GO:0001973

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Name adenosine receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0001973
Unique Molecular Interactions 155
Total Molecular Interactions 183
Total Single Events 2097
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for adenosine receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for adenosine receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
2 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
3 INT258170 Binding of Adora1 and Ppap2a 1 0.05 0.26 0.94
4 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
5 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
6 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85
7 INT140280 Negative_regulation of Binding of Adora2a and Grina 1 0.21 0.64 0.82
8 INT140281 Binding of Adora2a and Grina 1 0.19 0.64 0.82
9 INT252455 Binding of Adora2b and SLURP1 1 0.02 0.6 0.81
10 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
11 INT72017 Binding of Adora2a and Ptprg 2 0.07 0 0.77
12 INT76498 Binding of Tacr1 and Adora2a 1 0.09 0 0.77
13 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
14 INT82040 Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.11 0 0.75
15 INT82041 Positive_regulation of Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.12 0 0.72
16 INT194857 Positive_regulation of Adora2a Positive_regulation of Gene_expression of Vegfa 1 0.23 0.74 0.67
17 INT239501 Binding of Adora2a and Mtx1 1 0.24 0.95 0.64
18 INT215647 Adora1 Positive_regulation of Kcnj5 1 0.00 0 0.62
19 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
20 INT308895 Adp Positive_regulation of P2ry12 1 0.14 0.11 0.55
21 INT311256 Nt5e Positive_regulation of Positive_regulation of Adora1 1 0.49 0.19 0.54
22 INT164971 Binding of Rgs7 and Gnai2 1 0.01 0 0.54
23 INT164970 Binding of Rgs8 and Gnai2 1 0.01 0 0.53
24 INT233503 Tlr4 Positive_regulation of Adora2b 1 0.06 0.45 0.47
25 INT354235 Aif1 Regulation of P2ry12 1 0.20 0.49 0.45
26 INT72016 Positive_regulation of Binding of Gnai2 and Ptprg 1 0.02 0 0.44
27 INT165724 Bdkrb1 Positive_regulation of Adora1 1 0.24 1.65 0.43
28 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
29 INT215651 Binding of Adora1 and Cpa1 1 0.00 0 0.42
30 INT72018 Binding of Gnai2 and Ptprg 1 0.01 0 0.41
31 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
32 INT254123 Binding of Adora2b and Rai1 1 0.24 0.75 0.35
33 INT252453 Binding of AR and Adora2b 1 0.05 0 0.35
34 INT239503 Binding of Adora2a and Aes 1 0.24 0.85 0.35
35 INT115162 Adora2a Regulation of Gene_expression of Jun 1 0.49 0.36 0.34
36 INT115161 Adora2a Regulation of Gene_expression of Cpe 1 0.04 0.36 0.33
37 INT241739 Sdhb Regulation of Adora2b 1 0.04 0.63 0.31
38 INT254122 Adora2a Regulation of Aliq1 1 0.01 0.85 0.3
39 INT215645 Binding of Adora1 and Kcnj5 1 0.00 0.08 0.29
40 INT141438 Gnai2 Positive_regulation of Localization of ADCY1 1 0.01 0.43 0.29
41 INT215653 Binding of Adora1 and Adora3 1 0.39 0.07 0.27
42 INT88555 Adora2a Negative_regulation of Vegfc 1 0.00 0.17 0.25
43 INT215652 Binding of Adora1 and Npy1r 1 0.39 0.22 0.24
44 INT252456 IGKV2D-29 Regulation of Gene_expression of Adora2b 1 0.07 0 0.24
45 INT224135 Binding of ARRB2 and Adora2b 1 0.14 0.07 0.23
46 INT224130 Positive_regulation of Adora2a Positive_regulation of ADCY1 1 0.01 0.11 0.22
47 INT224087 Adrbk1 Negative_regulation of Adora2a 1 0.10 0.13 0.22
48 INT196823 Adcy5 Positive_regulation of Prkaca 1 0.13 0 0.22
49 INT72015 Binding of Adora2a and Gnai2 1 0.01 0 0.21
50 INT242250 Binding of P2ry1 and P2ry12 1 0.01 0.3 0.21
51 INT242244 Binding of P2ry12 and Adp 1 0.00 0.31 0.21
52 INT224133 Negative_regulation of Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
53 INT224134 Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
54 INT226542 Negative_regulation of Adora2b Positive_regulation of IL19 1 0.08 0.58 0.2
55 INT226525 Adora2b Positive_regulation of IL19 1 0.03 0.58 0.2
56 INT196822 Negative_regulation of Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
57 INT196815 Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
58 INT224094 Adrbk1 Regulation of Negative_regulation of Adora2a 1 0.06 0 0.17
59 INT252454 Negative_regulation of Binding of Adora2b and SLURP1 1 0.02 0.33 0.16
60 INT224136 ARRB2 Positive_regulation of Adora2b 1 0.19 0 0.16
61 INT224132 ARRB2 Negative_regulation of Positive_regulation of Adora2b 1 0.14 0.28 0.15
62 INT249322 Positive_regulation of Adora1 Regulation of Rit2 1 0.10 0 0.14
63 INT224129 Binding of DRD2 and Adora2a 1 0.03 0.19 0.14
64 INT196811 Binding of Pde1a and Adcy5 1 0.01 0 0.14
65 INT13014 Avp Positive_regulation of Adcy5 1 0.00 0.07 0.13
66 INT224127 Grk5 Positive_regulation of Phosphorylation of Adora3 1 0.06 0 0.13
67 INT224125 Adrbk2 Positive_regulation of Phosphorylation of Adora3 1 0.04 0 0.13
68 INT249321 Positive_regulation of Adora1 Regulation of Preb 1 0.20 0.09 0.12
69 INT241741 Sdhb Positive_regulation of Transcription of Adora2b 1 0.07 0.28 0.08
70 INT216788 Svs4 Positive_regulation of Gene_expression of P2ry12 1 0.04 0 0.03
71 INT233523 Tlr4 Regulation of P2ry12 1 0.04 0.07 0
72 INT216785 Svs4 Regulation of Positive_regulation of P2ry12 1 0.03 0.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for adenosine receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in adenosine receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
2 INT125947 Gene_expression of Adora2b 57 0.75 23.69 17
3 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
4 INT15042 Gene_expression of Adora2a 37 0.77 3.77 14.24
5 INT194850 Positive_regulation of Adora2b 43 0.61 20.57 13.89
6 INT108063 Gene_expression of Adora2a 29 0.78 13.11 13.78
7 INT148301 Gene_expression of P2ry12 23 0.75 14.24 13.63
8 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75
9 INT72784 Positive_regulation of Adora2a 26 0.70 16.52 11.47
10 INT19155 Binding of Adora1 25 0.47 6.41 10.72
11 INT114406 Gene_expression of Adora1 28 0.72 6.83 9.13
12 INT23209 Binding of Adora2a 17 0.38 2.04 8.35
13 INT54755 Negative_regulation of Adora2a 17 0.58 2.7 7.75
14 INT101699 Regulation of Adora1 14 0.61 3.7 7.59
15 INT40159 Negative_regulation of Adora1 13 0.51 3.51 7.13
16 INT9167 Binding of Adora1 6 0.40 0.53 6.9
17 INT148308 Regulation of P2ry12 8 0.44 6.2 6.23
18 INT111384 Gene_expression of Adora3 18 0.75 10.53 5.73
19 INT83014 Binding of Adora2a 13 0.48 5.57 5.33
20 INT89664 Negative_regulation of Adora2a 11 0.59 7.81 5.07
21 INT216840 Binding of Adora2b 3 0.47 5.23 4.85
22 INT51468 Regulation of Adora2a 8 0.48 1.5 4.84
23 INT150464 Positive_regulation of P2ry12 5 0.67 4.39 4.3
24 INT165182 Gene_expression of P2ry12 4 0.65 4.29 4.08
25 INT50228 Positive_regulation of Positive_regulation of Adora2a 8 0.39 0.1 4
26 INT65527 Positive_regulation of Positive_regulation of Adora1 4 0.46 0.67 3.71
27 INT101701 Regulation of Adora2a 8 0.45 2.3 3.63
28 INT224046 Negative_regulation of Adora2b 9 0.43 4 3.6
29 INT215604 Localization of Adora1 10 0.78 1.47 3.49
30 INT183249 Binding of P2ry12 12 0.47 7.4 3.3
31 INT148306 Transcription of P2ry12 4 0.69 2.45 3.14
32 INT54178 Regulation of Adora1 5 0.39 0.29 2.85
33 INT111385 Negative_regulation of Adora3 7 0.43 3.91 2.8
34 INT215608 Negative_regulation of Binding of Adora1 5 0.41 1.35 2.73
35 INT215601 Regulation of Positive_regulation of Adora1 9 0.60 1.74 2.66
36 INT215599 Positive_regulation of Positive_regulation of Adora1 7 0.47 2.29 2.58
37 INT114020 Gene_expression of Adora1 2 0.33 4.24 2.55
38 INT72013 Negative_regulation of Gnai2 5 0.35 0.09 2.44
39 INT254118 Negative_regulation of Gene_expression of Adora2a 3 0.42 2.54 2.43
40 INT183167 Positive_regulation of Gene_expression of Adora2a 4 0.70 2.37 2.31
41 INT354232 Regulation of Gene_expression of P2ry12 1 0.26 2.47 2.19
42 INT215611 Negative_regulation of Positive_regulation of Adora1 6 0.43 1.18 2.16
43 INT224047 Regulation of Adora2b 7 0.27 3.23 2.12
44 INT57939 Negative_regulation of Gene_expression of Adora2a 4 0.36 0.15 2.02
45 INT216839 Positive_regulation of Positive_regulation of Adora2b 5 0.45 2.27 2
46 INT72785 Positive_regulation of Positive_regulation of Adora2a 2 0.10 1.34 1.96
47 INT194847 Negative_regulation of Positive_regulation of Adora2a 3 0.32 4.52 1.88
48 INT124556 Negative_regulation of Positive_regulation of Adora1 3 0.51 1.2 1.81
49 INT52523 Positive_regulation of Adora3 2 0.49 1.39 1.79
50 INT168519 Positive_regulation of Gene_expression of Adora1 4 0.61 0.75 1.75
51 INT62972 Gene_expression of Adcy5 3 0.67 0.23 1.72
52 INT224049 Transcription of Adora2b 6 0.69 5.12 1.67
53 INT164544 Positive_regulation of Gene_expression of P2ry12 4 0.67 2.41 1.64
54 INT29763 Negative_regulation of Adora1 3 0.42 0 1.64
55 INT76496 Localization of Adora2a 3 0.48 0.3 1.54
56 INT107376 Negative_regulation of P2ry12 12 0.43 4.39 1.5
57 INT13013 Positive_regulation of Adcy5 4 0.67 0.3 1.49
58 INT72008 Gene_expression of Gnai2 4 0.38 0.42 1.49
59 INT241721 Positive_regulation of Transcription of Adora1 3 0.50 1.39 1.41
60 INT241737 Transcription of Adora1 3 0.72 0.89 1.32
61 INT194849 Negative_regulation of Gene_expression of Adora3 2 0.18 2.08 1.29
62 INT61429 Gene_expression of Adcy5 6 0.60 1.49 1.27
63 INT91595 Regulation of Gene_expression of Adora2a 1 0.52 0 1.19
64 INT241724 Localization of Adora2b 2 0.75 1.21 1.14
65 INT224042 Phosphorylation of Adora2b 1 0.29 0.25 1.08
66 INT196743 Binding of Adcy5 1 0.25 0 1.04
67 INT308875 Positive_regulation of P2ry12 1 0.43 0.9 1.02
68 INT52524 Regulation of Adora3 3 0.44 1.17 0.96
69 INT52090 Transcription of Adora2a 3 0.41 0.33 0.96
70 INT119214 Transcription of Gnai2 1 0.44 0.06 0.96
71 INT72006 Positive_regulation of Negative_regulation of Adora2a 2 0.40 0.26 0.94
72 INT217050 Positive_regulation of Gene_expression of Adora2b 3 0.50 1.19 0.92
73 INT252417 Negative_regulation of P2ry12 2 0.37 1.59 0.89
74 INT119213 Positive_regulation of Gnai2 1 0.42 0.06 0.88
75 INT215606 Positive_regulation of Localization of Adora1 3 0.49 0.44 0.87
76 INT196762 Negative_regulation of Adcy5 5 0.39 1.49 0.8
77 INT302869 Phosphorylation of Adora2a 1 0.49 0.25 0.78
78 INT302868 Positive_regulation of Phosphorylation of Adora2a 1 0.41 0.25 0.78
79 INT80147 Negative_regulation of Binding of Adora2a 2 0.43 0.15 0.77
80 INT194851 Protein_catabolism of Adora2b 1 0.17 0.6 0.75
81 INT89663 Localization of Adora2a 1 0.74 0.74 0.75
82 INT194852 Protein_catabolism of Adora2a 1 0.56 0.6 0.75
83 INT196734 Positive_regulation of Adcy5 1 0.35 0 0.75
84 INT148310 Regulation of Regulation of P2ry12 1 0.43 0.09 0.74
85 INT62973 Positive_regulation of Gene_expression of Adcy5 1 0.05 0.16 0.74
86 INT241715 Negative_regulation of Gene_expression of Adora2b 2 0.43 0.48 0.73
87 INT183250 Negative_regulation of Binding of P2ry12 2 0.16 0.98 0.73
88 INT148303 Localization of P2ry12 1 0.67 0.09 0.72
89 INT215602 Localization of Adora3 2 0.73 0.63 0.7
90 INT224109 Phosphorylation of Adora2a 1 0.52 0.07 0.69
91 INT354233 Positive_regulation of Regulation of P2ry12 1 0.45 0.33 0.68
92 INT252430 Negative_regulation of Binding of Adora2b 1 0.26 0.27 0.65
93 INT54183 Regulation of Positive_regulation of Adora1 1 0.17 0 0.65
94 INT215607 Positive_regulation of Negative_regulation of Adora1 1 0.45 0 0.63
95 INT215637 Regulation of Regulation of Adora2a 1 0.14 0.16 0.61
96 INT224056 Regulation of Gene_expression of Adora2b 2 0.27 0.12 0.59
97 INT141458 Regulation of Gene_expression of Adora2a 2 0.45 0.67 0.57
98 INT215639 Positive_regulation of Binding of Adora2a 1 0.24 0.24 0.55
99 INT224106 Regulation of Negative_regulation of Adora2a 1 0.17 0.26 0.51
100 INT279525 Negative_regulation of Transcription of Adora1 1 0.43 0.26 0.51
101 INT249309 Regulation of Gene_expression of Adora1 6 0.39 0.51 0.49
102 INT215600 Regulation of Binding of Adora1 1 0.08 0.09 0.48
103 INT224107 Negative_regulation of Negative_regulation of Adora2a 1 0.28 0.32 0.48
104 INT72143 Regulation of Binding of Adora2a 1 0.17 0 0.45
105 INT224043 Phosphorylation of Adora3 1 0.15 0.2 0.43
106 INT102385 Regulation of Transcription of Adora2a 1 0.21 0.09 0.4
107 INT72014 Negative_regulation of Gene_expression of Gnai2 1 0.24 0 0.4
108 INT279524 Protein_catabolism of Adora1 1 0.88 0.34 0.38
109 INT279523 Positive_regulation of Protein_catabolism of Adora1 1 0.50 0.34 0.38
110 INT323020 Positive_regulation of Binding of P2ry12 1 0.06 0.49 0.37
111 INT102387 Negative_regulation of Transcription of Adora2a 1 0.09 0.24 0.37
112 INT252432 Positive_regulation of Localization of Adora2b 1 0.30 0.06 0.37
113 INT252431 Negative_regulation of Positive_regulation of Adora2b 1 0.26 0.76 0.35
114 INT164337 Localization of Adcy5 1 0.38 0 0.33
115 INT164338 Regulation of Adcy5 1 0.14 0 0.33
116 INT215609 Transcription of Adora3 2 0.62 0.35 0.31
117 INT221765 Positive_regulation of Gene_expression of Adora2a 2 0.49 0.2 0.27
118 INT224108 Positive_regulation of Localization of Adora2a 1 0.32 0.14 0.27
119 INT224114 Regulation of Localization of Adora2a 1 0.29 0.14 0.27
120 INT196792 Binding of Adcy5 1 0.35 0 0.25
121 INT186700 Localization of Adora1 1 0.23 0 0.23
122 INT224117 Negative_regulation of Positive_regulation of Adora2a 1 0.27 0.11 0.22
123 INT224105 Regulation of Phosphorylation of Adora2a 1 0.17 0 0.21
124 INT308882 Transcription of P2ry12 1 0.46 0.61 0.19
125 INT224051 Regulation of Phosphorylation of Adora2b 1 0.09 0.09 0.18
126 INT224115 Positive_regulation of Phosphorylation of Adora2a 1 0.32 0 0.16
127 INT224055 Negative_regulation of Phosphorylation of Adora2b 1 0.15 0 0.16
128 INT224054 Positive_regulation of Phosphorylation of Adora2b 1 0.17 0 0.16
129 INT224103 Negative_regulation of Phosphorylation of Adora2a 1 0.27 0 0.16
130 INT249313 Negative_regulation of Gene_expression of Adora1 1 0.37 0 0.14
131 INT224050 Negative_regulation of Phosphorylation of Adora3 1 0.10 0.08 0.11
132 INT224044 Regulation of Regulation of Adora3 1 0.06 0.09 0.11
133 INT196776 Negative_regulation of Negative_regulation of Adcy5 1 0.22 0 0.11
134 INT252433 Regulation of Positive_regulation of Adora2b 1 0.44 0 0.09
135 INT241728 Regulation of Transcription of Adora2a 1 0.42 0.27 0.07
136 INT241734 Regulation of Transcription of Adora3 1 0.39 0.27 0.07
137 INT241720 Regulation of Transcription of Adora1 1 0.40 0.27 0.07
138 INT241725 Transcription of Adora2a 1 0.67 0.27 0.07
139 INT241716 Positive_regulation of Transcription of Adora2b 1 0.50 0.28 0.06
140 INT215605 Positive_regulation of Localization of Adora3 1 0.49 0 0.05
141 INT196788 Positive_regulation of Binding of Adcy5 1 0.22 0 0.05
142 INT183251 Negative_regulation of Regulation of P2ry12 1 0.16 0 0
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