GO:0003845

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Name 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
Categary Function
Go Slim No
Go Link GO:0003845
Unique Molecular Interactions 72
Total Molecular Interactions 94
Total Single Events 995
Pain Genes Associated 2

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity. They are ordered first by their pain relevance and then by number of times they were reported for 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT136141 Hsd11b1 Positive_regulation of Gene_expression of Agrp 1 0.64 0.2 0.47
2 INT273893 ARSA Positive_regulation of HSD11B1 1 0.00 0.61 0.4
3 INT122049 Binding of HSD11B1 and Lcat 1 0.21 0.83 0.31
4 INT136143 Positive_regulation of Binding of Agrp and Hsd11b1 1 0.43 0.56 0.3
5 INT136142 Binding of Agrp and Hsd11b1 1 0.33 0.56 0.3
6 INT226071 Binding of HSD11B1 and MMP9 1 0.09 0.47 0.19
7 INT155644 Binding of CAV1 and HSD11B1 1 0.39 0.77 0.15
8 INT156531 Binding of ABCA1 and HSD11B1 1 0.22 1.06 0.14
9 INT291622 HSD11B1 Regulation of CSTA 1 0.00 0.6 0.11
10 INT229986 Binding of CAMK4 and HSD11B1 1 0.01 1 0.1
11 INT300192 Gene_expression of APOA1 Positive_regulation of HSD11B1 1 0.16 1.08 0.08
12 INT262997 Binding of HSD11B1 and ADIPOQ 1 0.54 2.82 0.07
13 INT58648 Binding of HSD11B1 and INS 1 0.04 1.65 0.07
14 INT73794 Binding of HSD11B1 and Igfbp1 1 0.06 1.15 0.07
15 INT229291 BAS Positive_regulation of HSD11B1 1 0.09 0.22 0.06
16 INT79523 Binding of HSD11B1 and C9orf3 1 0.52 1.12 0.06
17 INT323056 LDLR Regulation of HSD11B1 1 0.01 1.2 0.05
18 INT231395 Binding of HSD11B1 and Apob 1 0.27 1.18 0.04
19 INT288853 Binding of HSD11B1 and LDLR 1 0.26 1.52 0.04
20 INT279899 Binding of HSD11B1 and USF1 1 0.31 0.79 0.04
21 INT288908 Apoa1 Positive_regulation of Gene_expression of HSD11B1 1 0.03 0.53 0.04
22 INT247439 Binding of APOA1 and HSD11B1 3 0.32 5.01 0.03
23 INT251963 Binding of HSD11B1 and LIPC 1 0.15 0.35 0.03
24 INT262994 Binding of CRP and HSD11B1 1 0.15 3.02 0.03
25 INT247442 Binding of HSD11B1 and SNRNP70 2 0.04 1.3 0
26 INT170210 Binding of CETP and HSD11B1 1 0.17 2.58 0
27 INT300191 Binding of C1S and HSD11B1 1 0.13 1.75 0
28 INT265954 Regulation of Binding of HSD11B1 and Clas4 1 0.00 0.87 0
29 INT213149 DAK Regulation of HSD11B1 1 0.00 1.42 0
30 INT265848 Binding of HSD11B1 and Cand1 1 0.40 0.85 0
31 INT297560 Binding of HSD11B1 and APOL1 1 0.04 0.88 0
32 INT326086 Binding of HSD11B1 and Abo 1 0.00 0.89 0
33 INT326997 HSD11B1 Negative_regulation of Hdl2 1 0.12 2.06 0
34 INT160520 Binding of HSD11B1 and Crp 1 0.02 0.29 0
35 INT170236 Lpl Regulation of HSD11B1 1 0.04 0.98 0
36 INT326061 Binding of HSD11B1 and LCAT 1 0.11 0.89 0
37 INT101943 Binding of CD40LG and HSD11B1 1 0.08 0.23 0
38 INT270759 Binding of HSD11B1 and TERT 1 0.07 1.67 0
39 INT197725 Negative_regulation of CETP Positive_regulation of Positive_regulation of HSD11B1 1 0.11 1.15 0
40 INT197726 Negative_regulation of CETP Positive_regulation of HSD11B1 1 0.11 0.76 0
41 INT170213 CETP Positive_regulation of Gene_expression of HSD11B1 1 0.21 1.49 0
42 INT251962 Binding of HSD11B1 and RS1 1 0.00 0.33 0
43 INT326980 HSD11B1 Negative_regulation of JPH3 1 0.03 2.05 0
44 INT170212 Gene_expression of PLTP Positive_regulation of HSD11B1 1 0.12 3.01 0
45 INT170214 PLTP Positive_regulation of HSD11B1 1 0.11 1.34 0
46 INT342584 Binding of HSD11B1 and Shbg 1 0.02 0.72 0
47 INT213146 TIMP1 Regulation of HSD11B1 1 0.02 0.7 0
48 INT170215 CETP Positive_regulation of HSD11B1 1 0.26 1.35 0
49 INT300194 HSD11B1 Negative_regulation of CHDH 1 0.08 2.19 0
50 INT343353 Binding of HSD11B1 and Egfl7 1 0.03 0.97 0
51 INT267974 APOB Negative_regulation of HSD11B1 1 0.01 0.75 0
52 INT250556 Binding of FGA and HSD11B1 1 0.33 0.57 0
53 INT297563 Binding of HSD11B1 and TBPL1 1 0.01 0.41 0
54 INT353062 HSD11B1 Regulation of Gene_expression of ADIPOQ 1 0.13 5.03 0
55 INT247437 Binding of HSD11B1 and SACM1L 1 0.01 0.98 0
56 INT265953 Binding of HSD11B1 and Clas4 1 0.00 0.87 0
57 INT170211 Binding of HSD11B1 and LPL 1 0.02 1.47 0
58 INT251965 Binding of HSD11B1 and FADS1 1 0.16 0.37 0
59 INT353061 HSD11B1 Regulation of Gene_expression of LEP 1 0.20 5.03 0
60 INT300196 Binding of HSD11B1 and CHDH 1 0.07 4.01 0
61 INT209986 Binding of HSD11B1 and SIGMAR1 1 0.00 0.1 0
62 INT300039 Binding of HSD11B1 and OLR1 1 0.01 1.56 0
63 INT342585 Binding of HSD11B1 and Dbp 1 0.05 0.42 0
64 INT265955 Clas4 Regulation of Negative_regulation of HSD11B1 1 0.00 1.14 0
65 INT250552 Binding of FGG and HSD11B1 1 0.25 0.57 0
66 INT301906 Binding of HMOX1 and HSD11B1 1 0.05 2.41 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity. They are ordered first by their pain relevance and then by number of times they were reported in 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36
2 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5
3 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52
4 INT17086 Binding of HSD11B1 84 0.47 122.28 6.16
5 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04
6 INT34585 Negative_regulation of Positive_regulation of HSD11B1 31 0.57 43.54 2.47
7 INT41986 Positive_regulation of Gene_expression of HSD11B1 26 0.49 32.84 1.52
8 INT8667 Localization of HSD11B1 22 0.73 22.74 1.25
9 INT34586 Positive_regulation of Negative_regulation of HSD11B1 6 0.49 4.39 1.05
10 INT136140 Positive_regulation of Hsd11b1 1 0.60 1.35 0.79
11 INT60151 Positive_regulation of Positive_regulation of HSD11B1 4 0.45 3.54 0.49
12 INT136135 Negative_regulation of Positive_regulation of Hsd11b1 1 0.51 0.2 0.47
13 INT165620 Negative_regulation of Gene_expression of HSD11B1 10 0.41 14.52 0.45
14 INT210938 Positive_regulation of Binding of HSD11B1 1 0.49 2.42 0.44
15 INT136136 Localization of Hsd11b1 1 0.69 0.45 0.41
16 INT8668 Regulation of Positive_regulation of HSD11B1 6 0.44 6.36 0.35
17 INT44942 Positive_regulation of Localization of HSD11B1 5 0.49 4.18 0.31
18 INT216869 Protein_catabolism of HSD11B1 2 0.86 2.3 0.26
19 INT216872 Regulation of Binding of HSD11B1 1 0.44 2.55 0.24
20 INT85647 Transcription of HSD11B1 5 0.67 3.61 0.23
21 INT41984 Regulation of Gene_expression of HSD11B1 4 0.44 4.18 0.23
22 INT41985 Regulation of Regulation of HSD11B1 2 0.44 1.6 0.17
23 INT136137 Positive_regulation of Gene_expression of Hsd11b1 1 0.60 0.56 0.03
24 INT136133 Gene_expression of Hsd11b1 1 0.67 0.56 0.03
25 INT187665 Negative_regulation of Negative_regulation of HSD11B1 2 0.42 2.82 0
26 INT213401 Regulation of Localization of HSD11B1 2 0.44 1 0
27 INT213155 Positive_regulation of Regulation of HSD11B1 1 0.04 0.41 0
28 INT330856 Regulation of Negative_regulation of HSD11B1 1 0.26 0.92 0
29 INT326991 Negative_regulation of Localization of HSD11B1 1 0.29 3.92 0
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