GO:0005070

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Name SH3/SH2 adaptor activity
Categary Function
Go Slim No
Go Link GO:0005070
Unique Molecular Interactions 254
Total Molecular Interactions 374
Total Single Events 1537
Pain Genes Associated 35

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for SH3/SH2 adaptor activity. They are ordered first by their pain relevance and then by number of times they were reported for SH3/SH2 adaptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT180813 Ngf Positive_regulation of Sorbs1 1 0.04 2.09 3.79
2 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
3 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12
4 INT299783 Binding of Cd28 and Cd80 7 0.14 6.49 2.49
5 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
6 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14
7 INT151965 SORBS1 Positive_regulation of TRPV1 1 0.18 0 1.89
8 INT180812 Gdnf Positive_regulation of Gene_expression of Sorbs1 1 0.02 0.83 1.61
9 INT180811 Gdnf Positive_regulation of Regulation of Sorbs1 1 0.01 0.83 1.61
10 INT180804 Bdnf Positive_regulation of Gene_expression of Sorbs1 1 0.01 0 1.44
11 INT180809 Ngf Positive_regulation of Positive_regulation of Sorbs1 1 0.03 0.84 1.4
12 INT180808 Ngf Positive_regulation of Gene_expression of Sorbs1 1 0.03 0.84 1.4
13 INT180802 Gdnf Positive_regulation of Sorbs1 1 0.02 0.98 1.34
14 INT180807 Calca Regulation of Sorbs1 1 0.02 0 1.32
15 INT121000 Binding of PAG1 and Nrm 1 0.13 0.67 1.25
16 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
17 INT346986 Binding of SHC3 and PAG1 1 0.35 1.02 1.12
18 INT239038 Negative_regulation of Binding of Cd28 and Cd86 3 0.17 1.5 1.05
19 INT180806 Ngf Positive_regulation of Regulation of Sorbs1 1 0.03 0.28 1.04
20 INT103928 Binding of Cd28 and Trav6-3 3 0.03 0.55 0.98
21 INT180803 Sorbs1 Regulation of Gdnf 1 0.01 0.28 0.95
22 INT265210 Binding of Ctla4 and Cd28 2 0.16 1.45 0.93
23 INT54854 Sorbs1 Regulation of Ins1 1 0.34 0.23 0.9
24 INT174509 Binding of CD4 and CD28 1 0.26 1.68 0.84
25 INT188567 IRF6 Positive_regulation of Gene_expression of CD28 1 0.05 1.28 0.82
26 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
27 INT266100 Binding of COMT and SH2B2 1 0.25 1.22 0.74
28 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
29 INT180805 Bdnf Regulation of Sorbs1 1 0.01 0.14 0.67
30 INT266064 Binding of PAG1 and Creb1 1 0.04 1.52 0.65
31 INT169285 PTPLA Positive_regulation of GRAP2 1 0.03 0.15 0.63
32 INT266065 Positive_regulation of Binding of Ceacam3 and PAG1 1 0.03 1.44 0.63
33 INT266062 Binding of Ceacam3 and PAG1 1 0.02 1.44 0.63
34 INT49398 Positive_regulation of Binding of SHB and MHB 1 0.36 0.15 0.6
35 INT49397 Binding of SHB and MHB 1 0.27 0.15 0.6
36 INT103937 Cps1 Negative_regulation of Gene_expression of Cd28 1 0.03 0.19 0.51
37 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5
38 INT149121 Binding of CD80 and Cd28 2 0.04 0.95 0.46
39 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
40 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
41 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
42 INT246024 IL23A Positive_regulation of SOCS2 1 0.01 0.99 0.43
43 INT246023 IL6 Positive_regulation of SOCS2 1 0.18 0.99 0.43
44 INT188565 IRF6 Regulation of Gene_expression of CD28 1 0.03 0.7 0.43
45 INT188572 CD14 Regulation of Gene_expression of CD28 1 0.11 0.6 0.4
46 INT287819 Binding of CD80 and Cd28 1 0.25 0.7 0.4
47 INT287818 Negative_regulation of Binding of CD80 and Cd28 1 0.29 0.7 0.4
48 INT222212 TFAM Negative_regulation of Cd28 1 0.02 1.17 0.39
49 INT118919 Binding of FRTS and Sh2b2 1 0.24 0 0.39
50 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
51 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
52 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
53 INT353020 Binding of CD80 and Positive_regulation of Gene_expression of CD28 1 0.13 0.35 0.34
54 INT299780 Binding of Cd28 and Cd80 1 0.21 1.36 0.34
55 INT311997 Regulation of STAM Regulation of BGLAP 1 0.00 0.61 0.32
56 INT299791 Negative_regulation of Binding of CD28 and CTLA4 1 0.18 0.77 0.32
57 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32
58 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31
59 INT311991 STAM Regulation of BGLAP 1 0.00 0.61 0.31
60 INT118853 Negative_regulation of SRC Negative_regulation of Positive_regulation of STAT3 1 0.41 0.08 0.28
61 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
62 INT118855 Binding of SRC and GNA14 1 0.01 0.13 0.27
63 INT213798 Sh2b2 Regulation of tf 1 0.12 0.53 0.27
64 INT213799 Sh2b2 Regulation of Tfeb 1 0.26 0.54 0.27
65 INT100680 IL4 Positive_regulation of SRC 1 0.42 0.66 0.26
66 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
67 INT118858 PRKCA Regulation of Phosphorylation of SRC 1 0.10 0.15 0.24
68 INT118850 GNA14 Positive_regulation of Phosphorylation of SRC 1 0.02 0.15 0.23
69 INT289959 Negative_regulation of Binding of CD28 and CD80 1 0.07 0.24 0.23
70 INT312517 Rapgef1 Negative_regulation of Rbp4 1 0.01 0.9 0.22
71 INT238006 Cxcl10 Positive_regulation of Gene_expression of Cd28 1 0.24 0.91 0.21
72 INT213812 Sh2b2 Positive_regulation of Tfeb 1 0.44 0.45 0.2
73 INT274080 Binding of ARHGAP4 and Map3k5 1 0.41 1.92 0.2
74 INT288006 Binding of CD28 and LRRC23 1 0.02 0.54 0.19
75 INT188568 Negative_regulation of IRF6 Positive_regulation of CD28 1 0.05 0.19 0.19
76 INT333171 Tlx2 Positive_regulation of Blnk 1 0.03 0.37 0.19
77 INT171127 Binding of CD28 and IFN1@ 1 0.39 0.36 0.19
78 INT333170 asa Positive_regulation of Blnk 1 0.07 0.38 0.19
79 INT188571 IRF6 Positive_regulation of CD28 1 0.06 0.19 0.19
80 INT58588 IFNG Positive_regulation of ARHGAP4 1 0.31 1.22 0.19
81 INT318298 MECOM Negative_regulation of Binding of CD28 1 0.00 1.08 0.18
82 INT161547 Trpv1 Regulation of Sorbs1 1 0.03 0.25 0.17
83 INT300753 Binding of Cd28 and Positive_regulation of Transcription of IL13 1 0.00 0 0.17
84 INT266101 Binding of HPS1 and SH2B2 1 0.17 0.67 0.16
85 INT194700 CD28 Positive_regulation of MAPK1 1 0.10 0.55 0.16
86 INT265215 Cd28 Regulation of Transcription of thd 1 0.00 0 0.15
87 INT266107 Binding of MET and SH2B2 1 0.02 0.67 0.15
88 INT306268 CRKL Positive_regulation of RASGRP1 1 0.02 0.54 0.14
89 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14
90 INT306272 CRKL Positive_regulation of JUN 1 0.05 0.54 0.14
91 INT275983 Binding of Lat and Lcp2 1 0.23 0.41 0.13
92 INT194817 CD28 Positive_regulation of Il4 1 0.15 0.41 0.13
93 INT194717 CD28 Positive_regulation of IL13 1 0.03 0.41 0.13
94 INT254488 Dtx1 Regulation of Sorbs1 1 0.01 0 0.12
95 INT266063 PAG1 Regulation of Gene_expression of Creb1 1 0.06 0.53 0.12
96 INT332687 Ros1 Positive_regulation of Crk 1 0.17 0.77 0.12
97 INT207112 Sh2b2 Positive_regulation of Phosphorylation of Akt2 1 0.68 0.24 0.12
98 INT207115 Sh2b2 Positive_regulation of Akt2 1 0.49 0.24 0.12
99 INT188356 Binding of Cd28 and Positive_regulation of Localization of Cd4 1 0.30 0.18 0.11
100 INT299782 Cd28 Regulation of Gene_expression of Il2 1 0.01 0.43 0.11
101 INT188360 Binding of Cd28 and Positive_regulation of Localization of Cd8a 1 0.09 0.18 0.11
102 INT292087 SRC Regulation of IL8 1 0.02 1.43 0.11
103 INT191184 Binding of EGFR and GRB2 7 0.35 1.06 0.1
104 INT275450 Binding of STAM and Syk 1 0.00 0.12 0.1
105 INT265212 Cd28 Negative_regulation of Gene_expression of Il17a 1 0.10 0 0.09
106 INT332486 Binding of HSH2D and OR2A5 1 0.00 0.26 0.09
107 INT228810 Vwf Regulation of Stap1 1 0.00 0.24 0.09
108 INT228811 Gtf3a Regulation of Stap1 1 0.00 0.24 0.09
109 INT311990 FCGR3B Regulation of STAM 1 0.01 0.27 0.09
110 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09
111 INT228812 Smad7 Regulation of Stap1 1 0.00 0.24 0.09
112 INT194674 CD28 Negative_regulation of Gene_expression of IL13 1 0.02 0.06 0.08
113 INT270201 Binding of CD28 and Cd86 1 0.10 0.58 0.08
114 INT221258 Negative_regulation of Binding of VDAC1 and Crk 1 0.00 0.22 0.08
115 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
116 INT265222 Binding of Cd28 and Gopc 1 0.04 0 0.08
117 INT221255 Binding of VDAC1 and Crk 1 0.00 0.22 0.08
118 INT270202 Binding of CD28 and Cd80 1 0.09 0.58 0.08
119 INT265221 Binding of Cd28 and Positive_regulation of Gene_expression of Il17a 1 0.15 0.09 0.08
120 INT174561 Binding of Cd28 and Ncl 1 0.00 0.62 0.07
121 INT175195 Binding of SH2B2 and NUP62 1 0.01 0 0.07
122 INT275800 Binding of Sh2d1a and Tacr1 1 0.01 0.29 0.07
123 INT299291 Negative_regulation of PTPN3 Positive_regulation of Phosphorylation of SRC 1 0.07 0.12 0.07
124 INT252353 Regulation of Binding of LCP2 and Cd28 1 0.37 0 0.06
125 INT252355 Binding of LCP2 and Cd28 1 0.30 0 0.06
126 INT275801 Binding of Hcrt and Sh2d1a 1 0.03 0.29 0.06
127 INT252338 Binding of Cd28 and Lat 1 0.30 0 0.06
128 INT237192 Cd28 Positive_regulation of LPT 1 0.01 0.15 0.06
129 INT194831 CD28 Positive_regulation of Gene_expression of Il4 1 0.15 0 0.06
130 INT252335 Regulation of Binding of Cd28 and Lat 1 0.37 0 0.06
131 INT235006 IgG Positive_regulation of SRC 1 0.01 0.82 0.05
132 INT235010 Positive_regulation of Positive_regulation of SRC 1 0.01 0.84 0.05
133 INT73194 GRB2 Positive_regulation of Positive_regulation of PLCG2 1 0.19 0.81 0.05
134 INT265224 Cd28 Positive_regulation of Gene_expression of IFN1@ 1 0.34 0.25 0.05
135 INT265218 Cd28 Positive_regulation of Gene_expression of Gopc 1 0.06 0.25 0.05
136 INT332488 OR2A5 Positive_regulation of HSH2D 1 0.00 0.19 0.05
137 INT265225 Cd28 Positive_regulation of IFN1@ 1 0.47 0.25 0.05
138 INT332484 ANXA1 Positive_regulation of HSH2D 1 0.18 0.19 0.05
139 INT299762 Binding of Cd28 and Positive_regulation of Gene_expression of Il2 1 0.03 0.07 0.04
140 INT197917 Binding of ESR1 and Sh2b2 1 0.01 0 0.04
141 INT128214 Binding of Il6 and Stap1 1 0.00 0 0.04
142 INT238113 SRC Regulation of Phosphorylation of STAT3 1 0.46 0 0.04
143 INT266105 SH2B2 Positive_regulation of Gene_expression of HPS1 1 0.24 0.62 0.03
144 INT288007 Binding of CD28 and CD40 1 0.05 0.51 0.03
145 INT211191 CD28 Positive_regulation of Gene_expression of IL2 1 0.15 0.15 0.03
146 INT302126 PTGER2 Positive_regulation of SRC 1 0.11 1.08 0.03
147 INT213905 ESR1 Positive_regulation of SRC 1 0.14 0.31 0.03
148 INT342094 Binding of Lat and Ie 1 0.05 1.9 0
149 INT338198 SRC Positive_regulation of STAT3 1 0.11 0.34 0
150 INT218308 Binding of HPRT1 and Grb10 1 0.26 0.07 0
151 INT221621 Binding of Lat and Fer 1 0.02 0 0
152 INT342095 Regulation of Binding of Lat and Ie 1 0.07 2.03 0
153 INT252354 TNF Negative_regulation of Cd28 1 0.05 0.48 0
154 INT225909 Binding of GRB2 and SOS1 1 0.01 0.11 0
155 INT299303 SRC Regulation of Phosphorylation of VEGFA 1 0.12 0.05 0
156 INT311992 Binding of FCGR3B and STAM 1 0.02 0 0
157 INT285579 Binding of S100A8 and SRC 1 0.05 0.2 0
158 INT262731 Binding of CHN1 and TAF1A 1 0.00 0 0
159 INT225892 Binding of GAB1 and RASA1 1 0.01 0.06 0
160 INT294825 Phosphorylation of GRAP2 Regulation of Gene_expression of REXO1 1 0.03 0.48 0
161 INT299305 VEGFA Positive_regulation of Positive_regulation of SRC 1 0.22 0 0
162 INT339104 Binding of ERBB2 and GRB7 1 0.30 1.29 0
163 INT225905 Binding of GRB2 and SHC1 1 0.00 0 0
164 INT299300 SRC Positive_regulation of Phosphorylation of AKT1 1 0.24 0 0
165 INT279289 TXK Regulation of SRC 1 0.04 0.68 0
166 INT191698 Binding of TAT and SORBS1 1 0.01 1.08 0
167 INT299296 SRC Regulation of RPTOR 1 0.32 0 0
168 INT225870 Binding of CRKL and Cbl 1 0.00 0 0
169 INT339117 Binding of EGFR and GRB7 1 0.28 1.18 0
170 INT194698 Binding of ZAP70 and LAT 1 0.04 0 0
171 INT191183 Binding of GRB2 and RECQL5 1 0.37 0.17 0
172 INT114712 SRC Positive_regulation of Gene_expression of IGF1R 1 0.63 0.51 0
173 INT225906 Binding of GAB1 and GRB2 1 0.01 0.27 0
174 INT338194 Regulation of VAV3 Regulation of AR 1 0.31 0.49 0
175 INT338189 SRC Positive_regulation of HGFAC 1 0.00 0.4 0
176 INT275974 Binding of Grb2 and Lat 1 0.33 0 0
177 INT299285 SRC Regulation of Gene_expression of QPCT 1 0.03 0 0
178 INT225903 Binding of GAB1 and PIK3CG 1 0.01 0.13 0
179 INT302174 Positive_regulation of SRC Positive_regulation of Phosphorylation of STAT3 1 0.11 1.01 0
180 INT302142 PTGER3 Positive_regulation of SRC 1 0.09 1.07 0
181 INT194711 LAT Positive_regulation of Binding of VAV1 1 0.03 0 0
182 INT275975 Grb2 Positive_regulation of Lcp2 1 0.24 0 0
183 INT122544 FGF2 Positive_regulation of Positive_regulation of GRAP2 1 0.20 0 0
184 INT173127 Binding of INS and SORBS1 1 0.02 0.22 0
185 INT303334 Binding of SOS1 and Grb2 1 0.00 0.11 0
186 INT320400 Binding of Vcp and Khdrbs1 1 0.01 0.07 0
187 INT262729 Binding of CHN1 and RN7SL2 1 0.02 0 0
188 INT299308 SRC Regulation of PI3 1 0.20 0 0
189 INT273716 Binding of Cd28 and Icam1 1 0.09 0 0
190 INT225902 Binding of CRKL and GAB1 1 0.01 0.1 0
191 INT277811 Binding of CD28 and DCPS 1 0.04 0.05 0
192 INT234970 Binding of Jup and Lat 1 0.01 0 0
193 INT171394 Binding of Grb2 and Shc1 1 0.05 0 0
194 INT299298 SRC Negative_regulation of PI3 1 0.19 0 0
195 INT194692 Binding of VAV1 and LAT 1 0.02 0 0
196 INT338195 Binding of SRC and FIBP 1 0.00 0.31 0
197 INT309906 Binding of EGF and SRC 1 0.11 0.64 0
198 INT275979 Binding of Grb2 and Lcp2 1 0.23 0 0
199 INT338187 VAV3 Regulation of CDCP1 1 0.00 1.47 0
200 INT114713 Binding of IGF1R and SRC 1 0.33 0.6 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for SH3/SH2 adaptor activity. They are ordered first by their pain relevance and then by number of times they were reported in SH3/SH2 adaptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79
2 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88
3 INT254567 Positive_regulation of Gene_expression of PAG1 10 0.39 31.15 24.26
4 INT99058 Regulation of PAG1 18 0.45 21.62 18.5
5 INT63553 Binding of PAG1 14 0.48 12.51 14.76
6 INT171134 Gene_expression of CD28 67 0.65 32.55 13.61
7 INT74838 Positive_regulation of Sorbs1 18 0.34 6.93 12.63
8 INT118905 Positive_regulation of Positive_regulation of PAG1 8 0.40 7.55 12.25
9 INT8533 Regulation of Sorbs1 9 0.27 3.01 11.98
10 INT73504 Binding of CD28 35 0.45 15.99 10.04
11 INT254566 Negative_regulation of Gene_expression of PAG1 7 0.33 9.51 9.91
12 INT8535 Localization of Sorbs1 9 0.80 2.71 9.07
13 INT72539 Gene_expression of Sorbs1 10 0.78 4.98 8.14
14 INT81419 Localization of PAG1 10 0.64 11.1 8.01
15 INT94125 Gene_expression of Cd28 38 0.67 21.73 7.75
16 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
17 INT92716 Negative_regulation of PAG1 6 0.51 5.82 6.32
18 INT43524 Positive_regulation of Sh2b2 16 0.58 2.95 5.78
19 INT254570 Regulation of Gene_expression of PAG1 3 0.35 6.72 5.76
20 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
21 INT72538 Negative_regulation of Sorbs1 7 0.59 4.49 4.61
22 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39
23 INT116902 Positive_regulation of CD28 17 0.47 13.56 4.27
24 INT92509 Regulation of Sh2b2 7 0.35 3.41 3.8
25 INT8536 Binding of Sorbs1 2 0.14 1.24 3.64
26 INT260159 Negative_regulation of Positive_regulation of PAG1 2 0.33 1.86 3.39
27 INT188355 Binding of Cd28 25 0.34 8.29 3.38
28 INT48292 Negative_regulation of Sh2b2 9 0.26 2.14 3.26
29 INT175262 Binding of SH2B2 18 0.36 22.85 3.18
30 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
31 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99
32 INT174527 Negative_regulation of CD28 13 0.35 5.06 2.65
33 INT182893 Gene_expression of Sh2b2 8 0.65 1.74 2.65
34 INT122060 Positive_regulation of Positive_regulation of Sorbs1 2 0.34 0.06 2.57
35 INT144652 Negative_regulation of Binding of CD28 6 0.55 3.09 2.28
36 INT8537 Negative_regulation of Regulation of Sorbs1 1 0.18 0 2.17
37 INT11183 Negative_regulation of SH2B2 4 0.34 6.99 2.12
38 INT255708 Transcription of PAG1 2 0.53 0.84 2.08
39 INT98464 Positive_regulation of Positive_regulation of SRC 10 0.67 5.71 1.86
40 INT174511 Positive_regulation of Gene_expression of CD28 7 0.41 4.31 1.83
41 INT82609 Phosphorylation of SRC 17 0.80 6.45 1.7
42 INT126760 Positive_regulation of Negative_regulation of SH2B2 1 0.05 1.01 1.6
43 INT171133 Localization of CD28 8 0.71 3.42 1.48
44 INT259036 Transcription of SH2B2 2 0.55 7.01 1.46
45 INT260160 Regulation of Positive_regulation of PAG1 1 0.35 1.1 1.4
46 INT94126 Positive_regulation of Cd28 9 0.50 4.23 1.33
47 INT114715 Binding of SRC 8 0.36 4.26 1.32
48 INT180763 Positive_regulation of Binding of Sorbs1 1 0.02 1.25 1.26
49 INT180762 Negative_regulation of Binding of Sorbs1 1 0.02 1.24 1.26
50 INT266050 Regulation of Binding of PAG1 1 0.06 2.96 1.25
51 INT254569 Regulation of Localization of PAG1 2 0.20 3.08 1.23
52 INT174557 Negative_regulation of Gene_expression of Cd28 7 0.43 4.42 1.2
53 INT219950 Negative_regulation of Gene_expression of SRC 2 0.29 1.32 1.15
54 INT266051 Phosphorylation of PAG1 1 0.10 2.51 1.11
55 INT174550 Negative_regulation of Cd28 7 0.33 4.7 1.06
56 INT138543 Negative_regulation of Cd28 3 0.11 2.1 1.01
57 INT266561 Negative_regulation of Positive_regulation of Sorbs1 1 0.01 1.01 0.88
58 INT332514 Gene_expression of HSH2D 1 0.65 3.22 0.85
59 INT147634 Regulation of Cd28 2 0.44 3.23 0.82
60 INT118004 Positive_regulation of Gene_expression of SRC 13 0.49 11.05 0.8
61 INT161609 Positive_regulation of HSH2D 2 0.45 2.16 0.77
62 INT43788 Localization of GRAP2 3 0.02 0.1 0.76
63 INT149698 Negative_regulation of Binding of Cd28 2 0.15 1.21 0.75
64 INT169301 Phosphorylation of GRAP2 6 0.21 2.89 0.74
65 INT149697 Binding of Cd28 2 0.12 1.16 0.74
66 INT117751 Binding of HSH2D 2 0.32 1.64 0.73
67 INT279357 Regulation of Binding of CD28 1 0.18 0.3 0.72
68 INT284739 Positive_regulation of Gene_expression of Sh2b2 2 0.26 0.83 0.71
69 INT188586 Negative_regulation of Gene_expression of CD28 6 0.34 1.9 0.69
70 INT182036 Gene_expression of Sh2b2 2 0.13 1.74 0.67
71 INT265207 Positive_regulation of Gene_expression of Cd28 3 0.43 1.47 0.66
72 INT329718 Transcription of Cd28 1 0.09 1.54 0.63
73 INT3501 Localization of Sh2b2 6 0.73 0.88 0.62
74 INT275787 Gene_expression of Sh2d1a 1 0.04 1.42 0.62
75 INT211489 Gene_expression of ARHGAP4 6 0.65 2.88 0.61
76 INT263969 Negative_regulation of Localization of PAG1 1 0.36 2.72 0.61
77 INT263967 Positive_regulation of Localization of PAG1 1 0.43 2.83 0.61
78 INT93728 Gene_expression of Cd28 8 0.35 7.11 0.59
79 INT50016 Positive_regulation of ARHGAP4 3 0.49 1.8 0.58
80 INT174556 Regulation of Gene_expression of Cd28 3 0.42 2.9 0.57
81 INT49400 Gene_expression of SHB 2 0.63 0.38 0.56
82 INT44434 Gene_expression of GRAP2 4 0.65 1.05 0.52
83 INT95709 Regulation of Localization of Stap1 1 0.01 0.22 0.52
84 INT333148 Negative_regulation of Blnk 1 0.09 0.49 0.51
85 INT95710 Localization of Stap1 1 0.02 0.22 0.51
86 INT323479 Phosphorylation of Sorbs1 1 0.06 1.8 0.49
87 INT82608 Positive_regulation of Phosphorylation of SRC 3 0.49 1.28 0.48
88 INT98072 Gene_expression of LAT 5 0.68 5.37 0.44
89 INT117752 Regulation of HSH2D 2 0.20 1.01 0.44
90 INT44433 Positive_regulation of Localization of GRAP2 1 0.00 0.1 0.44
91 INT199011 Binding of Lat 11 0.32 6.03 0.42
92 INT259035 Localization of SH2B2 3 0.43 1.77 0.42
93 INT270195 Positive_regulation of Positive_regulation of CD28 1 0.25 2.49 0.41
94 INT60976 Positive_regulation of Gene_expression of CHN1 1 0.14 3.91 0.39
95 INT197880 Binding of Sh2b2 2 0.19 0 0.38
96 INT287809 Negative_regulation of Positive_regulation of Cd28 1 0.26 0.65 0.38
97 INT114740 Binding of GRB2 8 0.36 2.24 0.37
98 INT254484 Positive_regulation of Gene_expression of Sorbs1 4 0.12 1.9 0.37
99 INT275954 Regulation of Lat 4 0.54 0.75 0.37
100 INT174476 Regulation of CD28 3 0.34 0.67 0.37
101 INT181575 Phosphorylation of Crk 1 0.61 1.78 0.36
102 INT339199 Gene_expression of GRB7 1 0.62 1.3 0.36
103 INT60977 Localization of CHN1 2 0.57 1.9 0.35
104 INT329720 Negative_regulation of Transcription of Cd28 1 0.08 0.9 0.35
105 INT138051 Negative_regulation of Positive_regulation of SRC 3 0.57 0.84 0.33
106 INT263968 Positive_regulation of Negative_regulation of PAG1 1 0.43 1.29 0.33
107 INT243808 Positive_regulation of Transcription of Sh2b2 1 0.29 0.86 0.33
108 INT243807 Transcription of Sh2b2 1 0.39 0.85 0.33
109 INT181580 Gene_expression of Crk 1 0.75 1.2 0.33
110 INT191211 Gene_expression of GRB2 5 0.62 0.96 0.32
111 INT50014 Negative_regulation of ARHGAP4 2 0.27 1.59 0.32
112 INT188577 Transcription of CD28 1 0.43 0.54 0.32
113 INT188583 Regulation of Transcription of CD28 1 0.22 0.54 0.32
114 INT313251 Negative_regulation of Positive_regulation of Sh2b2 1 0.12 0 0.29
115 INT211491 Positive_regulation of Gene_expression of ARHGAP4 1 0.49 1.18 0.29
116 INT266126 Regulation of SH2B2 1 0.30 0.84 0.27
117 INT171131 Protein_catabolism of CD28 1 0.73 0.47 0.27
118 INT284738 Positive_regulation of Localization of Sh2b2 1 0.09 0.6 0.26
119 INT278163 Negative_regulation of Localization of CD28 1 0.08 0.87 0.26
120 INT240034 Phosphorylation of GRB2 3 0.79 1.79 0.25
121 INT275791 Binding of Sh2d1a 1 0.03 0.91 0.24
122 INT22405 Positive_regulation of Crk 2 0.09 0.64 0.23
123 INT339177 Negative_regulation of GRB7 1 0.35 0.64 0.22
124 INT164162 Negative_regulation of Phosphorylation of SRC 3 0.29 2.12 0.21
125 INT252317 Negative_regulation of Binding of Cd28 3 0.31 1.09 0.21
126 INT175260 Negative_regulation of Gene_expression of SH2B2 2 0.25 4.41 0.21
127 INT255704 Positive_regulation of Transcription of PAG1 1 0.06 0.35 0.21
128 INT220835 Localization of Cd28 1 0.65 0.45 0.2
129 INT304145 Phosphorylation of Grb2 1 0.03 0.72 0.2
130 INT235725 Regulation of SRC 7 0.44 4.71 0.19
131 INT220837 Regulation of Cd28 2 0.41 0.14 0.19
132 INT60978 Gene_expression of CHN1 2 0.24 2.1 0.19
133 INT218284 Gene_expression of Grb10 15 0.72 1.85 0.18
134 INT270152 Positive_regulation of Lat 6 0.44 11.1 0.16
135 INT220838 Protein_catabolism of Cd28 1 0.60 0.46 0.16
136 INT135526 Positive_regulation of Gene_expression of Cd28 2 0.32 0.9 0.15
137 INT275446 Gene_expression of STAM 1 0.01 0.27 0.15
138 INT332526 Positive_regulation of Gene_expression of HSH2D 1 0.21 0.41 0.15
139 INT306283 Gene_expression of CRKL 1 0.36 0.42 0.14
140 INT306281 Gene_expression of SOCS2 1 0.01 0.52 0.14
141 INT44454 Positive_regulation of GRAP2 4 0.25 1.48 0.13
142 INT329712 Positive_regulation of Cd28 2 0.10 1 0.13
143 INT75168 Binding of CHN1 2 0.19 1.73 0.13
144 INT312008 Binding of STAM 1 0.02 0.34 0.13
145 INT50015 Negative_regulation of Positive_regulation of ARHGAP4 1 0.27 0.37 0.13
146 INT333147 Positive_regulation of Blnk 1 0.14 0.24 0.13
147 INT270171 Positive_regulation of Positive_regulation of Lat 2 0.32 1.91 0.12
148 INT332522 Regulation of Binding of HSH2D 1 0.19 0.17 0.12
149 INT225845 Binding of CRKL 2 0.23 0.42 0.11
150 INT338914 Negative_regulation of Phosphorylation of CRK 1 0.08 0 0.1
151 INT58594 Regulation of ARHGAP4 1 0.21 0.65 0.1
152 INT275796 Regulation of Gene_expression of Sh2d1a 1 0.02 0 0.1
153 INT338913 Phosphorylation of CRK 1 0.12 0 0.1
154 INT259038 Negative_regulation of Positive_regulation of SH2B2 1 0.25 1.83 0.09
155 INT221209 Localization of Crk 1 0.05 0.25 0.09
156 INT299357 Localization of SRC 1 0.51 0 0.09
157 INT98071 Localization of LAT 1 0.62 0.63 0.09
158 INT221203 Binding of Crk 1 0.06 0.22 0.08
159 INT44452 Negative_regulation of GRAP2 1 0.01 0 0.08
160 INT44453 Negative_regulation of Localization of GRAP2 1 0.01 0 0.08
161 INT58593 Regulation of Negative_regulation of ARHGAP4 1 0.21 0.53 0.07
162 INT332496 Negative_regulation of Positive_regulation of HSH2D 1 0.18 0.2 0.07
163 INT275447 Phosphorylation of STAM 1 0.02 0.05 0.07
164 INT275923 Gene_expression of Lat 6 0.59 13.31 0.05
165 INT238187 Regulation of Positive_regulation of SRC 2 0.26 1.37 0.05
166 INT275794 Localization of Sh2d1a 1 0.04 0.18 0.05
167 INT275933 Negative_regulation of Lat 1 0.51 0.07 0.04
168 INT338241 Positive_regulation of VAV3 1 0.56 1.28 0.04
169 INT194775 Positive_regulation of Positive_regulation of LAT 1 0.10 0 0.04
170 INT349238 Negative_regulation of LAT 1 0.23 0.11 0.03
171 INT259040 Phosphorylation of SH2B2 1 0.47 0.85 0.03
172 INT259029 Regulation of Phosphorylation of SH2B2 1 0.26 0.85 0.03
173 INT338258 Binding of VAV3 1 0.39 0.86 0.03
174 INT194788 Positive_regulation of LAT 1 0.10 0 0.03
175 INT332527 Positive_regulation of Binding of HSH2D 1 0.18 0.21 0.03
176 INT238193 Regulation of Gene_expression of SRC 1 0.44 0 0.03
177 INT275931 Binding of Grb2 5 0.26 0 0
178 INT108539 Gene_expression of Khdrbs1 3 0.12 0.9 0
179 INT114742 Positive_regulation of GRB2 3 0.49 1.59 0
180 INT173193 Binding of SORBS1 2 0.14 1.29 0
181 INT275949 Negative_regulation of Positive_regulation of Lat 2 0.37 2.34 0
182 INT221574 Transcription of Lat 2 0.44 1.3 0
183 INT342086 Regulation of Positive_regulation of Lat 1 0.29 1.99 0
184 INT342092 Regulation of Transcription of Lat 1 0.29 0.6 0
185 INT338234 Localization of VAV3 1 0.61 0.38 0
186 INT223596 Positive_regulation of Gene_expression of GRB2 1 0.03 0.51 0
187 INT338248 Negative_regulation of Gene_expression of VAV3 1 0.48 2.92 0
188 INT268145 Negative_regulation of Sh2b2 1 0.41 0.07 0
189 INT218292 Negative_regulation of Gene_expression of Grb10 1 0.40 0 0
190 INT218290 Negative_regulation of Grb10 1 0.40 0.06 0
191 INT339160 Positive_regulation of Gene_expression of GRB7 1 0.56 0.45 0
192 INT342076 Localization of Lat 1 0.47 2.56 0
193 INT268165 Binding of Sh2b2 1 0.36 0.13 0
194 INT262740 Positive_regulation of Binding of CHN1 1 0.20 0.14 0
195 INT201591 Regulation of Grb2 1 0.20 1.18 0
196 INT218295 Regulation of Gene_expression of Grb10 1 0.42 0.24 0
197 INT214434 Positive_regulation of Phosphorylation of GRAP2 1 0.10 0.34 0
198 INT218298 Positive_regulation of Gene_expression of Grb10 1 0.43 0.12 0
199 INT225857 Positive_regulation of CRKL 1 0.05 0 0
200 INT275930 Positive_regulation of Protein_catabolism of Lat 1 0.44 0.12 0
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