GO:0001817

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Name regulation of cytokine production
Categary Process
Go Slim No
Go Link GO:0001817
Unique Molecular Interactions 42
Total Molecular Interactions 50
Total Single Events 236
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of cytokine production. They are ordered first by their pain relevance and then by number of times they were reported for regulation of cytokine production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
2 INT209061 Il3 Positive_regulation of Elf1 1 0.06 0.38 0.73
3 INT209058 Il4 Positive_regulation of Elf1 1 0.08 0.38 0.73
4 INT209053 Il2 Positive_regulation of Elf1 1 0.06 0.38 0.73
5 INT209029 Il12b Positive_regulation of Elf1 1 0.24 0.37 0.72
6 INT209056 Il6 Positive_regulation of Elf1 1 0.10 0.38 0.72
7 INT209050 Il10 Positive_regulation of Elf1 1 0.10 0.37 0.72
8 INT316674 Binding of CRP and SFTPD 1 0.16 2.02 0.59
9 INT316675 Binding of CALR and SFTPD 1 0.35 0.96 0.37
10 INT316672 Binding of LRP1 and SFTPD 1 0.35 0.96 0.37
11 INT316676 Binding of CRX and SFTPD 1 0.05 0.65 0.33
12 INT180718 Binding of SARS and ACE2 3 0.12 7.76 0.25
13 INT306795 Binding of LEP and SFTPD 1 0.08 1.13 0.23
14 INT236307 SFTPD Positive_regulation of IGKV2D-38 1 0.03 0.57 0.18
15 INT323757 Negative_regulation of ACE2 Negative_regulation of ANG 1 0.18 1.73 0.17
16 INT323756 Negative_regulation of ACE2 Positive_regulation of ANG 1 0.19 1.73 0.17
17 INT277012 Binding of PAPPA and ACE2 1 0.02 1.26 0.15
18 INT129091 Binding of PIK3CG and Lyn 1 0.00 0.47 0.12
19 INT129075 Binding of Pik3r1 and Lyn 1 0.00 0.47 0.12
20 INT129093 Binding of Lyn and TCHP 1 0.00 0.49 0.12
21 INT129092 Binding of GRP and Lyn 1 0.00 0.48 0.12
22 INT26310 IL1B Positive_regulation of ACE2 1 0.18 0.46 0.07
23 INT323755 IGHG3 Negative_regulation of ACE2 1 0.01 1.09 0.05
24 INT353848 Binding of SCLY and Ubash3a 1 0.30 0.47 0.04
25 INT348024 Binding of Chuk and Traf3 1 0.13 0.65 0.04
26 INT200814 Epo Positive_regulation of Lyn 1 0.36 1.42 0.03
27 INT348028 Binding of Traf3 and Ticam1 1 0.01 0.56 0.03
28 INT278388 Msu Positive_regulation of Phosphorylation of Lyn 1 0.17 0.12 0
29 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0
30 INT180749 Binding of Pmel and ACE2 1 0.20 2.14 0
31 INT261843 Lyn Regulation of Regulation of Trpv4 1 0.03 0.19 0
32 INT202509 Positive_regulation of Binding of Ltbr and Traf3 1 0.07 0.51 0
33 INT347226 Hck Regulation of Gene_expression of Lyn 1 0.10 0.08 0
34 INT241539 Binding of Abl1 and Lyn 1 0.09 0.14 0
35 INT200818 Akt1 Positive_regulation of Negative_regulation of Lyn 1 0.25 1.02 0
36 INT202504 Binding of Ltbr and Traf3 1 0.05 0.51 0
37 INT241538 Negative_regulation of Binding of Abl1 and Lyn 1 0.11 0.14 0
38 INT347224 Lyn Regulation of Positive_regulation of Bcr 1 0.14 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of cytokine production. They are ordered first by their pain relevance and then by number of times they were reported in regulation of cytokine production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT236335 Gene_expression of SFTPD 26 0.75 15.92 4.59
2 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75
3 INT48902 Gene_expression of ACE2 22 0.78 17.91 3.24
4 INT162372 Positive_regulation of SFTPD 15 0.67 11.8 3.21
5 INT105694 Binding of SFTPD 11 0.46 8.47 2.45
6 INT146945 Positive_regulation of Lyn 6 0.49 2.81 2.25
7 INT26311 Negative_regulation of ACE2 8 0.59 16.35 1.94
8 INT245577 Localization of SFTPD 7 0.63 10.43 1.84
9 INT212048 Negative_regulation of SFTPD 3 0.42 5.45 1.61
10 INT209022 Gene_expression of Elf1 2 0.58 1.46 1.32
11 INT274898 Positive_regulation of Positive_regulation of Lyn 1 0.35 1.51 1.05
12 INT281919 Localization of ACE2 4 0.75 2.69 1.02
13 INT107288 Positive_regulation of ACE2 4 0.66 5.48 0.99
14 INT146939 Negative_regulation of Lyn 3 0.53 2.97 0.95
15 INT149383 Binding of Lyn 1 0.36 1.14 0.91
16 INT236328 Regulation of SFTPD 6 0.38 3.04 0.85
17 INT342130 Negative_regulation of Localization of ACE2 1 0.01 1.16 0.74
18 INT209024 Positive_regulation of Elf1 1 0.20 0.37 0.72
19 INT306800 Positive_regulation of Localization of SFTPD 1 0.16 2.1 0.68
20 INT48903 Protein_catabolism of ACE2 1 0.08 1.13 0.66
21 INT236330 Regulation of Gene_expression of SFTPD 2 0.59 1.55 0.65
22 INT288095 Negative_regulation of Gene_expression of Elf1 1 0.42 1.16 0.61
23 INT117091 Positive_regulation of Lyn 1 0.49 0.41 0.56
24 INT180739 Binding of ACE2 5 0.37 7.88 0.45
25 INT316678 Regulation of Positive_regulation of SFTPD 1 0.38 0.96 0.34
26 INT236323 Positive_regulation of Transcription of SFTPD 1 0.12 0.47 0.32
27 INT236324 Transcription of SFTPD 1 0.17 0.47 0.32
28 INT236327 Positive_regulation of Gene_expression of SFTPD 1 0.12 0.47 0.32
29 INT253424 Protein_catabolism of SFTPD 2 0.74 1.12 0.31
30 INT187828 Negative_regulation of Gene_expression of ACE2 2 0.29 0.54 0.26
31 INT187827 Regulation of Gene_expression of ACE2 1 0.02 0.45 0.26
32 INT261820 Phosphorylation of Lyn 5 0.30 1.41 0.2
33 INT304142 Negative_regulation of Phosphorylation of Lyn 1 0.12 1.11 0.2
34 INT278361 Positive_regulation of Gene_expression of Lyn 6 0.41 0.63 0.15
35 INT269971 Localization of Traf3 1 0.32 0.23 0.15
36 INT304452 Regulation of Lyn 1 0.17 0 0.15
37 INT323762 Regulation of ACE2 1 0.39 1.63 0.12
38 INT281931 Transcription of ACE2 2 0.69 0.57 0.07
39 INT323758 Negative_regulation of Transcription of ACE2 1 0.43 0.47 0.07
40 INT241509 Negative_regulation of Gene_expression of Lyn 2 0.20 1.02 0.05
41 INT315847 Positive_regulation of Negative_regulation of Lyn 1 0.18 0.61 0.05
42 INT281926 Positive_regulation of Gene_expression of ACE2 2 0.47 1.19 0.04
43 INT353846 Binding of Ubash3a 1 0.27 1.15 0.04
44 INT236333 Positive_regulation of Regulation of SFTPD 1 0.12 0.09 0.04
45 INT323759 Regulation of Binding of ACE2 1 0.45 0.22 0.04
46 INT353847 Localization of Ubash3a 1 0.54 0.49 0.03
47 INT209756 Positive_regulation of Negative_regulation of ACE2 1 0.49 0.38 0
48 INT202490 Binding of Traf3 1 0.17 0.5 0
49 INT179084 Gene_expression of Traf3 1 0.65 0.82 0
50 INT323761 Negative_regulation of Binding of ACE2 1 0.43 0 0
51 INT278323 Positive_regulation of Phosphorylation of Lyn 1 0.22 0 0
52 INT278322 Negative_regulation of Localization of Lyn 1 0.20 0.11 0
53 INT278356 Localization of Lyn 1 0.35 0.11 0
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