GO:0004118

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Latest revision as of 23:37, 27 January 2013

Name cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
Categary Function
Go Slim No
Go Link GO:0004118
Unique Molecular Interactions 40
Total Molecular Interactions 44
Total Single Events 259
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

[edit] Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cGMP-stimulated cyclic-nucleotide phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported for cGMP-stimulated cyclic-nucleotide phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
2 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
3 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42
4 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
5 INT163055 Negative_regulation of Pde10a Positive_regulation of Gene_expression of Qrfp 1 0.03 0 0.2
6 INT32162 POMC Negative_regulation of PDE11A 1 0.23 0 0.19
7 INT273017 Binding of PDE1B and PDE11A 1 0.08 0.35 0.14
8 INT135941 Positive_regulation of PDE2A Positive_regulation of Gene_expression of PRKG1 1 0.13 0.8 0.13
9 INT273020 Binding of FGF9 and PDE11A 1 0.22 0.3 0.11
10 INT135943 Positive_regulation of PRKG1 Regulation of PDE2A 1 0.08 0.73 0.1
11 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
12 INT148096 Vasp Regulation of Pde2a 1 0.00 0.23 0.08
13 INT98269 PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
14 INT98270 Positive_regulation of PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
15 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03
16 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0
17 INT325602 Binding of Ang and Pde2a 1 0.07 0.15 0
18 INT186239 Binding of ROS1 and Positive_regulation of PDE2A 1 0.00 0 0
19 INT186241 Gene_expression of ROS1 Positive_regulation of PDE2A 1 0.00 0 0
20 INT325603 Pde2a Regulation of Rgs2 1 0.03 0 0
21 INT325613 Pls1 Regulation of Pde2a 1 0.00 0 0
22 INT325593 Pde2a Positive_regulation of Negative_regulation of Nppa 1 0.11 0 0
23 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0
24 INT325612 Rgs2 Regulation of Pde2a 1 0.10 0 0
25 INT325609 Pde2a Positive_regulation of Gene_expression of Rgs2 1 0.12 0 0

[edit] Single Events

The table below shows the top 100 pain related interactions that have been reported for cGMP-stimulated cyclic-nucleotide phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported in cGMP-stimulated cyclic-nucleotide phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT160168 Gene_expression of Pde10a 10 0.74 8.66 7.94
2 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
3 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15
4 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77
5 INT24909 Negative_regulation of Pde10a 4 0.43 0.87 1.87
6 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81
7 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69
8 INT64529 Localization of Pde2a 1 0.59 0 1.63
9 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59
10 INT188855 Positive_regulation of Gene_expression of Pde2a 5 0.12 1.97 1.53
11 INT14195 Localization of Pde2a 4 0.16 0.34 1.33
12 INT7834 Gene_expression of Pde2a 5 0.51 1.9 1.01
13 INT160171 Localization of Pde10a 2 0.77 1.26 0.95
14 INT188851 Regulation of Gene_expression of Pde2a 1 0.04 0.75 0.94
15 INT89776 Positive_regulation of Pde2a 2 0.47 2.84 0.81
16 INT98275 Negative_regulation of PDE2A 4 0.17 3.96 0.79
17 INT183161 Regulation of Pde2a 2 0.05 0.5 0.67
18 INT75814 Regulation of Positive_regulation of PDE2A 1 0.23 0.26 0.56
19 INT162903 Localization of PDE2A 2 0.61 0.89 0.45
20 INT216759 Binding of PDE2A 1 0.00 0.08 0.44
21 INT235122 Negative_regulation of Positive_regulation of PDE2A 1 0.01 0.72 0.35
22 INT235113 Positive_regulation of Negative_regulation of PDE2A 1 0.01 0.72 0.35
23 INT135945 Positive_regulation of Positive_regulation of PDE2A 2 0.12 0.78 0.34
24 INT273021 Binding of PDE11A 1 0.35 0.78 0.26
25 INT32164 Positive_regulation of PDE11A 1 0.26 0 0.19
26 INT163053 Regulation of Negative_regulation of Pde10a 1 0.45 0 0.18
27 INT98276 Regulation of PDE2A 2 0.07 1.54 0.17
28 INT84749 Gene_expression of PDE2A 3 0.73 0.84 0.12
29 INT135946 Positive_regulation of Gene_expression of PDE2A 1 0.12 0.77 0.12
30 INT273022 Negative_regulation of PDE11A 1 0.40 0.24 0.11
31 INT135944 Regulation of Regulation of PDE2A 1 0.07 0.73 0.1
32 INT80630 Protein_catabolism of PDE2A 2 0.19 0.91 0.08
33 INT111440 Negative_regulation of Gene_expression of Pde2a 1 0.20 1.14 0.07
34 INT183439 Protein_catabolism of Pde2a 1 0.14 0.84 0.05
35 INT183425 Negative_regulation of Protein_catabolism of Pde2a 1 0.09 0.84 0.05
36 INT183437 Regulation of Pde10a 1 0.05 0.4 0.04
37 INT183433 Regulation of Localization of Pde2a 1 0.09 0.34 0.04
38 INT183438 Regulation of Localization of Pde10a 1 0.08 0.4 0.04
39 INT162918 Transcription of PDE2A 1 0.65 0 0
40 INT162909 Gene_expression of PDE11A 1 0.17 0 0
41 INT162914 Regulation of Localization of PDE2A 1 0.37 0 0
42 INT162916 Negative_regulation of Transcription of PDE2A 1 0.40 0 0
43 INT183430 Binding of Pde2a 1 0.07 0 0
44 INT325558 Negative_regulation of Gene_expression of Pde2a 1 0.11 0.38 0
45 INT80629 Negative_regulation of Protein_catabolism of PDE2A 1 0.12 0.18 0
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