GO:0003680

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Name AT DNA binding
Categary Function
Go Slim No
Go Link GO:0003680
Unique Molecular Interactions 106
Total Molecular Interactions 143
Total Single Events 997
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for AT DNA binding. They are ordered first by their pain relevance and then by number of times they were reported for AT DNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
2 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
3 INT168256 Binding of MLL and TNFRSF1B 1 0.00 1.2 0.53
4 INT321598 Binding of MLL and TNF 1 0.05 1.07 0.49
5 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
6 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
7 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
8 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
9 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
10 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
11 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
12 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
13 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
14 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
15 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
16 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
17 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
18 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
19 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
20 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29
21 INT185076 Bpifa2 Positive_regulation of Hand2 1 0.16 0.36 0.28
22 INT278209 Ciita Regulation of Hand2 1 0.36 1.53 0.28
23 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
24 INT278216 Ciita Regulation of Gene_expression of Hand2 1 0.36 1.53 0.28
25 INT246442 Hand2 Positive_regulation of Gene_expression of Cd79a 1 0.03 0.78 0.27
26 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
27 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26
28 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21
29 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
30 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2
31 INT338767 Positive_regulation of Binding of Hand1 and Hand2 1 0.07 0.5 0.2
32 INT226510 BTPs Negative_regulation of Hand2 1 0.03 0.22 0.2
33 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2
34 INT228737 Rae1 Negative_regulation of Hand2 1 0.08 1.07 0.19
35 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18
36 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18
37 INT181457 Binding of CCL16 and Hand2 1 0.04 0.92 0.17
38 INT294766 Cerk Regulation of Gene_expression of Hand2 1 0.13 0.32 0.15
39 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14
40 INT347015 Hand2 Regulation of Cd86 1 0.06 0 0.14
41 INT294764 Binding of Hand2 and Cerk 1 0.17 0.31 0.14
42 INT235546 Stat6 Positive_regulation of Positive_regulation of Hand2 1 0.02 0.9 0.14
43 INT347018 Cd80 Regulation of Hand2 1 0.03 0.05 0.13
44 INT347007 Cd86 Regulation of Hand2 1 0.06 0.05 0.13
45 INT223535 Binding of HAND1 and Pax6 1 0.33 0.92 0.13
46 INT223526 Binding of Pax6 and Tcf3 1 0.33 0.92 0.13
47 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
48 INT294760 Cerk Positive_regulation of Hand2 1 0.23 0.16 0.12
49 INT253077 Prok2 Regulation of Gene_expression of Hand2 1 0.10 0.11 0.12
50 INT294758 Regulation of Cerk Positive_regulation of Hand2 1 0.21 0.16 0.12
51 INT228746 Hspa9 Negative_regulation of Positive_regulation of Hand2 1 0.11 0.31 0.11
52 INT228760 Rae1 Negative_regulation of Positive_regulation of Hand2 1 0.08 0.31 0.11
53 INT175463 Sftpd Negative_regulation of Gene_expression of Hand2 1 0.17 0.96 0.11
54 INT232653 Binding of CD2 and MLL 1 0.02 0.27 0.1
55 INT215461 Binding of MLL and TNFSF13B 1 0.01 1.62 0.1
56 INT263495 Hand1 Regulation of Localization of Hand2 1 0.12 0.5 0.09
57 INT263496 Hand2 Regulation of Localization of Hand1 1 0.12 0.5 0.09
58 INT201349 Binding of Hand2 and Il4 1 0.17 0.67 0.09
59 INT238628 Mef2c Regulation of Gene_expression of Arc 1 0.09 0.16 0.08
60 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
61 INT286298 Binding of Hand2 and Negative_regulation of Gene_expression of Il12a 1 0.07 0.3 0.07
62 INT156144 MLL Positive_regulation of Epcam 1 0.00 0.47 0.06
63 INT156143 MLL Positive_regulation of PECAM1 1 0.00 0.47 0.06
64 INT278454 CSF2 Regulation of Hand2 1 0.02 0.66 0.05
65 INT278208 Ciita Negative_regulation of Gene_expression of Hand2 1 0.34 0.7 0.05
66 INT347020 Hand2 Regulation of Gene_expression of Cd86 1 0.08 0.19 0.04
67 INT170328 Gene_expression of Ido1 Positive_regulation of Hmga2 1 0.01 0.13 0.04
68 INT347009 Hand2 Regulation of Gene_expression of Il4 1 0.01 0.19 0.04
69 INT290437 Gene_expression of Mef2c Negative_regulation of Upf1 1 0.02 0.25 0.03
70 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
71 INT305845 Polk Positive_regulation of Regulation of Hand2 1 0.08 0.34 0
72 INT350706 Binding of Mef2c and Mir223 1 0.02 0.11 0
73 INT290439 Negative_regulation of Mef2c Positive_regulation of Gene_expression of Ppargc1a 1 0.21 0 0
74 INT184137 Binding of Socs5 and Regulation of Hand2 1 0.09 1.01 0
75 INT196959 Hmga2 Positive_regulation of Localization of E2f1 1 0.54 0.24 0
76 INT290441 Mef2c Regulation of Mef2b 1 0.09 0.11 0
77 INT297213 Myoz1 Regulation of Mef2c 1 0.02 0.09 0
78 INT196940 Positive_regulation of Hmga2 Positive_regulation of E2f1 1 0.50 0.47 0
79 INT290438 Mef2c Regulation of Mef2a 1 0.26 0.11 0
80 INT185271 Pax6 Regulation of Psmd1 1 0.02 0 0
81 INT196961 Binding of Hmga2 and Rb1 1 0.48 6.47 0
82 INT217151 Gene_expression of MIR98 Negative_regulation of HMGA2 1 0.24 1.08 0
83 INT268600 Mirlet7a-1 Regulation of HMGA2 1 0.01 0.72 0
84 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
85 INT196947 Binding of Rb1 and Positive_regulation of Hmga2 1 0.50 0.3 0
86 INT196951 Hmga2 Positive_regulation of E2f1 1 0.50 0.98 0
87 INT196942 Binding of E2f1 and Hmga2 1 0.39 0.87 0
88 INT305847 Polk Positive_regulation of Hand2 1 0.09 0.34 0
89 INT217142 MIR98 Regulation of Gene_expression of HMGA2 1 0.40 2.22 0
90 INT227843 Binding of ERCC6 and MLL 1 0.00 0.34 0
91 INT196953 Hmga2 Negative_regulation of Rb1 1 0.59 0.35 0
92 INT277611 Binding of Mef2c and Hdac4 1 0.34 1.12 0
93 INT283716 Neurod1 Positive_regulation of Pax6 1 0.23 0.46 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for AT DNA binding. They are ordered first by their pain relevance and then by number of times they were reported in AT DNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
2 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
3 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
4 INT173505 Localization of Hand2 63 0.57 45.32 13.66
5 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
6 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
7 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
8 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
9 INT156131 Binding of Hand2 14 0.25 10.35 3.99
10 INT66347 Gene_expression of MLL 29 0.65 14.82 3.18
11 INT34977 Gene_expression of Hmga2 11 0.76 12.39 3.07
12 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
13 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
14 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
15 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
16 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
17 INT34978 Negative_regulation of Gene_expression of Hmga2 2 0.42 1.53 0.95
18 INT277586 Negative_regulation of Mef2c 36 0.59 11.03 0.86
19 INT112014 Negative_regulation of Regulation of Hand2 3 0.34 2.07 0.86
20 INT202361 Gene_expression of Mef2c 28 0.78 5.53 0.67
21 INT271488 Negative_regulation of Negative_regulation of Hand2 3 0.18 2.36 0.67
22 INT88987 Gene_expression of HMGA2 8 0.77 10.46 0.64
23 INT132588 Positive_regulation of Negative_regulation of Hand2 1 0.03 0.47 0.58
24 INT139312 Negative_regulation of Gene_expression of MLL 2 0.00 1.22 0.56
25 INT168257 Binding of MLL 4 0.02 4.25 0.53
26 INT88170 Positive_regulation of HMGA2 2 0.69 2 0.48
27 INT78201 Regulation of MLL 2 0.02 0.79 0.48
28 INT325217 Regulation of Positive_regulation of Hand2 1 0.21 0.32 0.41
29 INT194745 Regulation of Regulation of Hand2 1 0.03 0.95 0.39
30 INT226424 Negative_regulation of Transcription of Hand2 1 0.08 0.66 0.37
31 INT88167 Negative_regulation of Positive_regulation of HMGA2 1 0.41 0.16 0.35
32 INT238560 Regulation of Mef2c 9 0.45 2.12 0.33
33 INT232656 Localization of MLL 2 0.05 2.33 0.29
34 INT88988 Positive_regulation of Gene_expression of HMGA2 1 0.69 4.05 0.29
35 INT196937 Positive_regulation of Hmga2 3 0.68 2.47 0.28
36 INT226394 Regulation of Phosphorylation of Hand2 1 0.05 0.97 0.28
37 INT100671 Positive_regulation of Transcription of Hand2 2 0.36 0.81 0.23
38 INT226390 Phosphorylation of Hand2 1 0.14 0.85 0.22
39 INT202355 Transcription of Mef2c 3 0.69 0.6 0.21
40 INT263492 Positive_regulation of Regulation of Hand2 3 0.19 4.76 0.21
41 INT227872 Positive_regulation of MLL 7 0.01 2.44 0.19
42 INT248543 Positive_regulation of Mef2c 7 0.69 2.82 0.18
43 INT284888 Regulation of Transcription of Hand2 1 0.16 0.32 0.18
44 INT185254 Gene_expression of Pax6 14 0.72 1.77 0.16
45 INT277602 Binding of Mef2c 10 0.39 4.35 0.16
46 INT170298 Regulation of Gene_expression of Hmga2 1 0.01 0.48 0.08
47 INT290404 Positive_regulation of Negative_regulation of Mef2c 1 0.50 0.72 0.08
48 INT277578 Regulation of Negative_regulation of Mef2c 2 0.45 1.17 0.07
49 INT88990 Binding of HMGA2 1 0.48 0.95 0.07
50 INT170300 Positive_regulation of Gene_expression of Hmga2 2 0.68 4.51 0.06
51 INT170302 Regulation of Hmga2 2 0.44 0.94 0.06
52 INT290417 Positive_regulation of Gene_expression of Mef2c 1 0.50 1.25 0.06
53 INT290407 Positive_regulation of Binding of Mef2c 1 0.44 0.93 0.04
54 INT206481 Transcription of Pax6 2 0.41 0.19 0.03
55 INT192401 Positive_regulation of Binding of Hand2 1 0.08 0 0.03
56 INT336419 Negative_regulation of Gene_expression of Pax6 1 0.45 0.12 0.03
57 INT290419 Regulation of Gene_expression of Mef2c 1 0.62 0.41 0.03
58 INT290399 Negative_regulation of Gene_expression of Mef2c 1 0.59 0.59 0.03
59 INT76371 Protein_catabolism of Hmga2 1 0.02 0.06 0.03
60 INT291889 Negative_regulation of Pax6 2 0.45 0.39 0
61 INT196931 Phosphorylation of Hmga2 1 0.80 0.4 0
62 INT290400 Regulation of Regulation of Mef2c 1 0.45 0.24 0
63 INT196923 Binding of Hmga2 1 0.47 2.5 0
64 INT300344 Localization of HMGA2 1 0.42 1.75 0
65 INT217195 Negative_regulation of HMGA2 1 0.55 3.54 0
66 INT324196 Positive_regulation of Gene_expression of Pax6 1 0.36 0 0
67 INT291888 Regulation of Gene_expression of Pax6 1 0.33 0 0
68 INT290429 Negative_regulation of Negative_regulation of Mef2c 1 0.37 0.05 0
69 INT290425 Negative_regulation of Binding of Mef2c 1 0.37 0 0
70 INT336416 Binding of Pax6 1 0.28 0 0
71 INT196932 Negative_regulation of Binding of Hmga2 1 0.42 0.24 0
72 INT196938 Negative_regulation of Hmga2 1 0.42 0.23 0
73 INT290409 Negative_regulation of Transcription of Mef2c 1 0.43 0.08 0
74 INT268581 Regulation of HMGA2 1 0.18 0.72 0
75 INT341085 Positive_regulation of Positive_regulation of MLL 1 0.01 0.15 0
76 INT336420 Positive_regulation of Binding of Pax6 1 0.38 0 0
77 INT217225 Negative_regulation of Negative_regulation of HMGA2 1 0.55 2.4 0
78 INT291885 Regulation of Pax6 1 0.15 0 0
79 INT196921 Localization of Hmga2 1 0.74 0.44 0
80 INT200852 Positive_regulation of Pax6 1 0.11 0 0
81 INT208927 Localization of Pax6 1 0.11 0 0
82 INT277587 Localization of Mef2c 1 0.65 0.43 0
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