GO:0004392

Name heme oxygenase (decyclizing) activity Categary Function Go Slim No Go Link GO:0004392

Unique Molecular Interactions 175 Total Molecular Interactions 217 Total Single Events 3388 Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for heme oxygenase (decyclizing) activity. They are ordered first by their pain relevance and then by number of times they were reported for heme oxygenase (decyclizing) activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT86518	Ass1 Positive_regulation of Hmox2	1	0.03	0.08	1.27
2	INT114635	Hmox2 Positive_regulation of Gene_expression of Fos	1	0.47	0.88	1.26
3	INT111221	MMEL1 Negative_regulation of HMOX1	1	0.01	1	1.16
4	INT231769	TNF Negative_regulation of Gene_expression of HMOX1	1	0.26	4.75	1.15
5	INT147474	Nfe2l2 Positive_regulation of Hmox1	1	0.43	0.38	0.9
6	INT81299	Ifng Positive_regulation of Gene_expression of Hmox1	1	0.52	0.75	0.76
7	INT99743	Olr1742 Regulation of Gene_expression of Hmox1	1	0.00	0	0.68
8	INT86519	Binding of Hmox1 and Hmox2	1	0.08	0.1	0.66
9	INT103868	IFNG Positive_regulation of Hmox1	1	0.09	0.83	0.65
10	INT99744	Calca Positive_regulation of Positive_regulation of Hmox1	1	0.48	0	0.64
11	INT103870	IRF6 Positive_regulation of Hmox1	1	0.14	0.83	0.64
12	INT172133	IL4 Negative_regulation of Gene_expression of HMOX2	1	0.00	0.81	0.58
13	INT81303	Tlr4 Positive_regulation of Gene_expression of Hmox1	1	0.03	0.55	0.56
14	INT270044	Il10 Positive_regulation of Positive_regulation of Hmox1	1	0.20	1.59	0.53
15	INT350076	Positive_regulation of Hmox1 Negative_regulation of Gene_expression of Ptger2	1	0.02	1.29	0.5
16	INT145435	Binding of CPOX and HMOX1	1	0.01	0.42	0.49
17	INT145433	Binding of CPOX and HMOX2	1	0.01	0.42	0.49
18	INT145434	Binding of HMOX1 and PTGS2	1	0.02	0.41	0.47
19	INT148466	Ccl4 Positive_regulation of Hmox1	1	0.28	0.06	0.47
20	INT145436	Binding of HMOX2 and PTGS2	1	0.02	0.41	0.47
21	INT242402	Negative_regulation of Bdkrb1 Positive_regulation of Hmox1	1	0.17	1.44	0.45
22	INT103871	Negative_regulation of IRF6 Positive_regulation of Hmox1	1	0.12	0.61	0.45
23	INT165677	NFE2L2 Negative_regulation of Positive_regulation of HMOX1	1	0.40	0.32	0.44
24	INT165678	NFE2L2 Negative_regulation of HMOX1	1	0.40	0.31	0.43
25	INT216881	Binding of Apoc4 and Hmox1	1	0.01	1.78	0.4
26	INT147473	Nfe2l2 Positive_regulation of Gene_expression of Hmox1	1	0.74	0.49	0.39
27	INT147472	co Positive_regulation of Gene_expression of Hmox1	1	0.01	0.57	0.36
28	INT91751	Binding of PTGS2 and Hmox1	1	0.00	0.21	0.27
29	INT270046	Ido1 Positive_regulation of Positive_regulation of Hmox1	1	0.15	0.8	0.27
30	INT216880	Apoc4 Positive_regulation of Hmox1	1	0.03	1.06	0.25
31	INT349652	Positive_regulation of Hmox1 Negative_regulation of Positive_regulation of Itk	1	0.01	0.85	0.25
32	INT350099	Gene_expression of Hmox1 Positive_regulation of Gene_expression of MRXS5	1	0.01	0.51	0.24
33	INT328228	Binding of Cpox and Hmox1	1	0.03	0.83	0.23
34	INT350065	Gene_expression of Hmox1 Negative_regulation of Gene_expression of Tlr4	1	0.18	0.35	0.22
35	INT260397	Positive_regulation of Hmox1 Positive_regulation of Gene_expression of Adipoq	1	0.37	0.78	0.22
36	INT103867	SFTPA1 Positive_regulation of Hmox1	1	0.00	0.35	0.22
37	INT64340	Zc3h15 Negative_regulation of Hmox1	1	0.12	0.47	0.22
38	INT350078	Hmox1 Negative_regulation of Gene_expression of Ptger2	1	0.02	0.35	0.22
39	INT103869	Binding of IRF6 and Positive_regulation of Hmox1	1	0.10	0.27	0.21
40	INT349647	Eif2ak1 Positive_regulation of Positive_regulation of Hmox1	1	0.00	1.07	0.2
41	INT350096	Hmox1 Negative_regulation of Gene_expression of MRXS5	1	0.01	0.32	0.2
42	INT266646	HMOX2 Regulation of Gene_expression of Hmox1	1	0.00	0.87	0.2
43	INT349646	Eif2ak1 Regulation of Gene_expression of Hmox1	1	0.00	0.78	0.2
44	INT260394	Positive_regulation of Hmox1 Positive_regulation of Adipoq	1	0.37	0.78	0.19
45	INT199192	Gnat3 Positive_regulation of Hmox1	1	0.27	0.23	0.19
46	INT81296	Positive_regulation of Pparg Regulation of Gene_expression of Hmox1	1	0.25	0.17	0.17
47	INT350072	Ptger2 Positive_regulation of Hmox1	1	0.02	0.2	0.15
48	INT231757	TLR4 Positive_regulation of Negative_regulation of HMOX1	1	0.26	1.37	0.15
49	INT216882	Tlr4 Positive_regulation of Hmox1	1	0.17	0.19	0.15
50	INT350081	Pik3r1 Positive_regulation of Hmox1	1	0.07	0.2	0.15
51	INT350069	Prkaca Positive_regulation of Hmox1	1	0.05	0.2	0.15
52	INT199195	Gnat3 Regulation of Transcription of Hmox1	1	0.24	0.12	0.14
53	INT295267	Binding of Hmox1 and Gtf3a	1	0.01	0.49	0.13
54	INT295261	Binding of Hmox1 and Nfe2l2	1	0.17	0.49	0.13
55	INT295264	Positive_regulation of Binding of Hmox1 and Nfe2l2	1	0.25	0.5	0.13
56	INT231761	TNF Negative_regulation of HMOX1	1	0.19	1.2	0.12
57	INT231764	TLR4 Negative_regulation of HMOX1	1	0.27	1.54	0.11
58	INT231768	Binding of HMOX1 and TLR4	1	0.23	0.95	0.11
59	INT231772	TNF Positive_regulation of Gene_expression of HMOX1	1	0.21	0.96	0.1
60	INT231773	IRF6 Negative_regulation of Gene_expression of HMOX1	1	0.06	1.27	0.09
61	INT201456	Hmox1 Positive_regulation of Gene_expression of Bcl2	1	0.06	0.74	0.08
62	INT260392	Hmox1 Positive_regulation of Adipoq	1	0.32	0.65	0.07
63	INT244290	Il6 Positive_regulation of Hmox1	1	0.38	0.09	0.07
64	INT244291	Nos2 Positive_regulation of Positive_regulation of Hmox1	1	0.34	0.07	0.07
65	INT231760	TNF Positive_regulation of Protein_catabolism of HMOX1	1	0.31	0.41	0.06
66	INT349645	Eif2ak1 Positive_regulation of Hmox1	1	0.00	0.18	0.05
67	INT231758	IRF6 Regulation of Gene_expression of HMOX1	1	0.08	0.23	0.05
68	INT231766	TLR4 Negative_regulation of Gene_expression of HMOX1	1	0.28	0.71	0.05
69	INT231771	Binding of HMOX1 and TNF	2	0.14	1.41	0.04
70	INT231759	IL10 Positive_regulation of Gene_expression of HMOX1	1	0.06	0.7	0.04
71	INT349648	Eif2ak1 Positive_regulation of Gene_expression of Hmox1	1	0.00	0.17	0.04
72	INT227333	Il2 Positive_regulation of Hmox1	1	0.05	0.93	0.04
73	INT231775	TLR4 Regulation of Gene_expression of HMOX1	1	0.29	0.68	0.04
74	INT231774	Gene_expression of TLR4 Positive_regulation of Gene_expression of HMOX1	1	0.30	0.68	0.04
75	INT231762	TLR4 Positive_regulation of Gene_expression of HMOX1	1	0.30	0.68	0.04
76	INT335492	CREM Positive_regulation of Transcription of HMOX1	1	0.00	0.9	0.03
77	INT350071	Hmox1 Regulation of Tlr4	1	0.22	0.33	0.03
78	INT229818	Fos Positive_regulation of Hmox1	1	0.43	0.37	0
79	INT350098	Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1	1	0.39	0	0
80	INT161415	Oprm1 Negative_regulation of Gene_expression of Hmox2	1	0.05	0	0
81	INT260395	Positive_regulation of Adipoq Negative_regulation of Gene_expression of Hmox1	1	0.34	1.4	0
82	INT259670	CSE Positive_regulation of Hmox1	1	0.06	0.97	0
83	INT330735	GSTK1 Regulation of HMOX1	1	0.08	0.25	0
84	INT260398	Dclk2 Regulation of Gene_expression of Hmox1	1	0.01	1.02	0
85	INT260393	Hmox1 Regulation of Positive_regulation of Bcl2	1	0.22	0.86	0
86	INT301906	Binding of HMOX1 and HSD11B1	1	0.05	2.41	0
87	INT350068	Positive_regulation of Hmox1 Negative_regulation of Gene_expression of Ptgs2	1	0.03	0.16	0

Single Events

The table below shows the top 100 pain related interactions that have been reported for heme oxygenase (decyclizing) activity. They are ordered first by their pain relevance and then by number of times they were reported in heme oxygenase (decyclizing) activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT73982	Gene_expression of Hmox1	141	0.78	119.43	32.17
2	INT86780	Positive_regulation of Hmox1	145	0.70	117.09	31.18
3	INT80223	Positive_regulation of Hmox1	128	0.68	77.71	17.64
4	INT76406	Gene_expression of Hmox1	140	0.78	85.86	17.15
5	INT80228	Positive_regulation of Gene_expression of Hmox1	68	0.70	62.88	14.01
6	INT116528	Gene_expression of HMOX1	106	0.78	86.13	12.8
7	INT111223	Positive_regulation of HMOX1	47	0.70	39.14	10.92
8	INT83886	Negative_regulation of HMOX2	27	0.43	11.69	10.78
9	INT84077	Gene_expression of Hmox2	18	0.77	6.41	10.66
10	INT82450	Negative_regulation of Hmox1	33	0.55	19.07	8.12
11	INT81293	Positive_regulation of Gene_expression of Hmox1	53	0.70	41.54	7.25
12	INT82451	Negative_regulation of HMOX1	18	0.51	13.29	5.74
13	INT116527	Positive_regulation of Gene_expression of HMOX1	29	0.70	25.79	4.87
14	INT86516	Positive_regulation of Hmox2	6	0.69	3.22	4.39
15	INT64338	Negative_regulation of Hmox1	16	0.56	12.72	4.2
16	INT97096	Regulation of Hmox1	18	0.61	6.42	3.9
17	INT83887	Gene_expression of HMOX2	10	0.77	7.99	3.85
18	INT80892	Negative_regulation of Hmox2	10	0.55	4.76	3.64
19	INT80224	Regulation of Hmox1	19	0.32	10.53	3.52
20	INT135773	Negative_regulation of Gene_expression of HMOX1	31	0.53	28.31	3.32
21	INT102634	Transcription of Hmox1	22	0.62	4.5	3.3
22	INT127904	Negative_regulation of Gene_expression of Hmox1	11	0.42	9.54	2.8
23	INT86517	Positive_regulation of Gene_expression of Hmox2	1	0.69	0.14	2.63
24	INT92545	Regulation of Hmox2	1	0.15	1.09	2.5
25	INT81291	Regulation of Gene_expression of Hmox1	11	0.60	8.78	2.46
26	INT97914	Negative_regulation of Gene_expression of Hmox2	3	0.49	1.73	2.26
27	INT92544	Localization of Hmox2	1	0.45	0.73	1.87
28	INT99742	Negative_regulation of Gene_expression of Hmox1	12	0.58	9.94	1.77
29	INT80227	Regulation of Gene_expression of Hmox1	12	0.44	11.04	1.61
30	INT91232	Regulation of Positive_regulation of Hmox1	5	0.45	2.43	1.55
31	INT97707	Regulation of HMOX2	4	0.18	1.96	1.5
32	INT103305	Positive_regulation of Positive_regulation of Hmox1	8	0.49	4.81	1.49
33	INT100420	Regulation of HMOX1	10	0.35	6.68	1.48
34	INT165680	Transcription of HMOX1	7	0.71	11.2	1.41
35	INT97704	Positive_regulation of Gene_expression of HMOX2	3	0.13	2.54	1.37
36	INT127283	Regulation of Gene_expression of HMOX1	14	0.61	11.8	1.28
37	INT91320	Localization of Hmox1	8	0.81	4.06	1.28
38	INT115831	Transcription of Hmox1	16	0.66	5.31	1.14
39	INT199187	Localization of Hmox1	2	0.78	3.36	1.11
40	INT116529	Binding of HMOX1	10	0.47	15.38	1.04
41	INT105445	Localization of HMOX1	5	0.71	3.11	0.98
42	INT201454	Positive_regulation of Positive_regulation of Hmox1	6	0.35	5.2	0.94
43	INT148461	Positive_regulation of Transcription of Hmox1	6	0.33	1.83	0.93
44	INT86515	Regulation of Gene_expression of Hmox2	1	0.61	0.09	0.91
45	INT97705	Positive_regulation of HMOX2	2	0.08	0.89	0.83
46	INT97703	Regulation of Gene_expression of HMOX2	1	0.01	0.89	0.83
47	INT97706	Regulation of Positive_regulation of HMOX2	1	0.02	0.89	0.83
48	INT82568	Protein_catabolism of Hmox1	5	0.86	1.03	0.79
49	INT287003	Negative_regulation of Positive_regulation of Hmox1	2	0.34	3.1	0.63
50	INT172168	Transcription of HMOX2	1	0.01	0.81	0.57
51	INT165681	Positive_regulation of Transcription of HMOX1	2	0.69	4.29	0.53
52	INT92546	Binding of Hmox2	1	0.27	0.25	0.51
53	INT92550	Negative_regulation of Localization of Hmox2	1	0.24	0.26	0.49
54	INT92548	Regulation of Localization of Hmox2	1	0.25	0.25	0.49
55	INT270030	Negative_regulation of Positive_regulation of Hmox1	3	0.30	2.49	0.47
56	INT83885	Negative_regulation of Gene_expression of HMOX2	1	0.09	0.26	0.42
57	INT103444	Binding of HMOX2	2	0.48	0.7	0.38
58	INT157157	Negative_regulation of Localization of HMOX1	1	0.37	0.74	0.37
59	INT281659	Regulation of Transcription of HMOX1	2	0.27	2.12	0.33
60	INT216879	Binding of Hmox1	4	0.36	2.82	0.31
61	INT145525	Positive_regulation of Regulation of HMOX2	1	0.18	0.43	0.3
62	INT135772	Regulation of Positive_regulation of HMOX1	3	0.39	1.52	0.29
63	INT328227	Positive_regulation of Localization of Hmox1	1	0.45	0.67	0.28
64	INT91231	Binding of Hmox1	4	0.36	0.29	0.27
65	INT201453	Protein_catabolism of Hmox1	3	0.95	4.25	0.23
66	INT350048	Negative_regulation of Regulation of Hmox1	1	0.30	0.37	0.23
67	INT115829	Regulation of Transcription of Hmox1	1	0.35	1.03	0.17
68	INT201467	Protein_catabolism of HMOX1	2	0.77	0.83	0.13
69	INT224332	Localization of HMOX2	1	0.02	1.15	0.11
70	INT115824	Positive_regulation of Transcription of Hmox1	3	0.45	0.43	0.06
71	INT293311	Positive_regulation of Positive_regulation of HMOX1	3	0.69	1.99	0.04
72	INT350052	Positive_regulation of Negative_regulation of Hmox1	1	0.35	0.34	0.04
73	INT337766	Phosphorylation of Hmox1	1	0.79	0.08	0
74	INT337767	Positive_regulation of Phosphorylation of Hmox1	1	0.49	0.08	0