GO:0004464

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Name leukotriene-C4 synthase activity
Categary Function
Go Slim No
Go Link GO:0004464
Unique Molecular Interactions 72
Total Molecular Interactions 97
Total Single Events 759
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for leukotriene-C4 synthase activity. They are ordered first by their pain relevance and then by number of times they were reported for leukotriene-C4 synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48162 RIMS3 Regulation of Localization of LTC4S 1 0.10 2.14 3.25
2 INT203168 PTGER2 Negative_regulation of Gene_expression of ALOX5AP 1 0.03 2.4 1.18
3 INT203162 PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 1.47 0.94
4 INT57746 Il1 Regulation of Gene_expression of Ltc4s 1 0.36 0.33 0.88
5 INT312101 ELANE Regulation of ALOX5AP 1 0.21 1.11 0.73
6 INT164286 Alox5ap Positive_regulation of Cysltr2 1 0.19 1.11 0.61
7 INT164285 Ltc4s Positive_regulation of Cysltr2 1 0.20 1.11 0.61
8 INT164283 Ltb4r Positive_regulation of Ltc4s 1 0.37 1.1 0.6
9 INT164284 Ltb4r Positive_regulation of Alox5ap 1 0.34 1.1 0.6
10 INT335432 Ltc4s Regulation of Cysltr2 1 0.11 0.38 0.58
11 INT335436 Ltc4s Regulation of Gene_expression of Cysltr2 1 0.18 0.38 0.58
12 INT193219 Binding of LTC4S and CYSLTR2 2 0.28 2.2 0.44
13 INT203167 Gene_expression of PTGER2 Positive_regulation of Gene_expression of ALOX5AP 1 0.03 0.67 0.38
14 INT312102 Binding of ALOX5 and ALOX5AP 1 0.10 0.65 0.36
15 INT44983 Ltc4s Positive_regulation of Rara 1 0.01 0.15 0.33
16 INT44984 KNG1 Regulation of Ltc4s 1 0.01 0.17 0.3
17 INT48161 RIMS3 Negative_regulation of Gene_expression of LTC4S 1 0.16 0.07 0.28
18 INT301671 Ltc4s Positive_regulation of Gene_expression of IL8 1 0.00 0.9 0.27
19 INT249893 Ltc4s Positive_regulation of Gpr17 1 0.04 0.92 0.2
20 INT49057 Positive_regulation of CEL Positive_regulation of Localization of LTC4S 1 0.41 0.28 0.18
21 INT312091 ALOX5AP Regulation of Transcription of ALOX5 1 0.13 0.37 0.18
22 INT33362 Binding of Ltc4s and Cysltr1 1 0.16 0.21 0.17
23 INT249895 Ltc4s Positive_regulation of P2ry4 1 0.00 0.71 0.17
24 INT312089 LTB4R Positive_regulation of ALOX5AP 1 0.01 0.32 0.16
25 INT193216 Binding of LTC4S and CYSLTR1 1 0.04 0.71 0.16
26 INT312126 ELANE Positive_regulation of ALOX5AP 1 0.20 0.25 0.15
27 INT56430 Ltc4s Regulation of NA 1 0.00 0 0.14
28 INT17437 LTC4S Positive_regulation of CYSLTR1 1 0.03 0.2 0.13
29 INT270996 TBXA2R Regulation of LTC4S 1 0.24 0.83 0.13
30 INT271002 Binding of LTC4S and Aia1 1 0.00 0.98 0.12
31 INT301307 Binding of GPR17 and LTC4S 1 0.00 0.42 0.11
32 INT312116 Negative_regulation of PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 0.2 0.1
33 INT273354 Binding of ALOX5 and LTC4S 1 0.04 0.19 0.09
34 INT313503 Binding of ALOX5AP and CXADRP1 1 0.01 1.51 0.08
35 INT312093 ELANE Regulation of Gene_expression of ALOX5AP 1 0.13 0.15 0.08
36 INT312113 ELANE Positive_regulation of Gene_expression of ALOX5AP 1 0.23 0.14 0.07
37 INT313504 Binding of ALOX5AP and SNRNP70 1 0.04 0.5 0.05
38 INT192263 LTC4S Positive_regulation of Gene_expression of TIMP1 1 0.00 0.28 0.04
39 INT312117 Negative_regulation of ELANE Positive_regulation of ALOX5AP 1 0.17 0.08 0.04
40 INT347514 Binding of CYSLTR1 and Ltc4s 1 0.01 0.58 0.03
41 INT313551 Binding of ALOX5AP and Cor 1 0.02 1.01 0.03
42 INT347516 Binding of CYSLTR2 and Ltc4s 1 0.01 0.4 0.03
43 INT313499 Binding of ALOX5AP and CRP 1 0.07 0.45 0
44 INT313502 Binding of ALOX5AP and ADIPOQ 1 0.05 0.44 0
45 INT172893 Binding of Lta4h and Ltc4s 1 0.00 0.24 0
46 INT298871 ALOX5AP Positive_regulation of RAB7A 1 0.09 0.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for leukotriene-C4 synthase activity. They are ordered first by their pain relevance and then by number of times they were reported in leukotriene-C4 synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT195414 Gene_expression of ALOX5AP 65 0.72 31.22 15.25
2 INT7997 Gene_expression of Ltc4s 51 0.76 34.28 13.8
3 INT4808 Gene_expression of LTC4S 37 0.73 18.36 9.62
4 INT4807 Localization of LTC4S 23 0.58 6.89 7.59
5 INT10606 Localization of Ltc4s 16 0.75 10.14 5.05
6 INT10605 Positive_regulation of Ltc4s 21 0.68 17.22 4.8
7 INT20743 Positive_regulation of Gene_expression of Ltc4s 13 0.60 12.3 3.86
8 INT16159 Regulation of Ltc4s 11 0.38 2.52 3.21
9 INT195415 Regulation of Gene_expression of ALOX5AP 10 0.45 6.43 3.13
10 INT4811 Positive_regulation of Gene_expression of LTC4S 5 0.65 3.29 2.92
11 INT195421 Positive_regulation of Gene_expression of ALOX5AP 12 0.49 5.17 2.82
12 INT16089 Gene_expression of Ltc4s 11 0.77 3.37 2.29
13 INT200779 Negative_regulation of Gene_expression of ALOX5AP 7 0.41 3.75 1.79
14 INT164275 Gene_expression of Alox5ap 3 0.55 3.79 1.72
15 INT200778 Positive_regulation of ALOX5AP 3 0.49 2.54 1.7
16 INT15996 Binding of Ltc4s 9 0.35 5.66 1.64
17 INT122204 Positive_regulation of Alox5ap 1 0.26 0.23 1.53
18 INT164277 Transcription of Ltc4s 3 0.47 2.69 1.36
19 INT12545 Negative_regulation of Ltc4s 8 0.42 2.53 1.07
20 INT24581 Negative_regulation of LTC4S 2 0.40 2.05 0.91
21 INT13543 Positive_regulation of LTC4S 5 0.58 2.26 0.88
22 INT16088 Negative_regulation of Gene_expression of Ltc4s 6 0.58 0.29 0.85
23 INT68926 Binding of ALOX5AP 8 0.36 4.02 0.84
24 INT13541 Positive_regulation of Localization of LTC4S 3 0.51 1.01 0.75
25 INT48164 Negative_regulation of Gene_expression of LTC4S 3 0.55 0.22 0.74
26 INT34859 Positive_regulation of Localization of Ltc4s 2 0.34 1.26 0.7
27 INT57111 Negative_regulation of Localization of Ltc4s 1 0.27 1.02 0.62
28 INT65607 Regulation of Gene_expression of LTC4S 1 0.58 0.25 0.61
29 INT164276 Localization of Alox5ap 1 0.61 1.1 0.6
30 INT49507 Negative_regulation of Ltc4s 1 0.16 0.61 0.59
31 INT28417 Negative_regulation of Regulation of Ltc4s 1 0.03 0 0.56
32 INT43459 Positive_regulation of Positive_regulation of Ltc4s 2 0.11 2.47 0.5
33 INT122205 Negative_regulation of Alox5ap 1 0.24 0 0.45
34 INT15997 Negative_regulation of Binding of Ltc4s 2 0.43 0.33 0.42
35 INT13542 Negative_regulation of Localization of LTC4S 1 0.27 1.02 0.39
36 INT195416 Regulation of ALOX5AP 2 0.53 0.8 0.38
37 INT195413 Negative_regulation of ALOX5AP 5 0.37 1.39 0.37
38 INT38789 Regulation of LTC4S 3 0.51 1.1 0.37
39 INT132064 Regulation of Binding of Ltc4s 1 0.22 1.02 0.37
40 INT309930 Regulation of Gene_expression of Ltc4s 1 0.08 2.79 0.34
41 INT20229 Negative_regulation of Positive_regulation of Ltc4s 2 0.23 0.87 0.29
42 INT171007 Transcription of LTC4S 1 0.16 0.61 0.28
43 INT273358 Binding of LTC4S 4 0.17 0.88 0.27
44 INT203173 Localization of ALOX5AP 3 0.48 0.78 0.21
45 INT259884 Negative_regulation of Binding of ALOX5AP 1 0.10 0.46 0.21
46 INT312127 Positive_regulation of Positive_regulation of ALOX5AP 1 0.35 0.37 0.19
47 INT33357 Positive_regulation of Gene_expression of Ltc4s 1 0.45 0.22 0.18
48 INT312137 Transcription of ALOX5AP 1 0.50 0.37 0.18
49 INT21351 Negative_regulation of Gene_expression of Ltc4s 3 0.19 1.14 0.17
50 INT312135 Negative_regulation of Regulation of ALOX5AP 1 0.30 0.19 0.13
51 INT166890 Regulation of Binding of ALOX5AP 1 0.44 0.1 0.1
52 INT60010 Regulation of Positive_regulation of Ltc4s 1 0.06 0 0.08
53 INT76914 Regulation of Localization of LTC4S 1 0.15 0.31 0.08
54 INT327731 Positive_regulation of Ltc4s 2 0.24 0.91 0.07
55 INT312129 Positive_regulation of Transcription of ALOX5AP 1 0.35 0.1 0.05
56 INT344420 Localization of Ltc4s 1 0.27 0.4 0.05
57 INT312132 Regulation of Regulation of ALOX5AP 1 0.28 0.06 0.03
58 INT16160 Regulation of Localization of Ltc4s 1 0.17 0.2 0.03
59 INT235707 Binding of Ltc4s 1 0.10 0 0
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