GO:0004962

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Name endothelin receptor activity
Categary Function
Go Slim No
Go Link GO:0004962
Unique Molecular Interactions 228
Total Molecular Interactions 339
Total Single Events 1923
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endothelin receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for endothelin receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
2 INT172500 Ednra Positive_regulation of Coc 1 0.01 1 1.2
3 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
4 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
5 INT123023 Ednra Regulation of Adarb1 1 0.00 0 0.93
6 INT123024 Csf2 Regulation of Ednra 1 0.06 0 0.92
7 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84
8 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84
9 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
10 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
11 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
12 INT219921 EDNRA Negative_regulation of Trpv1 1 0.13 0.36 0.63
13 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
14 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
15 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61
16 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6
17 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
18 INT130157 Pomc Regulation of Gene_expression of Ednrb 1 0.14 0 0.52
19 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
20 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
21 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
22 INT94093 Pnoc Positive_regulation of EDNRA 1 0.03 0.1 0.44
23 INT334763 Ednra Positive_regulation of Gabrg1 1 0.01 0 0.4
24 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
25 INT77683 Ednra Negative_regulation of LH 1 0.03 0.23 0.39
26 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
27 INT80444 Binding of EDNRA and SPR 1 0.05 0.1 0.36
28 INT152315 Ifng Regulation of Ednrb 1 0.19 0.22 0.36
29 INT152313 Il18 Regulation of Ednrb 1 0.30 0.22 0.36
30 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
31 INT201484 Negative_regulation of Prkcg Negative_regulation of Positive_regulation of Ednrb 1 0.34 0.96 0.32
32 INT303030 Binding of Ednra and MCPH1 1 0.00 1.02 0.32
33 INT119603 H2-Ab1 Regulation of EDNRA 1 0.00 0.07 0.32
34 INT119602 EDNRA Regulation of H2-Ab1 1 0.00 0.07 0.32
35 INT303005 Binding of Ednra and Pah 1 0.06 1.02 0.32
36 INT69365 Binding of EDNRA and Pnoc 1 0.00 0 0.31
37 INT284137 EDNRB Regulation of EDNRA 1 0.07 0.09 0.3
38 INT117588 Binding of C5AR1 and EDNRA 1 0.40 0.38 0.3
39 INT178102 EDNRA Positive_regulation of Localization of TIMP1 1 0.06 0.97 0.28
40 INT178088 EDNRA Positive_regulation of Transcription of TIMP1 1 0.06 0.97 0.28
41 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
42 INT124117 Apcs Negative_regulation of Ednra 1 0.09 0 0.26
43 INT219918 Positive_regulation of EDNRA Positive_regulation of Trpv1 1 0.13 0 0.26
44 INT36875 Binding of EDNRA and SYNCRIP 1 0.01 0 0.24
45 INT284139 EDNRB Positive_regulation of Gene_expression of EDNRA 1 0.12 0.45 0.22
46 INT36876 EDNRA Regulation of Negative_regulation of PRB1 1 0.00 0 0.21
47 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
48 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
49 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
50 INT334769 Ednra Positive_regulation of Car2 1 0.02 0.49 0.18
51 INT264276 Binding of Ednrb and P2rx1 1 0.00 0.17 0.16
52 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
53 INT115205 Positive_regulation of Ednra Positive_regulation of Localization of Avp 1 0.36 0 0.14
54 INT89940 Ednrb Positive_regulation of Positive_regulation of TNF 1 0.01 0.09 0.14
55 INT334770 Ednra Positive_regulation of Pla2g4a 1 0.00 0.24 0.14
56 INT334765 Ednra Positive_regulation of Positive_regulation of Car2 1 0.02 0.24 0.14
57 INT219920 EDNRA Positive_regulation of Trpv1 1 0.14 0 0.13
58 INT334759 Ednra Regulation of Gabrg1 1 0.01 0 0.13
59 INT89939 Ednrb Regulation of Gene_expression of TNF 1 0.00 0.09 0.13
60 INT334761 Binding of Ednra and Gopc 1 0.03 0 0.11
61 INT293627 GHRL Positive_regulation of EDNRA 1 0.00 0.96 0.1
62 INT284140 Binding of EDNRB and PAH 1 0.08 0.1 0.1
63 INT139476 Edn1 Positive_regulation of Ednra 1 0.00 1.07 0.1
64 INT284141 Binding of EDNRA and PAH 1 0.05 0.1 0.09
65 INT178089 Binding of EDNRA and Positive_regulation of PTK2 1 0.09 0.74 0.09
66 INT214752 EDNRA Positive_regulation of PLCB1 1 0.02 0 0.08
67 INT88752 Map3k7 Negative_regulation of Ednra 1 0.05 0 0.08
68 INT178072 Gene_expression of EDNRB Positive_regulation of EDN3 1 0.05 1.11 0.08
69 INT181584 Binding of EDNRB and Edn1 1 0.46 0.85 0.08
70 INT137632 Rasa1 Regulation of Ednrb 1 0.05 0 0.08
71 INT115204 Ednra Regulation of Localization of Avp 1 0.55 0 0.08
72 INT178100 Gene_expression of EDNRB Positive_regulation of EDN1 1 0.17 1.11 0.08
73 INT192908 Edn1 Positive_regulation of Ednra 1 0.21 0.35 0.07
74 INT178093 EDN3 Positive_regulation of Gene_expression of EDNRB 1 0.05 1.01 0.07
75 INT192907 Edn1 Positive_regulation of Ednrb 1 0.10 0.35 0.07
76 INT178096 EDN1 Positive_regulation of Gene_expression of EDNRB 1 0.17 1.01 0.07
77 INT337297 PTAFR Positive_regulation of EDNRA 1 0.04 1.2 0.06
78 INT178084 EDNRA Positive_regulation of Phosphorylation of GJA1 1 0.10 0.88 0.06
79 INT337303 Positive_regulation of PTAFR Positive_regulation of EDNRA 1 0.04 1.21 0.06
80 INT339778 Binding of EDNRA and PTH 1 0.12 0.35 0.05
81 INT274095 Binding of EDNRA and OPA1 1 0.12 0.65 0.04
82 INT306513 EDN3 Positive_regulation of EDNRB 1 0.14 0.98 0.04
83 INT306514 EDN1 Positive_regulation of EDNRB 1 0.11 0.98 0.04
84 INT107859 PRSS1 Positive_regulation of EDNRA 1 0.03 0.69 0.04
85 INT246450 Lta Positive_regulation of Ednrb 1 0.00 0 0.04
86 INT239229 Regulation of Binding of Edn1 and Ednra 1 0.01 0.37 0.03
87 INT256228 EDNRB Positive_regulation of EDN1 1 0.26 0.62 0.03
88 INT239225 Binding of Edn1 and Ednrb 1 0.02 0.36 0.03
89 INT239228 Regulation of Binding of Edn1 and Ednrb 1 0.02 0.37 0.03
90 INT239224 Positive_regulation of Binding of Edn1 and Ednrb 1 0.02 0.37 0.03
91 INT115611 Binding of EDNRA and ERBB2 1 0.08 0.78 0
92 INT186603 Binding of ERBB2 and Ednra 1 0.02 0.53 0
93 INT334771 Binding of Ednra and Gfap 1 0.03 0 0
94 INT92196 Binding of EDNRB and Edn3 1 0.03 0.91 0
95 INT156367 Ednra Positive_regulation of Gene_expression of Il10 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for endothelin receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in endothelin receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
2 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38
3 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
4 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68
5 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71
6 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19
7 INT77804 Regulation of Ednra 9 0.39 2.71 7.94
8 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
9 INT67170 Gene_expression of Ednra 22 0.65 9.35 7.57
10 INT167049 Binding of Ednra 3 0.07 3.47 6.84
11 INT78178 Gene_expression of Ednrb 21 0.75 7.1 6.37
12 INT119523 Gene_expression of EDNRB 32 0.75 26.47 5.75
13 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
14 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
15 INT92858 Negative_regulation of Ednra 6 0.57 1.25 4.81
16 INT246315 Localization of Ednra 22 0.15 2.73 4.64
17 INT21953 Binding of Ednra 12 0.33 4.72 4.56
18 INT29519 Gene_expression of Ednrb 8 0.66 1.99 4.55
19 INT92133 Negative_regulation of Ednrb 8 0.42 1.7 4.44
20 INT152312 Positive_regulation of Ednrb 7 0.49 1.46 4.04
21 INT115203 Negative_regulation of Positive_regulation of Ednra 5 0.33 1.27 3.32
22 INT84222 Regulation of Ednrb 4 0.45 2.24 3.25
23 INT49971 Regulation of Ednra 10 0.35 2.4 3.06
24 INT93058 Positive_regulation of Gene_expression of Ednra 8 0.28 4.11 2.88
25 INT76836 Positive_regulation of Ednra 6 0.55 2.65 2.72
26 INT128774 Regulation of Gene_expression of Ednrb 3 0.46 1 2.56
27 INT78177 Negative_regulation of Gene_expression of Ednrb 4 0.41 1.04 2.16
28 INT156677 Regulation of Gene_expression of Ednra 4 0.15 0.25 2.05
29 INT178130 Binding of EDNRB 12 0.36 6.18 1.84
30 INT201475 Negative_regulation of Positive_regulation of Ednrb 6 0.42 3.74 1.66
31 INT72021 Localization of Ednra 7 0.58 3.13 1.53
32 INT139514 Localization of EDNRB 7 0.73 4.63 1.52
33 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47
34 INT129488 Regulation of Gene_expression of EDNRA 5 0.51 3.39 1.44
35 INT114298 Positive_regulation of Gene_expression of Ednrb 4 0.36 0.79 1.42
36 INT60772 Negative_regulation of Ednrb 8 0.41 4.56 1.39
37 INT72024 Localization of EDNRA 11 0.57 8.22 0.96
38 INT76835 Negative_regulation of Gene_expression of Ednra 2 0.10 0.89 0.96
39 INT78181 Negative_regulation of EDNRB 6 0.57 4.46 0.95
40 INT139515 Positive_regulation of EDNRB 15 0.67 10.35 0.93
41 INT178133 Negative_regulation of Positive_regulation of EDNRA 2 0.35 2.18 0.88
42 INT178127 Positive_regulation of Gene_expression of EDNRB 7 0.51 5.24 0.78
43 INT186579 Positive_regulation of Gene_expression of Ednra 5 0.07 0.89 0.76
44 INT313697 Phosphorylation of Ednra 1 0.18 0 0.7
45 INT139513 Negative_regulation of Localization of EDNRB 2 0.41 0 0.62
46 INT114299 Transcription of Ednrb 2 0.19 0.32 0.59
47 INT186686 Regulation of Positive_regulation of EDNRA 5 0.22 2.35 0.51
48 INT126442 Negative_regulation of Gene_expression of Ednra 3 0.33 1.94 0.51
49 INT115202 Positive_regulation of Positive_regulation of Ednra 2 0.39 2.88 0.49
50 INT120405 Phosphorylation of EDNRA 1 0.61 0.38 0.48
51 INT201478 Regulation of Positive_regulation of Ednrb 1 0.35 0.68 0.44
52 INT324888 Transcription of Ednra 2 0.13 0.66 0.43
53 INT158057 Positive_regulation of Positive_regulation of EDNRA 2 0.15 0 0.41
54 INT131106 Positive_regulation of Positive_regulation of Ednrb 1 0.15 0.91 0.4
55 INT201476 Positive_regulation of Negative_regulation of Ednrb 1 0.49 0.62 0.36
56 INT72022 Positive_regulation of Localization of Ednra 2 0.32 0.07 0.3
57 INT350970 Negative_regulation of Binding of EDNRA 1 0.41 0.86 0.29
58 INT350971 Negative_regulation of Binding of EDNRB 1 0.13 0.86 0.29
59 INT334747 Regulation of Binding of Ednra 1 0.06 0.05 0.28
60 INT139512 Positive_regulation of Localization of EDNRB 3 0.37 0.69 0.26
61 INT334746 Positive_regulation of Localization of Ednra 1 0.07 0 0.2
62 INT324881 Regulation of Transcription of Ednra 1 0.08 0.66 0.19
63 INT55013 Localization of Ednrb 2 0.16 0.98 0.18
64 INT72023 Positive_regulation of Localization of EDNRA 1 0.02 0.07 0.18
65 INT72025 Negative_regulation of Localization of EDNRA 1 0.01 0.07 0.18
66 INT274098 Regulation of EDNRB 1 0.33 2.41 0.18
67 INT72020 Negative_regulation of Localization of Ednra 1 0.24 0.07 0.18
68 INT173335 Negative_regulation of Gene_expression of EDNRA 2 0.19 0.71 0.17
69 INT242342 Regulation of Ednrb 1 0.09 2.03 0.15
70 INT256229 Protein_catabolism of EDNRB 3 0.64 0.96 0.14
71 INT70908 Transcription of EDNRA 1 0.08 0.33 0.12
72 INT70906 Negative_regulation of Transcription of EDNRA 1 0.05 0.33 0.12
73 INT334742 Negative_regulation of Transcription of Ednra 1 0.06 0 0.08
74 INT334749 Positive_regulation of Transcription of Ednra 1 0.07 0 0.08
75 INT324892 Binding of Ednrb 1 0.06 0.32 0.06
76 INT283233 Regulation of Regulation of EDNRA 1 0.04 2.22 0.05
77 INT246353 Protein_catabolism of EDNRA 1 0.01 0.48 0.04
78 INT264273 Localization of Ednrb 1 0.01 0 0.03
79 INT334738 Negative_regulation of Positive_regulation of Ednra 1 0.06 0 0.03
80 INT334748 Positive_regulation of Positive_regulation of Ednra 1 0.07 0 0.03
81 INT246319 Regulation of Gene_expression of Ednra 1 0.05 0 0
82 INT284148 Positive_regulation of Positive_regulation of EDNRB 1 0.29 0.54 0
83 INT334743 Negative_regulation of Binding of Ednra 1 0.06 0 0
84 INT186688 Regulation of Binding of EDNRA 1 0.03 0.36 0
85 INT334741 Regulation of Localization of Ednra 1 0.06 0 0
86 INT186687 Negative_regulation of Regulation of EDNRA 1 0.03 0.28 0
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