GO:0005024

From wiki-pain
Revision as of 06:50, 22 January 2013 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Name transforming growth factor beta-activated receptor activity
Categary Function
Go Slim No
Go Link GO:0005024
Unique Molecular Interactions 184
Total Molecular Interactions 223
Total Single Events 1111
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transforming growth factor beta-activated receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for transforming growth factor beta-activated receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
2 INT31445 ENG Positive_regulation of Localization of Prl 4 0.01 0 1.77
3 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
4 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
5 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
6 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
7 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
8 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
9 INT31444 ENG Positive_regulation of Prl 1 0.01 0 1.14
10 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
11 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
12 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
13 INT32187 Binding of ENG and Negative_regulation of Localization of LH 1 0.01 0 0.91
14 INT291011 Pomc Regulation of Gene_expression of ENG 1 0.08 0.86 0.91
15 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81
16 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
17 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
18 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
19 INT148452 Inhbe Regulation of Acvrl1 1 0.01 0.69 0.69
20 INT32719 ENG Regulation of LH 2 0.00 0 0.64
21 INT31443 ENG Positive_regulation of Localization of Pomc 1 0.00 0 0.63
22 INT134214 CRH Regulation of Localization of ENG 1 0.14 0.39 0.53
23 INT32151 ENG Positive_regulation of Gene_expression of IFNA1 1 0.37 0 0.53
24 INT32291 ENG Negative_regulation of LH 2 0.00 0 0.52
25 INT171897 Binding of Bmpr2 and Il1 1 0.03 0.84 0.52
26 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
27 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
28 INT30618 Slc3a1 Regulation of ENG 1 0.00 0 0.5
29 INT30619 Pomc Regulation of ENG 1 0.00 0 0.5
30 INT102214 ENG Negative_regulation of HP 1 0.01 0 0.49
31 INT60872 Binding of ENG and Abat 1 0.00 0 0.49
32 INT60871 ENG Regulation of Localization of LH 1 0.00 0 0.49
33 INT43695 ENG Regulation of Regulation of Prl 1 0.00 0 0.47
34 INT60870 ENG Negative_regulation of Localization of LH 1 0.00 0 0.47
35 INT102213 Binding of ENG and HP 1 0.01 0 0.47
36 INT202516 Positive_regulation of Binding of ENG and Penk 1 0.03 0.58 0.42
37 INT202515 Binding of ENG and Penk 1 0.02 0.57 0.41
38 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
39 INT81991 Bmpr2 Positive_regulation of Gene_expression of ODF1 1 0.03 1.59 0.41
40 INT32720 Negative_regulation of ENG Regulation of LH 1 0.00 0 0.41
41 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41
42 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
43 INT194860 BMPR2 Positive_regulation of IL1B 1 0.01 0.61 0.34
44 INT55404 Binding of ENG and Th 1 0.02 0 0.3
45 INT29137 ENG Regulation of POMC 1 0.00 0 0.28
46 INT29139 ENG Regulation of Oprl1 1 0.00 0 0.28
47 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26
48 INT32156 Binding of ENG and Oprd1 1 0.00 0 0.26
49 INT32149 Binding of ENG and LLGL1 1 0.11 0 0.26
50 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
51 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25
52 INT43713 ENG Regulation of Prl 1 0.00 0 0.23
53 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
54 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
55 INT251347 Binding of Bmpr2 and Limk1 1 0.18 1.51 0.16
56 INT95103 TGFBR2 Positive_regulation of CD34 1 0.11 0.61 0.14
57 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
58 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
59 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14
60 INT32294 ENG Positive_regulation of Trh 1 0.01 0 0.13
61 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12
62 INT60399 ENG Regulation of Localization of Prl 1 0.04 0.57 0.1
63 INT158011 KLRF1 Positive_regulation of ENG 1 0.03 0.39 0.09
64 INT158012 Binding of ENG and FLT1 1 0.21 0.39 0.09
65 INT32290 ENG Regulation of Positive_regulation of Trh 1 0.01 0 0.09
66 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08
67 INT189550 Binding of BMPR2 and PAH 1 0.06 2.68 0.08
68 INT311915 Tgfbr1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
69 INT311903 Acvrl1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
70 INT25491 TFPI Regulation of Localization of ENG 1 0.27 0.31 0.06
71 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06
72 INT25490 Binding of ENG and TFPI 1 0.27 0.4 0.06
73 INT355586 Binding of LTBP1 and ANGPTL4 1 0.10 2.15 0.05
74 INT293360 Binding of CSH1 and FKBP1A 1 0.00 0.14 0.05
75 INT355589 Binding of EGFR and LTBP1 1 0.11 2.15 0.05
76 INT32293 ENG Regulation of Positive_regulation of Gnrh1 1 0.00 0 0.04
77 INT32297 ENG Regulation of Positive_regulation of LH 1 0.00 0 0.04
78 INT320786 Binding of Eng and Kdr 1 0.04 1.17 0.04
79 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03
80 INT265347 Binding of Ocln and Tgfbr1 1 0.18 0.06 0.03
81 INT265345 Binding of Tgfbr1 and Tjp1 1 0.09 0.06 0.03
82 INT293358 Binding of FKBP1A and CABIN1 1 0.00 0.07 0.03
83 INT319219 Bmpr2 Positive_regulation of Smad1 1 0.18 0.29 0.03
84 INT319217 Bmpr2 Positive_regulation of Gene_expression of Smad1 1 0.19 0.11 0.03
85 INT265343 Positive_regulation of Binding of Tgfbr1 and Tjp1 1 0.12 0.06 0.03
86 INT265348 Positive_regulation of Binding of Ocln and Tgfbr1 1 0.25 0.06 0.03
87 INT340614 Binding of ENG and MMP9 1 0.16 0.14 0
88 INT205409 Binding of BMP6 and BMPR2 1 0.07 0.05 0
89 INT314869 Binding of Gdf11 and Tgfbr3 1 0.29 0.14 0
90 INT275231 Binding of ACVRL1 and AK3 1 0.01 0.72 0
91 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
92 INT314373 Binding of Cd34 and Eng 1 0.08 0.9 0
93 INT310186 Binding of Gdf2 and Bmpr2 1 0.02 0 0
94 INT205452 Binding of BMP6 and Acvr2a 1 0.03 0.05 0
95 INT32148 POMC Regulation of ENG 1 0.24 0 0
96 INT314871 Binding of Tgfbr3 and Atoh7 1 0.33 0.09 0
97 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0
98 INT265344 sb Negative_regulation of Tgfbr1 1 0.00 0.06 0
99 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
100 INT268345 Binding of TGFB1 and TGFBR2 1 0.27 0.62 0
101 INT15847 Avp Positive_regulation of Localization of ENG 1 0.07 0 0
102 INT222539 Negative_regulation of Binding of Inhba and Acvr2a 1 0.01 0 0
103 INT340613 Binding of COL4A4 and ENG 1 0.07 0.14 0
104 INT329746 ENG Positive_regulation of SMAD1 1 0.15 0.44 0
105 INT205410 Binding of BMP2 and BMPR2 1 0.07 0.05 0
106 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
107 INT222504 Binding of Inhba and Acvr2a 1 0.01 0 0
108 INT228288 Binding of ENG and Ptprc 1 0.06 0.25 0
109 INT265234 Binding of FKBP1A and SGCG 1 0.03 0.35 0
110 INT310187 Acvrl1 Regulation of Gene_expression of Bmpr2 1 0.04 0 0
111 INT295571 Binding of Acvr2b and Mstn 1 0.08 0 0
112 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
113 INT228287 Binding of ENG and Cd14 1 0.20 0.25 0
114 INT313840 Binding of Acvr2b and Mstn 1 0.02 0.07 0
115 INT160761 Cma1 Regulation of Positive_regulation of ENG 1 0.01 0.07 0
116 INT310189 Binding of Acvrl1 and Gdf2 1 0.01 0 0
117 INT268340 TGFBR2 Positive_regulation of Phosphorylation of TGFB1 1 0.25 0.68 0
118 INT310192 Tgfbr1 Positive_regulation of Regulation of Acvrl1 1 0.01 0 0
119 INT351095 Binding of FKBP1A and RPS6KB1 1 0.24 0.36 0
120 INT351101 Negative_regulation of Binding of FKBP1A and RPS6KB1 1 0.27 0.36 0
121 INT337917 Binding of sb and Tgfbr1 1 0.00 1.06 0
122 INT314372 Binding of Eng and Ptprc 1 0.04 0.84 0
123 INT314853 Binding of Cdc7 and Tgfbr3 1 0.24 0.09 0
124 INT351096 Binding of FKBP1A and MTOR 1 0.28 1.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for transforming growth factor beta-activated receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in transforming growth factor beta-activated receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6
2 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69
3 INT10799 Localization of ENG 63 0.78 18.67 27.28
4 INT7674 Regulation of ENG 42 0.30 11.41 14.44
5 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61
6 INT23375 Binding of ENG 17 0.47 6.02 6.46
7 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
8 INT15844 Positive_regulation of Localization of ENG 7 0.67 4.2 3.47
9 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15
10 INT32222 Negative_regulation of Gene_expression of ENG 9 0.37 2.23 2.89
11 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
12 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74
13 INT22071 Positive_regulation of Gene_expression of ENG 13 0.50 5.44 2.62
14 INT13997 Regulation of Gene_expression of ENG 11 0.36 3.31 2.31
15 INT12133 Regulation of Localization of ENG 3 0.03 0.57 2.24
16 INT32135 Positive_regulation of Positive_regulation of ENG 2 0.02 0.98 1.99
17 INT104912 Gene_expression of Acvr2a 8 0.63 4.48 1.81
18 INT15845 Negative_regulation of Localization of ENG 3 0.05 0.76 1.71
19 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55
20 INT310167 Gene_expression of Acvrl1 2 0.40 5.47 1.4
21 INT32717 Negative_regulation of Regulation of ENG 3 0.00 0.43 1.25
22 INT90938 Gene_expression of Eng 48 0.72 15.76 1.24
23 INT310164 Negative_regulation of Gene_expression of Tgfbr1 9 0.40 6.11 1.17
24 INT51863 Negative_regulation of Negative_regulation of ENG 2 0.04 0.51 1.13
25 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03
26 INT230251 Binding of FKBP1A 6 0.28 2.24 0.94
27 INT265313 Positive_regulation of Tgfbr1 8 0.66 2.95 0.87
28 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87
29 INT107939 Regulation of TGFBR2 1 0.37 0.98 0.84
30 INT311884 Negative_regulation of Acvrl1 1 0.30 2.16 0.81
31 INT265328 Positive_regulation of Acvrl1 5 0.40 3.18 0.78
32 INT161947 Positive_regulation of TGFBR1 2 0.52 1.6 0.76
33 INT114604 Positive_regulation of Acvr2a 2 0.41 0 0.73
34 INT11763 Positive_regulation of Regulation of ENG 1 0.01 0.97 0.64
35 INT90939 Positive_regulation of Eng 9 0.64 4.62 0.57
36 INT144922 Gene_expression of TGFBR1 4 0.72 0.19 0.57
37 INT3831 Negative_regulation of TGFBR2 4 0.28 4.99 0.55
38 INT110924 Regulation of BMPR2 3 0.17 1.75 0.54
39 INT218293 Gene_expression of Acvr2b 14 0.76 4.22 0.44
40 INT292484 Negative_regulation of TGFBR1 3 0.19 0.75 0.39
41 INT120899 Positive_regulation of Gene_expression of Tgfbr2 1 0.29 0.46 0.38
42 INT311889 Negative_regulation of Gene_expression of Acvrl1 1 0.22 1.27 0.37
43 INT254816 Negative_regulation of Tgfbr1 20 0.55 9.24 0.34
44 INT150330 Gene_expression of BMPR2 7 0.29 4.22 0.34
45 INT251324 Binding of Bmpr2 5 0.23 2.99 0.34
46 INT201967 Positive_regulation of Bmpr2 4 0.31 1.24 0.34
47 INT311895 Regulation of Positive_regulation of Acvrl1 1 0.23 0.97 0.29
48 INT311881 Regulation of Positive_regulation of Tgfbr1 1 0.22 0.97 0.29
49 INT139741 Positive_regulation of Gene_expression of ACVRL1 2 0.38 1.33 0.28
50 INT251327 Regulation of Binding of Bmpr2 1 0.20 2.27 0.27
51 INT81981 Negative_regulation of Bmpr2 4 0.27 2.88 0.21
52 INT150332 Negative_regulation of Gene_expression of BMPR2 1 0.01 0 0.2
53 INT164519 Gene_expression of FKBP1A 2 0.39 0.22 0.19
54 INT150331 Positive_regulation of Gene_expression of BMPR2 2 0.02 0.59 0.19
55 INT311886 Phosphorylation of Tgfbr1 1 0.40 0.7 0.19
56 INT123935 Positive_regulation of BMPR2 3 0.26 1.65 0.18
57 INT131558 Protein_catabolism of ENG 1 0.01 0 0.18
58 INT189590 Positive_regulation of ACVRL1 3 0.08 1.3 0.16
59 INT189604 Negative_regulation of BMPR2 2 0.26 0.95 0.15
60 INT192082 Localization of BMPR2 1 0.32 0.55 0.15
61 INT90940 Binding of Eng 5 0.35 1.92 0.13
62 INT302662 Negative_regulation of Negative_regulation of TGFBR1 1 0.14 0 0.13
63 INT166623 Binding of BMPR2 1 0.29 0.35 0.13
64 INT293345 Negative_regulation of Binding of FKBP1A 1 0.02 0.19 0.13
65 INT222585 Transcription of Acvr2a 1 0.16 0 0.13
66 INT210224 Localization of Acvrl1 1 0.03 0.33 0.12
67 INT260148 Negative_regulation of Gene_expression of TGFBR2 3 0.38 3.71 0.1
68 INT201962 Transcription of Bmpr2 6 0.37 3.51 0.09
69 INT158018 Negative_regulation of LTBP1 1 0.04 0.39 0.09
70 INT26064 Regulation of Positive_regulation of ENG 1 0.01 0.1 0.09
71 INT254819 Regulation of Negative_regulation of Tgfbr1 1 0.15 1.2 0.09
72 INT299319 Localization of FKBP1A 1 0.44 0 0.09
73 INT90941 Negative_regulation of Eng 1 0.31 0.25 0.09
74 INT128091 Binding of TGFBR2 1 0.02 0.08 0.08
75 INT254332 Negative_regulation of Gene_expression of Bmpr2 3 0.22 2.41 0.07
76 INT311885 Positive_regulation of Gene_expression of Tgfbr1 2 0.44 0.35 0.06
77 INT265338 Regulation of Eng 2 0.42 0.94 0.05
78 INT299313 Positive_regulation of Gene_expression of FKBP1A 1 0.29 0 0.05
79 INT268389 Positive_regulation of TGFBR2 1 0.39 0.62 0.05
80 INT222608 Negative_regulation of Gene_expression of Acvr2a 3 0.10 0.29 0.03
81 INT278039 Phosphorylation of BMPR2 1 0.08 0.26 0.03
82 INT245858 Positive_regulation of Gene_expression of Eng 1 0.12 0 0.03
83 INT278022 Phosphorylation of Bmpr2 1 0.21 0.27 0.03
84 INT302312 Localization of Bmpr2 4 0.46 0.47 0
85 INT289876 Localization of Eng 3 0.44 0.59 0
86 INT190471 Transcription of ENG 3 0.21 1.76 0
87 INT219929 Positive_regulation of Gene_expression of Bmpr2 3 0.15 0.9 0
88 INT265340 Binding of Acvrl1 3 0.30 0.46 0
89 INT265314 Regulation of Gene_expression of Eng 2 0.42 0.68 0
90 INT265324 Negative_regulation of Gene_expression of Eng 2 0.40 0.9 0
91 INT265316 Binding of Tgfbr1 2 0.35 0.59 0
92 INT265326 Regulation of Tgfbr1 2 0.43 0.17 0
93 INT222633 Negative_regulation of Acvr2a 1 0.10 0 0
94 INT310166 Regulation of Acvrl1 1 0.07 0 0
95 INT286084 Regulation of Acvr2a 1 0.02 0.32 0
96 INT315214 Negative_regulation of Regulation of Tgfbr1 1 0.41 0 0
97 INT268388 Positive_regulation of Positive_regulation of TGFBR1 1 0.35 0.61 0
98 INT310163 Positive_regulation of Positive_regulation of Acvrl1 1 0.08 0 0
99 INT197394 Protein_catabolism of Eng 1 0.07 0.13 0
100 INT189611 Negative_regulation of Gene_expression of ACVRL1 1 0.06 0.29 0
101 INT286081 Regulation of Gene_expression of Acvr2a 1 0.05 0.32 0
102 INT218291 Positive_regulation of Gene_expression of Acvr2b 1 0.49 0.55 0
103 INT319209 Regulation of Positive_regulation of Bmpr2 1 0.28 0.08 0
104 INT189623 Transcription of BMPR2 1 0.32 0.71 0
105 INT355333 Regulation of Transcription of Bmpr2 1 0.03 0.15 0
106 INT297259 Regulation of ACVRL1 1 0.18 0.55 0
107 INT272228 Localization of TGFBR1 1 0.34 0.74 0
108 INT310177 Binding of Tgfbr2 1 0.24 0 0
109 INT310171 Phosphorylation of Eng 1 0.24 0.5 0
110 INT314839 Binding of Tgfbr3 1 0.42 0.09 0
111 INT265319 Positive_regulation of Negative_regulation of Tgfbr1 1 0.47 0.53 0
112 INT218282 Regulation of Acvr2a 1 0.23 0.33 0
113 INT144920 Positive_regulation of Gene_expression of TGFBR1 1 0.65 0 0
114 INT218296 Regulation of Acvr2b 1 0.12 0.33 0
115 INT310165 Negative_regulation of Transcription of Bmpr2 1 0.22 2.1 0
116 INT83122 Transcription of TGFBR2 1 0.09 0 0
117 INT310168 Phosphorylation of Tgfbr2 1 0.41 1.5 0
118 INT218286 Regulation of Gene_expression of Acvr2b 1 0.60 0.5 0
119 INT218289 Gene_expression of Acvr2a 1 0.65 1.44 0
120 INT314836 Gene_expression of Tgfbr3 1 0.59 0.09 0
121 INT310176 Localization of Tgfbr1 1 0.11 0.83 0
122 INT239992 Negative_regulation of Tgfbr2 1 0.06 0 0
123 INT260145 Positive_regulation of Gene_expression of TGFBR2 1 0.45 1.04 0
124 INT222620 Binding of Acvr2a 1 0.08 0 0
125 INT286082 Positive_regulation of Gene_expression of Acvr2a 1 0.06 1.25 0
126 INT218281 Binding of Acvr2b 1 0.36 0.07 0
127 INT319208 Regulation of Bmpr2 1 0.28 0.08 0
128 INT310179 Positive_regulation of Positive_regulation of Tgfbr1 1 0.08 0 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox