GO:0006693

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Name prostaglandin metabolic process
Categary Process
Go Slim No
Go Link GO:0006693
Unique Molecular Interactions 265
Total Molecular Interactions 330
Total Single Events 5673
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for prostaglandin metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for prostaglandin metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
2 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
3 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 0.42 2.39 1.82
4 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 0.42 2.45 1.63
5 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 0.01 0.81 1.31
6 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
7 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
8 INT52955 Binding of Slc6a3 and Pdpn 1 0.17 1.11 1.22
9 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
10 INT73311 Binding of Oprm1 and Pdpn 1 0.08 0.71 1.06
11 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
12 INT60213 Binding of Ptgs1 and Ptgs2 2 0.37 0.5 0.97
13 INT61037 Och Positive_regulation of Ptgs1 1 0.00 0 0.95
14 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
15 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87
16 INT289658 Tnfrsf1a Positive_regulation of Mcpt1 1 0.02 0.76 0.81
17 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79
18 INT158068 Positive_regulation of Pparg Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.28 0.76
19 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75
20 INT119314 Ptgs1 Regulation of Gene_expression of Ptger2 1 0.01 0.6 0.73
21 INT275285 Ros1 Positive_regulation of Tnfrsf1a 1 0.27 1.06 0.72
22 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
23 INT155139 Binding of MC1R and PTGES 3 0.09 0 0.7
24 INT114735 Mtx1 Regulation of Ptgs1 1 0.01 0.31 0.69
25 INT155457 Tnfrsf1a Positive_regulation of Mapk14 1 0.20 1.17 0.67
26 INT312106 EGR1 Regulation of Gene_expression of PTGES 1 0.31 1.06 0.64
27 INT155458 Tnfrsf1a Regulation of Gene_expression of Il6 1 0.22 1.11 0.63
28 INT71942 Negative_regulation of PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.62
29 INT101320 Negative_regulation of Ptgs1 Positive_regulation of Ptgs2 1 0.03 0.2 0.62
30 INT55672 Ptgs1 Positive_regulation of Gene_expression of Ik 1 0.03 0.75 0.61
31 INT71944 PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.61
32 INT125546 Arsa Negative_regulation of Gene_expression of PTGS2 1 0.00 0.53 0.58
33 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58
34 INT147071 NFKB1 Regulation of Gene_expression of PTGES 1 0.36 0.35 0.57
35 INT136758 TNF Positive_regulation of Gene_expression of PTGES 1 0.05 0.52 0.55
36 INT71943 Regulation of ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.54
37 INT129912 Skiv2l Negative_regulation of Gene_expression of PTGS2 1 0.00 0.87 0.54
38 INT71945 ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.53
39 INT105849 Il1b Positive_regulation of Positive_regulation of Ptgs1 1 0.07 0.38 0.51
40 INT312118 ELANE Regulation of PTGES 1 0.22 0.92 0.49
41 INT150205 Tnrc6a Negative_regulation of PTGS2 1 0.00 0.42 0.49
42 INT275286 Ros1 Regulation of Positive_regulation of Tnfrsf1a 1 0.16 0.55 0.49
43 INT135584 CSF2 Regulation of PTGS2 1 0.06 1.28 0.49
44 INT150788 ZNF398 Regulation of PTGS2 1 0.02 0.5 0.48
45 INT131809 Nfkb1 Positive_regulation of Gene_expression of Ptgs1 1 0.12 0.73 0.48
46 INT129551 Sag Negative_regulation of Gene_expression of Ptgs1 1 0.08 0.88 0.48
47 INT62164 Il1b Positive_regulation of PTGS2 1 0.00 0.49 0.47
48 INT62163 Il1b Positive_regulation of Positive_regulation of PTGS2 1 0.00 0.49 0.47
49 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
50 INT145436 Binding of HMOX2 and PTGS2 1 0.02 0.41 0.47
51 INT127662 Negative_regulation of PDE4A Negative_regulation of Gene_expression of PTGS2 1 0.15 0.75 0.47
52 INT252634 Binding of TNF and Tnfrsf1a 4 0.02 2.4 0.46
53 INT327995 Positive_regulation of TRPV1 Positive_regulation of Tnfrsf1a 1 0.16 0.63 0.46
54 INT103026 Ptgis Positive_regulation of Ptgs1 1 0.02 0.42 0.46
55 INT103029 Calca Positive_regulation of Positive_regulation of Ptgs1 1 0.12 0.41 0.46
56 INT116926 Cpox Regulation of AKR1C3 1 0.01 0.28 0.45
57 INT69163 Tlr4 Positive_regulation of Ptgs1 1 0.02 0.08 0.44
58 INT53470 Acsm3 Regulation of Ptgs1 1 0.15 0 0.42
59 INT53469 Negative_regulation of Acsm3 Regulation of Ptgs1 1 0.24 0 0.42
60 INT220193 PTGER2 Regulation of PTGES 1 0.06 0.66 0.41
61 INT53471 Binding of Ptgs1 and Acsm3 1 0.17 0 0.41
62 INT91107 Positive_regulation of Ptgs1 Positive_regulation of Localization of Crh 1 0.00 0.56 0.41
63 INT52954 Binding of Pdpn and Flvcr2 1 0.05 0.42 0.41
64 INT340301 Ea1 Positive_regulation of Gene_expression of ACOX1 1 0.01 0.72 0.4
65 INT50553 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Tbxa2r 1 0.02 1.37 0.38
66 INT144047 IL4 Positive_regulation of PTGES 1 0.29 0.43 0.37
67 INT157171 Binding of PTGS2 and Pla2g1b 1 0.02 0.26 0.37
68 INT144044 IRF6 Positive_regulation of PTGES 1 0.10 0.43 0.37
69 INT289661 Tnfrsf1a Positive_regulation of TNF 1 0.01 1.2 0.37
70 INT144043 IL13 Positive_regulation of PTGES 1 0.32 0.43 0.37
71 INT74244 Ptgs1 Regulation of Positive_regulation of Penk 1 0.09 0.19 0.37
72 INT93694 Binding of Hspa8 and Ptgs1 1 0.30 0.79 0.36
73 INT227904 TNFRSF1A Regulation of TNF 1 0.01 0.41 0.36
74 INT77791 fut10 Regulation of Regulation of Tnfrsf1a 1 0.02 0.85 0.36
75 INT144046 IL13 Negative_regulation of Gene_expression of PTGES 1 0.30 0.48 0.35
76 INT278766 HOXA9 Positive_regulation of Gene_expression of PTGS2 1 0.43 1.28 0.35
77 INT312124 EGR1 Regulation of Binding of PTGES 1 0.31 0.41 0.35
78 INT278749 NUP98 Positive_regulation of Gene_expression of PTGS2 1 0.46 1.28 0.35
79 INT144045 IFNG Negative_regulation of Gene_expression of PTGES 1 0.63 0.47 0.35
80 INT144050 IL4 Negative_regulation of Gene_expression of PTGES 1 0.27 0.48 0.35
81 INT144049 IL10 Negative_regulation of Gene_expression of PTGES 1 0.35 0.47 0.35
82 INT144048 IRF6 Positive_regulation of Gene_expression of PTGES 1 0.12 0.46 0.35
83 INT25354 Chi3l1 Negative_regulation of Ptgs1 1 0.00 0.39 0.34
84 INT134303 Cpox Negative_regulation of PTGS2 1 0.00 0.77 0.34
85 INT122169 AKR1C3 Regulation of PPARG 1 0.45 0.26 0.33
86 INT312119 ELANE Positive_regulation of Gene_expression of PTGES 1 0.18 0.74 0.33
87 INT77792 fut10 Negative_regulation of Positive_regulation of Tnfrsf1a 1 0.04 0.82 0.32
88 INT275284 Tnfrsf1a Positive_regulation of Gene_expression of Trpv1 1 0.54 0.36 0.32
89 INT108879 Negative_regulation of PTGS2 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.43 0.31
90 INT64859 Negative_regulation of PTGS1 Negative_regulation of PTGS2 1 0.07 0.05 0.31
91 INT116594 Negative_regulation of PTGS2 Negative_regulation of Gene_expression of IL6 1 0.22 0.45 0.31
92 INT156087 Binding of AKR1C3 and Akr1c1 1 0.05 0.31 0.3
93 INT139044 AKR1B1 Regulation of Gene_expression of PTGS2 1 0.09 0.37 0.3
94 INT140474 Tnfrsf1a Positive_regulation of PECAM1 1 0.00 1.18 0.3
95 INT156083 Binding of AKR1C2 and AKR1C3 1 0.05 0.31 0.3
96 INT156084 Binding of PTGS2 and AKR1C3 1 0.02 0.31 0.3
97 INT156082 Binding of PTGS1 and AKR1C3 1 0.01 0.31 0.3
98 INT62207 Binding of PTGS1 and PTGS2 3 0.06 0.07 0.29
99 INT265467 HRAS Negative_regulation of Gene_expression of PTGS2 1 0.01 0.84 0.29
100 INT81479 Binding of Ptgs1 and ZNF398 1 0.00 0.17 0.28
101 INT188517 Il1a Negative_regulation of Gene_expression of Ptges 1 0.00 0.17 0.28
102 INT102335 DFP Negative_regulation of Ptgs1 1 0.04 0.31 0.28
103 INT136759 TNF Positive_regulation of PTGES 1 0.03 0.29 0.28
104 INT188524 Il1a Positive_regulation of Ptges 1 0.00 0.31 0.28
105 INT158266 Olr1745 Negative_regulation of Ptgs1 1 0.01 0.52 0.27
106 INT91751 Binding of PTGS2 and Hmox1 1 0.00 0.21 0.27
107 INT142447 PTGS2 Regulation of Gene_expression of PTGIS 1 0.30 0.24 0.27
108 INT107392 PTGS2 Positive_regulation of PTGS1 2 0.31 1.01 0.26
109 INT107615 IL1B Positive_regulation of PTGES 2 0.55 0.05 0.26
110 INT69120 MOCS1 Regulation of PTGS2 1 0.00 0.39 0.26
111 INT96402 Binding of PTGS2 and TBXAS1 1 0.02 0.32 0.26
112 INT64860 PTGS1 Negative_regulation of PTGS2 1 0.07 0 0.26
113 INT96401 Binding of PTGER1 and PTGS2 1 0.00 0.32 0.26
114 INT53951 Negative_regulation of Trib3 Negative_regulation of Gene_expression of Ptgs1 1 0.01 0.43 0.26
115 INT3507 Ptges Regulation of Localization of LH 1 0.21 0 0.26
116 INT139357 Nr1h2 Regulation of Gene_expression of Ptges 1 0.07 0.5 0.25
117 INT312115 ELANE Positive_regulation of Transcription of PTGES 1 0.25 0.53 0.25
118 INT66257 Negative_regulation of Ptgs1 Positive_regulation of Gene_expression of Tnf 1 0.03 0.44 0.25
119 INT105542 PTGES Positive_regulation of DNTT 1 0.00 0.62 0.25
120 INT76224 Ptgs1 Regulation of Gene_expression of PECAM1 1 0.00 0.25 0.25
121 INT102625 IL6 Regulation of Gene_expression of PTGS2 1 0.11 0.29 0.24
122 INT126551 Agt Positive_regulation of Gene_expression of Ptgs1 1 0.25 0.92 0.24
123 INT136798 Spp1 Regulation of Gene_expression of PTGS2 1 0.08 0.65 0.24
124 INT102617 PTAFR Regulation of Gene_expression of PTGS2 1 0.12 0.29 0.24
125 INT298785 PPARA Positive_regulation of ACOX1 3 0.29 1.58 0.23
126 INT132382 Nos2 Positive_regulation of PTGS2 1 0.02 0.1 0.23
127 INT325028 TNF Negative_regulation of Ptgs1 1 0.00 1.79 0.23
128 INT272143 PTAFR Positive_regulation of Gene_expression of PTGS2 1 0.12 1.59 0.23
129 INT145014 Positive_regulation of GAST Positive_regulation of PTGS2 1 0.31 0.51 0.22
130 INT149882 Binding of Ptgs1 and Ptges 1 0.01 0.15 0.22
131 INT277995 TNF Positive_regulation of Gene_expression of Tnfrsf1a 1 0.03 1.48 0.22
132 INT145012 GAST Positive_regulation of PTGS2 1 0.42 0.51 0.22
133 INT277996 TNF Positive_regulation of Tnfrsf1a 1 0.03 1.48 0.22
134 INT69318 ST3GAL4 Positive_regulation of Gene_expression of PTGS2 1 0.35 0.09 0.21
135 INT60523 Binding of IL1B and TNFRSF1A 1 0.25 1.73 0.21
136 INT231639 Binding of PTGER2 and PTGS2 1 0.00 0.44 0.19
137 INT117517 PROC Positive_regulation of PTGS2 1 0.01 0.61 0.19
138 INT136462 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Sp1 1 0.01 0.65 0.19
139 INT79651 PTGS2 Positive_regulation of Phosphorylation of NR3C1 1 0.07 0.1 0.19
140 INT206089 Negative_regulation of FOSB Negative_regulation of Gene_expression of PTGS2 1 0.00 0.97 0.19
141 INT139015 STAT1 Negative_regulation of Gene_expression of PTGS2 1 0.01 0.36 0.19
142 INT73332 IL1B Positive_regulation of Transcription of PTGS2 1 0.44 0.54 0.18
143 INT127503 Mpz Positive_regulation of Ptgs1 1 0.14 0.9 0.18
144 INT139877 CPOX Regulation of Gene_expression of PTGES 1 0.17 0.07 0.18
145 INT139881 CPOX Regulation of Transcription of PTGES 1 0.17 0.07 0.18
146 INT314269 Binding of PTGES and PTGES3 1 0.12 0.68 0.18
147 INT312090 EGR1 Regulation of Positive_regulation of PTGES 1 0.42 0.21 0.18
148 INT73331 PTAFR Positive_regulation of Transcription of PTGS2 1 0.13 0.54 0.18
149 INT139878 PTGES Regulation of Gene_expression of CPOX 1 0.17 0.07 0.18
150 INT139879 PTGES Regulation of Transcription of CPOX 1 0.17 0.07 0.18
151 INT255431 Airn Negative_regulation of Gene_expression of Ptgs1 1 0.00 0.66 0.17
152 INT152024 Ptgs1 Regulation of Fgf2 1 0.04 0.9 0.17
153 INT93693 Positive_regulation of Binding of Hspa8 and Ptgs1 1 0.31 0.38 0.17
154 INT328484 Ptgs1 Positive_regulation of Ros1 1 0.00 0.58 0.16
155 INT69317 PTGS2 Positive_regulation of Gene_expression of PTGS1 1 0.42 0.09 0.16
156 INT146745 UGCG Positive_regulation of Gene_expression of PTGS2 1 0.23 0.1 0.16
157 INT168807 Binding of Nfkb1 and Ptges 1 0.04 0.35 0.16
158 INT352067 Binding of B4GALNT1 and HPGDS 1 0.01 0.12 0.16
159 INT312111 ELANE Regulation of Transcription of PTGES 1 0.22 0.23 0.16
160 INT327556 Ptgs1 Regulation of Gene_expression of Ptger2 1 0.01 0.85 0.15
161 INT176621 PTGS2 Regulation of Gene_expression of PTGER2 1 0.00 0.09 0.15
162 INT327558 Ptgs1 Regulation of Gene_expression of Ros1 1 0.01 0.87 0.15
163 INT87710 MYB Regulation of PTGS2 1 0.28 0.64 0.15
164 INT139336 Il1b Regulation of Tnfrsf1a 1 0.27 1.3 0.14
165 INT138321 PPA1 Positive_regulation of Gene_expression of PTGS2 1 0.02 0.09 0.14
166 INT139338 Cts8 Regulation of Tnfrsf1a 1 0.05 1.3 0.14
167 INT139346 Cts8 Regulation of Gene_expression of Tnfrsf1a 1 0.05 1.3 0.14
168 INT328851 Binding of PTGS2 and ZNF434 1 0.00 0.7 0.14
169 INT139347 Il1b Regulation of Gene_expression of Tnfrsf1a 1 0.27 1.3 0.14
170 INT234604 Tlr4 Positive_regulation of Ptges 1 0.04 0 0.14
171 INT134405 Binding of PTGS1 and HPGDS 1 0.01 0.33 0.14
172 INT102380 Ptgs1 Negative_regulation of Binding of Tbxa2r 1 0.04 0.16 0.14
173 INT81983 IL1A Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.27 0.13
174 INT252631 Binding of Casp3 and Tnfrsf1a 1 0.10 0.69 0.13
175 INT141881 Binding of MECOM and Tnfrsf1a 1 0.00 1.17 0.13
176 INT350097 Gtf3a Regulation of Gene_expression of PTGES 1 0.00 0.25 0.13
177 INT344314 PDPN Positive_regulation of Phosphorylation of MAPK8 1 0.35 0.67 0.13
178 INT67619 Inpp5k Negative_regulation of Ptgs1 1 0.03 0.5 0.13
179 INT235775 Binding of Tnfrsf1a and Tradd 3 0.31 3 0.12
180 INT306270 CCL4 Positive_regulation of Transcription of PTGS2 1 0.34 0.31 0.12
181 INT352488 Binding of EPO and TNFRSF1A 1 0.14 0.18 0.12
182 INT173129 PTGS2 Regulation of IER3 1 0.01 0.36 0.12
183 INT306262 NFKB1 Positive_regulation of Transcription of PTGS2 1 0.42 0.31 0.12
184 INT289660 Tnfrsf1a Negative_regulation of Transcription of Flt4 1 0.03 0.62 0.12
185 INT289657 Tnfrsf1a Negative_regulation of Gene_expression of Flt4 1 0.03 0.63 0.12
186 INT251568 Tnfrsf1b Positive_regulation of Tnfrsf1a 1 0.31 0.37 0.11
187 INT147073 NFKB1 Regulation of PTGS2 1 0.37 0 0.11
188 INT147072 NFKB1 Regulation of PTGES 1 0.36 0 0.11
189 INT133361 FABP6 Negative_regulation of PTGS2 1 0.01 0.07 0.11
190 INT312094 ELANE Positive_regulation of PTGES 1 0.29 0.34 0.11
191 INT220114 Tnfrsf1a Positive_regulation of Esr1 1 0.14 1.14 0.1
192 INT294454 KLK4 Negative_regulation of PTGS2 1 0.01 0 0.1
193 INT223754 Tlr4 Positive_regulation of Ptgs1 1 0.04 0 0.1
194 INT87921 Gm7869 Negative_regulation of Ptgs1 1 0.01 0.55 0.1
195 INT220116 Tnfrsf1a Negative_regulation of TNF 1 0.06 0.56 0.09
196 INT116788 Bsg Negative_regulation of Gene_expression of Ptges 1 0.00 0.17 0.09
197 INT314267 Binding of CPOX and PTGES 1 0.03 0.34 0.09
198 INT217271 Cpox Regulation of Gene_expression of Ptges 1 0.01 0.14 0.08
199 INT168808 Tlr4 Positive_regulation of Gene_expression of Ptges 1 0.02 0.13 0.08
200 INT140895 PTGS2 Positive_regulation of Gene_expression of VEGFA 1 0.27 0.07 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported for prostaglandin metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in prostaglandin metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26
2 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
3 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
4 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58
5 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97
6 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
7 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04
8 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41
9 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
10 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2
11 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
12 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31
13 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03
14 INT63419 Gene_expression of PTGES 109 0.77 40.83 23.67
15 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09
16 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54
17 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29
18 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
19 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49
20 INT53080 Positive_regulation of Ptgs1 42 0.42 23.58 14.37
21 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39
22 INT91413 Negative_regulation of PTGES 35 0.58 17.94 12.03
23 INT12992 Negative_regulation of Gene_expression of Ptgs1 33 0.42 20.47 11.77
24 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56
25 INT787 Localization of Ptgs1 31 0.80 12.36 11.55
26 INT106510 Gene_expression of Ptges 70 0.75 36.18 9.75
27 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53
28 INT23264 Negative_regulation of Positive_regulation of Ptgs1 16 0.39 8.47 8.9
29 INT52442 Binding of Ptgs1 16 0.35 9.05 8.78
30 INT6573 Regulation of Negative_regulation of Ptgs1 19 0.45 6.16 8.71
31 INT77790 Positive_regulation of Gene_expression of Tnfrsf1a 16 0.67 15.88 8.5
32 INT104679 Gene_expression of Ptges 33 0.41 10.14 7.89
33 INT20234 Regulation of Gene_expression of Ptgs1 11 0.44 6.55 7.72
34 INT91417 Positive_regulation of PTGES 36 0.68 18.45 7.64
35 INT90097 Localization of PTGS2 15 0.69 6.14 6.63
36 INT59079 Transcription of PTGS2 30 0.72 14.21 6.52
37 INT275265 Negative_regulation of Positive_regulation of Tnfrsf1a 1 0.56 4.41 6.35
38 INT25130 Positive_regulation of Negative_regulation of Ptgs1 14 0.50 5.07 6.29
39 INT67656 Positive_regulation of Positive_regulation of PTGS2 12 0.46 4.83 6.17
40 INT17370 Negative_regulation of Negative_regulation of Ptgs1 16 0.22 6.5 6.12
41 INT275272 Positive_regulation of Positive_regulation of Tnfrsf1a 8 0.48 6.44 5.97
42 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93
43 INT94118 Localization of Tnfrsf1a 9 0.72 7.24 5.81
44 INT105538 Negative_regulation of Tnfrsf1a 16 0.56 12.51 5.61
45 INT98685 Positive_regulation of Gene_expression of PTGES 28 0.68 9.46 5.55
46 INT111520 Regulation of Tnfrsf1a 10 0.61 7.25 5.41
47 INT143925 Negative_regulation of Ptges 18 0.42 10.5 5.18
48 INT52952 Binding of Pdpn 8 0.13 3.57 4.79
49 INT118926 Regulation of PTGES 17 0.51 5.79 4.69
50 INT62500 Transcription of Ptgs1 10 0.56 4.54 4.52
51 INT73309 Regulation of Negative_regulation of PTGS2 14 0.44 9.55 4.5
52 INT93739 Positive_regulation of Gene_expression of Tnfrsf1a 11 0.66 11.17 4.44
53 INT118230 Binding of Tnfrsf1a 15 0.42 7.63 4.39
54 INT187836 Binding of Tnfrsf1a 19 0.46 18.08 4.33
55 INT107620 Binding of PTGES 25 0.48 5.49 4.24
56 INT52616 Negative_regulation of Positive_regulation of PTGS2 13 0.43 4.95 4.13
57 INT108086 Negative_regulation of AKR1C3 17 0.58 7.7 3.99
58 INT77786 Negative_regulation of Tnfrsf1a 5 0.56 5.03 3.58
59 INT108814 Regulation of Gene_expression of PTGES 8 0.59 3.62 3.54
60 INT77788 Regulation of Tnfrsf1a 14 0.57 11.24 3.53
61 INT96700 Positive_regulation of Positive_regulation of Tnfrsf1a 6 0.69 3.93 3.42
62 INT104678 Positive_regulation of Ptges 18 0.34 6.29 3.39
63 INT52899 Positive_regulation of TNFRSF1A 16 0.46 19.04 3.34
64 INT134413 Gene_expression of HPGDS 20 0.77 8.93 3.28
65 INT77615 Positive_regulation of Negative_regulation of Ptgs1 6 0.50 1.55 3.11
66 INT313753 Negative_regulation of ACOX1 10 0.45 3.76 3.04
67 INT117582 Positive_regulation of Gene_expression of Ptges 12 0.27 4.22 2.98
68 INT90402 Positive_regulation of Gene_expression of Ptgs1 13 0.31 4.83 2.88
69 INT108813 Negative_regulation of Ptges 8 0.57 2.79 2.85
70 INT78146 Gene_expression of AKR1C3 24 0.77 5.71 2.77
71 INT130506 Regulation of Ptges 7 0.12 2.56 2.77
72 INT68505 Positive_regulation of Negative_regulation of PTGS2 8 0.49 2.26 2.76
73 INT134145 Negative_regulation of Gene_expression of PTGES 11 0.51 5.32 2.73
74 INT27607 Localization of Ptgs1 7 0.59 3.22 2.6
75 INT103238 Localization of PTGES 7 0.68 4.16 2.59
76 INT34969 Negative_regulation of Binding of Ptgs1 4 0.37 1.55 2.55
77 INT70197 Negative_regulation of Positive_regulation of Ptgs1 6 0.24 2.61 2.44
78 INT53476 Positive_regulation of Localization of Ptgs1 6 0.49 2.88 2.35
79 INT9887 Negative_regulation of Gene_expression of Ptgs1 7 0.42 2.94 2.3
80 INT88241 Positive_regulation of Positive_regulation of Ptgs1 3 0.45 1.71 2.25
81 INT275279 Positive_regulation of Localization of Tnfrsf1a 3 0.48 1.13 2.17
82 INT68865 Gene_expression of ACOX1 13 0.52 5.49 2.09
83 INT106508 Positive_regulation of Gene_expression of Ptges 12 0.20 5.37 2.06
84 INT97579 Negative_regulation of Localization of PTGS2 2 0.08 2.37 1.99
85 INT101985 Positive_regulation of Positive_regulation of Ptgs1 4 0.15 4.13 1.98
86 INT183381 Transcription of Tnfrsf1a 3 0.46 2.08 1.83
87 INT148705 Binding of TNFRSF1A 8 0.38 5.19 1.81
88 INT158772 Negative_regulation of Regulation of Ptges 1 0.03 0.07 1.81
89 INT53812 Regulation of Gene_expression of Ptgs1 5 0.38 0.89 1.78
90 INT78956 Regulation of Transcription of Ptgs1 3 0.35 1.42 1.7
91 INT118700 Positive_regulation of Ptges 12 0.49 5.04 1.68
92 INT23176 Gene_expression of Pdpn 6 0.75 4.06 1.65
93 INT60857 Negative_regulation of Regulation of Ptgs1 1 0.07 2.22 1.61
94 INT118699 Binding of Ptges 4 0.33 1.15 1.5
95 INT60528 Negative_regulation of TNFRSF1A 6 0.42 4.86 1.45
96 INT86823 Regulation of Transcription of PTGS2 3 0.19 1.48 1.4
97 INT89209 Negative_regulation of Binding of Ptgs1 6 0.06 2.7 1.39
98 INT107924 Localization of Tnfrsf1a 5 0.70 3.86 1.37
99 INT77785 Negative_regulation of Gene_expression of Tnfrsf1a 4 0.56 3.1 1.35
100 INT251554 Negative_regulation of Gene_expression of Tnfrsf1a 2 0.41 1.8 1.32
101 INT146381 Localization of Ptges 3 0.10 5.55 1.26
102 INT106509 Negative_regulation of Gene_expression of Ptges 6 0.17 1.95 1.25
103 INT179372 Positive_regulation of Localization of PTGS2 2 0.38 0.35 1.21
104 INT68359 Positive_regulation of HPGDS 9 0.32 4.63 1.18
105 INT59078 Positive_regulation of Transcription of PTGS2 5 0.69 2.36 1.17
106 INT77782 Negative_regulation of Positive_regulation of Tnfrsf1a 3 0.41 1.21 1.16
107 INT117579 Regulation of Gene_expression of Ptges 4 0.24 1.41 1.13
108 INT275264 Negative_regulation of Localization of Tnfrsf1a 1 0.41 0.6 1.13
109 INT139885 Transcription of PTGES 4 0.68 1.46 1.12
110 INT62981 Protein_catabolism of PTGS2 5 0.78 1.09 1.11
111 INT265004 Positive_regulation of Binding of Tnfrsf1a 1 0.36 1.23 1.1
112 INT64862 Negative_regulation of Negative_regulation of PTGS2 3 0.36 0.76 1.09
113 INT275270 Regulation of Localization of Tnfrsf1a 1 0.43 0.47 1.04
114 INT64177 Negative_regulation of Transcription of PTGS2 4 0.41 1.99 1.03
115 INT122647 Transcription of Tnfrsf1a 5 0.60 2.63 1.02
116 INT139333 Regulation of Gene_expression of Tnfrsf1a 3 0.40 5.41 0.98
117 INT63284 Transcription of Ptgs1 5 0.66 1.34 0.97
118 INT62980 Protein_catabolism of Ptgs1 3 0.59 0.93 0.97
119 INT117580 Positive_regulation of Positive_regulation of Ptges 3 0.20 1.48 0.93
120 INT93406 Positive_regulation of Regulation of Ptgs1 2 0.14 0 0.9
121 INT68866 Positive_regulation of ACOX1 4 0.31 4.98 0.87
122 INT91416 Negative_regulation of Positive_regulation of PTGES 3 0.40 1.88 0.82
123 INT275266 Regulation of Gene_expression of Tnfrsf1a 2 0.44 5.44 0.8
124 INT120057 Regulation of Localization of PTGS2 1 0.28 0.14 0.78
125 INT98131 Regulation of TNFRSF1A 5 0.31 5.28 0.76
126 INT108085 Positive_regulation of Gene_expression of AKR1C3 2 0.53 0.58 0.75
127 INT71950 Positive_regulation of Binding of PTGS2 2 0.31 0.31 0.74
128 INT67252 Regulation of Pdpn 1 0.00 0.9 0.74
129 INT82544 Regulation of Positive_regulation of PTGS2 4 0.39 1.41 0.71
130 INT139353 Regulation of Gene_expression of Ptges 3 0.18 2.05 0.71
131 INT264537 Transcription of HPGDS 1 0.33 1.33 0.69
132 INT156085 Negative_regulation of AKR1C2 3 0.54 0.79 0.66
133 INT93854 Positive_regulation of Transcription of Ptgs1 3 0.19 0.54 0.66
134 INT52951 Negative_regulation of Binding of Pdpn 1 0.16 0.63 0.66
135 INT23612 Regulation of Negative_regulation of Ptgs1 3 0.19 0.69 0.64
136 INT104677 Transcription of Ptges 3 0.49 0.36 0.61
137 INT108319 Regulation of Positive_regulation of Ptgs1 1 0.16 0.08 0.57
138 INT68360 Regulation of HPGDS 3 0.23 0.72 0.56
139 INT116925 Binding of AKR1C3 2 0.36 0.75 0.56
140 INT257406 Localization of TNFRSF1A 3 0.46 2.6 0.55
141 INT124836 Positive_regulation of Binding of Ptgs1 1 0.10 0.25 0.55
142 INT177864 Negative_regulation of HPGDS 6 0.49 1.92 0.54
143 INT87959 Phosphorylation of Ptgs1 3 0.63 0.37 0.51
144 INT97664 Binding of AKR1C2 1 0.48 0 0.51
145 INT234588 Transcription of Ptges 1 0.06 0.9 0.51
146 INT97663 Localization of AKR1C2 2 0.71 0.43 0.5
147 INT275268 Positive_regulation of Regulation of Tnfrsf1a 1 0.48 0.54 0.48
148 INT313752 Negative_regulation of Gene_expression of ACOX1 4 0.33 1.11 0.47
149 INT130391 Positive_regulation of AKR1C3 4 0.50 1.7 0.47
150 INT91220 Positive_regulation of Binding of Ptgs1 1 0.02 0.76 0.47
151 INT39228 Regulation of Regulation of Ptgs1 2 0.39 0.38 0.45
152 INT105408 Negative_regulation of Gene_expression of AKR1C3 1 0.23 0.56 0.45
153 INT146382 Positive_regulation of Localization of Ptges 1 0.00 0.36 0.45
154 INT134412 Binding of HPGDS 9 0.42 1.7 0.43
155 INT104676 Positive_regulation of Transcription of Ptges 1 0.34 0.3 0.42
156 INT191930 Negative_regulation of Negative_regulation of Ptgs1 1 0.07 0.94 0.42
157 INT253242 Positive_regulation of Transcription of Tnfrsf1a 2 0.44 0.77 0.38
158 INT144052 Positive_regulation of Regulation of PTGES 1 0.45 0.42 0.37
159 INT234585 Negative_regulation of Positive_regulation of Ptges 1 0.04 0.91 0.37
160 INT162900 Regulation of Negative_regulation of PTGES 1 0.14 0.72 0.37
161 INT169236 Negative_regulation of Binding of PTGES 2 0.36 0.37 0.36
162 INT77783 Regulation of Positive_regulation of Tnfrsf1a 1 0.44 0.85 0.36
163 INT234594 Positive_regulation of Transcription of Ptges 1 0.04 0.9 0.36
164 INT231345 Positive_regulation of Localization of Ptgs1 1 0.16 0.82 0.36
165 INT82545 Positive_regulation of Regulation of PTGS2 1 0.19 0.15 0.35
166 INT202106 Positive_regulation of Gene_expression of TNFRSF1A 3 0.22 1.17 0.31
167 INT151718 Regulation of Ptges 3 0.27 1.63 0.31
168 INT147074 Positive_regulation of Transcription of PTGES 2 0.44 0.33 0.3
169 INT68864 Positive_regulation of Positive_regulation of ACOX1 1 0.21 0.19 0.29
170 INT68863 Positive_regulation of Gene_expression of ACOX1 3 0.22 0.78 0.28
171 INT141727 Regulation of Binding of Ptgs1 1 0.11 0.33 0.28
172 INT313754 Binding of ACOX1 1 0.29 0.5 0.27
173 INT156086 Negative_regulation of Localization of AKR1C2 1 0.10 0.43 0.27
174 INT188510 Negative_regulation of Negative_regulation of Ptges 1 0.03 0 0.26
175 INT76218 Negative_regulation of Localization of Ptgs1 1 0.08 0.25 0.25
176 INT318437 Negative_regulation of Pdpn 1 0.47 0.87 0.25
177 INT264539 Localization of HPGDS 1 0.46 0.48 0.24
178 INT114896 Negative_regulation of Positive_regulation of TNFRSF1A 1 0.17 0.83 0.23
179 INT17849 Negative_regulation of Binding of PTGS2 2 0.38 0.16 0.2
180 INT330901 Phosphorylation of PTGES 1 0.29 0.3 0.2
181 INT350864 Negative_regulation of Gene_expression of HPGDS 1 0.36 0.52 0.2
182 INT350865 Negative_regulation of Binding of HPGDS 1 0.36 0.51 0.19
183 INT91414 Regulation of Positive_regulation of PTGES 1 0.14 0.28 0.19
184 INT148274 Negative_regulation of Regulation of PTGS2 1 0.01 0.47 0.19
185 INT152681 Gene_expression of PDPN 29 0.65 23.06 0.18
186 INT188509 Negative_regulation of Gene_expression of Ptges 3 0.04 0.15 0.18
187 INT269999 Regulation of Gene_expression of TNFRSF1A 2 0.44 0.53 0.17
188 INT160121 Localization of PDPN 1 0.73 1.07 0.16
189 INT1275 Gene_expression of AKR1C2 1 0.75 2.92 0.16
190 INT129433 Regulation of Binding of PTGS2 1 0.25 1.01 0.14
191 INT78144 Transcription of AKR1C3 4 0.72 1.21 0.13
192 INT340783 Transcription of TNFRSF1A 1 0.17 0.37 0.13
193 INT312134 Regulation of Transcription of PTGES 1 0.40 0.18 0.13
194 INT340784 Positive_regulation of Transcription of TNFRSF1A 1 0.17 0.37 0.13
195 INT251547 Positive_regulation of Binding of Tnfrsf1a 1 0.38 0.37 0.11
196 INT188508 Positive_regulation of Localization of Ptges 1 0.04 0 0.1
197 INT188504 Localization of Ptges 1 0.06 0 0.1
198 INT220109 Protein_catabolism of Tnfrsf1a 1 0.63 0.39 0.08
199 INT98128 Positive_regulation of Regulation of TNFRSF1A 2 0.30 1.95 0.07
200 INT164486 Positive_regulation of Negative_regulation of PTGES 1 0.41 0.15 0.07
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