Regulation of Protein_catabolism of Penk 17 0.62 0.96 13.3
78 INT18372 Positive_regulation of Transcription of Pdyn 30 0.69 2.48 12.83
79 INT1590 Binding of PENK 27 0.47 2.99 12.81
80 INT12232 Regulation of Gene_expression of PDYN 21 0.60 9.91 12.18
81 INT67213 Transcription of Pnoc 18 0.67 4.66 12.17
82 INT28770 Negative_regulation of Gene_expression of PDYN 16 0.57 4.95 12.06
83 INT20450 Regulation of Binding of Penk 11 0.60 0.47 11.92
84 INT7389 Positive_regulation of Localization of Pdyn 15 0.48 1.68 11.88
85 INT7490 Regulation of Localization of Pdyn 7 0.62 0.14 11.35
86 INT29964 Positive_regulation of Positive_regulation of PDYN 9 0.67 1.56 11.31
87 INT64484 Binding of PNOC 12 0.33 5.51 10.86
88 INT10119 Positive_regulation of Positive_regulation of Pdyn 14 0.69 2.67 10.81
89 INT78556 Gene_expression of PNOC 11 0.76 2.93 10.58
90 INT30438 Negative_regulation of Gene_expression of Pdyn 8 0.57 1.15 10.46
91 INT1459 Positive_regulation of Binding of Penk 15 0.67 0.08 10.45
92 INT2294 Protein_catabolism of PENK 19 1.00 0.64 10.22
93 INT10120 Negative_regulation of Positive_regulation of Pdyn 14 0.58 6.05 10.19
94 INT17233 Positive_regulation of Localization of PDYN 9 0.69 2.84 10.06
95 INT5854 Regulation of Gene_expression of Penk 22 0.61 6.91 10.03
96 INT2777 Positive_regulation of Regulation of Penk 21 0.67 0.63 9.96
97 INT81664 Positive_regulation of Gene_expression of Pnoc 12 0.68 2.51 9.75
98 INT9157 Negative_regulation of Negative_regulation of Penk 13 0.43 2.3 9.54
99 INT21214 Negative_regulation of Gene_expression of PENK 21 0.58 9.14 9.53
100 INT8524 Regulation of Transcription of Pdyn 20 0.60 5.47 9.03
101 INT18519 Positive_regulation of Negative_regulation of Pdyn 6 0.47 0.14 8.72
102 INT68971 Localization of Pnoc 10 0.73 2.95 8.43
103 INT87890 Regulation of Gene_expression of Pnoc 8 0.44 2.45 7.66
104 INT65206 Regulation of PNOC 8 0.38 1.61 7.43
105 INT1712 Positive_regulation of Negative_regulation of Penk 10 0.67 1.48 7.06
106 INT82811 Negative_regulation of Binding of Pnoc 6 0.37 0 7.04
107 INT8532 Regulation of Transcription of PDYN 10 0.44 4.97 6.95
108 INT154115 Positive_regulation of Localization of PENK 5 0.49 3.15 6.93
109 INT18428 Protein_catabolism of Pdyn 9 0.92 1.2 6.87
110 INT11276 Localization of Penk 10 0.00 2.94 6.63
111 INT18460 Positive_regulation of Transcription of PDYN 11 0.67 2.14 6.61
112 INT40178 Binding of Penk 11 0.44 0.23 6.21
113 INT20805 Regulation of Gene_expression of PENK 20 0.62 4.55 6.02
114 INT7489 Negative_regulation of Localization of Pdyn 9 0.59 0.15 5.97
115 INT8529 Regulation of Transcription of Penk 8 0.39 1.26 5.89
116 INT87786 Regulation of Gene_expression of Pnoc 3 0.61 3.06 5.66
117 INT6825 Negative_regulation of Transcription of Pdyn 12 0.53 0.35 5.22
118 INT69941 Positive_regulation of Gene_expression of Pnoc 9 0.67 1.53 5.16
119 INT26670 Regulation of Positive_regulation of Pdyn 11 0.45 0.94 4.96
120 INT19641 Negative_regulation of Gene_expression of Penk 11 0.58 1.12 4.91
121 INT17234 Positive_regulation of Negative_regulation of PDYN 4 0.45 0.66 4.89
122 INT72474 Positive_regulation of PNOC 9 0.68 1.76 4.84
123 INT9390 Negative_regulation of Negative_regulation of PDYN 5 0.42 1.31 4.54
124 INT20496 Positive_regulation of Protein_catabolism of Penk 7 0.50 0.86 4.42
125 INT81665 Positive_regulation of Localization of Pnoc 5 0.60 0.58 4.23
126 INT85741 Regulation of Negative_regulation of Pdyn 3 0.27 0.7 4.15
127 INT15618 Positive_regulation of Transcription of Penk 12 0.58 3.21 3.8
128 INT103579 Negative_regulation of Positive_regulation of PDYN 2 0.42 1.34 3.77
129 INT86371 Protein_catabolism of Pnoc 2 0.98 0.79 3.65
130 INT18518 Regulation of Regulation of Pdyn 6 0.60 0 3.6
131 INT18662 Negative_regulation of Binding of PDYN 5 0.57 0.34 3.58
132 INT68581 Transcription of Pnoc 4 0.70 1.21 3.54
133 INT24835 Negative_regulation of Localization of Pdyn 4 0.26 0.31 3.51
134 INT82669 Negative_regulation of Gene_expression of Pnoc 3 0.43 1.19 3.25
135 INT26539 Positive_regulation of Transcription of PENK 10 0.67 1.28 2.9
136 INT30701 Regulation of Localization of PDYN 4 0.27 0.31 2.79
137 INT119944 Regulation of Transcription of Pnoc 1 0.00 1.01 2.74
138 INT113007 Positive_regulation of Positive_regulation of Pdyn 7 0.49 2.28 2.68
139 INT72076 Regulation of Regulation of Pnoc 1 0.32 0.09 2.68
140 INT90932 Negative_regulation of Positive_regulation of Penk 3 0.41 0.36 2.66
141 INT7388 Negative_regulation of Negative_regulation of Pdyn 3 0.38 0.6 2.66
142 INT78557 Positive_regulation of Negative_regulation of Pnoc 2 0.59 0.45 2.59
143 INT148191 Positive_regulation of Localization of Penk 2 0.61 1.22 2.48
144 INT87785 Regulation of Regulation of Pnoc 2 0.39 1.85 2.45
145 INT9159 Negative_regulation of Regulation of Penk 7 0.43 3.05 2.41
146 INT72612 Negative_regulation of Regulation of Pdyn 2 0.38 0.77 2.3
147 INT97665 Negative_regulation of Regulation of Pnoc 3 0.43 0.72 2.29
148 INT57282 Positive_regulation of Negative_regulation of Penk 4 0.49 0.84 2.26
149 INT128511 Negative_regulation of Positive_regulation of Pnoc 2 0.42 0.45 2.26
150 INT67002 Negative_regulation of Regulation of Pdyn 2 0.43 0.43 2.2
151 INT72777 Positive_regulation of Positive_regulation of Pnoc 5 0.49 1.07 2.18
152 INT121274 Negative_regulation of PNOC 4 0.43 0.22 2.16
153 INT12832 Positive_regulation of Positive_regulation of PENK 6 0.67 1.13 2.13
154 INT11267 Protein_catabolism of Pdyn 3 0.45 0.29 2.09
155 INT108475 Transcription of PNOC 1 0.52 0.35 2.08
156 INT85740 Positive_regulation of Negative_regulation of Pdyn 2 0.18 0.74 2.05
157 INT133632 Negative_regulation of Transcription of PDYN 5 0.57 2.79 1.96
158 INT79821 Negative_regulation of Binding of Pnoc 2 0.29 0.44 1.93
159 INT186441 Regulation of Regulation of PDYN 2 0.26 1.81 1.92
160 INT14059 Negative_regulation of Negative_regulation of Pdyn 4 0.57 0.32 1.91
161 INT9662 Positive_regulation of Protein_catabolism of PDYN 5 0.57 0 1.9
162 INT66466 Regulation of Positive_regulation of Pdyn 3 0.39 2.46 1.89
163 INT24836 Negative_regulation of Positive_regulation of Pdyn 4 0.38 0.44 1.85
164 INT78479 Negative_regulation of Localization of PENK 2 0.43 1.9 1.81
165 INT1588 Positive_regulation of Binding of PENK 2 0.26 0.57 1.72
166 INT79484 Regulation of Negative_regulation of Pnoc 2 0.37 0.92 1.62
167 INT72373 Phosphorylation of Penk 4 0.62 0.18 1.56
168 INT15461 Phosphorylation of PENK 2 0.72 0.17 1.49
169 INT119945 Negative_regulation of Transcription of Pnoc 1 0.00 0.57 1.48
170 INT90933 Positive_regulation of Protein_catabolism of Penk 1 0.28 0 1.44
171 INT90934 Negative_regulation of Protein_catabolism of Penk 1 0.24 0 1.44
172 INT120747 Negative_regulation of Localization of Pnoc 1 0.37 0 1.42
173 INT29202 Negative_regulation of Regulation of PDYN 1 0.06 0 1.38
174 INT6175 Negative_regulation of Localization of PDYN 3 0.41 0.1 1.37
175 INT58164 Regulation of Transcription of Pdyn 3 0.27 0 1.33
176 INT27956 Negative_regulation of Positive_regulation of PENK 6 0.43 1.37 1.25
177 INT119946 Regulation of Transcription of Pnoc 1 0.42 0.48 1.2
178 INT29524 Positive_regulation of Binding of PDYN 2 0.45 0 1.19
179 INT24503 Positive_regulation of Regulation of Pdyn 2 0.50 0.16 1.18
180 INT160753 Negative_regulation of Gene_expression of PNOC 1 0.36 0.27 1.17
181 INT10091 Regulation of Protein_catabolism of PDYN 2 0.05 0 1.16
182 INT148598 Regulation of Binding of Pnoc 1 0.15 0.18 1.12
183 INT70015 Protein_catabolism of Penk 3 0.64 0 1.11
184 INT122379 Negative_regulation of Regulation of Pnoc 1 0.28 0.49 1.11
185 INT10686 Regulation of Binding of PDYN 3 0.43 0.61 1.1
186 INT30715 Positive_regulation of Binding of Pdyn 1 0.46 0 1.09
187 INT54682 Positive_regulation of Regulation of PDYN 1 0.17 0 1.09
188 INT11274 Positive_regulation of Positive_regulation of Penk 3 0.48 0.47 1.08
189 INT40176 Negative_regulation of Binding of Penk 2 0.54 0 1.08
190 INT107259 Phosphorylation of Pnoc 1 0.08 0.19 1.05
191 INT75064 Negative_regulation of Transcription of Penk 1 0.51 0 0.97
192 INT108474 Localization of PNOC 1 0.73 0.14 0.96
193 INT326658 Regulation of Localization of Penk 1 0.24 0.75 0.96
194 INT68014 Negative_regulation of Gene_expression of Pnoc 2 0.41 0.35 0.95
195 INT72471 Negative_regulation of Binding of PNOC 1 0.23 0 0.91
196 INT7027 Positive_regulation of Transcription of Pdyn 4 0.41 0.2 0.89
197 INT86757 Positive_regulation of Regulation of Pdyn 1 0.04 1.11 0.87
198 INT42734 Negative_regulation of Protein_catabolism of PDYN 2 0.06 0 0.86
199 INT1589 Regulation of Binding of PENK 1 0.23 0 0.84
200 INT32173 Regulation of Localization of PENK 2 0.23 0.1 0.83
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