GO:0006261

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Name DNA-dependent DNA replication
Categary Process
Go Slim No
Go Link GO:0006261
Unique Molecular Interactions 41
Total Molecular Interactions 54
Total Single Events 331
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA-dependent DNA replication. They are ordered first by their pain relevance and then by number of times they were reported for DNA-dependent DNA replication. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT222213 TFAM Positive_regulation of Gene_expression of Ccr1 1 0.02 3.96 1.4
2 INT133075 TFAM Positive_regulation of Transcription of OPRM1 1 0.03 0 1.04
3 INT306263 Binding of NFIB and TFAM 1 0.00 1.74 0.7
4 INT222181 TFAM Positive_regulation of XCR1 1 0.00 1.89 0.68
5 INT222211 TFAM Positive_regulation of Ccr1 1 0.02 1.89 0.68
6 INT156155 Binding of HCFC1 and TFAM 1 0.04 0.74 0.49
7 INT58578 Binding of RPA1 and TACR1 1 0.01 0 0.48
8 INT222180 Binding of HNF1B and TFAM 1 0.01 1.48 0.4
9 INT7636 RFC1 Negative_regulation of Localization of Oxt 1 0.14 0 0.39
10 INT222212 TFAM Negative_regulation of Cd28 1 0.02 1.17 0.39
11 INT7634 RFC1 Negative_regulation of Localization of AVP 1 0.46 0 0.39
12 INT222214 TFAM Positive_regulation of Cxcr1 1 0.03 1.13 0.37
13 INT156160 TFAM Regulation of Gene_expression of NTRK1 1 0.03 0.39 0.27
14 INT115143 MAPK1 Positive_regulation of TFAM 2 0.02 0.49 0.22
15 INT216883 Apoc4 Positive_regulation of TFAM 1 0.00 0.93 0.22
16 INT266405 S100b Positive_regulation of Gene_expression of TFAM 1 0.00 1.02 0.21
17 INT322017 RPA1 Positive_regulation of IL1B 1 0.00 0 0.21
18 INT91862 RPA1 Negative_regulation of Transcription of ATG9B 1 0.03 0.46 0.19
19 INT58579 Binding of INSRR and RPA1 1 0.00 0 0.18
20 INT239806 TFAM Positive_regulation of HSR 1 0.00 0.53 0.13
21 INT222179 CDC5L Regulation of TFAM 1 0.01 0.26 0.13
22 INT115145 PPARG Positive_regulation of TFAM 1 0.04 0.45 0.13
23 INT115144 TGM7 Positive_regulation of TFAM 1 0.03 0.44 0.12
24 INT194689 MAPKAPK2 Positive_regulation of TFAM 1 0.00 0.05 0.1
25 INT194837 Camk4 Positive_regulation of TFAM 1 0.00 0 0.1
26 INT306255 IRF6 Positive_regulation of TFAM 1 0.01 0 0.07
27 INT306260 TLR4 Positive_regulation of TFAM 1 0.01 0 0.07
28 INT308831 Binding of RFC1 and IGKV2D-29 1 0.02 0 0.06
29 INT322554 TFAM Negative_regulation of CDH16 1 0.00 1.6 0.04
30 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03
31 INT261691 Binding of TFAM and TCF23 1 0.01 0 0.03
32 INT177786 TFAM Regulation of Gene_expression of MT1F 1 0.00 0.17 0
33 INT249749 Nrf1 Regulation of Gene_expression of TFAM 1 0.01 0.06 0
34 INT268518 MIR19B1 Regulation of TFAM 1 0.00 0.39 0
35 INT323186 TFAM Positive_regulation of HIST1H1B 1 0.01 0.49 0
36 INT245217 Binding of CREM and TFAM 1 0.00 1.44 0
37 INT276759 ABCB1 Regulation of TOP2A 1 0.04 0.61 0
38 INT305543 Binding of Top2a and Trp53 1 0.37 0.91 0
39 INT251822 Binding of POLG and C10orf2 1 0.42 0.29 0
40 INT249750 Nfe2l2 Regulation of Gene_expression of TFAM 1 0.00 0.06 0
41 INT277368 Regulation of TFAM Positive_regulation of Gene_expression of TCF7L2 1 0.01 0.9 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA-dependent DNA replication. They are ordered first by their pain relevance and then by number of times they were reported in DNA-dependent DNA replication. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT61363 Positive_regulation of TFAM 43 0.69 26.43 8.14
2 INT130705 Gene_expression of TFAM 50 0.77 38.85 2.79
3 INT163359 Gene_expression of RFC1 9 0.65 3.34 2.64
4 INT68781 Negative_regulation of TFAM 15 0.58 10.01 2.42
5 INT109655 Binding of TFAM 11 0.08 7.9 2.41
6 INT58581 Binding of RPA1 8 0.44 1.68 1.44
7 INT91872 Gene_expression of RPA1 9 0.77 5.28 1.12
8 INT59768 Regulation of TFAM 7 0.45 4.64 1.08
9 INT121037 Positive_regulation of Positive_regulation of TFAM 5 0.42 2.56 1.02
10 INT226460 Phosphorylation of TFAM 5 0.01 2.74 0.98
11 INT252442 Binding of RFC1 3 0.05 0.3 0.84
12 INT182077 Positive_regulation of RFC1 3 0.07 1.65 0.81
13 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79
14 INT40476 Negative_regulation of RFC1 5 0.18 2.85 0.72
15 INT252443 Regulation of RFC1 1 0.03 0.35 0.59
16 INT61364 Negative_regulation of Positive_regulation of TFAM 4 0.12 1.68 0.56
17 INT158837 Binding of POLG 4 0.37 4.69 0.44
18 INT204342 Positive_regulation of Negative_regulation of TFAM 2 0.46 0.89 0.42
19 INT58580 Positive_regulation of Binding of RPA1 2 0.43 0 0.38
20 INT346245 Positive_regulation of Binding of TFAM 1 0.09 0.64 0.32
21 INT229244 Positive_regulation of Gene_expression of RFC1 1 0.09 0.07 0.3
22 INT346259 Regulation of Negative_regulation of TFAM 1 0.06 0.58 0.29
23 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23
24 INT40477 Negative_regulation of Negative_regulation of RFC1 1 0.18 0.4 0.22
25 INT169582 Phosphorylation of POLG 2 0.54 1.98 0.18
26 INT91870 Negative_regulation of Gene_expression of RPA1 1 0.58 0.4 0.16
27 INT184997 Gene_expression of TOP2A 6 0.63 1.65 0.15
28 INT91871 Transcription of RPA1 1 0.69 0.38 0.15
29 INT91866 Positive_regulation of Gene_expression of RPA1 1 0.69 0.38 0.15
30 INT204355 Transcription of TFAM 3 0.63 2.26 0.12
31 INT302679 Negative_regulation of Localization of POLG 1 0.39 0.99 0.11
32 INT302692 Localization of POLG 1 0.69 0.99 0.1
33 INT226076 Regulation of RPA1 1 0.25 0.43 0.1
34 INT204328 Positive_regulation of Transcription of TFAM 2 0.46 1.8 0.09
35 INT194320 Localization of RPA1 2 0.06 0.17 0.09
36 INT251829 Positive_regulation of POLG 1 0.53 1.5 0.08
37 INT182074 Negative_regulation of Gene_expression of RFC1 1 0.03 0.76 0.08
38 INT268846 Negative_regulation of Top2a 6 0.29 3.06 0.07
39 INT258473 Binding of TOP2A 3 0.05 1.65 0.05
40 INT251827 Regulation of POLG 3 0.59 2.94 0.04
41 INT266166 Negative_regulation of RPA1 2 0.08 1.65 0.03
42 INT204343 Positive_regulation of Gene_expression of TFAM 7 0.50 3.87 0
43 INT235686 Gene_expression of Top2a 5 0.60 4.34 0
44 INT118827 Regulation of TOP2A 4 0.04 1.75 0
45 INT36301 Negative_regulation of TOP2A 3 0.57 2.66 0
46 INT204345 Negative_regulation of Gene_expression of TFAM 3 0.42 1.48 0
47 INT268847 Binding of Top2a 2 0.24 0.6 0
48 INT266162 Transcription of POLG 2 0.68 0.76 0
49 INT299146 Positive_regulation of RPA1 1 0.01 0.15 0
50 INT204354 Negative_regulation of Transcription of TFAM 1 0.39 0.1 0
51 INT308260 Positive_regulation of TOP2A 1 0.03 0.58 0
52 INT266161 Regulation of Negative_regulation of POLG 1 0.38 0.56 0
53 INT256916 Regulation of Gene_expression of Top2a 1 0.47 1.2 0
54 INT266164 Negative_regulation of Gene_expression of POLG 1 0.41 1.08 0
55 INT266170 Negative_regulation of Transcription of POLG 1 0.36 1.43 0
56 INT284111 Negative_regulation of Binding of TFAM 1 0.07 0.49 0
57 INT251832 Positive_regulation of Positive_regulation of POLG 1 0.35 0.28 0
58 INT239664 Positive_regulation of Gene_expression of TOP2A 1 0.01 0.1 0
59 INT216318 Localization of RFC1 1 0.01 0.26 0
60 INT256921 Regulation of Top2a 1 0.21 1.28 0
61 INT305296 Regulation of Gene_expression of TFAM 1 0.45 2.68 0
62 INT268845 Positive_regulation of Binding of Top2a 1 0.05 0.33 0
63 INT273508 Negative_regulation of Gene_expression of Top2a 1 0.21 0.17 0
64 INT211818 Protein_catabolism of TFAM 1 0.01 0.09 0
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