GO:0005954

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Name calcium- and calmodulin-dependent protein kinase complex
Categary Component
Go Slim No
Go Link GO:0005954
Unique Molecular Interactions 82
Total Molecular Interactions 104
Total Single Events 833
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for calcium- and calmodulin-dependent protein kinase complex. They are ordered first by their pain relevance and then by number of times they were reported for calcium- and calmodulin-dependent protein kinase complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
2 INT124133 Camk2a Regulation of Phosphorylation of Creb1 1 0.46 0 2
3 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
4 INT136843 Binding of Camk2a and Nrgn 1 0.47 0 1.47
5 INT123387 Binding of Camk2a and Gria2 1 0.13 0.32 1.14
6 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 0.19 0 1.14
7 INT317534 Regulation of Binding of Camk2a and Grin1 1 0.20 0.06 1.05
8 INT157142 OPA1 Positive_regulation of Gene_expression of Camk2a 1 0.02 0.3 1.02
9 INT317544 Camk2a Regulation of Negative_regulation of Oprm1 1 0.20 0.07 1
10 INT142129 Nrgn Regulation of Camk2a 1 0.48 0.25 0.89
11 INT223867 Camk2a Positive_regulation of Positive_regulation of Ltp 1 0.25 0 0.87
12 INT150681 Pomc Positive_regulation of Camk2a 1 0.47 0.07 0.8
13 INT150679 Pomc Regulation of Gene_expression of Camk2a 1 0.30 0.07 0.79
14 INT147913 Phosphorylation of Camk2a Positive_regulation of Binding of Lpl 1 0.10 0 0.77
15 INT116803 Phosphorylation of Camk2b Positive_regulation of Camk4 1 0.03 0 0.76
16 INT116805 Phosphorylation of Camk2b Positive_regulation of Camk2a 1 0.07 0 0.76
17 INT71595 Camk2a Regulation of Negative_regulation of Oprm1 1 0.04 0 0.69
18 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66
19 INT186429 Camk2a Regulation of Regulation of Creb1 1 0.09 0.09 0.62
20 INT157141 Cpox Positive_regulation of Gene_expression of Camk2a 1 0.19 0.13 0.58
21 INT296472 Camk2a Positive_regulation of Prkaca 1 0.09 0.32 0.57
22 INT330553 Bcl2l11 Negative_regulation of Camk2a 1 0.01 0.38 0.52
23 INT296457 Camk2a Positive_regulation of Phosphorylation of Gria1 1 0.19 0.28 0.49
24 INT296471 Camk2a Regulation of Phosphorylation of Rbm39 1 0.00 0.27 0.47
25 INT317521 Camk2a Negative_regulation of Binding of Calm3 1 0.11 0 0.43
26 INT71596 Binding of Camk2a and Mpv17l 1 0.00 0 0.38
27 INT274933 Ephb2 Regulation of Phosphorylation of Camk2a 1 0.29 0 0.36
28 INT317566 Car2 Positive_regulation of Camk2a 2 0.19 0.58 0.32
29 INT317545 Calm3 Positive_regulation of Camk2a 1 0.17 0 0.31
30 INT235874 Camk2a Positive_regulation of Slc6a4 1 0.11 0.14 0.28
31 INT118852 Positive_regulation of GNA14 Positive_regulation of CAMK2G 1 0.01 0.09 0.27
32 INT118846 GNA14 Positive_regulation of CAMK2G 1 0.01 0.09 0.27
33 INT296454 Camk2a Positive_regulation of Gene_expression of Gria2 1 0.30 0.14 0.24
34 INT244023 Nsf Regulation of Camk2a 1 0.04 0.09 0.24
35 INT296443 Camk2a Positive_regulation of Gria2 1 0.28 0.14 0.24
36 INT296452 Camk2a Positive_regulation of Ltp 1 0.08 0.14 0.24
37 INT257218 Camk1 Negative_regulation of Nos1 1 0.04 0.09 0.19
38 INT257232 Negative_regulation of Binding of GRIN1 and Camk2a 1 0.13 0 0.19
39 INT257234 Binding of GRIN1 and Camk2a 1 0.12 0 0.19
40 INT170366 Gria1 Regulation of Phosphorylation of Camk2a 1 0.23 0.07 0.18
41 INT150365 Camk2a Regulation of Gene_expression of Pomc 1 0.08 0.17 0.17
42 INT276065 Camk2a Negative_regulation of Pde1b 1 0.56 0 0.17
43 INT332327 Camk2a Positive_regulation of Myoz1 1 0.05 0.4 0.15
44 INT196816 Binding of Calm3 and Camk2a 2 0.15 0 0.14
45 INT148174 Camk2a Positive_regulation of Positive_regulation of PRKG1 1 0.04 0 0.14
46 INT86551 Ppm1f Positive_regulation of Camk1g 1 0.49 0 0.13
47 INT276040 Binding of Camk2a and Ppp1cc 1 0.13 0 0.12
48 INT276079 Pde1b Negative_regulation of Camk2a 1 0.41 0 0.12
49 INT276069 Binding of Camk2a and Ppp1r1b 1 0.18 0 0.12
50 INT170368 Positive_regulation of Camk2a Positive_regulation of Regulation of Gria2 1 0.06 0 0.11
51 INT258714 Camk1g Positive_regulation of Gpd1 1 0.46 0.07 0.11
52 INT248209 Camk2a Positive_regulation of Phosphorylation of Mecp2 1 0.52 0 0.08
53 INT263767 Binding of Camk2a and Grin2b 1 0.18 0 0.06
54 INT254463 Binding of Camk2a and Cacna1c 1 0.00 0.17 0.06
55 INT218830 Camk2a Regulation of Phosphorylation of Gria1 1 0.36 0.63 0.06
56 INT332332 Camk2a Negative_regulation of Myoz1 1 0.04 0 0.04
57 INT332322 Myoz1 Positive_regulation of Camk2a 1 0.05 0 0.04
58 INT244049 Positive_regulation of Binding of Car2 and Camk2d 1 0.01 0 0.03
59 INT276076 Camk2a Positive_regulation of Rpa1 1 0.07 0 0.03
60 INT276038 Camk2a Negative_regulation of Pde1a 1 0.14 0 0.03
61 INT244042 Binding of Car2 and Camk2d 1 0.01 0 0.03
62 INT126180 Camk1 Positive_regulation of Camkk1 1 0.16 0 0
63 INT244026 Ppp1cc Regulation of Phosphorylation of Camk2a 1 0.03 0 0
64 INT325591 Olfml3 Positive_regulation of Camk2a 1 0.01 0.26 0
65 INT276078 Binding of Camk2a and Pde1b 1 0.36 0 0
66 INT276073 Camk2a Regulation of Ppp1cc 1 0.10 0 0
67 INT276052 Negative_regulation of Pde1b Negative_regulation of Camk2a 1 0.41 0 0
68 INT309746 CALM3 Positive_regulation of CAMK2G 1 0.02 0 0
69 INT276058 Camk2a Regulation of Pde1b 1 0.26 0 0
70 INT330049 Prkcg Negative_regulation of Pnck 1 0.01 0.28 0
71 INT276077 Binding of Camk2a and Car2 1 0.32 0 0
72 INT325598 Ang Positive_regulation of Camk2a 1 0.21 0.29 0
73 INT276047 Camk2a Regulation of Negative_regulation of Pde1b 1 0.43 0 0
74 INT276071 Pde1b Regulation of Positive_regulation of Camk2a 1 0.43 0 0
75 INT258716 Camk1g Positive_regulation of Kras 1 0.02 0.08 0
76 INT325601 Ang Positive_regulation of Phosphorylation of Camk2a 1 0.21 0.29 0
77 INT258713 Camk1g Positive_regulation of Ephb1 1 0.48 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for calcium- and calmodulin-dependent protein kinase complex. They are ordered first by their pain relevance and then by number of times they were reported in calcium- and calmodulin-dependent protein kinase complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7
2 INT115649 Gene_expression of Camk2a 95 0.78 33.22 38
3 INT114729 Phosphorylation of Camk2a 110 0.82 15.49 33.19
4 INT123386 Negative_regulation of Camk2a 48 0.58 12.57 23.78
5 INT115650 Positive_regulation of Gene_expression of Camk2a 37 0.70 17.68 15.73
6 INT86544 Positive_regulation of Camk2a 20 0.47 4.59 11.37
7 INT119527 Regulation of Camk2a 26 0.60 5.55 9.01
8 INT119529 Positive_regulation of Phosphorylation of Camk2a 16 0.60 1.49 8.94
9 INT71590 Gene_expression of Camk2a 17 0.78 2.3 8.63
10 INT119525 Negative_regulation of Positive_regulation of Camk2a 14 0.43 5.15 8.45
11 INT132468 Positive_regulation of Positive_regulation of Camk2a 20 0.70 2.76 6.7
12 INT121988 Negative_regulation of Gene_expression of Camk2a 8 0.59 4.76 5.72
13 INT80344 Regulation of Camk2a 9 0.56 0.99 5.66
14 INT147898 Binding of Camk2a 16 0.37 4.01 4.87
15 INT49060 Negative_regulation of Camk2a 10 0.45 2.59 4.67
16 INT151350 Regulation of Gene_expression of Camk2a 1 0.62 0.79 4.57
17 INT71594 Positive_regulation of Gene_expression of Camk2a 8 0.47 1.07 4.35
18 INT80347 Positive_regulation of Camk2b 2 0.69 0.33 3.67
19 INT80345 Gene_expression of Camk2b 3 0.77 0.5 3.44
20 INT71588 Phosphorylation of Camk2a 7 0.65 0.32 3.03
21 INT101779 Positive_regulation of Positive_regulation of Camk2a 5 0.31 1.57 3.02
22 INT80346 Negative_regulation of Camk2b 3 0.58 0.58 2.81
23 INT125998 Binding of Camk2a 3 0.36 0.89 2.67
24 INT218822 Negative_regulation of Phosphorylation of Camk2a 5 0.50 0.91 2.41
25 INT102908 Phosphorylation of Camk2b 2 0.62 0.42 2.17
26 INT89639 Phosphorylation of CAMK2G 5 0.48 0.66 1.78
27 INT86539 Positive_regulation of Phosphorylation of Camk2a 3 0.55 0.18 1.65
28 INT86545 Positive_regulation of Phosphorylation of Camk1g 1 0.62 0 1.65
29 INT86542 Positive_regulation of Camk1g 5 0.64 0.28 1.64
30 INT86540 Phosphorylation of Camk1g 1 0.74 0 1.63
31 INT119526 Regulation of Gene_expression of Camk2a 4 0.45 1.39 1.58
32 INT162811 Localization of Camk2a 4 0.71 0.61 1.42
33 INT171811 Gene_expression of Pnck 1 0.20 0.16 1.37
34 INT92976 Localization of Camk2a 1 0.61 0.21 1.23
35 INT80341 Regulation of Gene_expression of Camk2b 1 0.61 0.08 1.08
36 INT116801 Negative_regulation of Positive_regulation of Camk2b 1 0.29 0.1 1.02
37 INT80348 Regulation of Regulation of Camk2a 1 0.24 0.06 0.9
38 INT125993 Negative_regulation of Binding of Camk2a 1 0.08 0.07 0.85
39 INT151349 Transcription of Camk2a 1 0.72 0.09 0.8
40 INT86548 Negative_regulation of Phosphorylation of Camk1g 1 0.52 0 0.78
41 INT102906 Positive_regulation of Gene_expression of Camk2b 1 0.68 0.43 0.63
42 INT126355 Negative_regulation of Camk2d 1 0.49 0.23 0.63
43 INT102909 Positive_regulation of Phosphorylation of Camk2b 1 0.46 0.43 0.63
44 INT135667 Negative_regulation of Negative_regulation of Camk2a 3 0.42 0.22 0.6
45 INT148431 Positive_regulation of Regulation of Camk2a 1 0.45 0.16 0.6
46 INT220662 Gene_expression of Camk1 3 0.66 3.17 0.58
47 INT243933 Gene_expression of Camk2d 1 0.10 0 0.55
48 INT114450 Gene_expression of Camk1 4 0.03 1.17 0.52
49 INT194020 Regulation of Positive_regulation of Camk2a 2 0.45 1.29 0.52
50 INT64131 Negative_regulation of Camk1g 2 0.15 0.09 0.5
51 INT248205 Protein_catabolism of Camk2a 2 0.86 0.06 0.47
52 INT86541 Gene_expression of Camk1g 3 0.71 0.7 0.43
53 INT114447 Negative_regulation of Regulation of Camk1 1 0.00 0.72 0.43
54 INT114453 Regulation of Camk1 1 0.01 0.72 0.43
55 INT137337 Positive_regulation of Regulation of Camk2a 1 0.44 0.31 0.42
56 INT170352 Negative_regulation of Localization of Camk2a 3 0.37 0.37 0.4
57 INT190866 Phosphorylation of Camk2d 1 0.13 0.05 0.4
58 INT274914 Positive_regulation of Protein_catabolism of Camk2a 1 0.42 0 0.39
59 INT86543 Positive_regulation of Positive_regulation of Camk1g 1 0.42 0 0.37
60 INT86547 Negative_regulation of Positive_regulation of Camk1g 1 0.39 0 0.37
61 INT159665 Regulation of Camk1g 2 0.25 0.27 0.34
62 INT170349 Positive_regulation of Localization of Camk2a 1 0.43 0.37 0.32
63 INT243980 Regulation of Phosphorylation of Camk2a 4 0.23 0.19 0.31
64 INT194018 Positive_regulation of Binding of Camk2a 2 0.50 2.59 0.3
65 INT114448 Regulation of Gene_expression of Camk1 1 0.01 0.52 0.3
66 INT89637 Negative_regulation of CAMK2G 1 0.26 0 0.28
67 INT258697 Transcription of Camk1g 1 0.66 0.6 0.28
68 INT118866 Positive_regulation of CAMK2G 1 0.16 0.09 0.27
69 INT157138 Negative_regulation of Gene_expression of Camk2a 1 0.37 0.07 0.26
70 INT318140 Regulation of Negative_regulation of Camk2a 1 0.14 0.89 0.22
71 INT114452 Regulation of Regulation of Camk1 1 0.00 0.38 0.22
72 INT258695 Regulation of Gene_expression of Camk1g 1 0.41 0.13 0.16
73 INT258704 Positive_regulation of Gene_expression of Camk1g 1 0.46 0.23 0.16
74 INT114451 Negative_regulation of Camk1 1 0.00 0.35 0.14
75 INT114449 Negative_regulation of Gene_expression of Camk1 1 0.00 0.34 0.13
76 INT258684 Positive_regulation of Transcription of Camk1g 1 0.64 0.17 0.12
77 INT243944 Positive_regulation of Gene_expression of Camk2d 1 0.07 0 0.03
78 INT198752 Regulation of Binding of Camk2a 2 0.44 0 0
79 INT258701 Regulation of Transcription of Camk1g 1 0.56 0.06 0
80 INT316994 Regulation of Regulation of Camk2a 1 0.16 0.2 0
81 INT258690 Negative_regulation of Transcription of Camk1g 1 0.39 0.05 0
82 INT254436 Negative_regulation of Binding of Camk2a 1 0.24 0 0
83 INT298752 Negative_regulation of Camk1 1 0.37 0.74 0
84 INT183440 Binding of Camk1g 1 0.03 0.43 0
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