GO:0004527

Name exonuclease activity Categary Function Go Slim No Go Link GO:0004527

Unique Molecular Interactions 55 Total Molecular Interactions 63 Total Single Events 551 Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for exonuclease activity. They are ordered first by their pain relevance and then by number of times they were reported for exonuclease activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT251729	Binding of FEN1 and EXOSC1	1	0.19	1.13	0.74
2	INT253759	Hmgb1 Positive_regulation of Apex1	1	0.09	4.53	0.69
3	INT253760	Hmgb1 Positive_regulation of Gene_expression of Apex1	1	0.10	3.53	0.58
4	INT131810	Nfkb1 Negative_regulation of Localization of Apex1	1	0.01	0.52	0.57
5	INT253770	Hmgb1 Positive_regulation of Localization of Apex1	1	0.08	0.71	0.49
6	INT253766	Binding of Apex1 and Tlr4	1	0.03	0.53	0.32
7	INT253762	Binding of Apex1 and Hmgb1	1	0.09	1.29	0.32
8	INT253765	Apex1 Positive_regulation of Hmgb1	1	0.09	1.27	0.24
9	INT299787	Binding of IL2 and ISG20	1	0.04	0.82	0.21
10	INT218937	Akt1 Positive_regulation of Parn	1	0.01	0.65	0.16
11	INT104327	Fen1 Negative_regulation of Baat	1	0.31	0.75	0.12
12	INT104325	Regulation of Fen1 Negative_regulation of Baat	1	0.19	0.75	0.12
13	INT303815	Binding of Igfals and Tdp1	1	0.11	1.68	0.1
14	INT292623	ISG20 Positive_regulation of Gene_expression of IL9	1	0.10	0	0.09
15	INT204993	Eri1 Positive_regulation of Gene_expression of Pink1	1	0.22	0.61	0.08
16	INT253764	Atp9a Positive_regulation of Apex1	1	0.00	0.39	0.08
17	INT204998	Hmmr Positive_regulation of Eri1	1	0.00	0.58	0.06
18	INT229601	Binding of DIS3 and RLS	1	0.14	2.19	0.06
19	INT172349	Eri1 Regulation of Gene_expression of Agrp	1	0.03	0.28	0.05
20	INT351010	ISG20 Positive_regulation of Transcription of IL2	1	0.31	0.46	0.05
21	INT172348	Eri1 Negative_regulation of Gene_expression of Agrp	1	0.07	0.28	0.05
22	INT287814	Apex1 Positive_regulation of Gene_expression of Rnf128	1	0.03	0.15	0.03
23	INT282553	POU5F1 Positive_regulation of REXO1	1	0.21	0.1	0.03
24	INT294829	STAT3 Regulation of Gene_expression of REXO1	1	0.10	0.48	0
25	INT315263	Eri1 Regulation of Rela	1	0.00	0.49	0
26	INT315271	Eri1 Regulation of Nfe2l2	1	0.00	0.48	0
27	INT172347	Eri1 Negative_regulation of Hras1	1	0.00	0.76	0
28	INT315265	Eri1 Negative_regulation of Keap1	1	0.01	0.26	0
29	INT294825	Phosphorylation of GRAP2 Regulation of Gene_expression of REXO1	1	0.03	0.48	0
30	INT282557	NANOG Regulation of REXO1	1	0.07	0.23	0
31	INT315260	Eri1 Regulation of Keap1	1	0.00	0.48	0
32	INT294830	Phosphorylation of STAT3 Regulation of Gene_expression of REXO1	1	0.08	0.48	0
33	INT351013	PROK1 Regulation of ISG20	1	0.01	0.76	0
34	INT303822	Tdp1 Regulation of TREH	1	0.02	0.92	0
35	INT104328	Fen1 Positive_regulation of Baat	1	0.33	0.63	0
36	INT294881	Phosphorylation of Mdk Regulation of Gene_expression of REXO1	1	0.02	0.48	0
37	INT185353	Eri1 Negative_regulation of Transcription of Egfr	1	0.01	0.5	0
38	INT260128	Binding of ISG20 and Trav6-3	1	0.01	0	0
39	INT282547	SOX2 Regulation of REXO1	1	0.12	0.23	0
40	INT172345	Eri1 Negative_regulation of Gene_expression of Hras1	1	0.00	0.76	0
41	INT276665	Binding of Lig3 and Polg	1	0.32	0	0
42	INT104326	Regulation of Fen1 Positive_regulation of Baat	1	0.19	0.63	0
43	INT172344	Eri1 Negative_regulation of Positive_regulation of Hras1	1	0.00	0.76	0
44	INT229602	Binding of ETFA and DIS3	1	0.08	1.12	0
45	INT251822	Binding of POLG and C10orf2	1	0.42	0.29	0
46	INT245039	Binding of Xrcc1 and Tdp1	1	0.39	0.77	0
47	INT244063	Binding of Gabarap and Eri3	1	0.00	0	0
48	INT282544	GOPC Regulation of REXO1	1	0.03	0	0
49	INT294827	DPYD Positive_regulation of Gene_expression of REXO1	1	0.01	0.47	0
50	INT185357	Eri1 Negative_regulation of Gene_expression of Egfr	1	0.01	0.57	0
51	INT198006	ERI3 Negative_regulation of MCL1	1	0.01	1.63	0

Single Events

The table below shows the top 100 pain related interactions that have been reported for exonuclease activity. They are ordered first by their pain relevance and then by number of times they were reported in exonuclease activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT15804	Gene_expression of ISG20	83	0.75	44.33	10.58
2	INT131808	Localization of Apex1	2	0.16	13.46	4.61
3	INT15802	Positive_regulation of Gene_expression of ISG20	16	0.42	8.16	4.03
4	INT303796	Gene_expression of Tdp1	1	0.77	70.15	2.55
5	INT15799	Positive_regulation of ISG20	18	0.38	9.78	2.01
6	INT49867	Negative_regulation of Polg	7	0.39	4.07	1.86
7	INT253756	Gene_expression of Apex1	1	0.14	7.47	1.84
8	INT10669	Localization of Fen1	3	0.57	0.36	1.44
9	INT260114	Regulation of ISG20	5	0.37	4.98	1.27
10	INT260111	Localization of ISG20	6	0.41	3.46	1.25
11	INT82547	Negative_regulation of Gene_expression of ISG20	7	0.29	3.04	1.18
12	INT174516	Regulation of Gene_expression of ISG20	6	0.27	4.2	0.85
13	INT17246	Negative_regulation of POLG	16	0.56	9.69	0.79
14	INT117427	Gene_expression of Parn	1	0.44	1.18	0.79
15	INT142157	Positive_regulation of Protein_catabolism of Polg	1	0.04	0.32	0.77
16	INT142156	Protein_catabolism of Polg	1	0.06	0.32	0.75
17	INT251735	Binding of FEN1	1	0.17	1.13	0.74
18	INT44409	Gene_expression of Fen1	3	0.59	0	0.72
19	INT303799	Phosphorylation of Tdp1	1	0.82	22.84	0.71
20	INT253750	Positive_regulation of Gene_expression of Apex1	1	0.10	1.43	0.64
21	INT76623	Negative_regulation of Fen1	1	0.33	0.63	0.62
22	INT44413	Regulation of Fen1	2	0.39	0.44	0.6
23	INT303804	Localization of Tdp1	1	0.80	11.71	0.59
24	INT44410	Binding of Fen1	1	0.42	0.19	0.49
25	INT158837	Binding of POLG	4	0.37	4.69	0.44
26	INT169943	Gene_expression of Eri1	22	0.35	10.45	0.41
27	INT260121	Regulation of Localization of ISG20	1	0.14	0.81	0.41
28	INT44411	Positive_regulation of Fen1	1	0.49	0.76	0.38
29	INT303808	Positive_regulation of Gene_expression of Tdp1	1	0.69	9.07	0.35
30	INT303811	Binding of Tdp1	1	0.37	8.69	0.33
31	INT82541	Negative_regulation of ISG20	2	0.27	0.15	0.27
32	INT234410	Binding of ISG20	4	0.22	1.66	0.26
33	INT44412	Positive_regulation of Binding of Fen1	1	0.44	0.1	0.24
34	INT138715	Gene_expression of POLG	12	0.66	6.97	0.23
35	INT227426	Positive_regulation of Apex1	2	0.08	1.98	0.23
36	INT210199	Negative_regulation of Positive_regulation of ISG20	2	0.15	2.52	0.2
37	INT253752	Negative_regulation of Localization of Apex1	1	0.08	1.26	0.2
38	INT303812	Regulation of Tdp1	1	0.45	3.32	0.19
39	INT169582	Phosphorylation of POLG	2	0.54	1.98	0.18
40	INT218902	Phosphorylation of Parn	1	0.03	0.64	0.16
41	INT190110	Positive_regulation of Eri1	2	0.27	3.47	0.15
42	INT192952	Negative_regulation of DIS3	1	0.21	0.42	0.15
43	INT318836	Binding of ERI3	1	0.11	0.18	0.14
44	INT282602	Gene_expression of REXO1	6	0.35	6.38	0.13
45	INT230640	Negative_regulation of REXO1	3	0.33	1.28	0.12
46	INT204967	Negative_regulation of Eri1	2	0.17	1.41	0.12
47	INT230642	Positive_regulation of Negative_regulation of REXO1	2	0.36	0.49	0.12
48	INT302679	Negative_regulation of Localization of POLG	1	0.39	0.99	0.11
49	INT190501	Regulation of Apex1	1	0.12	0.32	0.1
50	INT302692	Localization of POLG	1	0.69	0.99	0.1
51	INT273338	Protein_catabolism of Apex1	4	0.05	0.57	0.09
52	INT169935	Positive_regulation of Gene_expression of Eri1	3	0.19	2.46	0.09
53	INT303805	Positive_regulation of Phosphorylation of Tdp1	1	0.50	3.27	0.09
54	INT172342	Regulation of Eri1	2	0.03	0.3	0.08
55	INT303795	Negative_regulation of Tdp1	1	0.43	1.71	0.08
56	INT251829	Positive_regulation of POLG	1	0.53	1.5	0.08
57	INT303806	Negative_regulation of Gene_expression of Tdp1	1	0.58	3.26	0.08
58	INT282574	Positive_regulation of Gene_expression of REXO1	3	0.22	2.71	0.07
59	INT294859	Regulation of Gene_expression of REXO1	1	0.19	0.57	0.07
60	INT349638	Positive_regulation of Transcription of ISG20	1	0.31	0	0.07
61	INT349639	Transcription of ISG20	1	0.43	0	0.07
62	INT303801	Positive_regulation of Tdp1	1	0.60	9.8	0.06
63	INT234416	Positive_regulation of Binding of ISG20	1	0.23	0.38	0.06
64	INT190102	Protein_catabolism of Eri1	3	0.25	1.69	0.04
65	INT282600	Positive_regulation of REXO1	3	0.31	1.44	0.04
66	INT251827	Regulation of POLG	3	0.59	2.94	0.04
67	INT303810	Positive_regulation of Localization of Tdp1	1	0.46	0.67	0.03
68	INT276649	Gene_expression of Polg	6	0.70	1.31	0
69	INT201547	Gene_expression of ERI3	4	0.20	2.19	0
70	INT138714	Positive_regulation of Polg	3	0.18	0.39	0
71	INT282577	Transcription of REXO1	3	0.24	0.51	0
72	INT233709	Positive_regulation of ERI3	2	0.16	0.08	0
73	INT282595	Negative_regulation of Transcription of REXO1	2	0.19	0.37	0
74	INT266162	Transcription of POLG	2	0.68	0.76	0
75	INT204991	Positive_regulation of Positive_regulation of Eri1	1	0.19	0.96	0
76	INT229605	Binding of DIS3	1	0.11	1.88	0
77	INT198044	Protein_catabolism of ERI3	1	0.01	1.17	0
78	INT309506	Positive_regulation of Tdp1	1	0.23	1.19	0
79	INT276663	Negative_regulation of Gene_expression of Polg	1	0.39	0	0
80	INT266161	Regulation of Negative_regulation of POLG	1	0.38	0.56	0
81	INT294848	Negative_regulation of Gene_expression of REXO1	1	0.18	0.91	0
82	INT266164	Negative_regulation of Gene_expression of POLG	1	0.41	1.08	0
83	INT303803	Transcription of Tdp1	1	0.53	0.56	0
84	INT294853	Phosphorylation of REXO1	1	0.27	0.54	0
85	INT283730	Binding of Eri1	1	0.01	0.26	0
86	INT266170	Negative_regulation of Transcription of POLG	1	0.36	1.43	0
87	INT219055	Regulation of Gene_expression of Eri1	1	0.00	0.1	0
88	INT251832	Positive_regulation of Positive_regulation of POLG	1	0.35	0.28	0
89	INT276659	Positive_regulation of Gene_expression of Polg	1	0.45	0	0
90	INT292660	Phosphorylation of ISG20	1	0.26	0	0
91	INT318842	Localization of ERI3	1	0.23	0	0
92	INT219496	Negative_regulation of FEN1	1	0.35	0.36	0
93	INT285950	Positive_regulation of Transcription of REXO1	1	0.06	0.14	0
94	INT282584	Localization of REXO1	1	0.33	0.17	0
95	INT294854	Negative_regulation of Phosphorylation of REXO1	1	0.18	0.54	0
96	INT204984	Transcription of Eri1	1	0.21	0.78	0