GO:0004667

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Latest revision as of 05:02, 29 January 2013

Name prostaglandin-D synthase activity
Categary Function
Go Slim No
Go Link GO:0004667
Unique Molecular Interactions 92
Total Molecular Interactions 108
Total Single Events 1138
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

[edit] Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for prostaglandin-D synthase activity. They are ordered first by their pain relevance and then by number of times they were reported for prostaglandin-D synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT25111 Binding of PTGDS and PLEKHM1 1 0.01 0 0.97
2 INT126766 Binding of PTGDS and PTGDR2 4 0.40 1.62 0.93
3 INT38905 Ptgfr Regulation of Ptgds 1 0.20 0 0.63
4 INT234599 Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44
5 INT234600 Negative_regulation of Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44
6 INT264522 Binding of GPER and PTGDS 1 0.03 1.22 0.4
7 INT264525 Binding of PTGDS and PTGFR 1 0.02 1.22 0.39
8 INT106505 Binding of Ptgds and Ptgs2 1 0.01 0.93 0.39
9 INT264527 IL1B Positive_regulation of Gene_expression of PTGDS 1 0.07 0.75 0.38
10 INT255555 Binding of Ptgds and Tfdp1 1 0.14 1.14 0.36
11 INT126767 Positive_regulation of Binding of PTGDS and PTGDR2 1 0.54 0.3 0.35
12 INT264521 PTGDS Negative_regulation of Positive_regulation of MMP1 1 0.06 1.42 0.34
13 INT147984 Ptgds Positive_regulation of Cpox 1 0.17 0.29 0.32
14 INT147982 Cpox Positive_regulation of Gene_expression of Ptgds 1 0.17 0.3 0.32
15 INT264523 PTGDS Positive_regulation of Gene_expression of COL2A1 1 0.03 1.24 0.3
16 INT46339 Ptgds Regulation of Localization of Lh 1 0.25 0 0.29
17 INT67529 PTGDS Positive_regulation of Positive_regulation of IL6 1 0.30 0.69 0.29
18 INT102923 Ptgds Regulation of Avp 1 0.02 0 0.27
19 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
20 INT139357 Nr1h2 Regulation of Gene_expression of Ptges 1 0.07 0.5 0.25
21 INT352890 Binding of PTGDS and ROS1 1 0.13 0.67 0.25
22 INT264524 PTGDS Negative_regulation of Gene_expression of MMP1 1 0.09 0.5 0.22
23 INT69869 Binding of Ptgdr and Ptgds 1 0.06 0 0.22
24 INT264526 PTGDS Negative_regulation of Gene_expression of MMP13 1 0.12 0.5 0.22
25 INT149882 Binding of Ptgs1 and Ptges 1 0.01 0.15 0.22
26 INT264517 PTGDS Positive_regulation of TFDP1 1 0.17 0.5 0.22
27 INT264519 PTGDS Negative_regulation of Positive_regulation of TFDP1 1 0.15 0.5 0.22
28 INT69868 Binding of Ptgds and Ptger1 1 0.01 0 0.18
29 INT352896 PTGDS Positive_regulation of Gene_expression of ROS1 1 0.12 0.91 0.18
30 INT207345 PTGDS Negative_regulation of Gene_expression of ABCA1 1 0.21 0 0.17
31 INT207342 PTGDS Negative_regulation of Gene_expression of CYP27A1 1 0.02 0 0.17
32 INT49058 Binding of IGHE and Positive_regulation of Localization of PTGDS 1 0.29 0.35 0.17
33 INT168807 Binding of Nfkb1 and Ptges 1 0.04 0.35 0.16
34 INT352067 Binding of B4GALNT1 and HPGDS 1 0.01 0.12 0.16
35 INT242318 Ptgds Positive_regulation of Trpa1 1 0.29 0.06 0.16
36 INT106506 Binding of Pparg and Ptgds 1 0.42 0.31 0.14
37 INT207360 PTGDS Negative_regulation of Negative_regulation of ABCA1 1 0.25 0 0.14
38 INT207335 PTGDS Negative_regulation of Negative_regulation of CYP27A1 1 0.02 0 0.14
39 INT234604 Tlr4 Positive_regulation of Ptges 1 0.04 0 0.14
40 INT134405 Binding of PTGS1 and HPGDS 1 0.01 0.33 0.14
41 INT207358 PTGDS Negative_regulation of CPOX 1 0.05 0 0.14
42 INT227556 Ptgds Positive_regulation of Ppara 1 0.18 0.62 0.13
43 INT116788 Bsg Negative_regulation of Gene_expression of Ptges 1 0.00 0.17 0.09
44 INT168808 Tlr4 Positive_regulation of Gene_expression of Ptges 1 0.02 0.13 0.08
45 INT106515 Binding of Ptges and Cpox 1 0.00 0.17 0.04
46 INT269545 PTGDS Regulation of PTGIR 1 0.01 0 0.04
47 INT207361 PTGDS Regulation of Gene_expression of CYP27A1 1 0.01 0.05 0.03
48 INT269567 TMPO Positive_regulation of PTGDS 1 0.07 0 0
49 INT352064 Binding of PTGS2 and HPGDS 1 0.20 0 0
50 INT352065 Binding of PTGDS and PTGS2 1 0.28 0 0
51 INT269582 Negative_regulation of TMPO Positive_regulation of PTGDS 1 0.06 0 0

[edit] Single Events

The table below shows the top 100 pain related interactions that have been reported for prostaglandin-D synthase activity. They are ordered first by their pain relevance and then by number of times they were reported in prostaglandin-D synthase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01
2 INT28420 Gene_expression of Ptgds 59 0.78 31.72 12.67
3 INT4804 Positive_regulation of Gene_expression of PTGDS 10 0.68 21.43 11.14
4 INT106510 Gene_expression of Ptges 70 0.75 36.18 9.75
5 INT69866 Positive_regulation of Ptgds 26 0.70 16.25 8.33
6 INT4810 Localization of PTGDS 20 0.81 4.19 6.97
7 INT7996 Gene_expression of Ptgds 18 0.64 6.47 5.51
8 INT143925 Negative_regulation of Ptges 18 0.42 10.5 5.18
9 INT27758 Positive_regulation of PTGDS 20 0.67 10.74 4.22
10 INT6994 Binding of Ptgds 15 0.36 7.06 3.54
11 INT50143 Negative_regulation of Gene_expression of Ptgds 10 0.48 5.82 3.54
12 INT134413 Gene_expression of HPGDS 20 0.77 8.93 3.28
13 INT50149 Positive_regulation of Gene_expression of Ptgds 12 0.61 4.88 2.73
14 INT25119 Binding of PTGDS 9 0.35 3.86 2.54
15 INT50139 Regulation of Gene_expression of Ptgds 6 0.50 3.5 2.39
16 INT14596 Localization of Ptgds 11 0.73 4.41 2.12
17 INT108982 Regulation of Gene_expression of Ptgds 6 0.51 1.64 2.07
18 INT106508 Positive_regulation of Gene_expression of Ptges 12 0.20 5.37 2.06
19 INT118700 Positive_regulation of Ptges 12 0.49 5.04 1.68
20 INT27438 Negative_regulation of Ptgds 3 0.51 0.24 1.61
21 INT28425 Regulation of Ptgds 4 0.28 2.07 1.53
22 INT118699 Binding of Ptges 4 0.33 1.15 1.5
23 INT6991 Negative_regulation of Ptgds 5 0.55 3.83 1.32
24 INT44917 Negative_regulation of Gene_expression of PTGDS 6 0.50 2.98 1.27
25 INT146381 Localization of Ptges 3 0.10 5.55 1.26
26 INT106509 Negative_regulation of Gene_expression of Ptges 6 0.17 1.95 1.25
27 INT68359 Positive_regulation of HPGDS 9 0.32 4.63 1.18
28 INT33803 Positive_regulation of Ptgds 4 0.50 1.09 1.1
29 INT89524 Transcription of Ptgds 3 0.46 1.34 1.09
30 INT111613 Regulation of PTGDS 6 0.52 3.29 0.93
31 INT220275 Protein_catabolism of Ptgds 1 0.81 2.18 0.74
32 INT89525 Positive_regulation of Transcription of Ptgds 1 0.41 0.32 0.73
33 INT139353 Regulation of Gene_expression of Ptges 3 0.18 2.05 0.71
34 INT264537 Transcription of HPGDS 1 0.33 1.33 0.69
35 INT115952 Negative_regulation of Positive_regulation of Ptgds 1 0.02 0.43 0.65
36 INT51284 Negative_regulation of Localization of PTGDS 1 0.51 0 0.6
37 INT46338 Negative_regulation of Regulation of Ptgds 1 0.37 0 0.58
38 INT68360 Regulation of HPGDS 3 0.23 0.72 0.56
39 INT28421 Negative_regulation of Regulation of Ptgds 1 0.26 0 0.56
40 INT177864 Negative_regulation of HPGDS 6 0.49 1.92 0.54
41 INT151360 Positive_regulation of Binding of Ptgds 1 0.39 1.3 0.54
42 INT234588 Transcription of Ptges 1 0.06 0.9 0.51
43 INT104675 Positive_regulation of Gene_expression of Ptgds 1 0.13 0.34 0.48
44 INT206864 Transcription of PTGDS 3 0.45 1.04 0.45
45 INT147980 Regulation of Localization of Ptgds 1 0.26 0.34 0.45
46 INT146382 Positive_regulation of Localization of Ptges 1 0.00 0.36 0.45
47 INT58360 Negative_regulation of Positive_regulation of Ptgds 1 0.15 0.8 0.45
48 INT6992 Negative_regulation of Binding of Ptgds 2 0.39 0.93 0.44
49 INT134412 Binding of HPGDS 9 0.42 1.7 0.43
50 INT234585 Negative_regulation of Positive_regulation of Ptges 1 0.04 0.91 0.37
51 INT270028 Positive_regulation of Localization of Ptgds 2 0.45 0.61 0.36
52 INT234594 Positive_regulation of Transcription of Ptges 1 0.04 0.9 0.36
53 INT44916 Negative_regulation of PTGDS 3 0.43 1.6 0.33
54 INT220269 Positive_regulation of Phosphorylation of Ptgds 1 0.41 1.12 0.32
55 INT220278 Phosphorylation of Ptgds 1 0.66 1.06 0.32
56 INT151718 Regulation of Ptges 3 0.27 1.63 0.31
57 INT46337 Regulation of Ptgds 1 0.39 0 0.29
58 INT264539 Localization of HPGDS 1 0.46 0.48 0.24
59 INT140796 Localization of Ptgds 1 0.69 0.56 0.24
60 INT159475 Positive_regulation of Binding of PTGDS 1 0.04 0.1 0.23
61 INT161817 Regulation of Localization of PTGDS 1 0.10 0.39 0.22
62 INT350864 Negative_regulation of Gene_expression of HPGDS 1 0.36 0.52 0.2
63 INT350865 Negative_regulation of Binding of HPGDS 1 0.36 0.51 0.19
64 INT100734 Binding of Ptgds 1 0.31 0.19 0.19
65 INT264543 Positive_regulation of Positive_regulation of PTGDS 1 0.42 0.35 0.14
66 INT264533 Regulation of Regulation of PTGDS 1 0.38 0.23 0.12
67 INT264540 Regulation of Gene_expression of PTGDS 1 0.52 0.23 0.06
68 INT206878 Negative_regulation of Transcription of PTGDS 1 0.25 0.07 0
69 INT245086 Positive_regulation of Negative_regulation of PTGDS 1 0.26 0.75 0
70 INT200111 Phosphorylation of PTGDS 1 0.10 0.41 0
71 INT264547 Regulation of Positive_regulation of PTGDS 1 0.38 0 0
72 INT206867 Positive_regulation of Transcription of PTGDS 1 0.29 0.14 0
73 INT81680 Regulation of Binding of Ptgds 1 0.09 0 0
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