GO:0007094

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Name mitotic cell cycle spindle assembly checkpoint
Categary Process
Go Slim No
Go Link GO:0007094
Unique Molecular Interactions 109
Total Molecular Interactions 143
Total Single Events 868
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for mitotic cell cycle spindle assembly checkpoint. They are ordered first by their pain relevance and then by number of times they were reported for mitotic cell cycle spindle assembly checkpoint. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
2 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
3 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56
4 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
5 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
6 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
7 INT177794 BUB1B Positive_regulation of Gene_expression of ASNS 1 0.11 0.77 0.46
8 INT177781 BUB1B Positive_regulation of ATF4 1 0.07 0.76 0.46
9 INT177780 BUB1B Positive_regulation of ASNS 1 0.05 0.76 0.46
10 INT177787 BUB1B Positive_regulation of MTHFD2 1 0.15 0.76 0.46
11 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
12 INT241072 Tpr Positive_regulation of Regulation of Oprm1 1 0.01 0.08 0.36
13 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
14 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
15 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
16 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
17 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
18 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
19 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
20 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
21 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
22 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
23 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
24 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
25 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
26 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
27 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
28 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
29 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
30 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
31 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18
32 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18
33 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
34 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
35 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
36 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
37 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
38 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
39 INT241075 Klf16 Negative_regulation of Tpr 1 0.00 0.13 0.12
40 INT241073 Klf16 Positive_regulation of Tpr 1 0.01 0.13 0.12
41 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
42 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
43 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
44 INT283539 Binding of Litaf and Mad2l1bp 1 0.00 0.67 0.11
45 INT264839 Positive_regulation of Binding of Eno2 and Tpr 1 0.00 0.17 0.1
46 INT264836 Binding of Eno2 and Tpr 1 0.00 0.17 0.1
47 INT262255 Binding of APC and F2R 1 0.05 3 0.1
48 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
49 INT270197 Binding of Apc and Cd86 1 0.02 0.58 0.08
50 INT270198 Binding of Apc and Cd80 1 0.02 0.58 0.08
51 INT264835 Binding of Creb1 and Tpr 1 0.01 0.05 0.06
52 INT176095 Binding of Apc and EC 1 0.04 0.51 0.05
53 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
54 INT299460 Foxl2 Positive_regulation of Tpr 1 0.01 0.56 0.05
55 INT334107 Binding of APC and APCS 1 0.16 1.52 0.04
56 INT241071 Cish Positive_regulation of Tpr 1 0.00 0 0.04
57 INT241076 Binding of Oprm1 and Positive_regulation of Tpr 1 0.01 0 0.04
58 INT225585 Regulation of Binding of Med1 and Tpr 1 0.00 0.07 0
59 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
60 INT225583 Binding of Ncoa1 and Tpr 1 0.00 0.07 0
61 INT213034 Hdl1 Positive_regulation of Apc 1 0.08 1.21 0
62 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
63 INT225484 Binding of Acp5 and Tpr 1 0.01 0 0
64 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
65 INT341502 Negative_regulation of Binding of Apc and Pdcd1 1 0.00 0.53 0
66 INT333456 ATM Positive_regulation of CHEK2 1 0.20 0 0
67 INT333446 ATM Positive_regulation of CHEK1 1 0.20 0 0
68 INT333455 ATM Positive_regulation of TP53 1 0.18 0 0
69 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
70 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
71 INT333451 ATM Positive_regulation of Negative_regulation of CHEK1 1 0.14 0 0
72 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0
73 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
74 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
75 INT333460 ATM Positive_regulation of Negative_regulation of CHEK2 1 0.14 0 0
76 INT213007 Hdl1 Regulation of Regulation of Apc 1 0.08 1.24 0
77 INT301674 Binding of APC and CD80 1 0.01 0.53 0
78 INT228109 Binding of Atm and Chrm2 1 0.09 0.21 0
79 INT195661 Binding of APC and PROC 1 0.23 0.89 0
80 INT253019 APC Positive_regulation of Protein_catabolism of Pttg1 1 0.06 0 0
81 INT253012 APC Positive_regulation of Binding of Pttg1 1 0.06 0 0
82 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0
83 INT191095 Positive_regulation of Binding of Apc and Esr1 1 0.06 1.08 0
84 INT301677 Binding of APC and CD8A 1 0.03 1.48 0
85 INT299443 Gene_expression of Foxl2 Positive_regulation of Tpr 1 0.01 0.05 0
86 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
87 INT268395 Binding of APC and Kras 1 0.04 1.21 0
88 INT333458 ATM Positive_regulation of MDM2 1 0.25 0 0
89 INT213009 Hdl1 Positive_regulation of Positive_regulation of Apc 1 0.09 1.14 0
90 INT225541 Binding of Med1 and Tpr 1 0.00 0.07 0
91 INT78634 ATM Positive_regulation of AGT 1 0.17 0.16 0
92 INT225547 Binding of Tpr and Cytip 1 0.00 0 0
93 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0
94 INT80660 INS Positive_regulation of APC 1 0.32 0.65 0
95 INT283362 AXIN2 Negative_regulation of APC 1 0.10 1.67 0
96 INT191098 Binding of Apc and Esr1 1 0.04 1.06 0
97 INT195659 APC Positive_regulation of Gene_expression of PROC 1 0.26 0.31 0
98 INT225563 Binding of Tpr and Ep300 1 0.00 0 0
99 INT333452 ATM Positive_regulation of Negative_regulation of TP53 1 0.18 0 0
100 INT213025 Vtn Positive_regulation of Apc 1 0.01 1.19 0
101 INT252549 ATM Positive_regulation of Positive_regulation of CHEK2 1 0.02 0 0
102 INT213054 Hdl1 Regulation of Apc 1 0.05 1.24 0
103 INT207814 Negative_regulation of Parp1 Positive_regulation of Positive_regulation of Atm 1 0.53 0.08 0
104 INT299449 Foxl2 Regulation of Tpr 1 0.00 0.26 0
105 INT80659 Positive_regulation of INS Positive_regulation of APC 1 0.32 0.65 0
106 INT236721 Binding of Apc and Ctnnd2 1 0.25 1.03 0
107 INT207812 Binding of Parp1 and Atm 1 0.54 0.99 0
108 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0
109 INT341501 Binding of Apc and Pdcd1 1 0.00 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for mitotic cell cycle spindle assembly checkpoint. They are ordered first by their pain relevance and then by number of times they were reported in mitotic cell cycle spindle assembly checkpoint. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
2 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
3 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
4 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
5 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
6 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
7 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
8 INT63121 Binding of APC 29 0.41 23.02 3.8
9 INT3818 Regulation of Apc 13 0.39 12.52 1.68
10 INT220177 Binding of Apc 21 0.37 15.34 1.37
11 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
12 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26
13 INT123413 Positive_regulation of Tpr 7 0.03 1.05 1.25
14 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
15 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
16 INT242134 Localization of Apc 8 0.74 4.83 0.88
17 INT57062 Regulation of APC 24 0.58 14.3 0.7
18 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
19 INT28118 Binding of Atm 13 0.38 12.24 0.68
20 INT48212 Binding of ATM 5 0.47 3.89 0.57
21 INT160778 Transcription of ATM 1 0.40 1.03 0.57
22 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
23 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53
24 INT177556 Gene_expression of Tpr 9 0.34 2.71 0.48
25 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46
26 INT177869 Gene_expression of BUB1B 2 0.65 2.11 0.45
27 INT177866 Negative_regulation of BUB1B 1 0.32 1.23 0.45
28 INT177845 Negative_regulation of Gene_expression of BUB1B 1 0.23 0.75 0.45
29 INT152151 Regulation of Gene_expression of Apc 4 0.44 3.87 0.42
30 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4
31 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39
32 INT144275 Negative_regulation of Atm 9 0.59 8.48 0.36
33 INT220170 Regulation of Positive_regulation of Apc 1 0.10 0.46 0.35
34 INT118243 Transcription of APC 4 0.45 3.33 0.33
35 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
36 INT225667 Transcription of Apc 3 0.52 3.73 0.32
37 INT195672 Localization of APC 7 0.74 3.76 0.3
38 INT167438 Localization of ATM 3 0.55 1.61 0.27
39 INT177548 Regulation of Tpr 9 0.01 3.87 0.26
40 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25
41 INT35719 Gene_expression of Atm 34 0.78 15.75 0.24
42 INT225666 Regulation of Transcription of Apc 1 0.29 0.33 0.22
43 INT173166 Negative_regulation of Binding of APC 3 0.40 3.01 0.19
44 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17
45 INT228603 Positive_regulation of Positive_regulation of Apc 1 0.24 0.24 0.17
46 INT250790 Negative_regulation of Localization of APC 2 0.13 2.3 0.13
47 INT250792 Positive_regulation of Localization of APC 1 0.15 0.48 0.13
48 INT278288 Regulation of Localization of ATM 1 0.09 0.95 0.13
49 INT167440 Regulation of ATM 2 0.20 0.68 0.12
50 INT242140 Regulation of Localization of Apc 1 0.12 0.12 0.11
51 INT241052 Binding of Tpr 1 0.01 0 0.11
52 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1
53 INT268372 Phosphorylation of APC 3 0.81 3.39 0.09
54 INT207804 Negative_regulation of Gene_expression of Atm 2 0.59 6.22 0.09
55 INT224949 Regulation of Regulation of Tpr 2 0.01 1.57 0.07
56 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06
57 INT195679 Positive_regulation of Positive_regulation of APC 6 0.50 4.43 0.05
58 INT235057 Positive_regulation of Negative_regulation of Apc 2 0.30 0.66 0.05
59 INT212459 Positive_regulation of Binding of Atm 1 0.40 0.88 0.04
60 INT207803 Regulation of Atm 3 0.41 1.15 0.03
61 INT242139 Protein_catabolism of Apc 1 0.17 0.27 0.03
62 INT195681 Positive_regulation of Negative_regulation of APC 5 0.47 3.9 0
63 INT207807 Localization of Atm 4 0.74 0.21 0
64 INT219066 Transcription of Tpr 2 0.01 0.1 0
65 INT157290 Regulation of Gene_expression of ATM 2 0.44 0.86 0
66 INT252642 Transcription of Atm 1 0.53 0.18 0
67 INT230109 Positive_regulation of Gene_expression of BUB1B 1 0.42 0.65 0
68 INT337657 Negative_regulation of Negative_regulation of APC 1 0.37 0.99 0
69 INT104591 Negative_regulation of Negative_regulation of Apc 1 0.04 0.16 0
70 INT337673 Regulation of Positive_regulation of APC 1 0.38 1.44 0
71 INT354742 Phosphorylation of ATM 1 0.50 1.74 0
72 INT191087 Regulation of Regulation of Apc 1 0.06 1.02 0
73 INT252645 Positive_regulation of Gene_expression of Atm 1 0.50 2.35 0
74 INT219064 Negative_regulation of Tpr 1 0.01 0.79 0
75 INT283365 Positive_regulation of Binding of APC 1 0.50 1.43 0
76 INT337667 Regulation of Transcription of APC 1 0.23 1 0
77 INT241058 Protein_catabolism of Tpr 1 0.01 0.16 0
78 INT286093 Regulation of Binding of Apc 1 0.39 1.08 0
79 INT252644 Regulation of Gene_expression of Atm 1 0.27 0.39 0
80 INT207808 Positive_regulation of Positive_regulation of Atm 1 0.50 0.08 0
81 INT252643 Negative_regulation of Positive_regulation of Atm 1 0.38 0.6 0
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