GO:0001946

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Name lymphangiogenesis
Categary Process
Go Slim No
Go Link GO:0001946
Unique Molecular Interactions 64
Total Molecular Interactions 118
Total Single Events 443
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for lymphangiogenesis. They are ordered first by their pain relevance and then by number of times they were reported for lymphangiogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT52955 Binding of Slc6a3 and Pdpn 1 0.17 1.11 1.22
2 INT73311 Binding of Oprm1 and Pdpn 1 0.08 0.71 1.06
3 INT214595 Binding of FOXC1 and TIMP1 1 0.02 0.96 0.66
4 INT302838 TNF Positive_regulation of Sox18 1 0.00 0.71 0.5
5 INT52954 Binding of Pdpn and Flvcr2 1 0.05 0.42 0.41
6 INT345012 GSN Regulation of CCBE1 1 0.00 0.82 0.36
7 INT345009 DBP Regulation of CCBE1 1 0.00 0.81 0.36
8 INT165305 CSF2 Positive_regulation of Localization of CCBE1 1 0.06 1.34 0.35
9 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
10 INT214615 FOXC1 Positive_regulation of Gene_expression of Ang 1 0.01 0.29 0.28
11 INT214594 Binding of FOXC1 and IBD9 1 0.00 1.81 0.28
12 INT320794 Binding of VEGFA and Flt4 4 0.08 3.04 0.27
13 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19
14 INT214591 FOXC1 Regulation of ICAM1 1 0.05 0.29 0.19
15 INT197097 IL1B Regulation of FLT4 1 0.03 0.66 0.19
16 INT197098 TNF Regulation of FLT4 1 0.14 0.66 0.19
17 INT214593 Binding of FOXC1 and OAP 1 0.01 0.25 0.13
18 INT344314 PDPN Positive_regulation of Phosphorylation of MAPK8 1 0.35 0.67 0.13
19 INT289660 Tnfrsf1a Negative_regulation of Transcription of Flt4 1 0.03 0.62 0.12
20 INT289657 Tnfrsf1a Negative_regulation of Gene_expression of Flt4 1 0.03 0.63 0.12
21 INT345371 Binding of Flt4 and Kdr 1 0.10 1.12 0.05
22 INT292094 Binding of FLT4 and TXK 1 0.02 1.53 0.04
23 INT344312 PDPN Positive_regulation of ITK 1 0.05 0.26 0.04
24 INT292093 Negative_regulation of Binding of FLT4 and TXK 1 0.03 1.53 0.04
25 INT344317 PDPN Negative_regulation of VEGFA 1 0.08 0.67 0.03
26 INT344308 Positive_regulation of PDPN Negative_regulation of VEGFA 1 0.09 0.24 0.03
27 INT51875 CCBE1 Regulation of POMC 1 0.00 1.06 0
28 INT344315 MAPK8 Positive_regulation of Negative_regulation of PDPN 1 0.35 0.56 0
29 INT51876 CCBE1 Regulation of GHRH 1 0.01 1.07 0
30 INT197096 VEGFA Positive_regulation of FLT4 1 0.04 1.43 0
31 INT345374 VEGFA Positive_regulation of Flt4 1 0.01 2.95 0
32 INT344313 PDPN Positive_regulation of VEGFA 1 0.09 0.8 0
33 INT197099 Negative_regulation of Binding of FLT4 and VEGFA 1 0.04 1.04 0
34 INT344319 MAPK8 Positive_regulation of PDPN 1 0.35 0.5 0
35 INT51878 CCBE1 Regulation of CRH 1 0.01 1.06 0
36 INT344307 PDPN Negative_regulation of Gene_expression of VEGFA 1 0.08 0.36 0
37 INT326729 Foxc1 Positive_regulation of Gene_expression of Ehf 1 0.23 0.26 0
38 INT344318 PDPN Positive_regulation of Positive_regulation of RHOA 1 0.11 0.92 0
39 INT51877 CCBE1 Regulation of NPY 1 0.01 1.06 0
40 INT344316 VEGFA Positive_regulation of PDPN 1 0.09 0.4 0
41 INT344311 PDPN Positive_regulation of Negative_regulation of VEGFA 1 0.09 0.81 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for lymphangiogenesis. They are ordered first by their pain relevance and then by number of times they were reported in lymphangiogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT43707 Positive_regulation of CCBE1 11 0.07 8.22 4.86
2 INT52952 Binding of Pdpn 8 0.13 3.57 4.79
3 INT22949 Gene_expression of CCBE1 8 0.19 4.27 3.25
4 INT31875 Regulation of CCBE1 8 0.04 4.18 2.64
5 INT134628 Gene_expression of Flt4 9 0.48 7.52 1.94
6 INT23176 Gene_expression of Pdpn 6 0.75 4.06 1.65
7 INT11553 Negative_regulation of CCBE1 3 0.03 1.1 1.25
8 INT39711 Negative_regulation of FOXC1 4 0.41 4.29 1.2
9 INT81311 Gene_expression of FOXC1 9 0.44 3.46 1.18
10 INT156427 Localization of FOXC1 2 0.73 1.36 1.07
11 INT214609 Positive_regulation of Gene_expression of FOXC1 1 0.08 1.78 1
12 INT46334 Binding of FOXC1 2 0.36 2.66 0.99
13 INT43131 Regulation of FOXC1 3 0.36 1.09 0.98
14 INT197105 Negative_regulation of FLT4 13 0.42 11.48 0.92
15 INT67252 Regulation of Pdpn 1 0.00 0.9 0.74
16 INT289649 Regulation of Gene_expression of Flt4 1 0.21 0.66 0.72
17 INT169421 Positive_regulation of FOXC1 4 0.49 2.42 0.7
18 INT198330 Gene_expression of Sox18 1 0.18 0.18 0.67
19 INT52951 Negative_regulation of Binding of Pdpn 1 0.16 0.63 0.66
20 INT289655 Regulation of Flt4 1 0.29 0.63 0.6
21 INT181790 Gene_expression of FLT4 13 0.72 11.73 0.56
22 INT18475 Protein_catabolism of CCBE1 1 0.01 0 0.53
23 INT134629 Positive_regulation of Gene_expression of Flt4 3 0.32 2.13 0.52
24 INT43898 Regulation of Gene_expression of CCBE1 1 0.01 0.17 0.5
25 INT196002 Positive_regulation of Flt4 4 0.22 3.51 0.37
26 INT165306 Localization of CCBE1 1 0.09 1.34 0.35
27 INT128754 Binding of Foxc1 1 0.01 0.43 0.32
28 INT196006 Regulation of FLT4 2 0.25 2.24 0.27
29 INT214611 Positive_regulation of Localization of FOXC1 1 0.07 0.34 0.26
30 INT318437 Negative_regulation of Pdpn 1 0.47 0.87 0.25
31 INT40062 Binding of CCBE1 1 0.03 1.3 0.21
32 INT197104 Positive_regulation of Gene_expression of FLT4 1 0.56 3.45 0.19
33 INT152681 Gene_expression of PDPN 29 0.65 23.06 0.18
34 INT197102 Localization of FLT4 4 0.65 2.89 0.17
35 INT160121 Localization of PDPN 1 0.73 1.07 0.16
36 INT185203 Regulation of Regulation of FOXC1 1 0.16 0 0.15
37 INT197103 Binding of FLT4 2 0.29 3.08 0.14
38 INT198328 Negative_regulation of Sox18 1 0.11 0 0.12
39 INT289653 Negative_regulation of Transcription of Flt4 1 0.20 0.62 0.12
40 INT289652 Transcription of Flt4 1 0.34 0.62 0.12
41 INT143835 Gene_expression of Foxc1 2 0.39 1.17 0.09
42 INT143833 Positive_regulation of Foxc1 2 0.42 1.02 0.09
43 INT143836 Negative_regulation of Foxc1 1 0.35 0.92 0.09
44 INT196007 Positive_regulation of FLT4 2 0.56 5.44 0.08
45 INT198325 Binding of Sox18 1 0.09 0 0.08
46 INT197101 Positive_regulation of Localization of FLT4 1 0.38 0.77 0.06
47 INT320783 Binding of Flt4 2 0.26 0.98 0.05
48 INT198332 Regulation of Sox18 1 0.11 0 0.05
49 INT344332 Positive_regulation of Gene_expression of PDPN 1 0.58 0.72 0.04
50 INT344330 Phosphorylation of PDPN 1 0.53 0.15 0.04
51 INT185206 Transcription of FOXC1 1 0.31 0 0.03
52 INT185204 Positive_regulation of Transcription of FOXC1 1 0.27 0 0.03
53 INT319335 Transcription of FLT4 1 0.18 0.99 0.03
54 INT185208 Positive_regulation of Positive_regulation of FOXC1 1 0.29 0 0.03
55 INT248544 Transcription of Foxc1 2 0.67 0.48 0
56 INT344342 Binding of PDPN 1 0.31 0.74 0
57 INT347528 Negative_regulation of Flt4 1 0.29 0.13 0
58 INT344340 Negative_regulation of Gene_expression of PDPN 1 0.36 1.53 0
59 INT344339 Positive_regulation of PDPN 1 0.39 0.98 0
60 INT198334 Localization of Sox18 1 0.17 0.2 0
61 INT317440 Regulation of Localization of FLT4 1 0.03 0.64 0
62 INT198329 Negative_regulation of Gene_expression of Sox18 1 0.10 0 0
63 INT344335 Regulation of PDPN 1 0.38 0.41 0
64 INT344343 Transcription of PDPN 1 0.60 0.54 0
65 INT344337 Regulation of Negative_regulation of PDPN 1 0.23 0.05 0
66 INT344334 Negative_regulation of PDPN 1 0.36 2.76 0
67 INT344333 Negative_regulation of Binding of PDPN 1 0.36 0.74 0
68 INT202389 Phosphorylation of Pdpn 1 0.61 0 0
69 INT198326 Positive_regulation of Sox18 1 0.12 0 0
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