GO:0001649

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Name osteoblast differentiation
Categary Process
Go Slim No
Go Link GO:0001649
Unique Molecular Interactions 1008
Total Molecular Interactions 1435
Total Single Events 9731
Pain Genes Associated 63

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for osteoblast differentiation. They are ordered first by their pain relevance and then by number of times they were reported for osteoblast differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT69032 IL18 Positive_regulation of IFNA1 12 0.23 7.87 3.83
3 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
4 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
5 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
6 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
7 INT69030 IL18 Positive_regulation of IL12A 3 0.31 5.57 2.72
8 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
9 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
10 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94
11 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
12 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
13 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
14 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
15 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
16 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
17 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37
18 INT176368 IL18 Positive_regulation of Gene_expression of IFNA1 1 0.16 2.53 1.35
19 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
20 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
21 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
22 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
23 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
24 INT203178 IL18 Positive_regulation of Gene_expression of Lts1 1 0.01 1.98 1.02
25 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
26 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
27 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
28 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
29 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
30 INT222979 Negative_regulation of Binding of COL1A1 and FN1 1 0.01 1.64 0.93
31 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
32 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
33 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
34 INT222978 Binding of COL1A1 and FN1 1 0.01 1.64 0.92
35 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
36 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
37 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
38 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
39 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
40 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
41 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
42 INT63594 Snai1 Negative_regulation of Binding of Ugt1a2 1 0.05 0.32 0.82
43 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
44 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
45 INT63596 Snai1 Negative_regulation of ITS 1 0.00 0.31 0.81
46 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
47 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
48 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
49 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79
50 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
51 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
52 INT136795 Spp1 Positive_regulation of Chuk 1 0.11 1.54 0.77
53 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
54 INT137321 Gabrg1 Negative_regulation of Positive_regulation of Gabbr1 1 0.22 0 0.75
55 INT244062 Gabrg1 Regulation of Gabbr1 1 0.01 0.09 0.74
56 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
57 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
58 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
59 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
60 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71
61 INT120018 VEGFA Positive_regulation of CCL3 1 0.01 1 0.7
62 INT224580 Gene_expression of IL18 Positive_regulation of SERPINH1 1 0.00 1.34 0.7
63 INT120017 CCL2 Positive_regulation of CCL3 1 0.01 0.99 0.7
64 INT120019 IL8 Positive_regulation of CCL3 1 0.02 0.99 0.7
65 INT185802 Binding of MMP7 and SPP1 1 0.33 1.71 0.68
66 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
67 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
68 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
69 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
70 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
71 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
72 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
73 INT264775 Binding of Gabbr1 and Abat 1 0.03 0 0.64
74 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
75 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
76 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
77 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
78 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
79 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
80 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
81 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
82 INT185809 Binding of PDX1 and SPP1 1 0.02 1.69 0.57
83 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
84 INT176370 IL18BP Negative_regulation of IL18 1 0.15 0.76 0.56
85 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
86 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
87 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
88 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
89 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
90 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
91 INT226360 IL18 Positive_regulation of Gene_expression of IL4 1 0.05 2.66 0.54
92 INT226348 IL18 Positive_regulation of Gene_expression of IL13 1 0.03 2.66 0.54
93 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
94 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
95 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
96 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
97 INT235390 HTR1A Regulation of BGLAP 1 0.03 0.23 0.51
98 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
99 INT185800 SPP1 Negative_regulation of Gene_expression of MMP1 1 0.26 1.03 0.49
100 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
101 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
102 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
103 INT309126 Edc4 Positive_regulation of Akt1 1 0.02 0.99 0.47
104 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
105 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
106 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
107 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
108 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
109 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
110 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
111 INT222284 Negative_regulation of Casp1 Negative_regulation of Il18 1 0.01 0.79 0.46
112 INT354395 TNFSF12 Regulation of Gene_expression of IL18 1 0.47 0.79 0.45
113 INT235389 Binding of BGLAP and HTR1A 1 0.03 0.15 0.45
114 INT355540 Gnptg Positive_regulation of AMELX 1 0.00 2.16 0.44
115 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
116 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
117 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42
118 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
119 INT172136 IL18 Positive_regulation of Gene_expression of IFN1@ 1 0.09 0.63 0.42
120 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
121 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
122 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
123 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
124 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4
125 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
126 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
127 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
128 INT176361 Positive_regulation of LBR Positive_regulation of Gene_expression of IL18 1 0.10 0.84 0.39
129 INT185811 SPP1 Positive_regulation of MMP3 1 0.14 0.83 0.38
130 INT185814 Binding of MMP3 and SPP1 1 0.15 0.83 0.38
131 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
132 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
133 INT185804 MMP2 Positive_regulation of SPP1 1 0.15 0.88 0.37
134 INT185795 MMP7 Positive_regulation of SPP1 1 0.38 0.81 0.37
135 INT296306 Binding of BGLAP and SPIN1 1 0.05 1.69 0.37
136 INT185798 SPP1 Positive_regulation of Gene_expression of MMP2 1 0.26 0.87 0.37
137 INT340609 Bdnf Regulation of Gene_expression of Wnt3a 1 0.53 0.31 0.36
138 INT185807 SPP1 Positive_regulation of MMP7 1 0.56 0.79 0.36
139 INT133307 Binding of CD44 and SPP1 5 0.26 2.6 0.35
140 INT176373 IL18 Regulation of FASLG 1 0.41 0.4 0.35
141 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
142 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
143 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
144 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
145 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
146 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
147 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
148 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
149 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
150 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33
151 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
152 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33
153 INT300729 IL18 Positive_regulation of IL13 1 0.00 0 0.33
154 INT149895 Ihh Regulation of Localization of Mmp7 1 0.03 0.98 0.33
155 INT242995 Agt Positive_regulation of Spp1 1 0.36 1.82 0.33
156 INT174265 IL18 Regulation of Gene_expression of F3 1 0.00 3.21 0.33
157 INT149902 Ihh Positive_regulation of SGCG 1 0.45 0.76 0.32
158 INT311997 Regulation of STAM Regulation of BGLAP 1 0.00 0.61 0.32
159 INT98013 Il18 Positive_regulation of Gene_expression of IFNG 1 0.66 0.44 0.32
160 INT176362 Binding of IL18 and IL18BP 1 0.12 0.49 0.32
161 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
162 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
163 INT282420 Spp1 Positive_regulation of Ins1 1 0.20 1.25 0.32
164 INT191616 Binding of Cbln1 and Nf1 1 0.01 0.2 0.32
165 INT191620 Binding of Nf1 and Gopc 1 0.08 0.2 0.32
166 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
167 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
168 INT303063 Akt1 Negative_regulation of Gene_expression of Syn1 1 0.09 0.45 0.31
169 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
170 INT311991 STAM Regulation of BGLAP 1 0.00 0.61 0.31
171 INT127974 RAX2 Positive_regulation of SPP1 1 0.03 1.49 0.31
172 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
173 INT144500 CCL3 Positive_regulation of Gene_expression of Tnfsf11 1 0.77 1.62 0.31
174 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
175 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
176 INT191611 Nf1 Regulation of ras 1 0.26 0.18 0.3
177 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
178 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3
179 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
180 INT219151 IL18 Positive_regulation of CASP1 1 0.01 1.05 0.3
181 INT132585 GABBR1 Positive_regulation of Binding of Gabbr1 1 0.01 0.6 0.3
182 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
183 INT140386 Spp1 Positive_regulation of NFKB1 1 0.21 1.29 0.3
184 INT251388 Binding of Fbln2 and Gabbr1 1 0.08 0.07 0.3
185 INT140385 Spp1 Negative_regulation of FOXO3 1 0.04 1.29 0.3
186 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
187 INT334499 Binding of AMELX and IL4 1 0.12 0.47 0.29
188 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
189 INT132367 Lgals1 Positive_regulation of Akt1 1 0.22 0.13 0.28
190 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
191 INT185813 Binding of MMP7 and Positive_regulation of SPP1 1 0.46 0.85 0.28
192 INT185818 SPP1 Positive_regulation of Gene_expression of COL7A1 1 0.10 0.82 0.28
193 INT225101 TGFB1 Positive_regulation of Localization of COL1A1 1 0.03 0.59 0.28
194 INT137014 Positive_regulation of Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
195 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
196 INT225100 TGFB1 Positive_regulation of Gene_expression of COL1A1 1 0.04 0.59 0.28
197 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
198 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
199 INT176372 Positive_regulation of IL18 Positive_regulation of IFNA1 1 0.16 0.36 0.28
200 INT137012 Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28

Single Events

The table below shows the top 100 pain related interactions that have been reported for osteoblast differentiation. They are ordered first by their pain relevance and then by number of times they were reported in osteoblast differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
2 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
3 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
4 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
5 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22
6 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
7 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
8 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
9 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95
10 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
11 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
12 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
13 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31
14 INT6351 Positive_regulation of Gabbr1 40 0.64 11.99 19
15 INT87861 Gene_expression of Il18 33 0.78 30.44 18.42
16 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01
17 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15
18 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
19 INT10433 Positive_regulation of Junb 35 0.70 6.55 12.42
20 INT9483 Gene_expression of Junb 34 0.78 3.24 12.08
21 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
22 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35
23 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
24 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81
25 INT5476 Regulation of Gabbr1 21 0.45 4.01 10.26
26 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9
27 INT6356 Binding of Gabbr1 30 0.48 4.62 9.82
28 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
29 INT87863 Positive_regulation of IL18 40 0.69 34.08 9.53
30 INT340600 Gene_expression of Wnt3a 1 0.68 2.14 9.14
31 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
32 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
33 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
34 INT1223 Negative_regulation of Snai1 15 0.38 2.05 8.46
35 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26
36 INT6352 Negative_regulation of Gabbr1 7 0.59 4.84 7.93
37 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
38 INT20914 Positive_regulation of Snai1 13 0.41 3.41 7.69
39 INT122901 Positive_regulation of Spp1 67 0.67 58.03 7.49
40 INT94127 Positive_regulation of Il18 14 0.69 14 7.47
41 INT9478 Positive_regulation of Gene_expression of Junb 19 0.70 2.34 7.41
42 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
43 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
44 INT91721 Binding of IL18 21 0.48 21.17 6.56
45 INT122902 Positive_regulation of Gene_expression of Spp1 54 0.70 56.3 6.33
46 INT91657 Negative_regulation of IL18 20 0.48 15.97 6.12
47 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
48 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
49 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98
50 INT113420 Positive_regulation of Gene_expression of IL18 22 0.69 19.96 5.53
51 INT43506 Regulation of Gene_expression of Gabbr1 2 0.61 4.88 5.52
52 INT88935 Positive_regulation of SPP1 36 0.70 31.07 5.49
53 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
54 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
55 INT4864 Regulation of BGLAP 22 0.34 10.8 5.07
56 INT264765 Positive_regulation of Gene_expression of Gabbr1 2 0.70 4.88 5.07
57 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
58 INT346257 Binding of RUNX2 1 0.44 9.05 4.64
59 INT68260 Localization of BGLAP 34 0.78 16.04 4.63
60 INT134657 Localization of Akt1 37 0.68 11.58 4.62
61 INT68216 Binding of NF1 40 0.48 51.24 4.59
62 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
63 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38
64 INT117244 Gene_expression of GABBR1 5 0.33 2.19 4.36
65 INT75136 Binding of Akt1 27 0.27 8.81 4.15
66 INT79234 Positive_regulation of CCL3 15 0.67 11.43 4.15
67 INT15239 Regulation of Junb 13 0.62 1.14 4.1
68 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
69 INT97128 Localization of SPP1 32 0.80 21.75 4.02
70 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
71 INT6513 Positive_regulation of Gene_expression of BGLAP 24 0.67 11.69 3.96
72 INT35175 Localization of IL18 18 0.80 12.96 3.83
73 INT25709 Negative_regulation of Igf2 11 0.56 9.38 3.76
74 INT340603 Regulation of Gene_expression of Wnt3a 1 0.54 0.49 3.75
75 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
76 INT136692 Localization of Akt1 12 0.78 2.14 3.65
77 INT346244 Positive_regulation of RUNX2 1 0.63 7.42 3.54
78 INT148151 Regulation of Il18 7 0.28 5.4 3.5
79 INT136791 Negative_regulation of Spp1 24 0.59 23.6 3.33
80 INT81229 Binding of COL1A1 24 0.35 12.07 3.3
81 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
82 INT16562 Negative_regulation of Positive_regulation of Gabbr1 5 0.43 2.67 3.24
83 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12
84 INT340595 Positive_regulation of Gene_expression of Wnt3a 1 0.61 0.86 3.11
85 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
86 INT88130 Gene_expression of Spp1 13 0.74 12.96 3.07
87 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
88 INT91341 Negative_regulation of Gene_expression of BGLAP 17 0.55 4.91 3.02
89 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
90 INT176383 Negative_regulation of Binding of IL18 1 0.35 5.91 2.91
91 INT91342 Negative_regulation of Negative_regulation of BGLAP 2 0.55 1.39 2.88
92 INT113041 Gene_expression of IHH 9 0.78 5.83 2.87
93 INT116540 Binding of Twist1 35 0.48 16.32 2.85
94 INT9335 Gene_expression of Igf2 18 0.72 12.76 2.78
95 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
96 INT54495 Binding of GABBR1 9 0.35 1.82 2.76
97 INT139562 Transcription of IL18 10 0.68 6.14 2.73
98 INT1225 Regulation of Snai1 10 0.30 1.05 2.72
99 INT119855 Localization of Gabbr1 21 0.79 3.15 2.7
100 INT214355 Binding of Akt1 13 0.36 3.72 2.59
101 INT222289 Localization of Il18 4 0.30 3.24 2.58
102 INT68091 Localization of COL1A1 19 0.66 9.13 2.56
103 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55
104 INT8890 Transcription of Col1a1 10 0.63 4.02 2.48
105 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45
106 INT71681 Positive_regulation of Gene_expression of CCL3 8 0.54 8.21 2.41
107 INT61434 Regulation of Nf1 3 0.26 1.39 2.4
108 INT9327 Localization of Igf2 8 0.80 5.07 2.36
109 INT114773 Negative_regulation of GABBR1 4 0.43 0.55 2.33
110 INT133567 Regulation of IL18 11 0.50 9.54 2.31
111 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3
112 INT64700 Binding of Nf1 14 0.45 15.24 2.29
113 INT176517 Negative_regulation of Gene_expression of Spp1 18 0.59 15.31 2.28
114 INT269217 Gene_expression of SNAI1 81 0.76 80.49 2.26
115 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
116 INT57132 Positive_regulation of Igf2 9 0.50 5.15 2.22
117 INT148152 Binding of Il18 4 0.46 4.44 2.19
118 INT91340 Regulation of Localization of BGLAP 5 0.58 2.82 2.14
119 INT94128 Positive_regulation of Gene_expression of Il18 6 0.50 3.64 2.06
120 INT118305 Negative_regulation of Gene_expression of IL18 7 0.39 6.52 2.05
121 INT58352 Negative_regulation of Gene_expression of Gabbr1 5 0.43 1.36 2.05
122 INT186893 Binding of BGLAP 10 0.37 6.19 2.02
123 INT98888 Negative_regulation of Gene_expression of Il18 3 0.43 1.72 2.02
124 INT113717 Negative_regulation of Gene_expression of COL1A1 21 0.41 6.14 2.01
125 INT176510 Binding of Spp1 21 0.42 22.1 2
126 INT220211 Gene_expression of RUNX2 7 0.71 7.31 2
127 INT120857 Localization of Col1a1 10 0.71 2.33 1.93
128 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93
129 INT176516 Localization of Spp1 28 0.76 19.39 1.9
130 INT68181 Binding of Nf1 6 0.48 8.14 1.88
131 INT6353 Positive_regulation of Positive_regulation of Gabbr1 2 0.46 0.79 1.85
132 INT120014 Transcription of CCL3 5 0.69 3.03 1.82
133 INT96116 Transcription of COL1A1 10 0.44 4.57 1.81
134 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
135 INT230954 Negative_regulation of RUNX2 3 0.39 4.54 1.79
136 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
137 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
138 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
139 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
140 INT32024 Positive_regulation of Positive_regulation of Snai1 2 0.25 0.32 1.7
141 INT133311 Binding of SPP1 10 0.37 9.47 1.65
142 INT55302 Binding of Snai1 2 0.31 1.94 1.63
143 INT346250 Positive_regulation of Binding of RUNX2 1 0.63 3.19 1.63
144 INT117714 Regulation of Positive_regulation of Akt1 3 0.61 0.44 1.61
145 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
146 INT88136 Positive_regulation of Gene_expression of Spp1 8 0.66 4.5 1.57
147 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
148 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52
149 INT88934 Regulation of SPP1 9 0.54 6.94 1.47
150 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
151 INT104250 Positive_regulation of Gene_expression of SPP1 17 0.69 13.22 1.44
152 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
153 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
154 INT340596 Negative_regulation of Gene_expression of Wnt3a 1 0.51 0.38 1.4
155 INT10873 Localization of Twist1 21 0.74 10.43 1.37
156 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
157 INT55108 Negative_regulation of Negative_regulation of Gabbr1 1 0.02 0 1.35
158 INT120860 Positive_regulation of Gene_expression of Col1a1 12 0.44 4.84 1.34
159 INT88133 Positive_regulation of Spp1 8 0.66 10.07 1.33
160 INT159598 Positive_regulation of Transcription of IL18 3 0.48 1.84 1.32
161 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
162 INT69037 Regulation of Gene_expression of IL18 4 0.43 3.29 1.31
163 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
164 INT52212 Gene_expression of Bmp6 6 0.64 2.38 1.27
165 INT65699 Localization of CCL3 7 0.78 2.56 1.25
166 INT123828 Regulation of CCL3 3 0.60 0.79 1.25
167 INT143759 Gene_expression of SOX2 46 0.55 11.12 1.24
168 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24
169 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
170 INT59473 Negative_regulation of Col1a1 4 0.25 1.33 1.24
171 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23
172 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
173 INT71845 Positive_regulation of Positive_regulation of Col1a1 1 0.34 0.15 1.23
174 INT9324 Negative_regulation of Gene_expression of Igf2 6 0.50 5.12 1.2
175 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
176 INT1867 Positive_regulation of GABBR1 6 0.69 0.55 1.18
177 INT25710 Regulation of Igf2 6 0.62 3.1 1.17
178 INT176379 Regulation of Binding of IL18 1 0.37 2.37 1.17
179 INT124008 Positive_regulation of Wwox 2 0.67 7.64 1.16
180 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15
181 INT9477 Regulation of Gene_expression of Junb 5 0.45 0.88 1.15
182 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
183 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
184 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
185 INT58174 Gene_expression of Junb 9 0.78 1.38 1.09
186 INT35174 Positive_regulation of Localization of IL18 7 0.69 5.22 1.08
187 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
188 INT97032 Gene_expression of Snai1 3 0.52 0.58 1.04
189 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
190 INT184547 Localization of Spp1 4 0.58 4.44 1.02
191 INT119674 Localization of GLI2 6 0.52 2.84 0.99
192 INT156614 Regulation of Gene_expression of COL1A1 6 0.33 2.51 0.99
193 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
194 INT220203 Positive_regulation of Gene_expression of RUNX2 3 0.63 3.4 0.97
195 INT6355 Regulation of Positive_regulation of Gabbr1 1 0.27 0 0.96
196 INT43484 Binding of Runx2 7 0.37 3.22 0.95
197 INT61030 Negative_regulation of Positive_regulation of Junb 2 0.41 0.93 0.95
198 INT340604 Regulation of Wnt3a 1 0.24 0 0.95
199 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
200 INT52213 Regulation of Localization of Bmp6 1 0.44 0.39 0.93
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