GO:0004708

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Name MAP kinase kinase activity
Categary Function
Go Slim No
Go Link GO:0004708
Unique Molecular Interactions 186
Total Molecular Interactions 210
Total Single Events 1824
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for MAP kinase kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for MAP kinase kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
2 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
3 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
4 INT108546 BCL2L10 Regulation of MAPKAPK5 1 0.03 1.22 1.1
5 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
6 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
7 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
8 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
9 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
10 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
11 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
12 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
13 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
14 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
15 INT278694 TNF Positive_regulation of MAPK14 1 0.03 0.79 0.56
16 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
17 INT169478 TGFB3 Positive_regulation of Tgfa 1 0.01 0.9 0.44
18 INT346237 MAP2K6 Positive_regulation of MAP2K3 1 0.49 1 0.44
19 INT278964 MAPK14 Negative_regulation of Localization of EPHB2 1 0.15 0.47 0.43
20 INT346222 Positive_regulation of Braf Positive_regulation of Map2k1 1 0.15 0.67 0.39
21 INT346221 Positive_regulation of Braf Positive_regulation of Positive_regulation of Map2k2 1 0.11 0.67 0.39
22 INT346219 Positive_regulation of Braf Positive_regulation of Map2k2 1 0.11 0.67 0.39
23 INT278970 MAPK14 Positive_regulation of Gene_expression of IL8 1 0.11 0.66 0.37
24 INT278938 MAPK14 Positive_regulation of Gene_expression of PRKCA 1 0.05 0.65 0.37
25 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
26 INT346228 MAP2K6 Positive_regulation of Positive_regulation of MAPK14 1 0.44 0.68 0.34
27 INT346229 PREP Positive_regulation of MAPK14 1 0.13 0.63 0.34
28 INT346236 Binding of MAPK14 and MAP2K6 1 0.32 0.65 0.33
29 INT124475 MAP2K1 Positive_regulation of Positive_regulation of CPOX 1 0.04 0.68 0.33
30 INT346231 Binding of MAPK14 and MAP2K3 1 0.33 0.65 0.33
31 INT297972 MAPK14 Negative_regulation of ING5 1 0.21 1.67 0.33
32 INT255944 MAPK14 Positive_regulation of Tauph 1 0.00 0.1 0.32
33 INT151132 Negative_regulation of Map2k7 Negative_regulation of Gene_expression of Litaf 1 0.01 0.29 0.32
34 INT259639 MAPK14 Regulation of Gene_expression of IL8 1 0.02 1.2 0.32
35 INT255945 MAPK14 Positive_regulation of Rps6ka5 1 0.06 0.1 0.32
36 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
37 INT346235 IL1B Positive_regulation of Gene_expression of MAPK14 1 0.15 0.64 0.32
38 INT112799 Positive_regulation of CASP1 Positive_regulation of MAPK14 1 0.02 0.16 0.3
39 INT67199 Tgfa Regulation of Localization of IL8 1 0.00 0.66 0.28
40 INT67198 IL8 Regulation of Tgfa 1 0.00 0.65 0.27
41 INT123663 F2R Positive_regulation of MAPK14 1 0.12 0.42 0.26
42 INT123662 Negative_regulation of F2R Positive_regulation of MAPK14 1 0.08 0.42 0.26
43 INT171907 MAPK8 Positive_regulation of Gene_expression of MAPK14 1 0.06 0.77 0.26
44 INT123661 COL7A1 Positive_regulation of MAPK14 1 0.08 0.42 0.26
45 INT171911 MAPK8IP3 Positive_regulation of Gene_expression of MAPK14 1 0.05 0.77 0.26
46 INT179230 Binding of MAPK14 and GSR 1 0.03 0.5 0.23
47 INT112794 CASP1 Positive_regulation of MAPK14 1 0.02 0.16 0.23
48 INT346224 Braf Negative_regulation of Phosphorylation of Map2k1 1 0.14 0.62 0.22
49 INT112793 IL4I1 Positive_regulation of Positive_regulation of MAPK14 1 0.04 0 0.22
50 INT341778 DBT Positive_regulation of MAP2K6 1 0.00 0 0.21
51 INT297965 MAPK14 Negative_regulation of GADD45A 1 0.05 1 0.21
52 INT9715 Binding of Egf and Tgfa 1 0.18 0 0.21
53 INT254687 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Mmp13 1 0.06 0.2 0.2
54 INT254683 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Plaur 1 0.01 0.07 0.18
55 INT254691 Gopc Positive_regulation of Positive_regulation of Map2k2 1 0.07 0.07 0.18
56 INT254698 Gopc Positive_regulation of Positive_regulation of Map2k1 1 0.06 0.07 0.18
57 INT254685 Map2k2 Positive_regulation of Mmp3 1 0.04 0.08 0.18
58 INT65744 Map3k7 Negative_regulation of Gene_expression of Il2 1 0.10 0.74 0.18
59 INT304537 Map2k1 Positive_regulation of PRKG1 1 0.01 0.66 0.16
60 INT304503 Map2k1 Positive_regulation of Nos1 1 0.07 0.66 0.16
61 INT226518 Il1rl1 Positive_regulation of MAPK14 1 0.04 0.2 0.15
62 INT246365 CALM1 Regulation of MAP2K6 1 0.00 0.34 0.15
63 INT226520 Il1rl1 Positive_regulation of Gene_expression of MAPK14 1 0.03 0.2 0.15
64 INT295480 MAPK14 Positive_regulation of Localization of TNF 1 0.08 1.08 0.12
65 INT179424 Map2k2 Regulation of Mapk3 1 0.00 0.17 0.12
66 INT297967 MAPK14 Negative_regulation of SCUBE3 1 0.01 0.67 0.12
67 INT291260 Map3k8 Regulation of Gene_expression of MAPK14 1 0.07 0.52 0.11
68 INT304499 Map2k1 Positive_regulation of Mapk1 1 0.12 0.8 0.1
69 INT224531 Positive_regulation of Map2k1 Positive_regulation of Positive_regulation of Ankh 1 0.07 0.54 0.09
70 INT88752 Map3k7 Negative_regulation of Ednra 1 0.05 0 0.08
71 INT182268 Negative_regulation of MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
72 INT182274 MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
73 INT173659 Map2k3 Positive_regulation of MAPK8 1 0.15 0.28 0.07
74 INT140289 ROS1 Positive_regulation of MAPK14 1 0.44 1.27 0.06
75 INT339101 ERBB2 Positive_regulation of TGFA 1 0.33 0.68 0.06
76 INT164128 TNFSF10 Positive_regulation of MAPK14 1 0.28 2.09 0.05
77 INT182264 EDN1 Positive_regulation of Positive_regulation of MAPK14 1 0.26 0.1 0.05
78 INT194727 MAP3K4 Positive_regulation of MAP2K6 1 0.06 0 0.04
79 INT194699 MAP2K1 Positive_regulation of MAPK8 1 0.05 0 0.04
80 INT194703 MAP2K1 Positive_regulation of MAP2K6 1 0.21 0 0.04
81 INT194677 Binding of GADD45A and MAP2K1 1 0.27 0 0.04
82 INT194719 MAP2K1 Positive_regulation of MAPK1 1 0.27 0 0.04
83 INT194681 MAP3K4 Positive_regulation of MAP2K3 1 0.07 0 0.04
84 INT194701 MAP2K1 Positive_regulation of MAP2K4 1 0.21 0 0.04
85 INT194732 MAP2K1 Positive_regulation of Gene_expression of MAPK1 1 0.27 0 0.04
86 INT194691 MAP2K1 Positive_regulation of MAP2K3 1 0.23 0 0.04
87 INT295479 PRKCA Positive_regulation of MAP2K1 1 0.14 0.35 0.03
88 INT237682 LDHA Positive_regulation of MAPK14 1 0.02 0.16 0.03
89 INT269502 Lta Negative_regulation of Map2k1 1 0.17 0.48 0.03
90 INT209927 MAPK14 Positive_regulation of IL1B 1 0.13 0.05 0.03
91 INT298002 Gene_expression of Gadd45b Positive_regulation of MAPK14 1 0.29 0.67 0.03
92 INT297962 MAP3K4 Positive_regulation of MAPK14 1 0.21 0.66 0.03
93 INT295474 IRF6 Positive_regulation of MAP2K1 1 0.18 0.41 0.03
94 INT342733 Gene_expression of Lrrk2 Positive_regulation of Apaf1 1 0.10 0.74 0.03
95 INT254689 Gene_expression of Map2k2 Positive_regulation of Map2k1 1 0.30 0.4 0
96 INT348018 Map3k7 Positive_regulation of Chuk 1 0.19 0.06 0
97 INT178440 Map2k4 Positive_regulation of Mapk14 1 0.04 0.13 0
98 INT254707 Positive_regulation of Map2k1 Regulation of Gene_expression of BAK1 1 0.05 0.67 0
99 INT254692 Positive_regulation of Map2k1 Regulation of Gene_expression of Mdk 1 0.05 0.42 0
100 INT350429 Negative_regulation of MAPK14 Regulation of Gene_expression of ATF3 1 0.12 0.78 0
101 INT254695 Positive_regulation of Map2k2 Regulation of Mcl1 1 0.03 0.84 0
102 INT209925 Binding of MAPK14 and IL1B 1 0.09 0 0
103 INT254693 Gene_expression of Map2k1 Regulation of Map2k2 1 0.29 0.78 0
104 INT178445 Map2k4 Positive_regulation of Mapk8 1 0.11 0.13 0
105 INT254686 Gene_expression of Map2k1 Regulation of Gene_expression of Mdk 1 0.08 0.42 0
106 INT254703 Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 0.91 0
107 INT254696 Map2k2 Regulation of Map2k1 1 0.18 0.78 0
108 INT254708 Map2k2 Positive_regulation of Phosphorylation of MAPK1 1 0.11 0.86 0
109 INT348035 Map3k7 Positive_regulation of Binding of Chuk 1 0.20 0.06 0
110 INT254699 Positive_regulation of Map2k2 Regulation of Bcl2l1 1 0.04 0.89 0
111 INT178432 Map2k7 Positive_regulation of Mapk8 1 0.11 0.13 0
112 INT254706 Positive_regulation of Map2k1 Positive_regulation of Phosphorylation of MAPK3 1 0.07 0.91 0
113 INT194675 MAPK14 Positive_regulation of CREB1 1 0.07 0.33 0
114 INT254688 Gene_expression of Map2k2 Regulation of Gene_expression of Mdk 1 0.09 0.42 0
115 INT254704 Positive_regulation of Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 1.43 0
116 INT194684 MAPK14 Positive_regulation of Transcription of CREB1 1 0.07 0.33 0
117 INT254702 Map2k1 Positive_regulation of Phosphorylation of MAPK3 1 0.07 0.91 0
118 INT254684 Map2k2 Positive_regulation of Map2k1 1 0.45 0.4 0
119 INT254705 Map2k2 Positive_regulation of Phosphorylation of MAPK3 1 0.08 0.86 0
120 INT254694 Positive_regulation of Map2k2 Regulation of Bcl2 1 0.02 0.89 0
121 INT336606 Binding of Mapk8 and Map2k1 1 0.09 0.72 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for MAP kinase kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in MAP kinase kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
2 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
3 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
4 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
5 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
6 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8
7 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
8 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49
9 INT135440 Positive_regulation of Phosphorylation of Map2k1 5 0.49 1.32 5.22
10 INT85126 Negative_regulation of MAP2K6 19 0.39 12.12 4.39
11 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31
12 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18
13 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
14 INT179391 Phosphorylation of Map2k2 1 0.02 7.01 3.89
15 INT264972 Positive_regulation of MAP2K3 4 0.65 6.92 3.68
16 INT119420 Phosphorylation of MAP2K6 8 0.79 4.89 3.52
17 INT133086 Positive_regulation of Phosphorylation of Map2k7 1 0.05 4.34 3.27
18 INT133082 Phosphorylation of Map2k7 5 0.15 4.27 3.05
19 INT134470 Positive_regulation of Map2k1 74 0.49 46.07 3.02
20 INT173179 Binding of MAPK14 13 0.29 4.51 2.92
21 INT179396 Positive_regulation of Map2k2 7 0.30 2.84 2.56
22 INT102646 Positive_regulation of MAP2K6 3 0.63 4.37 2.44
23 INT110179 Negative_regulation of Phosphorylation of MAPK14 11 0.36 5.25 2.38
24 INT117924 Gene_expression of MAP2K3 2 0.72 5.82 2.32
25 INT128926 Gene_expression of Map2k7 5 0.23 3.01 2.31
26 INT150547 Phosphorylation of MAP2K3 2 0.79 4.92 2.3
27 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13
28 INT173647 Positive_regulation of Gene_expression of MAPK14 15 0.39 7.54 2.05
29 INT127756 Negative_regulation of Map2k1 10 0.41 6.69 2.04
30 INT133084 Positive_regulation of Gene_expression of Map2k7 3 0.17 2.56 1.8
31 INT135444 Regulation of Map2k1 4 0.44 1.15 1.77
32 INT119422 Negative_regulation of Phosphorylation of MAP2K6 3 0.38 2.09 1.76
33 INT173173 Regulation of Positive_regulation of MAPK14 6 0.38 2.59 1.64
34 INT179420 Positive_regulation of Phosphorylation of Map2k2 1 0.01 2.17 1.58
35 INT182297 Positive_regulation of Phosphorylation of MAPK14 7 0.42 3.36 1.53
36 INT109916 Positive_regulation of Positive_regulation of MAP2K6 2 0.45 2.28 1.45
37 INT173654 Localization of MAPK14 12 0.62 3.16 1.43
38 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
39 INT175525 Positive_regulation of Phosphorylation of Map2k1 8 0.33 7.02 1.37
40 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37
41 INT254666 Positive_regulation of Map2k2 37 0.56 23.85 1.35
42 INT27656 Gene_expression of Tgfa 6 0.74 3.37 1.32
43 INT36337 Localization of Tgfa 4 0.73 0.83 1.32
44 INT222843 Positive_regulation of Map3k7 4 0.24 3.04 1.24
45 INT112823 Negative_regulation of Positive_regulation of MAPK14 5 0.36 1.49 1.22
46 INT102615 Positive_regulation of Gene_expression of Tgfa 5 0.44 3.93 1.17
47 INT108551 Gene_expression of MAPKAPK5 1 0.15 1.23 1.1
48 INT108553 Negative_regulation of Gene_expression of MAPKAPK5 1 0.09 1.23 1.1
49 INT108552 Regulation of MAPKAPK5 1 0.10 1.19 1.08
50 INT138287 Gene_expression of Map2k1 69 0.65 46.14 1.02
51 INT150546 Positive_regulation of Phosphorylation of MAP2K6 3 0.49 1.14 0.93
52 INT194875 Regulation of Negative_regulation of MAPK14 1 0.04 2.39 0.91
53 INT346253 Positive_regulation of Positive_regulation of MAP2K3 1 0.47 1.79 0.87
54 INT24327 Gene_expression of Tgfa 6 0.64 3.61 0.86
55 INT107161 Positive_regulation of MAPKAPK5 2 0.16 1.15 0.82
56 INT71778 Positive_regulation of Gene_expression of MAP2K1 2 0.36 0.37 0.81
57 INT77295 Positive_regulation of Tgfa 2 0.34 0.05 0.8
58 INT346246 Positive_regulation of Gene_expression of MAP2K6 1 0.45 1.74 0.78
59 INT346248 Positive_regulation of Gene_expression of MAP2K3 1 0.47 1.73 0.78
60 INT211909 Regulation of Positive_regulation of Map2k1 1 0.21 0.47 0.76
61 INT211908 Regulation of Positive_regulation of Map2k2 1 0.27 0.48 0.76
62 INT151468 Regulation of MAP2K6 2 0.11 0.68 0.74
63 INT150548 Positive_regulation of Phosphorylation of MAP2K3 2 0.49 1.6 0.73
64 INT128925 Negative_regulation of Map2k7 2 0.10 0.66 0.68
65 INT139840 Positive_regulation of Negative_regulation of MAPK14 2 0.21 1.55 0.67
66 INT165963 Gene_expression of Map2k2 37 0.75 20.68 0.66
67 INT211910 Negative_regulation of Map2k2 2 0.26 0.59 0.63
68 INT120400 Negative_regulation of MAP2K3 2 0.40 0.54 0.62
69 INT58742 Localization of MAP2K6 1 0.61 0.16 0.58
70 INT179409 Regulation of Phosphorylation of Map2k2 1 0.01 0.74 0.56
71 INT179405 Positive_regulation of Map2k7 1 0.16 1.32 0.55
72 INT104120 Positive_regulation of Positive_regulation of MAP2K1 1 0.49 0 0.54
73 INT209936 Negative_regulation of Gene_expression of MAPK14 7 0.20 4.95 0.53
74 INT346255 Regulation of Positive_regulation of MAP2K3 1 0.42 1.38 0.53
75 INT59386 Binding of Tgfa 2 0.06 0.41 0.52
76 INT151125 Negative_regulation of Localization of Map2k7 1 0.08 0.61 0.51
77 INT128924 Regulation of Map2k7 3 0.08 0.87 0.5
78 INT151121 Localization of Map2k7 1 0.14 0.59 0.5
79 INT236915 Binding of Map2k1 2 0.15 1.51 0.49
80 INT121027 Regulation of Phosphorylation of MAPK14 2 0.38 1.1 0.46
81 INT130270 Gene_expression of Map2k2 2 0.24 0.25 0.45
82 INT346258 Negative_regulation of Gene_expression of MAP2K6 1 0.38 1.08 0.45
83 INT346247 Negative_regulation of Phosphorylation of MAP2K3 1 0.40 1.07 0.45
84 INT346262 Regulation of Gene_expression of MAP2K3 1 0.42 1.09 0.45
85 INT346251 Negative_regulation of Gene_expression of MAP2K3 1 0.40 1.08 0.45
86 INT346260 Regulation of Gene_expression of MAP2K6 1 0.41 1.09 0.45
87 INT173625 Positive_regulation of Localization of MAPK14 3 0.17 1.05 0.44
88 INT179170 Protein_catabolism of MAPK14 3 0.43 0.88 0.43
89 INT255902 Positive_regulation of Binding of MAPK14 1 0.17 0.93 0.42
90 INT202347 Gene_expression of Map2k4 13 0.74 11.68 0.4
91 INT138282 Positive_regulation of Gene_expression of Map2k1 13 0.49 7.46 0.39
92 INT304528 Gene_expression of Map2k1 3 0.58 1.76 0.37
93 INT128918 Negative_regulation of Gene_expression of Map2k7 1 0.02 0.37 0.37
94 INT202349 Positive_regulation of Map2k3 3 0.52 1.26 0.36
95 INT274074 Binding of Map2k4 1 0.08 1.98 0.36
96 INT304526 Binding of Map2k1 1 0.11 0.6 0.32
97 INT77294 Regulation of Gene_expression of Tgfa 1 0.59 0.27 0.3
98 INT202360 Positive_regulation of Map2k4 2 0.48 9.89 0.29
99 INT105246 Negative_regulation of Tgfa 1 0.07 1.08 0.29
100 INT118345 Binding of Tgfa 1 0.29 0 0.29
101 INT240205 Regulation of MAP2K1 3 0.26 0.44 0.28
102 INT255923 Positive_regulation of Regulation of MAPK14 1 0.17 0.41 0.28
103 INT222012 Negative_regulation of Map2k3 1 0.41 1.62 0.27
104 INT11156 Gene_expression of TGFA 4 0.61 3.03 0.26
105 INT222841 Phosphorylation of Map3k7 1 0.16 0.55 0.25
106 INT65739 Gene_expression of Map3k7 1 0.54 1.41 0.25
107 INT11155 Binding of TGFA 2 0.34 0.95 0.23
108 INT175506 Regulation of Positive_regulation of Map2k1 2 0.32 1.58 0.23
109 INT304519 Positive_regulation of Gene_expression of Map2k1 1 0.15 0.41 0.22
110 INT254675 Regulation of Positive_regulation of Map2k2 1 0.36 0.85 0.2
111 INT71544 Positive_regulation of Gene_expression of Tgfa 2 0.16 1.45 0.19
112 INT151131 Negative_regulation of Phosphorylation of Map2k7 1 0.10 0.31 0.19
113 INT65544 Localization of TGFA 1 0.41 0.64 0.17
114 INT14870 Positive_regulation of Gene_expression of TGFA 2 0.46 2.12 0.15
115 INT27655 Transcription of Tgfa 1 0.41 0.06 0.15
116 INT267610 Negative_regulation of Negative_regulation of MAPK14 1 0.03 1.08 0.15
117 INT254671 Regulation of Map2k1 5 0.43 1.83 0.14
118 INT265533 Negative_regulation of Phosphorylation of Map2k1 1 0.41 0 0.14
119 INT175527 Localization of Map2k1 4 0.31 2.41 0.13
120 INT222015 Regulation of Negative_regulation of Map2k3 1 0.43 0.79 0.12
121 INT254673 Positive_regulation of Positive_regulation of Map2k1 3 0.35 1.65 0.11
122 INT179397 Positive_regulation of Positive_regulation of Map2k2 1 0.01 0.17 0.11
123 INT302772 Regulation of Map2k7 1 0.02 0.33 0.11
124 INT347994 Positive_regulation of Gene_expression of Map3k7 1 0.26 1.27 0.11
125 INT347985 Gene_expression of Map3k7 1 0.35 1.26 0.11
126 INT202357 Gene_expression of Map2k3 13 0.65 1.94 0.09
127 INT188350 Localization of Map2k4 2 0.67 0.46 0.09
128 INT346252 Regulation of Gene_expression of MAPK14 1 0.38 0 0.09
129 INT349818 Positive_regulation of Tgfa 1 0.20 0.22 0.09
130 INT222014 Negative_regulation of Gene_expression of Map2k3 1 0.41 1.55 0.09
131 INT215418 Positive_regulation of Phosphorylation of MAP2K1 1 0.03 0.51 0.08
132 INT215420 Phosphorylation of MAP2K1 1 0.05 0.51 0.08
133 INT347978 Positive_regulation of Phosphorylation of Map2k7 1 0.27 1.08 0.08
134 INT254667 Positive_regulation of Gene_expression of Map2k2 5 0.56 2.98 0.07
135 INT190543 Localization of Map3k7 1 0.33 0.74 0.07
136 INT339179 Positive_regulation of TGFA 1 0.17 0.66 0.06
137 INT281759 Negative_regulation of Map2k7 1 0.03 0.2 0.05
138 INT202363 Phosphorylation of Map2k4 11 0.79 2.94 0.04
139 INT182288 Negative_regulation of Binding of MAPK14 1 0.21 0.08 0.04
140 INT274075 Positive_regulation of Gene_expression of Map2k4 1 0.16 4.28 0.04
141 INT349814 Regulation of Tgfa 1 0.12 0.47 0.04
142 INT182280 Negative_regulation of Localization of MAPK14 1 0.21 0.39 0.04
143 INT342721 Localization of Lrrk2 1 0.39 0.67 0.04
144 INT347987 Phosphorylation of Map2k7 1 0.37 0.53 0.04
145 INT281764 Negative_regulation of Gene_expression of Map2k1 1 0.18 1.11 0.04
146 INT342722 Gene_expression of Lrrk2 2 0.41 1.81 0.03
147 INT228192 Negative_regulation of Map2k2 2 0.35 0.96 0.03
148 INT342711 Positive_regulation of Gene_expression of Lrrk2 1 0.36 0.73 0.03
149 INT222018 Positive_regulation of Map2k7 1 0.02 0.77 0.03
150 INT329571 Binding of MAP2K1 2 0.11 0.4 0
151 INT254677 Positive_regulation of Positive_regulation of Map2k2 1 0.40 0.94 0
152 INT254676 Regulation of Gene_expression of Map2k2 1 0.32 0.17 0
153 INT266482 Phosphorylation of Map3k7 1 0.18 0.26 0
154 INT202366 Phosphorylation of Map2k3 1 0.80 0.08 0
155 INT202379 Positive_regulation of Gene_expression of Map2k3 1 0.45 0 0
156 INT254674 Negative_regulation of Positive_regulation of Map2k2 1 0.34 0.51 0
157 INT281758 Positive_regulation of Protein_catabolism of Map2k1 1 0.29 0.13 0
158 INT339181 Negative_regulation of TGFA 1 0.33 0.85 0
159 INT254672 Negative_regulation of Gene_expression of Map2k2 1 0.35 0.78 0
160 INT254678 Phosphorylation of Map2k2 1 0.66 2.21 0
161 INT333592 Positive_regulation of Transcription of MAP2K3 1 0.17 0.09 0
162 INT281756 Protein_catabolism of Map2k1 1 0.42 0.13 0
163 INT175533 Regulation of Gene_expression of Map2k1 1 0.20 1.55 0
164 INT202343 Transcription of Map2k3 1 0.70 0.29 0
165 INT347996 Binding of Map3k7 1 0.19 0.06 0
166 INT254682 Regulation of Map2k2 1 0.36 0.99 0
167 INT202386 Transcription of Map2k4 1 0.69 0.15 0
168 INT333626 Transcription of MAP2K3 1 0.23 0.09 0
169 INT202367 Positive_regulation of Phosphorylation of Map2k4 1 0.48 0.15 0
170 INT202342 Negative_regulation of Map2k4 1 0.36 0 0
171 INT202345 Localization of Map2k3 1 0.68 0.08 0
172 INT202354 Negative_regulation of Transcription of Map2k4 1 0.36 0 0
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