GO:0003326

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Name pancreatic A cell fate commitment
Categary Process
Go Slim No
Go Link GO:0003326
Unique Molecular Interactions 37
Total Molecular Interactions 42
Total Single Events 322
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for pancreatic A cell fate commitment. They are ordered first by their pain relevance and then by number of times they were reported for pancreatic A cell fate commitment. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56499 Neurod1 Positive_regulation of Maoa 1 0.47 0 0.8
2 INT111194 Binding of NEUROD1 and Pck1 1 0.39 0 0.75
3 INT81769 Binding of Chrna4 and Neurod1 1 0.35 0.07 0.69
4 INT154263 NEUROD1 Positive_regulation of Gene_expression of GAL 1 0.50 0.06 0.63
5 INT119745 NEUROD1 Regulation of Gene_expression of BHLHE22 1 0.11 0.26 0.53
6 INT95042 Binding of NEUROD1 and Olr1246 1 0.02 0.23 0.51
7 INT162499 Binding of AHR and NEUROD1 3 0.25 0.19 0.49
8 INT171185 Binding of NEUROD1 and ACOT1 1 0.01 0.37 0.42
9 INT70010 Binding of Neurod1 and Insrr 1 0.01 0.11 0.37
10 INT298277 Pou4f1 Negative_regulation of Gene_expression of Neurod1 1 0.58 0.48 0.27
11 INT167488 Binding of NEUROD1 and GGNBP2 1 0.08 0 0.27
12 INT68298 Binding of Neurod1 and Abt1 1 0.24 0 0.26
13 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25
14 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
15 INT70661 Binding of Hrasls and Nkx2-2 1 0.02 0 0.24
16 INT203527 Pou4f1 Negative_regulation of Neurod1 1 0.32 0.54 0.2
17 INT18966 TNF Positive_regulation of NEUROD1 1 0.53 0.83 0.2
18 INT244054 Prkaca Regulation of Neurod1 1 0.02 0.06 0.19
19 INT10731 NEUROD1 Regulation of CD4 1 0.42 1.3 0.12
20 INT10732 NEUROD1 Regulation of CD9 1 0.49 1.29 0.12
21 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
22 INT139558 Chrna4 Regulation of Neurod1 1 0.17 0 0.1
23 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
24 INT297548 Neurod1 Regulation of Hes1 1 0.05 0.2 0.1
25 INT171188 Positive_regulation of Binding of NEUROD1 and TNIP1 1 0.08 0 0.1
26 INT139557 Chrna4 Regulation of Gene_expression of Neurod1 1 0.17 0 0.1
27 INT171184 Binding of NEUROD1 and TNIP1 1 0.06 0 0.1
28 INT244018 Binding of Neurod1 and Trak2 1 0.01 0 0.04
29 INT249898 Binding of Neurod1 and Olig2 1 0.09 0.14 0.03
30 INT314863 Binding of Neurod1 and Atoh7 1 0.18 0.27 0
31 INT197309 Ascl1 Regulation of Neurod1 1 0.01 0.13 0
32 INT197313 Atoh1 Regulation of Neurod1 1 0.01 0.13 0
33 INT314851 Positive_regulation of Binding of Neurod1 and Atoh7 1 0.23 0.27 0
34 INT240011 Ass1 Positive_regulation of Gene_expression of Nkx2-2 1 0.00 0 0
35 INT314864 Binding of Neurod1 and Positive_regulation of Gene_expression of Atoh7 1 0.25 0.27 0
36 INT283716 Neurod1 Positive_regulation of Pax6 1 0.23 0.46 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for pancreatic A cell fate commitment. They are ordered first by their pain relevance and then by number of times they were reported in pancreatic A cell fate commitment. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT13409 Gene_expression of NEUROD1 52 0.75 14.17 12.23
2 INT6019 Positive_regulation of NEUROD1 37 0.67 17.3 8.89
3 INT64370 Gene_expression of Neurod1 22 0.75 5.19 7.1
4 INT6097 Negative_regulation of NEUROD1 30 0.57 9.71 6.24
5 INT6098 Binding of NEUROD1 17 0.47 3.4 5.99
6 INT48840 Gene_expression of Nkx2-2 8 0.23 1.55 5.44
7 INT15257 Positive_regulation of Nkx2-2 10 0.21 1.75 4.2
8 INT51180 Regulation of Nkx2-2 5 0.26 2.16 4.14
9 INT8600 Binding of Nkx2-2 6 0.10 0.87 3.82
10 INT20011 Regulation of NEUROD1 10 0.44 3.83 3.53
11 INT39856 Binding of Neurod1 8 0.47 1.44 2.88
12 INT82048 Positive_regulation of Neurod1 7 0.49 2.39 2.13
13 INT13999 Positive_regulation of Positive_regulation of NEUROD1 5 0.67 4.07 1.86
14 INT65602 Negative_regulation of Neurod1 7 0.42 2.52 1.55
15 INT112845 Negative_regulation of Binding of Nkx2-2 2 0.12 0.14 1.47
16 INT64371 Positive_regulation of Gene_expression of Neurod1 4 0.64 1.56 1.45
17 INT132081 Regulation of Gene_expression of Nkx2-2 2 0.10 0.24 1.43
18 INT27356 Localization of NEUROD1 8 0.78 3.44 1.39
19 INT18971 Positive_regulation of Gene_expression of NEUROD1 8 0.67 1.91 1.23
20 INT97369 Regulation of Gene_expression of NEUROD1 1 0.26 0.25 1.12
21 INT94210 Regulation of Neurod1 2 0.33 0.07 1.04
22 INT51906 Negative_regulation of Gene_expression of NEUROD1 4 0.57 1.56 0.91
23 INT52187 Regulation of Binding of NEUROD1 1 0.44 0 0.77
24 INT138396 Transcription of Nkx2-2 1 0.26 0.05 0.75
25 INT138395 Positive_regulation of Transcription of Nkx2-2 1 0.19 0.05 0.75
26 INT76845 Regulation of Gene_expression of Neurod1 2 0.44 0.28 0.44
27 INT154042 Localization of Neurod1 1 0.02 0.08 0.44
28 INT48503 Positive_regulation of Positive_regulation of Nkx2-2 1 0.15 0 0.42
29 INT60952 Negative_regulation of Regulation of NEUROD1 1 0.42 0.3 0.41
30 INT60953 Negative_regulation of Negative_regulation of NEUROD1 1 0.41 0.3 0.41
31 INT156490 Protein_catabolism of Neurod1 1 0.34 0.16 0.37
32 INT51266 Transcription of Neurod1 2 0.69 0.19 0.35
33 INT47995 Positive_regulation of Regulation of NEUROD1 1 0.45 0.68 0.34
34 INT24861 Regulation of Positive_regulation of NEUROD1 2 0.44 0.39 0.33
35 INT122619 Gene_expression of Nkx2-2 6 0.36 0.15 0.31
36 INT104311 Positive_regulation of Transcription of NEUROD1 1 0.49 0.28 0.29
37 INT104309 Transcription of NEUROD1 1 0.69 0.28 0.29
38 INT208497 Localization of Nkx2-2 1 0.01 0 0.26
39 INT82049 Negative_regulation of Positive_regulation of Neurod1 1 0.41 0.61 0.18
40 INT48771 Positive_regulation of Localization of NEUROD1 2 0.49 1.5 0.16
41 INT36311 Protein_catabolism of NEUROD1 1 0.86 0.51 0.09
42 INT117620 Regulation of Localization of NEUROD1 1 0.60 0.24 0.07
43 INT122620 Negative_regulation of Gene_expression of Nkx2-2 1 0.20 0 0.04
44 INT248201 Phosphorylation of Neurod1 1 0.28 0.07 0.04
45 INT143655 Transcription of Nkx2-2 1 0.58 0 0
46 INT143654 Positive_regulation of Transcription of Nkx2-2 1 0.56 0 0
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