GO:0002755

Name MyD88-dependent toll-like receptor signaling pathway Categary Process Go Slim No Go Link GO:0002755

Unique Molecular Interactions 1124 Total Molecular Interactions 1537 Total Single Events 9926 Pain Genes Associated 53

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for MyD88-dependent toll-like receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for MyD88-dependent toll-like receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT182124	Binding of IRF6 and TLR4	14	0.10	16.11	4.65
2	INT61359	TNF Positive_regulation of NFKB1	11	0.63	6.66	3.89
3	INT190167	Binding of JUN and MMP12	1	0.26	0.82	2.76
4	INT238914	Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1	1	0.19	3.22	2.35
5	INT139723	PROC Positive_regulation of MAPK8	1	0.01	2.98	2.33
6	INT264953	Binding of POMC and TLR4	1	0.03	0.89	1.96
7	INT157767	Binding of TLR4 and LY96	8	0.54	4.05	1.95
8	INT264947	Binding of POMC and TLR2	1	0.03	0.89	1.95
9	INT81920	Binding of IL1B and NFKB1	1	0.04	1.54	1.85
10	INT81914	Binding of HSF1 and NFKB1	1	0.05	1.54	1.85
11	INT116092	TFF2 Positive_regulation of NFKB1	1	0.17	0.06	1.77
12	INT94203	SP5 Positive_regulation of FOS	1	0.25	1.41	1.72
13	INT215096	Binding of Hmgb1 and Tlr2	9	0.38	11.61	1.61
14	INT105112	Plat Positive_regulation of JUN	1	0.01	1.55	1.58
15	INT144280	ACP1 Negative_regulation of Phosphorylation of MAPK1	1	0.37	0.78	1.56
16	INT116093	OPRM1 Positive_regulation of Positive_regulation of NFKB1	1	0.36	0.08	1.56
17	INT254205	Binding of Myd88 and Tlr4	12	0.19	3.17	1.54
18	INT134679	FSCN1 Positive_regulation of MAPK8	1	0.01	0.56	1.39
19	INT106071	Positive_regulation of Oprl1 Positive_regulation of MAPK3	1	0.12	0.16	1.34
20	INT294775	IRF6 Positive_regulation of TLR4	6	0.08	2.04	1.32
21	INT70181	PRCP Positive_regulation of FOS	1	0.58	0.36	1.26
22	INT139724	PROC Positive_regulation of MAPK14	1	0.00	1.57	1.25
23	INT151648	TLR4 Regulation of Gene_expression of ICAM1	1	0.00	2.86	1.24
24	INT133046	TNF Positive_regulation of Positive_regulation of NFKB1	5	0.54	3.23	1.19
25	INT55162	Binding of NFKB1 and RELA	10	0.30	2.82	1.18
26	INT330379	Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14	1	0.00	1.95	1.18
27	INT121191	KCNMA1 Positive_regulation of Phosphorylation of MAPK1	1	0.06	0.61	1.18
28	INT238916	CNR1 Positive_regulation of Phosphorylation of MAPK1	1	0.19	1.61	1.17
29	INT150191	CEACAM3 Positive_regulation of Gene_expression of FOS	1	0.34	0.14	1.16
30	INT147447	ADCYAP1 Regulation of Localization of RELA	1	0.50	1.12	1.15
31	INT147448	ADCYAP1 Regulation of Localization of NFKB1	1	0.47	1.12	1.15
32	INT101715	PLAT Positive_regulation of NFKB1	2	0.11	0.99	1.09
33	INT164378	MAPK3 Positive_regulation of Transcription of PDYN	1	0.50	0.2	1.09
34	INT164382	MAPK3 Positive_regulation of Gene_expression of Fos	1	0.75	0.2	1.08
35	INT164383	Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos	1	0.54	0.2	1.08
36	INT105113	Plat Positive_regulation of NFKB1	1	0.03	1.06	1.06
37	INT105109	Cxcl12 Positive_regulation of JUN	1	0.01	1.07	1.05
38	INT185373	IRF6 Positive_regulation of Gene_expression of TLR2	1	0.08	2.96	1.04
39	INT182125	Binding of CD14 and TLR4	7	0.25	3.78	1.03
40	INT156245	NFKB1 Positive_regulation of Regulation of TNF	1	0.45	0.76	1.03
41	INT101067	MAP3K15 Positive_regulation of MAPK1	1	0.21	0.47	1.03
42	INT101065	MAP3K15 Positive_regulation of JUN	1	0.43	0.46	1.02
43	INT113453	Ngf Positive_regulation of JUN	1	0.27	0.6	1.01
44	INT140652	IGF1 Positive_regulation of Phosphorylation of MAPK1	1	0.26	0.63	0.98
45	INT94206	SP5 Regulation of Gene_expression of FOS	1	0.22	0.7	0.98
46	INT100018	TNF Positive_regulation of MAPK1	3	0.24	1.56	0.94
47	INT152388	Binding of NFKB1 and OPRM1	1	0.04	0.14	0.94
48	INT152390	Negative_regulation of Binding of JUN and OPRM1	1	0.13	0.14	0.94
49	INT152387	Binding of JUN and OPRM1	1	0.15	0.14	0.94
50	INT144281	ACP1 Negative_regulation of Positive_regulation of MAPK1	1	0.27	0.58	0.94
51	INT102554	HGF Positive_regulation of Phosphorylation of RPS6KA1	1	0.21	0.93	0.94
52	INT152389	Negative_regulation of Binding of NFKB1 and OPRM1	1	0.05	0.14	0.94
53	INT219154	Binding of HMGB1 and TLR4	2	0.17	4.45	0.93
54	INT144285	ACP1 Negative_regulation of MAPK1	1	0.37	0.58	0.93
55	INT343918	IgG Positive_regulation of Phosphorylation of MAPK1	1	0.01	3.57	0.91
56	INT343909	IgG Positive_regulation of Gene_expression of TLR4	1	0.04	3.49	0.91
57	INT276964	Binding of Tlr1 and Tlr2	11	0.24	4.22	0.89
58	INT249347	Binding of FOS and JUN	4	0.19	6.15	0.89
59	INT90387	ROS1 Positive_regulation of NFKB1	4	0.32	2.35	0.87
60	INT209928	IL1B Positive_regulation of MAPK14	2	0.15	1.69	0.87
61	INT188196	LIF Regulation of MAPK1	1	0.21	2.26	0.87
62	INT188214	OSM Regulation of MAPK1	1	0.20	2.27	0.87
63	INT161308	POMC Negative_regulation of Positive_regulation of JUN	1	0.12	0.27	0.86
64	INT124878	Gnat3 Negative_regulation of Gene_expression of FOS	1	0.09	0.16	0.85
65	INT190183	MAPK1 Regulation of CDCP1	1	0.00	1.19	0.85
66	INT161307	JUN Positive_regulation of IL2	1	0.14	0.25	0.84
67	INT161305	NFKB1 Positive_regulation of IL2	1	0.25	0.25	0.83
68	INT106312	NFKB1 Regulation of S100A4	1	0.14	1.1	0.83
69	INT124877	Gnat3 Negative_regulation of FOS	1	0.09	0.15	0.82
70	INT124876	Gnat3 Negative_regulation of Positive_regulation of FOS	1	0.09	0.15	0.82
71	INT66206	Negative_regulation of TNF Positive_regulation of NFKB1	2	0.53	1.71	0.81
72	INT341367	CRX Positive_regulation of Positive_regulation of FOS	1	0.04	0.83	0.8
73	INT190182	JUN Positive_regulation of MMP12	1	0.34	0.08	0.8
74	INT140966	NFKB1 Positive_regulation of Positive_regulation of CPOX	1	0.08	0.66	0.8
75	INT104831	Binding of GLI2 and NFKB1	1	0.08	0	0.8
76	INT276988	Binding of Tlr6 and Tlr2	11	0.26	4.89	0.79
77	INT132894	CHUK Regulation of Gene_expression of Nos2	1	0.00	0.21	0.79
78	INT158684	MAPK8 Positive_regulation of Gene_expression of BCL2L11	1	0.51	0.44	0.78
79	INT346234	MAP2K6 Positive_regulation of MAPK14	1	0.44	1.65	0.77
80	INT163830	ERBB2 Positive_regulation of MAPK1	1	0.06	1.63	0.76
81	INT151809	JUN Positive_regulation of Positive_regulation of OPRM1	1	0.32	0	0.74
82	INT190169	Regulation of JUN Positive_regulation of Localization of MMP12	1	0.30	0.07	0.74
83	INT186445	Creb1 Regulation of Transcription of FOS	1	0.49	0.44	0.73
84	INT186443	Phosphorylation of Creb1 Regulation of Transcription of FOS	1	0.49	0.44	0.73
85	INT186444	Creb1 Regulation of FOS	1	0.49	0.43	0.72
86	INT186442	Phosphorylation of Creb1 Regulation of FOS	1	0.49	0.43	0.72
87	INT146463	TNFSF10 Positive_regulation of NFKB1	2	0.08	2.45	0.71
88	INT146461	IFNG Positive_regulation of NFKB1	1	0.01	1.44	0.71
89	INT153123	NFKBIA Negative_regulation of Phosphorylation of RELA	1	0.03	2.01	0.71
90	INT103134	DCSTAMP Positive_regulation of NFKB1	2	0.07	1.43	0.7
91	INT320633	Positive_regulation of MAPK1 Regulation of BCL2	1	0.04	1.21	0.7
92	INT194685	MAPK1 Regulation of Gene_expression of IL10	1	0.06	1.18	0.7
93	INT320634	Positive_regulation of MAPK1 Regulation of PBX2	1	0.03	1.21	0.7
94	INT66581	Binding of JUN and Rare2	1	0.00	0.07	0.69
95	INT66582	Binding of FOS and Rare2	1	0.00	0.07	0.69
96	INT316690	Binding of Myd88 and Il1	2	0.06	1.75	0.66
97	INT62059	Positive_regulation of SCN5A Positive_regulation of Gene_expression of FOS	1	0.01	0.42	0.66
98	INT270763	IL1B Negative_regulation of IKBKB	1	0.04	1.13	0.66
99	INT343851	Positive_regulation of Binding of IRF6 and TLR4	1	0.07	1.96	0.66
100	INT124477	MAP2K1 Positive_regulation of Positive_regulation of MAPK1	1	0.12	1.35	0.65
101	INT160119	EPO Regulation of Gene_expression of NFKB1	1	0.02	0.2	0.64
102	INT158685	ROS1 Regulation of Positive_regulation of MAPK8	1	0.21	0.39	0.64
103	INT169296	PTPLA Positive_regulation of MAPK3	1	0.10	0.15	0.63
104	INT169295	PTPLA Positive_regulation of MAPK8	1	0.10	0.15	0.63
105	INT120851	NFKB1 Positive_regulation of Localization of TNF	3	0.04	2.05	0.62
106	INT66207	Positive_regulation of TNF Positive_regulation of NFKB1	1	0.42	0.08	0.61
107	INT144248	CGA Regulation of Positive_regulation of NFKB1	1	0.15	1.66	0.61
108	INT144256	CGA Regulation of Gene_expression of NFKB1	1	0.21	1.66	0.61
109	INT237907	Tlr4 Positive_regulation of Gene_expression of Tlr2	7	0.40	5.85	0.6
110	INT224419	Binding of NFKB2 and TNFRSF11B	1	0.11	1.37	0.6
111	INT113962	OPRM1 Regulation of CREB1	1	0.39	0.31	0.6
112	INT224420	Regulation of Binding of NFKB2 and TNFRSF11B	1	0.13	1.39	0.6
113	INT242883	INS Negative_regulation of Gene_expression of TLR2	1	0.17	2.35	0.6
114	INT81916	HSF1 Positive_regulation of FOS	1	0.76	0.66	0.59
115	INT81918	HSF1 Negative_regulation of FOS	1	0.64	0.66	0.59
116	INT115146	MAPK1 Positive_regulation of EGR1	3	0.13	2.43	0.57
117	INT162789	Binding of TLR2 and NOD2	1	0.37	0.51	0.57
118	INT162790	Binding of TLR4 and NOD2	1	0.36	0.51	0.57
119	INT236783	IRF6 Negative_regulation of Gene_expression of TLR4	1	0.01	1.17	0.57
120	INT147071	NFKB1 Regulation of Gene_expression of PTGES	1	0.36	0.35	0.57
121	INT27871	Binding of FCGR1B and HSPD1	1	0.01	1.93	0.56
122	INT27872	Positive_regulation of Binding of FCGR1B and HSPD1	1	0.01	1.93	0.56
123	INT278694	TNF Positive_regulation of MAPK14	1	0.03	0.79	0.56
124	INT278689	TNF Positive_regulation of MAPK8	1	0.04	0.79	0.56
125	INT175323	Tlr4 Positive_regulation of Gene_expression of TLR2	1	0.02	0.31	0.56
126	INT113548	NFKB1 Regulation of Localization of PLAU	1	0.26	1.93	0.55
127	INT201949	CXCL10 Positive_regulation of Phosphorylation of MAPK1	1	0.15	0.79	0.55
128	INT121994	EGF Positive_regulation of Positive_regulation of MAPK1	1	0.25	0	0.55
129	INT99486	OPRM1 Positive_regulation of MAPK3	1	0.22	0	0.55
130	INT156246	NFKB1 Regulation of Gene_expression of TNF	1	0.17	0.35	0.54
131	INT343913	Binding of FOS and Smad3	1	0.19	0.92	0.54
132	INT105111	Negative_regulation of Plat Positive_regulation of NFKB1	1	0.03	0.53	0.54
133	INT323146	PRKCA Positive_regulation of MAPK1	1	0.02	0	0.54
134	INT85125	IL3 Positive_regulation of MAPK1	1	0.30	0.81	0.53
135	INT105110	Cxcl12 Positive_regulation of NFKB1	1	0.06	0.54	0.53
136	INT85121	CSF2 Positive_regulation of MAPK1	1	0.07	0.8	0.53
137	INT85115	IL5 Positive_regulation of MAPK1	1	0.14	0.81	0.53
138	INT105108	Negative_regulation of Cxcl12 Positive_regulation of NFKB1	1	0.05	0.54	0.53
139	INT106394	MAPK3 Positive_regulation of ADRBK1	1	0.48	0.06	0.53
140	INT171909	MAPK8 Positive_regulation of Gene_expression of MAPK1	1	0.08	1.55	0.52
141	INT171910	MAPK1 Positive_regulation of MAPK9	1	0.10	1.55	0.52
142	INT201939	CXCL10 Positive_regulation of MAPK1	1	0.11	0.72	0.52
143	INT171906	MAPK1 Positive_regulation of Gene_expression of MAPK14	1	0.08	1.55	0.52
144	INT191947	NFKB2 Positive_regulation of Gene_expression of NOS2	1	0.08	1.51	0.52
145	INT171914	MAPK8IP3 Positive_regulation of Gene_expression of MAPK1	1	0.06	1.55	0.52
146	INT122872	SEMA6A Positive_regulation of MAPK1	1	0.56	0	0.52
147	INT343838	EDA Positive_regulation of TLR4	1	0.11	0.87	0.51
148	INT131368	MAPK1 Positive_regulation of Bcar3	1	0.00	0.37	0.51
149	INT285911	Binding of TLR4 and Cd14	1	0.05	1.13	0.51
150	INT131371	MAPK3 Positive_regulation of Il4	1	0.02	0.37	0.51
151	INT131367	MAPK3 Positive_regulation of Bcar3	1	0.00	0.37	0.51
152	INT131370	MAPK3 Positive_regulation of Gene_expression of Il4	1	0.02	0.37	0.51
153	INT131369	MAPK1 Positive_regulation of Il4	1	0.01	0.37	0.51
154	INT139834	NFKB1 Regulation of Gene_expression of SELE	1	0.18	0.49	0.5
155	INT139835	NFKB1 Regulation of SELE	1	0.41	0.49	0.5
156	INT324816	Hspd1 Positive_regulation of Gene_expression of Ik	1	0.00	1.59	0.5
157	INT194676	Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10	1	0.05	0.34	0.5
158	INT179507	Tlr4 Positive_regulation of Tlr2	2	0.17	1.07	0.49
159	INT306019	Binding of Tlr4 and LY96	1	0.06	0.91	0.49
160	INT115184	Regulation of CASP1 Positive_regulation of MAPK9	1	0.09	0	0.49
161	INT106072	NFKB1 Positive_regulation of Gene_expression of A2M	1	0.19	0.75	0.49
162	INT135588	Positive_regulation of IKBKE Positive_regulation of NFKB1	1	0.18	1.29	0.48
163	INT115183	CASP1 Positive_regulation of Positive_regulation of MAPK9	1	0.16	0	0.48
164	INT135587	IKBKE Positive_regulation of NFKB1	1	0.18	1.28	0.48
165	INT102553	HGF Positive_regulation of Phosphorylation of MAPK1	1	0.40	0.49	0.48
166	INT115185	CASP1 Positive_regulation of MAPK9	1	0.15	0	0.48
167	INT116932	PTK2 Negative_regulation of Positive_regulation of MAPK8	1	0.35	0.17	0.48
168	INT191948	NFKB1 Regulation of Gene_expression of NOS2	1	0.38	1	0.47
169	INT322264	Binding of MPZ and TLR4	1	0.18	1.68	0.47
170	INT191950	NFKB2 Regulation of Gene_expression of NOS2	1	0.08	1	0.47
171	INT102552	HGF Positive_regulation of MAPK3	1	0.38	0.47	0.47
172	INT102556	HGF Positive_regulation of Phosphorylation of ELK1	1	0.10	0.46	0.47
173	INT185917	Binding of AR and MAPK1	1	0.07	0.5	0.47
174	INT106073	IL1B Positive_regulation of Positive_regulation of NFKB1	1	0.41	0.7	0.47
175	INT102555	HGF Positive_regulation of MAPK1	1	0.38	0.47	0.47
176	INT117703	OPRK1 Positive_regulation of Positive_regulation of JUN	1	0.01	0.08	0.47
177	INT246938	Binding of Tlr4 and Tlr2	3	0.39	2.88	0.46
178	INT142826	UPF1 Positive_regulation of CREB1	1	0.11	0	0.46
179	INT116928	PTK2 Positive_regulation of JUN	1	0.20	0.15	0.46
180	INT116933	SRC Positive_regulation of JUN	1	0.33	0.15	0.46
181	INT116929	OPRK1 Positive_regulation of JUN	1	0.28	0.15	0.46
182	INT108332	EGF Positive_regulation of Phosphorylation of MAPK1	5	0.48	1.85	0.45
183	INT144245	CGA Negative_regulation of Positive_regulation of NFKB1	1	0.13	0.79	0.45
184	INT329794	TLR2 Positive_regulation of Positive_regulation of IL12A	1	0.01	1.05	0.44
185	INT343846	MAPK1 Positive_regulation of FOS	1	0.04	1.29	0.44
186	INT346237	MAP2K6 Positive_regulation of MAP2K3	1	0.49	1	0.44
187	INT230461	Binding of TLR1 and TLR2	3	0.33	2.06	0.43
188	INT104016	RPGR Positive_regulation of Gene_expression of FOS	1	0.16	0	0.43
189	INT103132	Positive_regulation of DCSTAMP Positive_regulation of JUN	1	0.03	0.73	0.43
190	INT189197	RASGRP1 Positive_regulation of JUN	1	0.07	1.26	0.43
191	INT278950	MAPK8 Negative_regulation of Localization of EPHB2	1	0.25	0.47	0.43
192	INT188211	IL6 Regulation of MAPK1	1	0.16	1.13	0.43
193	INT278964	MAPK14 Negative_regulation of Localization of EPHB2	1	0.15	0.47	0.43
194	INT116931	OPRK1 Regulation of MAPK8	1	0.31	0.07	0.43
195	INT103128	Positive_regulation of DCSTAMP Positive_regulation of NFKB1	1	0.07	0.73	0.43
196	INT103129	DCSTAMP Positive_regulation of JUN	1	0.03	0.72	0.43
197	INT106396	DYT10 Positive_regulation of MAPK3	1	0.50	0	0.42
198	INT238913	MAPK3 Regulation of Positive_regulation of MAPK1	1	0.11	0.39	0.42
199	INT185381	TNF Regulation of TLR2	2	0.31	1.9	0.41
200	INT194722	Negative_regulation of MAPK1 Negative_regulation of Gene_expression of CRP	1	0.09	1.49	0.41

Single Events

The table below shows the top 100 pain related interactions that have been reported for MyD88-dependent toll-like receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in MyD88-dependent toll-like receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT6665	Gene_expression of FOS	520	0.77	165.31	217.66
2	INT17459	Positive_regulation of Gene_expression of FOS	182	0.67	53.45	96.38
3	INT71789	Positive_regulation of MAPK1	396	0.70	234.44	89.27
4	INT54571	Positive_regulation of NFKB1	263	0.70	138.99	87.32
5	INT5356	Positive_regulation of FOS	153	0.69	54.21	56.74
6	INT17458	Negative_regulation of Gene_expression of FOS	98	0.57	36.77	55.69
7	INT117223	Gene_expression of TLR4	348	0.78	206.18	54.42
8	INT71786	Phosphorylation of MAPK1	256	0.82	110.09	46.17
9	INT80690	Positive_regulation of MAPK8	223	0.68	125.63	36.75
10	INT133028	Gene_expression of TLR2	209	0.73	131.92	36.17
11	INT56072	Negative_regulation of NFKB1	94	0.59	53.16	28.19
12	INT83708	Negative_regulation of MAPK1	156	0.57	84.93	27.85
13	INT17331	Positive_regulation of JUN	132	0.69	60.4	27.03
14	INT48979	Regulation of Gene_expression of FOS	52	0.61	14.4	25.95
15	INT11014	Phosphorylation of CREB1	72	0.81	26.35	25.64
16	INT12124	Gene_expression of MAPK1	141	0.75	82.4	25.58
17	INT71781	Phosphorylation of MAPK3	62	0.80	27.73	23.73
18	INT86534	Positive_regulation of MAPK14	81	0.62	57.81	23.62
19	INT134651	Binding of TLR4	89	0.48	66.96	23.19
20	INT55170	Gene_expression of NFKB1	97	0.77	52.75	23.04
21	INT69322	Negative_regulation of MAPK14	70	0.54	42.92	22.71
22	INT66208	Positive_regulation of Positive_regulation of NFKB1	45	0.68	20.17	22.62
23	INT142594	Gene_expression of Tlr2	165	0.78	139.73	22.26
24	INT171924	Gene_expression of MAPK14	60	0.65	54.38	21.68
25	INT91462	Positive_regulation of Phosphorylation of MAPK1	99	0.67	40.28	18.99
26	INT71787	Positive_regulation of MAPK3	37	0.67	17.5	17.88
27	INT116950	Negative_regulation of MAPK8	103	0.57	44.48	17.53
28	INT117220	Positive_regulation of TLR4	64	0.69	53.61	17.33
29	INT109929	Phosphorylation of MAPK8	102	0.81	39.98	16.54
30	INT25517	Regulation of NFKB1	41	0.61	22.28	16.09
31	INT54572	Negative_regulation of Positive_regulation of NFKB1	46	0.58	21.45	15.47
32	INT75531	Regulation of MAPK1	70	0.61	34.39	15.42
33	INT60197	Gene_expression of JUN	90	0.78	42.32	14.61
34	INT80688	Positive_regulation of Positive_regulation of MAPK1	72	0.69	39.35	14.11
35	INT39733	Localization of NFKB1	59	0.79	22.76	13.99
36	INT142593	Positive_regulation of Tlr2	85	0.70	75.9	13.62
37	INT80685	Gene_expression of MAPK8	90	0.72	51.91	13.36
38	INT55168	Binding of NFKB1	55	0.48	22.94	13.15
39	INT15246	Regulation of FOS	32	0.60	15.34	12.94
40	INT117222	Positive_regulation of Gene_expression of TLR4	80	0.70	51.6	12.9
41	INT75525	Negative_regulation of Positive_regulation of MAPK1	40	0.59	25.15	11.15
42	INT133030	Positive_regulation of Gene_expression of TLR2	53	0.65	38.15	10.65
43	INT150540	Binding of TLR2	50	0.45	35.86	10.43
44	INT111335	Gene_expression of HSPD1	57	0.75	55.51	10.38
45	INT110178	Phosphorylation of MAPK14	40	0.68	19.38	10.37
46	INT60198	Binding of JUN	54	0.48	11.56	10.27
47	INT54588	Positive_regulation of CREB1	38	0.67	12.01	9.18
48	INT94196	Negative_regulation of Phosphorylation of MAPK1	60	0.59	31.64	9.16
49	INT48978	Negative_regulation of FOS	41	0.57	11.94	9.14
50	INT66213	Localization of RELA	63	0.78	14.71	8.77
51	INT17333	Positive_regulation of Positive_regulation of FOS	17	0.67	6.06	8.4
52	INT71785	Gene_expression of MAPK3	22	0.75	11.35	8.21
53	INT87271	Positive_regulation of Phosphorylation of CREB1	27	0.66	12.87	7.91
54	INT91618	Positive_regulation of Phosphorylation of MAPK3	21	0.67	7.99	7.65
55	INT80686	Positive_regulation of Positive_regulation of MAPK8	42	0.68	26.95	7.63
56	INT47848	Negative_regulation of Positive_regulation of FOS	14	0.57	3.78	7.63
57	INT103909	Gene_expression of NOD2	37	0.77	21.9	7.36
58	INT86867	Regulation of CREB1	15	0.46	4.95	7.28
59	INT75497	Regulation of JUN	28	0.61	11.04	7.09
60	INT66210	Regulation of Positive_regulation of NFKB1	16	0.60	9.46	7.08
61	INT12771	Positive_regulation of IKBKG	27	0.69	5.99	7.02
62	INT60196	Binding of FOS	33	0.47	13.11	6.95
63	INT142596	Positive_regulation of Gene_expression of Tlr2	42	0.69	38.41	6.67
64	INT68653	Negative_regulation of JUN	34	0.58	14.27	6.56
65	INT5847	Transcription of FOS	31	0.69	11.11	6.41
66	INT137206	Positive_regulation of TLR2	47	0.65	33.36	6.4
67	INT94197	Negative_regulation of Phosphorylation of MAPK3	13	0.57	5.51	6.18
68	INT97797	Localization of TLR4	18	0.77	13.78	6
69	INT130111	Regulation of Positive_regulation of MAPK1	14	0.36	11.01	5.9
70	INT6667	Gene_expression of CREB1	27	0.77	6.29	5.84
71	INT47976	Protein_catabolism of NFKBIA	17	0.88	7.57	5.79
72	INT143158	Negative_regulation of Gene_expression of TLR4	31	0.56	20.62	5.69
73	INT142595	Negative_regulation of Tlr2	24	0.52	19.17	5.43
74	INT71779	Positive_regulation of Gene_expression of MAPK1	27	0.47	21.41	5.39
75	INT78728	Negative_regulation of Binding of NFKB1	18	0.58	6.89	5.39
76	INT99487	Negative_regulation of MAPK3	15	0.57	7.13	5.39
77	INT66209	Negative_regulation of Localization of NFKB1	23	0.58	8.2	5.31
78	INT197491	Gene_expression of Myd88	32	0.74	14.59	5.29
79	INT174688	Binding of Tlr2	45	0.42	36.65	5.25
80	INT145767	Negative_regulation of TLR4	18	0.43	11.03	5.25
81	INT109928	Negative_regulation of Positive_regulation of MAPK8	19	0.42	10.42	5.23
82	INT145756	Gene_expression of Tlr2	23	0.74	20.77	5.18
83	INT66211	Positive_regulation of Localization of NFKB1	20	0.68	8.18	5.01
84	INT185398	Negative_regulation of Gene_expression of TLR2	34	0.55	27.21	4.73
85	INT91463	Positive_regulation of NFKB2	19	0.40	17.7	4.6
86	INT54911	Localization of FOS	20	0.78	3.27	4.56
87	INT55171	Gene_expression of RELA	80	0.75	17.17	4.47
88	INT149197	Negative_regulation of NFKB2	14	0.25	10.55	4.46
89	INT142752	Positive_regulation of Myd88	26	0.66	12.07	4.4
90	INT85126	Negative_regulation of MAP2K6	19	0.39	12.12	4.39
91	INT117920	Regulation of MAPK14	14	0.38	8.75	4.31
92	INT75523	Regulation of MAPK8	21	0.33	11.18	4.28
93	INT109935	Positive_regulation of Phosphorylation of MAPK8	35	0.68	13.13	4.18
94	INT117921	Positive_regulation of Positive_regulation of MAPK14	9	0.44	9.93	4.18
95	INT67936	Transcription of JUN	18	0.52	9.52	4.13
96	INT12772	Positive_regulation of Positive_regulation of IKBKG	9	0.69	0.84	4.12
97	INT110181	Negative_regulation of Phosphorylation of MAPK8	20	0.57	9.43	4.06
98	INT106065	Negative_regulation of MAP2K1	27	0.57	12.69	3.97
99	INT132103	Positive_regulation of Gene_expression of MAPK8	26	0.46	16.54	3.94
100	INT56077	Protein_catabolism of NFKB1	16	0.98	8.03	3.94
101	INT110180	Phosphorylation of JUN	23	0.80	11.21	3.83
102	INT56075	Transcription of NFKB1	13	0.71	9.03	3.83
103	INT142754	Binding of Myd88	20	0.36	9.61	3.8
104	INT186808	Transcription of TLR4	22	0.69	12.77	3.73
105	INT73981	Gene_expression of Hspd1	18	0.75	5.69	3.72
106	INT264972	Positive_regulation of MAP2K3	4	0.65	6.92	3.68
107	INT79231	Positive_regulation of Gene_expression of NFKB1	18	0.67	9.16	3.66
108	INT134149	Negative_regulation of Gene_expression of NFKB1	7	0.55	4.25	3.63
109	INT143159	Regulation of Gene_expression of TLR4	28	0.62	15.08	3.54
110	INT119420	Phosphorylation of MAP2K6	8	0.79	4.89	3.52
111	INT73557	Positive_regulation of RELA	57	0.46	8.7	3.43
112	INT264970	Positive_regulation of Localization of TLR2	1	0.11	4.21	3.37
113	INT109914	Positive_regulation of MAPK9	16	0.56	7.64	3.27
114	INT81453	Positive_regulation of Gene_expression of JUN	18	0.50	9.39	3.23
115	INT11015	Regulation of Phosphorylation of CREB1	4	0.46	1.45	3.17
116	INT139801	Phosphorylation of NFKB1	9	0.66	5.2	3.13
117	INT66212	Negative_regulation of Localization of RELA	13	0.57	2.48	3.09
118	INT71783	Positive_regulation of Gene_expression of MAPK3	9	0.59	4.59	3.05
119	INT186805	Transcription of TLR2	12	0.63	9.66	3.04
120	INT68651	Negative_regulation of Positive_regulation of JUN	11	0.58	4.28	3.04
121	INT87288	Positive_regulation of Positive_regulation of MAPK3	5	0.67	1.62	3.04
122	INT12770	Negative_regulation of Positive_regulation of IKBKG	7	0.56	0.34	3.02
123	INT145768	Regulation of TLR4	19	0.45	8.31	2.96
124	INT103910	Binding of NOD2	19	0.47	12.24	2.93
125	INT173179	Binding of MAPK14	13	0.29	4.51	2.92
126	INT102565	Positive_regulation of Phosphorylation of RPS6KA1	1	0.25	2.77	2.85
127	INT6025	Negative_regulation of RIPK2	4	0.57	0.96	2.82
128	INT108358	Phosphorylation of FOS	12	0.80	6.33	2.79
129	INT49653	Gene_expression of NFKB2	12	0.61	9.51	2.73
130	INT19421	Positive_regulation of RIPK2	6	0.49	5.63	2.72
131	INT162792	Gene_expression of NOD1	19	0.71	6.11	2.71
132	INT53443	Gene_expression of IKBKG	15	0.65	7.5	2.71
133	INT107968	Positive_regulation of NFKBIA	9	0.46	5.27	2.69
134	INT47974	Negative_regulation of Protein_catabolism of NFKBIA	7	0.49	2.38	2.69
135	INT209889	Gene_expression of TRAF6	13	0.63	6.85	2.67
136	INT98919	Negative_regulation of Phosphorylation of CREB1	8	0.58	2.4	2.63
137	INT133029	Regulation of TLR2	18	0.56	11.31	2.62
138	INT186799	Localization of TLR2	5	0.68	2.51	2.58
139	INT122003	Phosphorylation of NFKBIA	9	0.59	5.44	2.51
140	INT71305	Regulation of Gene_expression of NFKB1	9	0.61	5.41	2.44
141	INT102646	Positive_regulation of MAP2K6	3	0.63	4.37	2.44
142	INT12769	Localization of IKBKG	6	0.15	1.66	2.43
143	INT110179	Negative_regulation of Phosphorylation of MAPK14	11	0.36	5.25	2.38
144	INT123682	Localization of JUN	8	0.50	4.15	2.38
145	INT87284	Negative_regulation of Positive_regulation of MAPK3	7	0.41	2.65	2.38
146	INT48980	Positive_regulation of Transcription of FOS	10	0.67	3.07	2.34
147	INT60199	Positive_regulation of Binding of JUN	5	0.49	1.3	2.34
148	INT186116	Regulation of Gene_expression of MAPK1	9	0.44	5.85	2.32
149	INT117924	Gene_expression of MAP2K3	2	0.72	5.82	2.32
150	INT150547	Phosphorylation of MAP2K3	2	0.79	4.92	2.3
151	INT132893	Binding of CHUK	1	0.00	0.63	2.25
152	INT27880	Positive_regulation of HSPD1	17	0.65	18.16	2.23
153	INT204775	Regulation of Tlr2	21	0.41	13.6	2.18
154	INT152436	Positive_regulation of Gene_expression of HSPD1	12	0.67	10.06	2.16
155	INT109908	Localization of MAPK8	10	0.73	3.86	2.14
156	INT291336	Gene_expression of MAP2K6	4	0.70	7.8	2.13
157	INT173647	Positive_regulation of Gene_expression of MAPK14	15	0.39	7.54	2.05
158	INT129318	Negative_regulation of NFKBIA	10	0.38	6.19	2.02
159	INT148456	Gene_expression of LY96	7	0.19	4.35	2.02
160	INT109906	Localization of MAPK1	12	0.54	1.68	2.01
161	INT83709	Negative_regulation of Gene_expression of MAPK1	12	0.41	6.57	2.01
162	INT132892	Positive_regulation of CHUK	3	0.08	1.62	2.01
163	INT123530	Phosphorylation of RELA	9	0.80	3.46	1.99
164	INT110925	Positive_regulation of Positive_regulation of JUN	14	0.49	6.22	1.98
165	INT243689	Regulation of NFKB2	1	0.35	2.72	1.97
166	INT26317	Gene_expression of NFKBIA	5	0.45	2.97	1.96
167	INT56080	Transcription of NFKBIA	2	0.40	2.16	1.93
168	INT130208	Positive_regulation of Phosphorylation of JUN	4	0.38	3.07	1.92
169	INT56078	Negative_regulation of Protein_catabolism of NFKB1	7	0.42	4.44	1.83
170	INT117221	Positive_regulation of Gene_expression of NOD2	7	0.65	4.39	1.83
171	INT118683	Regulation of Phosphorylation of MAPK3	3	0.44	2.92	1.82
172	INT109921	Phosphorylation of MAPK9	9	0.67	5.07	1.81
173	INT27881	Binding of HSPD1	10	0.31	9.2	1.78
174	INT162793	Regulation of NOD2	6	0.45	7.61	1.78
175	INT119422	Negative_regulation of Phosphorylation of MAP2K6	3	0.38	2.09	1.76
176	INT76608	Regulation of Negative_regulation of NFKB1	1	0.33	0.53	1.75
177	INT55169	Binding of RELA	40	0.36	4.91	1.74
178	INT228195	Negative_regulation of Gene_expression of Tlr2	14	0.40	12.17	1.74
179	INT108875	Positive_regulation of Localization of RELA	9	0.49	1.43	1.72
180	INT221433	Binding of NFKB2	6	0.11	4.74	1.7
181	INT126236	Positive_regulation of Positive_regulation of NFKBIA	4	0.46	2.18	1.69
182	INT71788	Gene_expression of MAP3K1	13	0.70	4.9	1.66
183	INT165446	Positive_regulation of Phosphorylation of NFKB1	3	0.56	1.88	1.66
184	INT87282	Regulation of MAPK3	9	0.60	7.61	1.65
185	INT233975	Positive_regulation of Gene_expression of Myd88	7	0.66	4.17	1.65
186	INT188584	Positive_regulation of Positive_regulation of TLR4	8	0.65	5.98	1.64
187	INT173173	Regulation of Positive_regulation of MAPK14	6	0.38	2.59	1.64
188	INT132890	Positive_regulation of Binding of CHUK	1	0.00	0.44	1.6
189	INT157769	Binding of LY96	8	0.47	2.5	1.59
190	INT69917	Negative_regulation of CREB1	8	0.58	2.28	1.59
191	INT175307	Regulation of Gene_expression of TLR2	9	0.56	7.08	1.58
192	INT132891	Gene_expression of CHUK	1	0.01	0.47	1.58
193	INT182297	Positive_regulation of Phosphorylation of MAPK14	7	0.42	3.36	1.53
194	INT47972	Positive_regulation of Protein_catabolism of NFKBIA	5	0.46	2.09	1.53
195	INT130019	Regulation of Phosphorylation of MAPK1	6	0.49	3.6	1.5
196	INT171029	Positive_regulation of Transcription of JUN	4	0.14	2.87	1.48
197	INT109916	Positive_regulation of Positive_regulation of MAP2K6	2	0.45	2.28	1.45
198	INT157362	Negative_regulation of MAPK9	7	0.35	4.27	1.44
199	INT173654	Localization of MAPK14	12	0.62	3.16	1.43
200	INT34912	Regulation of IKBKG	5	0.08	2.41	1.42