GO:0003755

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Name peptidyl-prolyl cis-trans isomerase activity
Categary Function
Go Slim No
Go Link GO:0003755
Unique Molecular Interactions 124
Total Molecular Interactions 153
Total Single Events 852
Pain Genes Associated 22

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for peptidyl-prolyl cis-trans isomerase activity. They are ordered first by their pain relevance and then by number of times they were reported for peptidyl-prolyl cis-trans isomerase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT187175 Binding of BSG and PPIA 1 0.14 2.23 1.64
2 INT228681 Fkbp4 Negative_regulation of Trib3 1 0.00 0.57 1.2
3 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
4 INT161512 Ppig Negative_regulation of Positive_regulation of S100a8 1 0.02 0.23 1.12
5 INT252602 Binding of Cxcl10 and Ppig 1 0.08 1.55 0.96
6 INT90959 PPIG Regulation of CYP2C9 1 0.43 0 0.75
7 INT252603 Ppig Positive_regulation of Gene_expression of Cx3cl1 1 0.10 1.8 0.69
8 INT252605 Ppig Positive_regulation of Gene_expression of Cx3cr1 1 0.09 1.81 0.69
9 INT77098 Nlrp1a Negative_regulation of Positive_regulation of Ppig 1 0.47 0.68 0.53
10 INT92802 Binding of PPIG and GRHPR 1 0.03 0.11 0.47
11 INT115914 AHR Regulation of Gene_expression of PPIG 1 0.25 0.36 0.44
12 INT326303 Binding of CRP and FKBP4 1 0.15 1.22 0.41
13 INT304340 FKBP5 Regulation of NR3C1 1 0.05 0.71 0.37
14 INT202810 Pin1 Regulation of Csf2 1 0.03 0.82 0.36
15 INT202808 Binding of Pin1 and Hnrpd 1 0.08 0.84 0.22
16 INT252600 Ppig Regulation of Hand1 1 0.06 0.43 0.17
17 INT198523 Ranbp2 Negative_regulation of Cox11 1 0.42 0 0.17
18 INT198540 Ranbp2 Negative_regulation of HK1 1 0.19 0 0.17
19 INT252598 Ppig Regulation of Gene_expression of Hand1 1 0.06 0.43 0.17
20 INT56010 Binding of FN1 and FKBPL 1 0.00 0.54 0.15
21 INT202813 Pin1 Positive_regulation of Regulation of TH1L 1 0.50 0 0.14
22 INT262289 Regulation of Binding of PPIG and CC2D1A 1 0.01 1.52 0.13
23 INT262290 Binding of PPIG and CC2D1A 1 0.01 1.52 0.13
24 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12
25 INT198525 Binding of Kif5b and Ranbp2 1 0.23 0 0.1
26 INT317032 Binding of Caml and Ppib 1 0.06 0.08 0.09
27 INT231561 Binding of CYP2A and PPIG 1 0.06 0 0.09
28 INT202807 Pin1 Regulation of Binding of Hnrpd 1 0.06 0.14 0.08
29 INT218672 Binding of Ppib and Olr811 1 0.00 0.46 0.08
30 INT166732 BATF Negative_regulation of PPIA 1 0.05 1.45 0.06
31 INT166734 BATF Negative_regulation of PPIL1 1 0.04 1.45 0.06
32 INT262209 Positive_regulation of Nr1i2 Positive_regulation of Transcription of Ppig 1 0.03 0 0.06
33 INT293360 Binding of CSH1 and FKBP1A 1 0.00 0.14 0.05
34 INT218668 Binding of Ppia and Olr811 1 0.00 0.98 0.05
35 INT207760 Fkbp1a Regulation of MSMB 1 0.12 0.69 0.04
36 INT198533 Ranbp2 Regulation of HK1 1 0.12 0.06 0.04
37 INT252801 PPP2R4 Regulation of Positive_regulation of CREB1 1 0.01 2.71 0.04
38 INT252780 Positive_regulation of CREB1 Positive_regulation of PPP2R4 1 0.01 2.71 0.04
39 INT252818 PPP2R4 Regulation of Positive_regulation of DDIT3 1 0.04 3.07 0.04
40 INT198537 Binding of HK1 and Ranbp2 1 0.22 0.05 0.04
41 INT199406 Binding of CYP3A4 and PPIB 1 0.40 0 0.04
42 INT198524 Cox11 Negative_regulation of Ranbp2 1 0.19 0.08 0.04
43 INT293367 Binding of CABIN1 and Ppia 1 0.00 0.19 0.03
44 INT293358 Binding of FKBP1A and CABIN1 1 0.00 0.07 0.03
45 INT293368 Binding of CSH1 and Ppia 1 0.00 0.19 0.03
46 INT221243 Binding of Hspa9 and Ppif 1 0.01 0.67 0.03
47 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
48 INT293355 Binding of Fkbp1a and CABIN1 1 0.00 0.12 0
49 INT198541 Ranbp2 Positive_regulation of Binding of HK1 1 0.22 0 0
50 INT273116 Binding of Fkbp1a and Mtor 1 0.37 0 0
51 INT307155 Char1 Regulation of Ppig 1 0.00 0.92 0
52 INT340914 Binding of Hsp90aa1 and Fkbp6 1 0.12 0.26 0
53 INT219503 Binding of AHR and Ppib 1 0.27 0 0
54 INT307160 Regulation of Binding of Cyp2a5 and Ppig 1 0.05 1.22 0
55 INT307159 Cyp2a5 Regulation of Ppig 1 0.03 0.91 0
56 INT198527 Binding of Ranbp2 and Cox11 1 0.47 0 0
57 INT293357 RORC Regulation of PPP2R4 1 0.00 0 0
58 INT293354 Binding of CSH1 and Fkbp1a 1 0.00 0.12 0
59 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
60 INT340919 Binding of Fkbp8 and Ptplad1 1 0.14 0.17 0
61 INT262288 CC2D1A Regulation of PPIG 1 0.00 1.39 0
62 INT340913 Fkbp6 Negative_regulation of Binding of Hsp90aa1 1 0.14 0.26 0
63 INT219505 ARNT Positive_regulation of Positive_regulation of Ppib 1 0.50 0 0
64 INT265234 Binding of FKBP1A and SGCG 1 0.03 0.35 0
65 INT293366 Binding of CABIN1 and Fkbp1a 1 0.00 0.05 0
66 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
67 INT174205 PPIG Positive_regulation of CPA1 1 0.01 0.33 0
68 INT271999 Binding of Fkbp1a and Positive_regulation of Negative_regulation of Mtor 1 0.00 0.18 0
69 INT198526 Ranbp2 Positive_regulation of Hk1 1 0.51 0 0
70 INT190681 Binding of Bcl2 and Fkbp1a 1 0.01 0.46 0
71 INT271994 Binding of Fkbp1a and Mtor 1 0.00 0.22 0
72 INT307158 Binding of Cyp2a5 and Ppig 1 0.04 1.22 0
73 INT198529 Ranbp2 Positive_regulation of Cox11 1 0.68 0 0
74 INT219504 AHR Regulation of Gene_expression of Ppib 1 0.21 1.12 0
75 INT351095 Binding of FKBP1A and RPS6KB1 1 0.24 0.36 0
76 INT351101 Negative_regulation of Binding of FKBP1A and RPS6KB1 1 0.27 0.36 0
77 INT219502 TSPO Positive_regulation of Positive_regulation of Ppib 1 0.01 0 0
78 INT260264 Binding of MTOR and FKBP7 1 0.26 0.87 0
79 INT351096 Binding of FKBP1A and MTOR 1 0.28 1.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for peptidyl-prolyl cis-trans isomerase activity. They are ordered first by their pain relevance and then by number of times they were reported in peptidyl-prolyl cis-trans isomerase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54
2 INT60764 Positive_regulation of PPIG 39 0.67 17.08 13.48
3 INT50580 Binding of PPIG 39 0.36 11.17 12.34
4 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93
5 INT127037 Gene_expression of Ppig 26 0.65 16.08 6.84
6 INT77076 Positive_regulation of Ppig 16 0.49 13.54 5.91
7 INT60575 Binding of Fkbp1a 9 0.26 2.09 4.46
8 INT50581 Regulation of PPIG 26 0.55 8.96 4.32
9 INT127039 Negative_regulation of Ppig 13 0.21 5.29 3.87
10 INT198495 Gene_expression of Ranbp2 1 0.78 3.31 3.14
11 INT202792 Negative_regulation of Pin1 1 0.56 3.77 2.37
12 INT149975 Negative_regulation of Ppif 1 0.41 0.44 2.36
13 INT217253 Positive_regulation of Positive_regulation of PPIG 2 0.08 0.55 2.33
14 INT228675 Binding of Fkbp4 1 0.01 1.14 2.28
15 INT104220 Positive_regulation of Gene_expression of PPIG 14 0.49 7.38 1.7
16 INT112418 Gene_expression of FKBP5 3 0.43 1.97 1.62
17 INT112420 Negative_regulation of Gene_expression of FKBP5 1 0.16 0.85 1.42
18 INT114822 Negative_regulation of PPP2R4 2 0.57 1.89 1.28
19 INT252582 Positive_regulation of Gene_expression of Ppig 3 0.12 2.62 1.13
20 INT142777 Phosphorylation of PPP2R4 2 0.61 1.03 1.07
21 INT142776 Positive_regulation of Phosphorylation of PPP2R4 1 0.45 1.04 1.07
22 INT187188 Binding of PPIA 3 0.47 1.1 1.01
23 INT24809 Positive_regulation of Fkbp4 3 0.40 1.57 1
24 INT106023 Localization of PPIG 8 0.57 4.08 0.96
25 INT230251 Binding of FKBP1A 6 0.28 2.24 0.94
26 INT163995 Negative_regulation of Gene_expression of Ppig 4 0.24 2.07 0.89
27 INT22698 Regulation of Ppia 2 0.15 0.09 0.88
28 INT202790 Binding of Pin1 1 0.46 3.02 0.88
29 INT202786 Regulation of Pin1 1 0.43 2.16 0.83
30 INT198501 Negative_regulation of Ranbp2 1 0.43 0.92 0.78
31 INT6157 Positive_regulation of Ppia 4 0.68 1.24 0.75
32 INT83246 Regulation of Positive_regulation of PPIG 1 0.44 1.61 0.72
33 INT100542 Regulation of Ppig 6 0.17 11.78 0.69
34 INT157849 Negative_regulation of FKBP5 1 0.32 1.72 0.69
35 INT66461 Binding of Ppia 2 0.21 1.44 0.68
36 INT202806 Gene_expression of Pin1 1 0.74 1.87 0.66
37 INT16022 Gene_expression of Ppia 4 0.66 0.43 0.64
38 INT196866 Localization of Ppig 2 0.17 0.58 0.64
39 INT304344 Positive_regulation of FKBP5 1 0.41 1.36 0.64
40 INT117899 Positive_regulation of Protein_catabolism of PPIG 1 0.21 0 0.63
41 INT103782 Binding of Ppig 5 0.12 2.57 0.58
42 INT198506 Negative_regulation of Gene_expression of Ranbp2 1 0.43 0.63 0.54
43 INT121100 Positive_regulation of Binding of PPIG 2 0.49 0.08 0.53
44 INT157848 Regulation of FKBP5 1 0.34 1.74 0.53
45 INT202801 Positive_regulation of Pin1 1 0.67 1.37 0.52
46 INT87094 Protein_catabolism of PPIG 2 0.55 0 0.51
47 INT164518 Gene_expression of PPIA 7 0.75 3.92 0.5
48 INT279363 Binding of FKBP4 1 0.05 0.22 0.49
49 INT120235 Negative_regulation of Gene_expression of PPIG 4 0.41 0.92 0.43
50 INT307141 Regulation of Gene_expression of Ppig 3 0.08 1.84 0.43
51 INT202805 Negative_regulation of Negative_regulation of Pin1 1 0.41 0.77 0.43
52 INT198505 Positive_regulation of Gene_expression of Ranbp2 1 0.50 0.49 0.42
53 INT208895 Gene_expression of PPIL1 1 0.09 0.37 0.38
54 INT187184 Localization of PPIA 1 0.27 0.64 0.37
55 INT83287 Regulation of Gene_expression of PPIG 4 0.46 1.74 0.36
56 INT198494 Regulation of Ranbp2 1 0.45 0.16 0.35
57 INT207064 Gene_expression of Fkbp1a 2 0.32 1.52 0.34
58 INT252595 Regulation of Negative_regulation of Ppig 1 0.12 0.78 0.34
59 INT252581 Positive_regulation of Positive_regulation of Ppig 1 0.11 1.26 0.34
60 INT157850 Positive_regulation of Negative_regulation of FKBP5 1 0.37 0.87 0.34
61 INT304343 Positive_regulation of Positive_regulation of FKBP5 1 0.41 0.68 0.33
62 INT207065 Localization of Fkbp1a 1 0.36 0.82 0.33
63 INT190676 Binding of Fkbp1a 15 0.36 3.11 0.28
64 INT202802 Regulation of Fkbp1a 4 0.26 0.96 0.28
65 INT202812 Phosphorylation of PPIL1 1 0.02 0.61 0.28
66 INT202811 Binding of PPIL1 1 0.02 0.61 0.28
67 INT202791 Phosphorylation of Pin1 1 0.78 0.61 0.28
68 INT115923 Negative_regulation of Positive_regulation of PPIG 1 0.22 0.18 0.27
69 INT6158 Transcription of Ppia 2 0.70 0.35 0.22
70 INT202789 Positive_regulation of Gene_expression of Pin1 1 0.67 0.62 0.22
71 INT198478 Binding of Ranbp2 1 0.48 0.54 0.21
72 INT198483 Localization of Ranbp2 1 0.75 0 0.21
73 INT164519 Gene_expression of FKBP1A 2 0.39 0.22 0.19
74 INT307151 Negative_regulation of Positive_regulation of Ppig 1 0.07 1.02 0.19
75 INT307138 Positive_regulation of Negative_regulation of Ppig 2 0.06 1.01 0.18
76 INT93575 Regulation of Binding of PPIG 1 0.44 0.15 0.18
77 INT252583 Positive_regulation of Binding of Ppig 1 0.12 0.46 0.16
78 INT202796 Regulation of Negative_regulation of Pin1 1 0.59 0.23 0.15
79 INT202797 Negative_regulation of Binding of Pin1 1 0.41 0.74 0.15
80 INT166737 Positive_regulation of Gene_expression of PPIA 1 0.68 2.5 0.15
81 INT307142 Regulation of Positive_regulation of Ppig 1 0.03 0.98 0.15
82 INT218689 Binding of Ppib 1 0.04 1.33 0.15
83 INT78375 Localization of PPP2R4 1 0.73 0.43 0.14
84 INT293345 Negative_regulation of Binding of FKBP1A 1 0.02 0.19 0.13
85 INT56013 Binding of FKBPL 1 0.00 0.54 0.12
86 INT198488 Positive_regulation of Ranbp2 1 0.44 0.27 0.12
87 INT327446 Positive_regulation of Localization of PPIG 1 0.07 0.3 0.12
88 INT198489 Regulation of Gene_expression of Ranbp2 1 0.45 0.33 0.12
89 INT217251 Transcription of PPIG 2 0.11 0 0.11
90 INT202794 Negative_regulation of Protein_catabolism of Pin1 1 0.41 0.15 0.11
91 INT198490 Positive_regulation of Localization of Ranbp2 1 0.50 0 0.11
92 INT202793 Protein_catabolism of Pin1 1 0.63 0.15 0.11
93 INT299319 Localization of FKBP1A 1 0.44 0 0.09
94 INT330998 Negative_regulation of Binding of PPIG 2 0.06 0.1 0.08
95 INT331004 Positive_regulation of Negative_regulation of PPIG 1 0.08 0 0.08
96 INT307154 Negative_regulation of Negative_regulation of Ppig 1 0.06 0.47 0.08
97 INT355751 Positive_regulation of Transcription of PPIG 1 0.02 0 0.08
98 INT199785 Transcription of Ppig 2 0.15 0.6 0.06
99 INT166739 Positive_regulation of PPIA 1 0.45 1.39 0.06
100 INT262035 Positive_regulation of Transcription of Ppig 1 0.03 0.05 0.06
101 INT197045 Gene_expression of PPIB 6 0.70 2.32 0.05
102 INT299313 Positive_regulation of Gene_expression of FKBP1A 1 0.29 0 0.05
103 INT198493 Protein_catabolism of Ranbp2 1 0.88 0.12 0.05
104 INT198500 Positive_regulation of Protein_catabolism of Ranbp2 1 0.50 0.12 0.05
105 INT331765 Protein_catabolism of Ppig 1 0.13 0.06 0.03
106 INT217255 Regulation of Transcription of PPIG 1 0.07 0 0.03
107 INT199412 Positive_regulation of PPIB 2 0.49 0.09 0
108 INT340871 Binding of Fkbp6 1 0.21 0.13 0
109 INT332156 Positive_regulation of Ppib 1 0.05 0.3 0
110 INT260277 Gene_expression of FKBP7 1 0.55 0.14 0
111 INT166736 Negative_regulation of PPIL1 1 0.37 1.2 0
112 INT293342 Regulation of PPP2R4 1 0.03 0 0
113 INT290522 Regulation of PPIA 1 0.04 0.18 0
114 INT217254 Binding of PPIB 1 0.36 0 0
115 INT346431 Positive_regulation of Regulation of PPIG 1 0.01 0.17 0
116 INT291075 Regulation of Gene_expression of PPIA 1 0.31 0.35 0
117 INT219501 Positive_regulation of Ppib 1 0.67 0 0
118 INT235550 Regulation of Ppif 1 0.10 0.09 0
119 INT199782 Regulation of Ppib 1 0.26 0.44 0
120 INT260283 Binding of FKBP7 1 0.34 0 0
121 INT217250 Negative_regulation of Positive_regulation of PPIB 1 0.41 0 0
122 INT340903 Gene_expression of Fkbp6 1 0.43 0.13 0
123 INT199411 Negative_regulation of Negative_regulation of PPIG 1 0.07 0.08 0
124 INT208897 Regulation of PPIL1 1 0.03 0 0
125 INT322320 Transcription of PPIA 1 0.30 0.67 0
126 INT199766 Gene_expression of Ppib 1 0.75 1.71 0
127 INT199781 Regulation of Regulation of Ppig 1 0.07 1.14 0
128 INT219500 Gene_expression of Ppib 1 0.58 0.56 0
129 INT166738 Negative_regulation of PPIA 1 0.42 1.2 0
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