GO:0001516

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Name prostaglandin biosynthetic process
Categary Process
Go Slim No
Go Link GO:0001516
Unique Molecular Interactions 1002
Total Molecular Interactions 1296
Total Single Events 21177
Pain Genes Associated 34

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for prostaglandin biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for prostaglandin biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
2 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
3 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
4 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37
5 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
6 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
7 INT203149 Binding of Mif and Osm 1 0.02 2.93 1.78
8 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
9 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
10 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
11 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
12 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 0.01 0.81 1.31
13 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
14 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
15 INT105295 WAS Regulation of PTGS1 1 0.02 0.13 1.27
16 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
17 INT253999 Binding of Cxcl12 and Mif 1 0.41 2.26 1.22
18 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
19 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
20 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
21 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
22 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
23 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
24 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
25 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
26 INT60213 Binding of Ptgs1 and Ptgs2 2 0.37 0.5 0.97
27 INT25111 Binding of PTGDS and PLEKHM1 1 0.01 0 0.97
28 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
29 INT61037 Och Positive_regulation of Ptgs1 1 0.00 0 0.95
30 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
31 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
32 INT126766 Binding of PTGDS and PTGDR2 4 0.40 1.62 0.93
33 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
34 INT40636 Mif Negative_regulation of Pomc 1 0.25 0.07 0.9
35 INT253992 Cxcl12 Positive_regulation of Mif 1 0.46 1.31 0.88
36 INT203148 Mif Positive_regulation of Gene_expression of S100a8 1 0.00 1.56 0.87
37 INT116559 Olr1627 Negative_regulation of Regulation of Ptgs2 1 0.01 1.52 0.86
38 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
39 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
40 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
41 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
42 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
43 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
44 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
45 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
46 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
47 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79
48 INT200094 Negative_regulation of Jun Negative_regulation of Gene_expression of Ptgs2 1 0.01 2.87 0.78
49 INT158068 Positive_regulation of Pparg Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.28 0.76
50 INT119314 Ptgs1 Regulation of Gene_expression of Ptger2 1 0.01 0.6 0.73
51 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
52 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
53 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
54 INT155139 Binding of MC1R and PTGES 3 0.09 0 0.7
55 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
56 INT40703 Mif Negative_regulation of Negative_regulation of POMC 1 0.24 0.49 0.7
57 INT253994 Cyp3a23/3a1 Positive_regulation of Localization of Mif 1 0.09 0.96 0.69
58 INT114735 Mtx1 Regulation of Ptgs1 1 0.01 0.31 0.69
59 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
60 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
61 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
62 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
63 INT94020 Binding of EDN2 and INSRR 1 0.03 0 0.65
64 INT312106 EGR1 Regulation of Gene_expression of PTGES 1 0.31 1.06 0.64
65 INT38905 Ptgfr Regulation of Ptgds 1 0.20 0 0.63
66 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
67 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
68 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
69 INT71942 Negative_regulation of PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.62
70 INT101320 Negative_regulation of Ptgs1 Positive_regulation of Ptgs2 1 0.03 0.2 0.62
71 INT55672 Ptgs1 Positive_regulation of Gene_expression of Ik 1 0.03 0.75 0.61
72 INT71944 PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.61
73 INT164990 Mif Positive_regulation of Gene_expression of Grina 1 0.24 0.53 0.6
74 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
75 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
76 INT137247 Slc6a14 Negative_regulation of Ptgs2 2 0.19 1.38 0.58
77 INT137248 Slc6a14 Negative_regulation of Gene_expression of Ptgs2 1 0.19 1.32 0.58
78 INT125546 Arsa Negative_regulation of Gene_expression of PTGS2 1 0.00 0.53 0.58
79 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58
80 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
81 INT147071 NFKB1 Regulation of Gene_expression of PTGES 1 0.36 0.35 0.57
82 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55
83 INT254197 Mif Regulation of Ptgs2 1 0.02 1.08 0.55
84 INT136758 TNF Positive_regulation of Gene_expression of PTGES 1 0.05 0.52 0.55
85 INT71943 Regulation of ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.54
86 INT129912 Skiv2l Negative_regulation of Gene_expression of PTGS2 1 0.00 0.87 0.54
87 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
88 INT76200 CASP1 Positive_regulation of Gene_expression of PTGS1 1 0.05 0.16 0.54
89 INT161251 Ptgs2 Regulation of Mapk14 1 0.16 0.82 0.54
90 INT71945 ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.53
91 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
92 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
93 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
94 INT69882 Ptger2 Positive_regulation of Gene_expression of Ptgs2 1 0.19 0.6 0.52
95 INT116541 Binding of Ptgs2 and ZNF398 1 0.00 0.68 0.52
96 INT346205 Binding of CD74 and TPPP 1 0.02 0.87 0.51
97 INT105849 Il1b Positive_regulation of Positive_regulation of Ptgs1 1 0.07 0.38 0.51
98 INT78590 Nos2 Positive_regulation of PTGS1 2 0.00 0.85 0.5
99 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
100 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
101 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
102 INT312118 ELANE Regulation of PTGES 1 0.22 0.92 0.49
103 INT150205 Tnrc6a Negative_regulation of PTGS2 1 0.00 0.42 0.49
104 INT135584 CSF2 Regulation of PTGS2 1 0.06 1.28 0.49
105 INT150788 ZNF398 Regulation of PTGS2 1 0.02 0.5 0.48
106 INT348402 LPA Positive_regulation of Gene_expression of Ptgs2 1 0.01 0.62 0.48
107 INT94018 Binding of EDN2 and EDN3 1 0.19 0 0.48
108 INT131809 Nfkb1 Positive_regulation of Gene_expression of Ptgs1 1 0.12 0.73 0.48
109 INT129551 Sag Negative_regulation of Gene_expression of Ptgs1 1 0.08 0.88 0.48
110 INT162329 Tmc1 Negative_regulation of Gene_expression of Ptges2 1 0.03 0.58 0.47
111 INT62164 Il1b Positive_regulation of PTGS2 1 0.00 0.49 0.47
112 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
113 INT62163 Il1b Positive_regulation of Positive_regulation of PTGS2 1 0.00 0.49 0.47
114 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
115 INT195769 MIF Regulation of Gene_expression of TP53I11 1 0.19 1.24 0.47
116 INT145436 Binding of HMOX2 and PTGS2 1 0.02 0.41 0.47
117 INT127662 Negative_regulation of PDE4A Negative_regulation of Gene_expression of PTGS2 1 0.15 0.75 0.47
118 INT253997 Binding of Cd200r1 and Mif 1 0.03 1.02 0.46
119 INT103027 Ptgis Positive_regulation of Nos3 1 0.06 0.42 0.46
120 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46
121 INT103026 Ptgis Positive_regulation of Ptgs1 1 0.02 0.42 0.46
122 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
123 INT103029 Calca Positive_regulation of Positive_regulation of Ptgs1 1 0.12 0.41 0.46
124 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
125 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
126 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
127 INT355571 MIF Positive_regulation of IL8 1 0.04 1.05 0.44
128 INT103028 Calca Positive_regulation of Gene_expression of Ptgis 1 0.17 0.58 0.44
129 INT234599 Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44
130 INT314263 Binding of CPOX and PTGES3 1 0.01 1.7 0.44
131 INT234600 Negative_regulation of Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44
132 INT355568 MIF Positive_regulation of IL6 1 0.05 1.05 0.44
133 INT69163 Tlr4 Positive_regulation of Ptgs1 1 0.02 0.08 0.44
134 INT121364 ZNF398 Negative_regulation of Transcription of MIF 1 0.00 0.9 0.43
135 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
136 INT53470 Acsm3 Regulation of Ptgs1 1 0.15 0 0.42
137 INT121378 Fancl Positive_regulation of MIF 1 0.01 0.92 0.42
138 INT53469 Negative_regulation of Acsm3 Regulation of Ptgs1 1 0.24 0 0.42
139 INT220193 PTGER2 Regulation of PTGES 1 0.06 0.66 0.41
140 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
141 INT53471 Binding of Ptgs1 and Acsm3 1 0.17 0 0.41
142 INT91107 Positive_regulation of Ptgs1 Positive_regulation of Localization of Crh 1 0.00 0.56 0.41
143 INT264522 Binding of GPER and PTGDS 1 0.03 1.22 0.4
144 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
145 INT264525 Binding of PTGDS and PTGFR 1 0.02 1.22 0.39
146 INT106505 Binding of Ptgds and Ptgs2 1 0.01 0.93 0.39
147 INT200096 Negative_regulation of Il1a Negative_regulation of Gene_expression of Ptgs2 1 0.00 1.45 0.39
148 INT121365 ZNF398 Negative_regulation of Gene_expression of MIF 1 0.00 0.73 0.38
149 INT50553 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Tbxa2r 1 0.02 1.37 0.38
150 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
151 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
152 INT264527 IL1B Positive_regulation of Gene_expression of PTGDS 1 0.07 0.75 0.38
153 INT144047 IL4 Positive_regulation of PTGES 1 0.29 0.43 0.37
154 INT157171 Binding of PTGS2 and Pla2g1b 1 0.02 0.26 0.37
155 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
156 INT144044 IRF6 Positive_regulation of PTGES 1 0.10 0.43 0.37
157 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
158 INT144043 IL13 Positive_regulation of PTGES 1 0.32 0.43 0.37
159 INT74244 Ptgs1 Regulation of Positive_regulation of Penk 1 0.09 0.19 0.37
160 INT106511 Binding of Cpox and Ptges3 2 0.01 0.7 0.36
161 INT355570 MIF Positive_regulation of Gene_expression of IL8 1 0.07 1.11 0.36
162 INT93694 Binding of Hspa8 and Ptgs1 1 0.30 0.79 0.36
163 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
164 INT255555 Binding of Ptgds and Tfdp1 1 0.14 1.14 0.36
165 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
166 INT167045 TRPA1 Regulation of PTGS1 1 0.19 0.1 0.35
167 INT126767 Positive_regulation of Binding of PTGDS and PTGDR2 1 0.54 0.3 0.35
168 INT174459 IL8 Positive_regulation of Gene_expression of Cd74 1 0.00 0.61 0.35
169 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
170 INT144046 IL13 Negative_regulation of Gene_expression of PTGES 1 0.30 0.48 0.35
171 INT278766 HOXA9 Positive_regulation of Gene_expression of PTGS2 1 0.43 1.28 0.35
172 INT312124 EGR1 Regulation of Binding of PTGES 1 0.31 0.41 0.35
173 INT278749 NUP98 Positive_regulation of Gene_expression of PTGS2 1 0.46 1.28 0.35
174 INT144045 IFNG Negative_regulation of Gene_expression of PTGES 1 0.63 0.47 0.35
175 INT32212 POMC Regulation of Gene_expression of Mif 1 0.00 1.01 0.35
176 INT144050 IL4 Negative_regulation of Gene_expression of PTGES 1 0.27 0.48 0.35
177 INT89501 Il6 Positive_regulation of Ptgs2 1 0.01 1.07 0.35
178 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
179 INT144049 IL10 Negative_regulation of Gene_expression of PTGES 1 0.35 0.47 0.35
180 INT144048 IRF6 Positive_regulation of Gene_expression of PTGES 1 0.12 0.46 0.35
181 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
182 INT25354 Chi3l1 Negative_regulation of Ptgs1 1 0.00 0.39 0.34
183 INT89505 Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
184 INT5388 PTGS1 Negative_regulation of APRT 1 0.21 0.4 0.34
185 INT134303 Cpox Negative_regulation of PTGS2 1 0.00 0.77 0.34
186 INT72953 Mif Positive_regulation of Localization of Prl 1 0.42 0 0.34
187 INT264521 PTGDS Negative_regulation of Positive_regulation of MMP1 1 0.06 1.42 0.34
188 INT89502 Positive_regulation of Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
189 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
190 INT68557 ZNF697 Negative_regulation of PTGS1 1 0.02 0.59 0.33
191 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
192 INT312119 ELANE Positive_regulation of Gene_expression of PTGES 1 0.18 0.74 0.33
193 INT188521 Binding of Hsp90aa1 and Ptges3 1 0.02 0.61 0.33
194 INT147984 Ptgds Positive_regulation of Cpox 1 0.17 0.29 0.32
195 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
196 INT353333 Positive_regulation of F2r Positive_regulation of Localization of Mif 1 0.46 0.26 0.32
197 INT72951 Mif Regulation of Prl 1 0.41 0 0.32
198 INT52700 Prkcg Positive_regulation of Ptgs2 1 0.12 0.3 0.32
199 INT353334 F2r Positive_regulation of Mif 1 0.68 0 0.32
200 INT147982 Cpox Positive_regulation of Gene_expression of Ptgds 1 0.17 0.3 0.32

Single Events

The table below shows the top 100 pain related interactions that have been reported for prostaglandin biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in prostaglandin biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26
2 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
3 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6
4 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
5 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58
6 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97
7 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
8 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
9 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5
10 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
11 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04
12 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
13 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
14 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
15 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41
16 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
17 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
18 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
19 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18
20 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95
21 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
22 INT116737 Localization of Mif 63 0.81 52.97 28.11
23 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
24 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31
25 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
26 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01
27 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
28 INT63419 Gene_expression of PTGES 109 0.77 40.83 23.67
29 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29
30 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
31 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
32 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49
33 INT40750 Gene_expression of Mif 61 0.78 34.59 20.28
34 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
35 INT5048 Binding of Edn1 55 0.47 18.86 19.16
36 INT134298 Gene_expression of Ptges2 96 0.54 56.52 17.19
37 INT9197 Binding of PTGS1 44 0.48 18.48 16.26
38 INT116736 Positive_regulation of Mif 40 0.70 31.93 15.37
39 INT9191 Localization of EDN1 94 0.81 57.01 14.78
40 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44
41 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
42 INT53080 Positive_regulation of Ptgs1 42 0.42 23.58 14.37
43 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
44 INT6365 Localization of Edn1 56 0.81 18.84 13.83
45 INT2385 Gene_expression of MIF 57 0.68 40.74 12.78
46 INT28420 Gene_expression of Ptgds 59 0.78 31.72 12.67
47 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
48 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39
49 INT91413 Negative_regulation of PTGES 35 0.58 17.94 12.03
50 INT12992 Negative_regulation of Gene_expression of Ptgs1 33 0.42 20.47 11.77
51 INT72949 Binding of Mif 31 0.46 23.12 11.65
52 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56
53 INT787 Localization of Ptgs1 31 0.80 12.36 11.55
54 INT53082 Positive_regulation of Gene_expression of Ptgs2 47 0.64 25.39 11.39
55 INT4804 Positive_regulation of Gene_expression of PTGDS 10 0.68 21.43 11.14
56 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6
57 INT53081 Negative_regulation of Gene_expression of Ptgs2 29 0.59 15.83 10.39
58 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
59 INT85535 Negative_regulation of Gene_expression of Ptgs2 27 0.51 16.04 10.01
60 INT106510 Gene_expression of Ptges 70 0.75 36.18 9.75
61 INT6361 Localization of Edn1 30 0.81 19.09 9.7
62 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53
63 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27
64 INT12991 Negative_regulation of Gene_expression of PTGS1 28 0.41 13.39 8.9
65 INT23264 Negative_regulation of Positive_regulation of Ptgs1 16 0.39 8.47 8.9
66 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
67 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
68 INT52442 Binding of Ptgs1 16 0.35 9.05 8.78
69 INT6573 Regulation of Negative_regulation of Ptgs1 19 0.45 6.16 8.71
70 INT117553 Regulation of MIF 10 0.56 12.76 8.67
71 INT10237 Binding of EDN1 40 0.48 16 8.48
72 INT69866 Positive_regulation of Ptgds 26 0.70 16.25 8.33
73 INT5114 Gene_expression of Ptgis 41 0.50 21.43 8.1
74 INT104679 Gene_expression of Ptges 33 0.41 10.14 7.89
75 INT32210 Gene_expression of Mif 13 0.75 28.48 7.79
76 INT20234 Regulation of Gene_expression of Ptgs1 11 0.44 6.55 7.72
77 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
78 INT91417 Positive_regulation of PTGES 36 0.68 18.45 7.64
79 INT52688 Transcription of Ptgs2 16 0.69 8.31 7.52
80 INT49751 Negative_regulation of Positive_regulation of PTGS1 12 0.45 4.73 7.23
81 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
82 INT4810 Localization of PTGDS 20 0.81 4.19 6.97
83 INT90097 Localization of PTGS2 15 0.69 6.14 6.63
84 INT517 Regulation of Mif 16 0.62 5.43 6.55
85 INT59079 Transcription of PTGS2 30 0.72 14.21 6.52
86 INT25130 Positive_regulation of Negative_regulation of Ptgs1 14 0.50 5.07 6.29
87 INT67656 Positive_regulation of Positive_regulation of PTGS2 12 0.46 4.83 6.17
88 INT142904 Negative_regulation of Ptges2 14 0.47 9.49 6.15
89 INT17370 Negative_regulation of Negative_regulation of Ptgs1 16 0.22 6.5 6.12
90 INT121370 Positive_regulation of MIF 22 0.70 17.79 6.08
91 INT516 Negative_regulation of Mif 13 0.59 6.69 6.08
92 INT78955 Regulation of Gene_expression of Ptgs2 12 0.62 7.22 6.02
93 INT48004 Positive_regulation of Negative_regulation of PTGS1 12 0.49 4.07 5.87
94 INT112530 Localization of Ptgs2 13 0.70 7.77 5.86
95 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71
96 INT162328 Regulation of Ptges2 21 0.19 12.07 5.56
97 INT98685 Positive_regulation of Gene_expression of PTGES 28 0.68 9.46 5.55
98 INT7996 Gene_expression of Ptgds 18 0.64 6.47 5.51
99 INT50491 Regulation of Gene_expression of PTGS1 17 0.47 6 5.4
100 INT143925 Negative_regulation of Ptges 18 0.42 10.5 5.18
101 INT83442 Negative_regulation of MIF 18 0.57 9.51 5.12
102 INT39256 Localization of PTGS1 17 0.74 6.62 5.1
103 INT19934 Negative_regulation of Ptgis 18 0.32 6.18 5.03
104 INT134297 Positive_regulation of Gene_expression of Ptges2 22 0.41 13.12 4.97
105 INT174339 Positive_regulation of Localization of Mif 7 0.61 8.27 4.95
106 INT62291 Gene_expression of PTGES2 14 0.68 8.34 4.75
107 INT121372 Positive_regulation of Gene_expression of MIF 17 0.60 14.78 4.73
108 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
109 INT118926 Regulation of PTGES 17 0.51 5.79 4.69
110 INT62500 Transcription of Ptgs1 10 0.56 4.54 4.52
111 INT73309 Regulation of Negative_regulation of PTGS2 14 0.44 9.55 4.5
112 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
113 INT107620 Binding of PTGES 25 0.48 5.49 4.24
114 INT27758 Positive_regulation of PTGDS 20 0.67 10.74 4.22
115 INT52616 Negative_regulation of Positive_regulation of PTGS2 13 0.43 4.95 4.13
116 INT253970 Positive_regulation of Cd74 3 0.48 8.16 4.09
117 INT66242 Gene_expression of Ptgis 15 0.64 6.73 3.84
118 INT115773 Negative_regulation of Localization of Ptgs2 6 0.43 2.99 3.81
119 INT6956 Gene_expression of PTGIS 29 0.76 12.1 3.8
120 INT134296 Positive_regulation of Ptges2 20 0.19 14.85 3.8
121 INT116738 Positive_regulation of Gene_expression of Mif 14 0.68 10.99 3.8
122 INT6994 Binding of Ptgds 15 0.36 7.06 3.54
123 INT53200 Binding of Ptgs2 11 0.48 5.08 3.54
124 INT50143 Negative_regulation of Gene_expression of Ptgds 10 0.48 5.82 3.54
125 INT108814 Regulation of Gene_expression of PTGES 8 0.59 3.62 3.54
126 INT187168 Binding of Cd74 13 0.27 11.2 3.44
127 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
128 INT104678 Positive_regulation of Ptges 18 0.34 6.29 3.39
129 INT134413 Gene_expression of HPGDS 20 0.77 8.93 3.28
130 INT139355 Regulation of Gene_expression of Ptges2 11 0.17 6.37 3.19
131 INT52694 Negative_regulation of Positive_regulation of Ptgs2 9 0.43 4.72 3.11
132 INT77615 Positive_regulation of Negative_regulation of Ptgs1 6 0.50 1.55 3.11
133 INT130226 Positive_regulation of Gene_expression of Mif 4 0.58 15.75 3.03
134 INT53374 Binding of Edn1 17 0.43 11.66 2.98
135 INT117582 Positive_regulation of Gene_expression of Ptges 12 0.27 4.22 2.98
136 INT90402 Positive_regulation of Gene_expression of Ptgs1 13 0.31 4.83 2.88
137 INT108813 Negative_regulation of Ptges 8 0.57 2.79 2.85
138 INT167039 Gene_expression of Cd74 24 0.40 17.12 2.84
139 INT163290 Binding of MIF 9 0.31 7.57 2.8
140 INT130506 Regulation of Ptges 7 0.12 2.56 2.77
141 INT68505 Positive_regulation of Negative_regulation of PTGS2 8 0.49 2.26 2.76
142 INT50149 Positive_regulation of Gene_expression of Ptgds 12 0.61 4.88 2.73
143 INT134145 Negative_regulation of Gene_expression of PTGES 11 0.51 5.32 2.73
144 INT243350 Binding of CD74 2 0.11 4.86 2.72
145 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
146 INT203137 Binding of Mif 6 0.31 9.46 2.71
147 INT27607 Localization of Ptgs1 7 0.59 3.22 2.6
148 INT120011 Localization of MIF 6 0.58 5.72 2.6
149 INT103238 Localization of PTGES 7 0.68 4.16 2.59
150 INT127176 Transcription of Ptgs2 8 0.58 4.68 2.58
151 INT34969 Negative_regulation of Binding of Ptgs1 4 0.37 1.55 2.55
152 INT25119 Binding of PTGDS 9 0.35 3.86 2.54
153 INT139354 Negative_regulation of Gene_expression of Ptges2 11 0.23 4.28 2.51
154 INT17846 Binding of Ptgs2 8 0.32 4.66 2.48
155 INT40748 Negative_regulation of Mif 6 0.56 8.33 2.46
156 INT70197 Negative_regulation of Positive_regulation of Ptgs1 6 0.24 2.61 2.44
157 INT106513 Gene_expression of Ptges3 7 0.73 3.57 2.42
158 INT50139 Regulation of Gene_expression of Ptgds 6 0.50 3.5 2.39
159 INT53476 Positive_regulation of Localization of Ptgs1 6 0.49 2.88 2.35
160 INT9887 Negative_regulation of Gene_expression of Ptgs1 7 0.42 2.94 2.3
161 INT78958 Regulation of Negative_regulation of Ptgs2 6 0.42 2.61 2.3
162 INT88241 Positive_regulation of Positive_regulation of Ptgs1 3 0.45 1.71 2.25
163 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
164 INT54823 Phosphorylation of PTGS1 4 0.51 1.61 2.14
165 INT14596 Localization of Ptgds 11 0.73 4.41 2.12
166 INT32557 Negative_regulation of Negative_regulation of PTGS1 8 0.43 3.44 2.1
167 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
168 INT108982 Regulation of Gene_expression of Ptgds 6 0.51 1.64 2.07
169 INT106508 Positive_regulation of Gene_expression of Ptges 12 0.20 5.37 2.06
170 INT103304 Positive_regulation of Mif 6 0.48 8.66 2.05
171 INT97579 Negative_regulation of Localization of PTGS2 2 0.08 2.37 1.99
172 INT101985 Positive_regulation of Positive_regulation of Ptgs1 4 0.15 4.13 1.98
173 INT66237 Positive_regulation of Ptgis 5 0.33 1.49 1.96
174 INT66240 Localization of Ptgis 9 0.58 1.36 1.95
175 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
176 INT77805 Regulation of Gene_expression of Ptgs2 6 0.51 2.7 1.92
177 INT52691 Positive_regulation of Transcription of Ptgs2 5 0.44 3 1.9
178 INT62290 Positive_regulation of Gene_expression of PTGES2 5 0.28 3.14 1.88
179 INT253975 Binding of Cd74 4 0.27 4.57 1.88
180 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
181 INT103024 Positive_regulation of Gene_expression of Ptgis 5 0.48 4.02 1.83
182 INT158772 Negative_regulation of Regulation of Ptges 1 0.03 0.07 1.81
183 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
184 INT53812 Regulation of Gene_expression of Ptgs1 5 0.38 0.89 1.78
185 INT19831 Binding of Ptgis 3 0.08 3.33 1.77
186 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
187 INT64915 Regulation of Negative_regulation of PTGS1 4 0.20 1.81 1.76
188 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
189 INT15916 Positive_regulation of Ptgis 11 0.39 6.6 1.74
190 INT184154 Transcription of Ptges2 4 0.20 2.4 1.71
191 INT78956 Regulation of Transcription of Ptgs1 3 0.35 1.42 1.7
192 INT118700 Positive_regulation of Ptges 12 0.49 5.04 1.68
193 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
194 INT59077 Transcription of PTGS1 11 0.43 2.37 1.65
195 INT44149 Regulation of Gene_expression of Mif 6 0.54 2.45 1.63
196 INT27438 Negative_regulation of Ptgds 3 0.51 0.24 1.61
197 INT60857 Negative_regulation of Regulation of Ptgs1 1 0.07 2.22 1.61
198 INT353326 Negative_regulation of Localization of Mif 1 0.45 1.28 1.59
199 INT28425 Regulation of Ptgds 4 0.28 2.07 1.53
200 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
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