GO:0004716

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Name receptor signaling protein tyrosine kinase activity
Categary Function
Go Slim No
Go Link GO:0004716
Unique Molecular Interactions 411
Total Molecular Interactions 676
Total Single Events 6805
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for receptor signaling protein tyrosine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for receptor signaling protein tyrosine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
2 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
3 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
4 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
5 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
6 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
8 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
9 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
10 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
11 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
12 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
13 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
14 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
15 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
16 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
17 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
18 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
19 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
20 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
21 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
22 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
23 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
24 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
25 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
26 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
27 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
28 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
29 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
30 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
31 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
32 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
33 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
34 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
35 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
36 INT220741 Binding of EGFR and SOAT1 1 0.02 0.37 0.49
37 INT237154 LGALS4 Positive_regulation of KIT 1 0.10 1.99 0.47
38 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
39 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
40 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
41 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
42 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
43 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
44 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
45 INT324525 PGE Positive_regulation of Positive_regulation of Egfr 1 0.41 1.05 0.33
46 INT324522 PGE Positive_regulation of Phosphorylation of Egfr 1 0.56 1.04 0.33
47 INT324524 PGE Positive_regulation of Egfr 1 0.38 1.05 0.33
48 INT326090 Binding of Erbb2 and Mmp2 1 0.09 1.39 0.31
49 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3
50 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
51 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
52 INT166093 Negative_regulation of ROS1 Negative_regulation of Positive_regulation of EGFR 1 0.12 0.33 0.28
53 INT144434 Gene_expression of Erbb2 Positive_regulation of ras 1 0.16 0.6 0.28
54 INT166094 Negative_regulation of CSK Negative_regulation of Positive_regulation of EGFR 1 0.02 0.33 0.28
55 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26
56 INT41406 Binding of Insr and Thtpa 1 0.05 0 0.25
57 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24
58 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24
59 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23
60 INT272753 Positive_regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.23
61 INT89158 Grpr Positive_regulation of Localization of Insr 1 0.02 0 0.23
62 INT291352 Positive_regulation of CXCL12 Positive_regulation of ERBB2 1 0.17 0.88 0.22
63 INT237201 Cd3e Positive_regulation of KIT 1 0.03 0 0.21
64 INT144433 Gene_expression of Erbb2 Positive_regulation of Positive_regulation of Mapk3 1 0.41 0.56 0.21
65 INT352355 Binding of CNR1 and EGFR 1 0.19 0.76 0.2
66 INT145152 Binding of EGF and EGFR 4 0.15 2.45 0.19
67 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
68 INT351088 Negative_regulation of ERBB2 Positive_regulation of FOXO3 1 0.17 0.66 0.18
69 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
70 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
71 INT249962 Binding of KIT and KITLG 6 0.19 3.69 0.17
72 INT222300 Binding of ERBB2 and PGR 2 0.34 1.89 0.17
73 INT115610 Binding of ERBB2 and KLF1 1 0.02 2.12 0.17
74 INT352354 EGFR Regulation of Gene_expression of CNR1 1 0.23 1.16 0.17
75 INT112132 Gast Positive_regulation of Positive_regulation of Egfr 1 0.33 0.13 0.16
76 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
77 INT139538 Binding of CD34 and KIT 2 0.39 2.73 0.14
78 INT175398 Binding of ERBB2 and VEGFA 2 0.16 1.34 0.13
79 INT175401 Binding of EGFR and VEGFA 2 0.13 1.49 0.13
80 INT178446 Binding of Egfr and ras 1 0.04 0.13 0.13
81 INT178431 Positive_regulation of Binding of Egfr and ras 1 0.05 0.13 0.13
82 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13
83 INT279799 ATP6V0A2 Regulation of ERBB3 1 0.00 1.77 0.12
84 INT341828 Binding of BTC and EGFR 1 0.22 0.95 0.12
85 INT315829 Binding of EGFR and TKT 1 0.03 1.14 0.12
86 INT211996 Erbb3 Positive_regulation of Nrg1 2 0.03 0.67 0.11
87 INT171390 Src Positive_regulation of Phosphorylation of Egfr 1 0.13 0 0.11
88 INT272750 Prkaca Positive_regulation of EGFR 1 0.02 0 0.11
89 INT236401 Binding of Flt1 and Mthfs 1 0.01 0.28 0.11
90 INT171385 Ppp1cc Positive_regulation of Phosphorylation of Egfr 1 0.15 0 0.11
91 INT272752 Regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.11
92 INT236403 Binding of Flt1 and Negative_regulation of Gene_expression of VEGFA 1 0.04 0.3 0.11
93 INT191184 Binding of EGFR and GRB2 7 0.35 1.06 0.1
94 INT291353 IL8 Positive_regulation of Binding of EGFR 1 0.32 0.52 0.1
95 INT275451 Binding of ZAP70 and Syk 1 0.02 0.12 0.1
96 INT275450 Binding of STAM and Syk 1 0.00 0.12 0.1
97 INT220743 Binding of AR and EGFR 1 0.01 0.46 0.1
98 INT291351 Binding of EGFR and SHC1 1 0.05 0.57 0.1
99 INT291350 IL8 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.52 0.1
100 INT299955 Binding of KDR and FTSJ3 1 0.04 1.07 0.09
101 INT231273 Binding of Egfr and Nrg1 1 0.12 0 0.09
102 INT341826 Binding of ERBB2 and TNC 1 0.18 0.63 0.09
103 INT145153 JUN Positive_regulation of EGFR 1 0.24 0.94 0.09
104 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09
105 INT145154 Positive_regulation of JUN Positive_regulation of EGFR 1 0.24 0.95 0.09
106 INT341008 Nrg1 Regulation of Binding of Erbb4 1 0.04 0 0.09
107 INT232557 Erbb2 Positive_regulation of Esr1 1 0.23 0.26 0.09
108 INT302167 PTGER2 Positive_regulation of EGFR 1 0.10 3.08 0.09
109 INT250661 Binding of EGF and ERBB2 2 0.11 0.82 0.08
110 INT325059 Insr Positive_regulation of Ang 1 0.02 1.4 0.08
111 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
112 INT309904 Binding of ERBB2 and TXK 1 0.01 0.23 0.08
113 INT244640 AGK Negative_regulation of KIT 1 0.00 0.69 0.08
114 INT249332 GPNMB Positive_regulation of EGFR 1 0.17 2.63 0.08
115 INT244638 AGK Negative_regulation of KDR 1 0.00 0.68 0.08
116 INT339111 Binding of ERBB2 and JUP 1 0.38 0.62 0.07
117 INT300446 VEGFA Positive_regulation of Flt1 1 0.09 2.62 0.07
118 INT265750 Binding of FLT1 and KDR 1 0.37 0.54 0.07
119 INT293813 ERBB2 Positive_regulation of Positive_regulation of AR 1 0.09 0.45 0.07
120 INT120569 Binding of Egfr and Pik3r1 1 0.40 1.22 0.06
121 INT339101 ERBB2 Positive_regulation of TGFA 1 0.33 0.68 0.06
122 INT120570 Positive_regulation of Binding of Egfr and Pik3r1 1 0.55 1.22 0.06
123 INT237197 KIT Positive_regulation of LPT 1 0.00 0.15 0.06
124 INT251776 Negative_regulation of TXK Negative_regulation of ERBB4 1 0.04 1.07 0.06
125 INT17920 Penk Positive_regulation of Insr 1 0.05 0.14 0.06
126 INT339099 ERBB2 Positive_regulation of IGF2R 1 0.33 0.67 0.06
127 INT221368 EGFR Regulation of Gene_expression of MUC1 1 0.05 3.82 0.06
128 INT210146 Binding of EGFR and TXN 1 0.15 0.09 0.06
129 INT339105 ERBB2 Positive_regulation of EGFR 1 0.37 0.68 0.06
130 INT251774 Negative_regulation of TXK Negative_regulation of EGFR 1 0.07 1.06 0.06
131 INT339110 ERBB2 Positive_regulation of GATA6 1 0.31 0.67 0.06
132 INT105268 VEGFA Positive_regulation of KDR 2 0.18 0.22 0.05
133 INT279290 EGFR Regulation of CDCP1 1 0.01 0.98 0.05
134 INT105267 Negative_regulation of VEGFA Positive_regulation of KDR 1 0.16 0.22 0.05
135 INT251778 Negative_regulation of TXK Positive_regulation of KDR 1 0.03 0.99 0.05
136 INT302165 PTGER2 Positive_regulation of Localization of EGFR 1 0.06 1.73 0.05
137 INT184123 Socs3 Positive_regulation of Protein_catabolism of Insr 1 0.03 0.41 0.05
138 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05
139 INT355583 Binding of EGFR and ANGPTL4 1 0.12 2.14 0.05
140 INT120573 Positive_regulation of Binding of Egfr and Gab1 1 0.63 1.22 0.05
141 INT120572 Positive_regulation of Binding of Egfr and Cltc 1 0.38 1.21 0.05
142 INT355589 Binding of EGFR and LTBP1 1 0.11 2.15 0.05
143 INT120571 Binding of Egfr and Gab1 1 0.44 1.21 0.05
144 INT120568 Binding of Egfr and Cltc 1 0.28 1.21 0.05
145 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
146 INT184085 Socs1 Positive_regulation of Protein_catabolism of Insr 1 0.04 0.41 0.05
147 INT251779 TXK Positive_regulation of KDR 1 0.03 0.99 0.05
148 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04
149 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04
150 INT292089 Binding of KIT and TXK 1 0.02 1.54 0.04
151 INT188737 Egfr Positive_regulation of EGFR 1 0.21 0.6 0.04
152 INT315913 VEGFA Regulation of KDR 1 0.03 0.32 0.04
153 INT292090 Negative_regulation of Binding of KIT and TXK 1 0.02 1.54 0.04
154 INT292083 Binding of KDR and TXK 1 0.04 1.52 0.04
155 INT213901 EGFR Positive_regulation of ERBB2 1 0.52 0.41 0.04
156 INT339112 Binding of ERBB2 and TAB2 1 0.00 0.05 0.04
157 INT225259 Egfr Regulation of Gene_expression of S100a7a 1 0.04 0.98 0.04
158 INT302166 Positive_regulation of PTGER2 Positive_regulation of EGFR 1 0.07 1.49 0.04
159 INT186097 EGF Positive_regulation of Positive_regulation of EGFR 1 0.20 0.38 0.04
160 INT265772 Binding of KDR and NRP1 1 0.29 0 0.04
161 INT292095 Negative_regulation of Binding of KDR and TXK 1 0.04 1.53 0.04
162 INT352356 Gene_expression of CNR1 Positive_regulation of Gene_expression of EGFR 1 0.24 0.95 0.04
163 INT302291 Positive_regulation of EGFR Positive_regulation of Myc 1 0.18 1.3 0.04
164 INT342170 Insr Regulation of Localization of Cd320 1 0.08 0.92 0.04
165 INT188735 EGFR Positive_regulation of Egfr 1 0.21 0.6 0.04
166 INT188732 EGFR Positive_regulation of Gene_expression of Egfr 1 0.21 0.6 0.04
167 INT213906 EGFR Positive_regulation of Gene_expression of ERBB2 1 0.52 0.42 0.04
168 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04
169 INT205480 Egfr Positive_regulation of Stat3 5 0.58 4.11 0.03
170 INT231276 Erbb4 Positive_regulation of Nrg1 2 0.35 0.06 0.03
171 INT316057 Binding of Erbb4 and Nrg1 2 0.03 0.38 0.03
172 INT224305 Positive_regulation of Binding of KDR and VEGFA 2 0.45 0.36 0.03
173 INT337727 ADAMTS2 Positive_regulation of Gene_expression of KIT 1 0.02 0 0.03
174 INT234196 ERBB2 Positive_regulation of Negative_regulation of HSP90AA1 1 0.19 0.79 0.03
175 INT224304 KDR Positive_regulation of Binding of VEGFA 1 0.24 0.36 0.03
176 INT316060 Binding of Erbb4 and Ncor2 1 0.12 0.41 0.03
177 INT341847 ERBB2 Positive_regulation of Gene_expression of ESYT1 1 0.02 1.42 0.03
178 INT316061 Positive_regulation of Binding of Erbb4 and Nrg1 1 0.03 0.38 0.03
179 INT188736 Egfr Regulation of IGLV3-1 1 0.46 0.59 0.03
180 INT188731 Egfr Regulation of EGFR 1 0.46 0.59 0.03
181 INT213902 ESR1 Positive_regulation of EGFR 1 0.48 0.31 0.03
182 INT231275 Erbb4 Positive_regulation of Gene_expression of Nrg1 1 0.35 0 0.03
183 INT316055 Binding of Erbb4 and Tab2 1 0.23 0.4 0.03
184 INT224306 KDR Positive_regulation of VEGFA 1 0.24 0.36 0.03
185 INT287268 Binding of ERBB2 and ERBB3 5 0.16 2.74 0
186 INT115609 Binding of ERBB2 and SFRP5 3 0.15 1.83 0
187 INT300448 Binding of VEGFA and Flt1 3 0.10 1.93 0
188 INT187640 Binding of EGFR and KLF1 3 0.01 2.54 0
189 INT258524 IPMK Negative_regulation of KDR 2 0.00 1.98 0
190 INT294088 Binding of ERBB2 and ERBB4 2 0.13 0.88 0
191 INT294089 Negative_regulation of Binding of ERBB2 and ERBB4 1 0.08 0.6 0
192 INT278404 Syk Positive_regulation of Mapk1 1 0.13 0 0
193 INT351090 Phosphorylation of TXK Positive_regulation of EGFR 1 0.04 0.33 0
194 INT250665 EGFR Positive_regulation of PIK3CB 1 0.21 1.39 0
195 INT144761 Binding of INSR and Insr 1 0.05 0 0
196 INT198016 Localization of KDR Negative_regulation of VEGFA 1 0.08 0.95 0
197 INT80013 BTC Positive_regulation of ERBB4 1 0.31 0.26 0
198 INT298684 ecs Positive_regulation of Gene_expression of KDR 1 0.01 1.2 0
199 INT289672 Binding of GNRH1 and INSR 1 0.02 0 0
200 INT315163 Erbb2 Negative_regulation of Akt1 1 0.17 0.83 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for receptor signaling protein tyrosine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in receptor signaling protein tyrosine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
2 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
3 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
4 INT8691 Localization of Insr 85 0.80 9.27 30.32
5 INT5300 Regulation of Insr 54 0.60 11.33 29.26
6 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
7 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
8 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
9 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
10 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
11 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
12 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95
13 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
14 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
15 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
16 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
17 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
18 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
19 INT11154 Binding of EGFR 149 0.48 96.23 6.29
20 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
21 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
22 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
23 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
24 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
25 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
26 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
27 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
28 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
29 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38
30 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
31 INT51084 Binding of Insr 13 0.30 4.25 4.23
32 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13
33 INT83035 Binding of INSR 16 0.47 9.29 4.11
34 INT100372 Gene_expression of Flt1 47 0.71 24.33 4.09
35 INT10116 Localization of INSR 11 0.57 5.43 3.48
36 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
37 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
38 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
39 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11
40 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
41 INT8095 Gene_expression of ERBB3 47 0.77 24.85 2.82
42 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
43 INT103917 Positive_regulation of Phosphorylation of Egfr 12 0.68 7.23 2.18
44 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
45 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17
46 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15
47 INT278340 Gene_expression of Syk 7 0.51 4.92 2.09
48 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
49 INT100371 Positive_regulation of Flt1 11 0.63 6.42 2.02
50 INT65545 Localization of EGFR 35 0.79 20.8 1.88
51 INT114059 Localization of Insr 10 0.46 3.49 1.87
52 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86
53 INT112131 Positive_regulation of Positive_regulation of Egfr 10 0.49 9.95 1.85
54 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82
55 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8
56 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
57 INT232645 Transcription of INSR 2 0.09 1.19 1.71
58 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68
59 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
60 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54
61 INT19342 Regulation of Insr 12 0.24 6.11 1.54
62 INT52962 Binding of ERBB2 77 0.47 50.03 1.49
63 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48
64 INT237409 Localization of Erbb4 3 0.57 1.31 1.41
65 INT96993 Positive_regulation of Phosphorylation of EGFR 15 0.59 5.44 1.37
66 INT100373 Negative_regulation of Gene_expression of Flt1 11 0.53 10 1.37
67 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34
68 INT127725 Negative_regulation of Positive_regulation of EGFR 6 0.57 2.69 1.3
69 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
70 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
71 INT105270 Positive_regulation of KDR 25 0.49 11.49 1.2
72 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
73 INT118293 Regulation of Phosphorylation of EGFR 2 0.61 1.01 1.1
74 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
75 INT293487 Regulation of Gene_expression of Erbb2 4 0.61 3.4 1.06
76 INT86384 Negative_regulation of Localization of EGFR 4 0.43 2.5 0.97
77 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96
78 INT275940 Negative_regulation of Syk 3 0.39 2.08 0.95
79 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
80 INT213917 Negative_regulation of Phosphorylation of ERBB2 9 0.54 8.68 0.91
81 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
82 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86
83 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
84 INT117347 Positive_regulation of Positive_regulation of EGFR 15 0.69 11.17 0.84
85 INT88718 Negative_regulation of Erbb2 11 0.58 12.98 0.84
86 INT71649 Localization of ERBB2 23 0.78 13.63 0.83
87 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83
88 INT173100 Binding of KDR 39 0.39 22.48 0.81
89 INT176588 Phosphorylation of ERBB2 27 0.78 16.37 0.81
90 INT171361 Regulation of Egfr 16 0.62 8.36 0.81
91 INT131286 Binding of Egfr 26 0.44 13.58 0.78
92 INT138955 Transcription of EGFR 18 0.71 11.39 0.78
93 INT108044 Phosphorylation of Syk 3 0.25 1.39 0.77
94 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77
95 INT186119 Protein_catabolism of EGFR 6 0.98 3.68 0.76
96 INT159982 Negative_regulation of ERBB3 11 0.26 8.44 0.75
97 INT81396 Regulation of Gene_expression of ERBB2 14 0.43 10.73 0.74
98 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7
99 INT117392 Binding of Insr 8 0.23 4.88 0.68
100 INT186117 Negative_regulation of Protein_catabolism of EGFR 1 0.42 0.67 0.68
101 INT186118 Positive_regulation of Protein_catabolism of EGFR 1 0.68 0.66 0.68
102 INT171366 Positive_regulation of Localization of Insr 3 0.18 0.63 0.66
103 INT237411 Negative_regulation of Localization of Erbb4 1 0.25 0.08 0.64
104 INT18445 Regulation of Transcription of Insr 1 0.12 0.84 0.63
105 INT18446 Transcription of Insr 2 0.18 0.84 0.62
106 INT100374 Positive_regulation of Positive_regulation of Flt1 1 0.09 0.99 0.62
107 INT204254 Localization of KIT 8 0.73 6.78 0.61
108 INT132324 Localization of SYK 2 0.78 1.9 0.59
109 INT278152 Negative_regulation of Syk 1 0.24 1.93 0.59
110 INT129783 Positive_regulation of Gene_expression of KIT 16 0.50 18.12 0.58
111 INT132325 Positive_regulation of Localization of SYK 1 0.49 0.56 0.54
112 INT308979 Regulation of Localization of Insr 1 0.24 0.44 0.53
113 INT109390 Regulation of Gene_expression of Flt1 4 0.41 4.08 0.51
114 INT202196 Transcription of Erbb2 3 0.69 3.87 0.51
115 INT154180 Negative_regulation of SYK 3 0.43 4.67 0.5
116 INT302775 Negative_regulation of Gene_expression of Syk 1 0.27 0.84 0.48
117 INT128376 Binding of KIT 26 0.48 14.24 0.47
118 INT103916 Negative_regulation of Phosphorylation of Egfr 12 0.59 7.03 0.47
119 INT186998 Negative_regulation of Gene_expression of KIT 20 0.43 16.77 0.46
120 INT154182 Phosphorylation of SYK 6 0.82 5.54 0.43
121 INT169355 Localization of Egfr 6 0.75 3.24 0.43
122 INT283838 Gene_expression of Erbb4 5 0.59 2.37 0.42
123 INT131773 Regulation of KDR 12 0.49 12.01 0.39
124 INT114062 Negative_regulation of Localization of Insr 1 0.19 0.31 0.39
125 INT154181 Positive_regulation of Phosphorylation of SYK 4 0.70 4.71 0.37
126 INT148797 Phosphorylation of KDR 7 0.80 5.15 0.36
127 INT199559 Binding of Erbb2 5 0.36 4.23 0.36
128 INT144755 Negative_regulation of INSR 5 0.41 2.09 0.36
129 INT185350 Negative_regulation of Gene_expression of Egfr 24 0.59 13.21 0.35
130 INT138954 Regulation of Transcription of EGFR 2 0.27 0.82 0.35
131 INT154175 Regulation of SYK 2 0.62 1.48 0.34
132 INT145155 Regulation of Positive_regulation of EGFR 6 0.38 4.54 0.33
133 INT186115 Negative_regulation of Negative_regulation of EGFR 5 0.57 3.42 0.33
134 INT173097 Localization of KDR 20 0.73 12.73 0.31
135 INT179687 Negative_regulation of Gene_expression of KDR 6 0.22 5.37 0.31
136 INT83030 Positive_regulation of Binding of INSR 2 0.49 2.35 0.31
137 INT108043 Negative_regulation of Phosphorylation of Syk 1 0.13 0.53 0.31
138 INT142132 Positive_regulation of Erbb3 3 0.27 0.82 0.3
139 INT154559 Positive_regulation of Syk 2 0.20 0.74 0.3
140 INT21789 Positive_regulation of ERBB3 7 0.47 4.26 0.29
141 INT181756 Positive_regulation of Erbb2 6 0.46 4.12 0.28
142 INT278530 Regulation of Positive_regulation of Insr 1 0.01 1.96 0.28
143 INT173091 Transcription of KDR 3 0.55 1.39 0.27
144 INT148798 Regulation of Phosphorylation of KDR 1 0.44 0 0.27
145 INT80017 Gene_expression of ERBB4 10 0.77 6.94 0.26
146 INT278155 Regulation of Negative_regulation of Syk 1 0.18 0.55 0.26
147 INT124735 Positive_regulation of Positive_regulation of Insr 1 0.08 0 0.25
148 INT115253 Negative_regulation of Phosphorylation of Insr 1 0.27 0.56 0.25
149 INT124944 Regulation of KIT 15 0.60 11.84 0.24
150 INT178191 Regulation of Erbb2 7 0.36 4.11 0.24
151 INT236397 Binding of Flt1 5 0.33 1.91 0.24
152 INT223597 Negative_regulation of Binding of EGFR 12 0.43 7.97 0.23
153 INT234614 Phosphorylation of KIT 6 0.78 4.85 0.23
154 INT192957 Transcription of KIT 5 0.69 2.19 0.23
155 INT252723 Gene_expression of SYK 3 0.25 2.67 0.23
156 INT237188 Negative_regulation of Localization of KIT 1 0.08 0 0.22
157 INT278154 Regulation of Syk 1 0.05 0.98 0.22
158 INT278147 Localization of Syk 1 0.30 0.98 0.22
159 INT153075 Phosphorylation of Erbb2 5 0.73 2.06 0.19
160 INT153074 Negative_regulation of Phosphorylation of Erbb2 3 0.52 1.41 0.19
161 INT318204 Positive_regulation of Positive_regulation of KDR 2 0.14 0.68 0.19
162 INT339167 Positive_regulation of Localization of ERBB2 2 0.49 1.49 0.17
163 INT181787 Transcription of ERBB2 13 0.71 10.03 0.16
164 INT185352 Regulation of Gene_expression of Egfr 5 0.62 2.33 0.16
165 INT171378 Negative_regulation of Binding of Egfr 3 0.43 1.48 0.16
166 INT171365 Negative_regulation of Regulation of Egfr 1 0.33 0.06 0.16
167 INT231264 Gene_expression of Erbb3 9 0.35 1.45 0.15
168 INT105044 Negative_regulation of Flt1 4 0.39 2.99 0.15
169 INT275937 Phosphorylation of Syk 3 0.54 1.67 0.15
170 INT105269 Negative_regulation of Positive_regulation of KDR 2 0.41 1.35 0.15
171 INT175416 Regulation of Negative_regulation of EGFR 4 0.60 3.94 0.14
172 INT236400 Regulation of Flt1 3 0.25 1.84 0.14
173 INT154177 Negative_regulation of Phosphorylation of SYK 1 0.43 1.51 0.14
174 INT130572 Positive_regulation of Gene_expression of Flt1 2 0.46 3.24 0.13
175 INT92634 Negative_regulation of Binding of Insr 1 0.25 0.08 0.12
176 INT308981 Positive_regulation of Negative_regulation of Insr 1 0.27 0.95 0.11
177 INT323945 Positive_regulation of Binding of Insr 1 0.08 0.94 0.11
178 INT314718 Negative_regulation of Localization of ERBB2 1 0.37 1.13 0.11
179 INT8098 Positive_regulation of Gene_expression of ERBB3 7 0.69 3.79 0.1
180 INT220434 Negative_regulation of Gene_expression of ERBB3 1 0.03 0.4 0.1
181 INT184509 Regulation of Negative_regulation of ERBB3 1 0.01 0.47 0.1
182 INT153073 Positive_regulation of Phosphorylation of Erbb2 1 0.39 0.47 0.1
183 INT275411 Binding of Syk 1 0.09 0.12 0.1
184 INT80018 Binding of ERBB4 5 0.35 2.84 0.09
185 INT224335 Negative_regulation of Phosphorylation of KDR 5 0.35 5.24 0.09
186 INT80019 Regulation of ERBB4 2 0.27 1.52 0.09
187 INT258561 Negative_regulation of Negative_regulation of KDR 1 0.11 0.91 0.09
188 INT8099 Binding of ERBB3 7 0.36 3.09 0.08
189 INT206683 Negative_regulation of Binding of KDR 3 0.34 2.54 0.08
190 INT231258 Binding of Erbb4 3 0.23 0.16 0.08
191 INT226648 Negative_regulation of Positive_regulation of Egfr 1 0.10 0 0.08
192 INT211211 Positive_regulation of Negative_regulation of Egfr 1 0.50 1.36 0.08
193 INT229184 Regulation of Protein_catabolism of EGFR 1 0.25 1.11 0.08
194 INT232550 Negative_regulation of Gene_expression of Erbb2 9 0.43 4.96 0.07
195 INT266934 Regulation of Binding of EGFR 3 0.45 1.16 0.07
196 INT199076 Positive_regulation of Syk 3 0.31 0.12 0.07
197 INT221674 Localization of Erbb2 2 0.38 1.28 0.07
198 INT295429 Positive_regulation of Phosphorylation of KIT 1 0.42 0.84 0.07
199 INT185035 Regulation of ERBB3 3 0.42 6.5 0.06
200 INT251797 Positive_regulation of ERBB4 3 0.33 3.14 0.06
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