GO:0007205

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Name activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
Categary Process
Go Slim No
Go Link GO:0007205
Unique Molecular Interactions 951
Total Molecular Interactions 1402
Total Single Events 12104
Pain Genes Associated 53

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT10161 Binding of Cck and Penk 6 0.53 0.97 11.15
2 INT11250 Cck Positive_regulation of Gene_expression of Fos 14 0.78 0.08 7.29
3 INT51497 Cck Negative_regulation of Localization of Trim13 1 0.34 0 4.53
4 INT11613 Cck Positive_regulation of Localization of Oxt 3 0.53 0 4.17
5 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
6 INT11252 Cck Positive_regulation of Fos 6 0.78 0 3.79
7 INT69938 Cck Positive_regulation of Localization of Abat 2 0.29 0 3.78
8 INT1151 Binding of CCK and GAST 7 0.49 0.73 3.08
9 INT28235 Binding of Cck and Gast 5 0.38 0.73 2.96
10 INT324927 Syt17 Positive_regulation of Bdkrb1 1 0.04 4.29 2.96
11 INT69937 Cck Positive_regulation of Abat 2 0.31 0 2.88
12 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
13 INT30133 Binding of Cck and Penk 1 0.27 2.49 2.71
14 INT151381 St8sia1 Positive_regulation of Cck 1 0.19 0.45 2.7
15 INT62450 Il2 Positive_regulation of Localization of Crh 1 0.43 0.59 2.64
16 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
17 INT111789 Cck Regulation of Gene_expression of Penk 1 0.49 1.68 2.57
18 INT111786 Penk Regulation of Gene_expression of Cck 1 0.49 1.66 2.55
19 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39
20 INT214159 Cck Positive_regulation of Nts 1 0.03 0.93 2.34
21 INT14781 Cck Regulation of Gast 3 0.38 0.28 2.3
22 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
23 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
24 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08
25 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
26 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
27 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
28 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
29 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
30 INT82867 Cck Regulation of Localization of Pgc 1 0.05 0 1.83
31 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
32 INT253895 Binding of Htr1b and Htr1d 1 0.40 0.52 1.74
33 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
34 INT90658 Abat Regulation of Localization of Cck 2 0.24 0 1.64
35 INT30743 Cck Regulation of Localization of Acot1 1 0.02 0 1.64
36 INT67966 Cck Positive_regulation of Adarb1 2 0.03 0 1.63
37 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
38 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
39 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
40 INT66713 Binding of BDKRB1 and KNG1 2 0.22 0.39 1.53
41 INT42001 Cck Regulation of Vip 1 0.28 0 1.51
42 INT42000 Trpv1 Positive_regulation of Cck 1 0.04 0 1.49
43 INT27932 Binding of CCK and NCOR2 1 0.01 0.91 1.47
44 INT21536 Binding of Il2 and Il1 1 0.28 0 1.47
45 INT118812 Cck Positive_regulation of Rvm 1 0.21 0.65 1.46
46 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
47 INT27123 Binding of Pomc and Cck 2 0.31 0 1.38
48 INT30089 Cck Regulation of Localization of Oxt 2 0.45 0.19 1.36
49 INT86172 Pdyn Positive_regulation of Gene_expression of Il2 1 0.20 0 1.33
50 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
51 INT116102 Cck Positive_regulation of Negative_regulation of Pnoc 1 0.51 0.41 1.33
52 INT62448 Il2 Positive_regulation of Crh 1 0.59 0.36 1.3
53 INT330124 Positive_regulation of Bdkrb1 Positive_regulation of RT1-O2-ps 1 0.02 1.97 1.3
54 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
55 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
56 INT57956 LOC365260 Negative_regulation of Cck 1 0.11 0 1.3
57 INT89943 Binding of Oprm1 and Il2 1 0.03 0.53 1.28
58 INT154203 Binding of Pick1 and Grm7 1 0.41 1.64 1.28
59 INT30744 Sst Regulation of Cck 1 0.28 0.43 1.27
60 INT47956 Cck Positive_regulation of Gast 1 0.02 0.09 1.25
61 INT71070 Positive_regulation of Oprl1 Positive_regulation of Gene_expression of Cck 1 0.26 0 1.24
62 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
63 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
64 INT82754 Cck Positive_regulation of Positive_regulation of Pomc 1 0.39 0.3 1.21
65 INT329956 Binding of IL2 and IL23R 1 0.33 4.58 1.21
66 INT142154 Trpv1 Positive_regulation of Gene_expression of Il2 1 0.22 0 1.21
67 INT88193 Binding of IL2 and IL4 1 0.13 1.7 1.2
68 INT172500 Ednra Positive_regulation of Coc 1 0.01 1 1.2
69 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
70 INT203016 CCK Positive_regulation of Localization of PYY 3 0.68 1.19 1.17
71 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
72 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
73 INT253827 Cck Regulation of Cartpt 1 0.41 0 1.16
74 INT299985 BDKRB2 Regulation of Gene_expression of BDKRB1 1 0.21 0.75 1.16
75 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
76 INT34422 Cck Positive_regulation of Negative_regulation of Npepo 1 0.31 0 1.14
77 INT21267 Cck Negative_regulation of Binding of Oprd1 1 0.50 0 1.12
78 INT296950 Tacr1 Negative_regulation of Gene_expression of Cck 1 0.30 0.94 1.11
79 INT122268 Binding of Grin2b and Grm5 1 0.40 0.52 1.1
80 INT74185 Cck Negative_regulation of Drd1a 1 0.30 0.1 1.1
81 INT40451 Cck Regulation of Prl 1 0.49 0 1.09
82 INT60783 Binding of Oprd1 and Cck 1 0.26 0.47 1.09
83 INT60584 Positive_regulation of Htr3a Positive_regulation of Localization of Cck 1 0.52 0.43 1.09
84 INT88614 Penk Negative_regulation of Il2 1 0.23 0 1.08
85 INT296458 Binding of Gria2 and Pick1 3 0.24 1.86 1.07
86 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
87 INT54501 beta-End6-31 Positive_regulation of Gene_expression of Il2 1 0.03 0 1.06
88 INT162250 Binding of TRPV1 and Grm5 1 0.01 0.8 1.03
89 INT56743 LIF Positive_regulation of Cck 1 0.08 0.18 1.02
90 INT130607 Hcrt Positive_regulation of H1 1 0.59 0.39 1.02
91 INT11251 Negative_regulation of Cck Positive_regulation of Fos 2 0.48 0 1
92 INT21415 POMC Positive_regulation of Gene_expression of IL2 1 0.00 0.27 1
93 INT5612 Cck Positive_regulation of Localization of Crh 1 0.65 0.16 1
94 INT6077 Cck Negative_regulation of Localization of Penk 1 0.06 0 0.99
95 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
96 INT157522 GRM5 Regulation of Gene_expression of OPRM1 1 0.28 0 0.97
97 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
98 INT11392 Cck Positive_regulation of Cckbr 1 0.52 0 0.96
99 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
100 INT66714 Negative_regulation of Binding of BDKRB1 and KNG1 1 0.13 0.22 0.96
101 INT74184 Cck Regulation of Localization of Drd1a 1 0.32 0.06 0.95
102 INT53823 Cck Regulation of Localization of Pdyn 1 0.09 0 0.95
103 INT53822 Cck Regulation of Pdyn 1 0.02 0 0.95
104 INT253836 Cck Regulation of DST 1 0.03 0.42 0.95
105 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
106 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
107 INT253826 Cck Regulation of Nts 1 0.21 0.36 0.94
108 INT123023 Ednra Regulation of Adarb1 1 0.00 0 0.93
109 INT207149 Binding of F2r and Par2 1 0.17 1.64 0.92
110 INT94501 Il2 Positive_regulation of Gene_expression of Ifng 1 0.03 1.63 0.92
111 INT123024 Csf2 Regulation of Ednra 1 0.06 0 0.92
112 INT161769 Cck Regulation of Cckar 1 0.27 0.53 0.92
113 INT85485 Phax Regulation of Gene_expression of Cck 1 0.07 0.61 0.91
114 INT207439 Binding of HCRT and ERAL1 1 0.00 3.06 0.87
115 INT213977 Pax3 Negative_regulation of Gene_expression of Il2 1 0.00 0.25 0.86
116 INT213976 Calca Negative_regulation of Gene_expression of Il2 1 0.03 0.25 0.86
117 INT161306 POMC Negative_regulation of Transcription of IL2 1 0.24 0.27 0.85
118 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84
119 INT161307 JUN Positive_regulation of IL2 1 0.14 0.25 0.84
120 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84
121 INT41863 Avp Regulation of Cck 1 0.00 0 0.84
122 INT41859 Agtr2 Regulation of Cck 1 0.00 0 0.84
123 INT2881 SST Negative_regulation of Positive_regulation of CCK 1 0.32 0.1 0.84
124 INT41869 GRP Regulation of Cck 1 0.00 0 0.84
125 INT127240 Bdkrb1 Regulation of Ssr1 1 0.01 0.08 0.84
126 INT2880 SST Negative_regulation of CCK 1 0.32 0.1 0.84
127 INT41866 Nts Regulation of Cck 1 0.01 0 0.84
128 INT41861 Vip Regulation of Cck 1 0.02 0 0.84
129 INT67908 Binding of Cck and Plxna3 1 0.04 0.54 0.84
130 INT161305 NFKB1 Positive_regulation of IL2 1 0.25 0.25 0.83
131 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
132 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
133 INT140280 Negative_regulation of Binding of Adora2a and Grina 1 0.21 0.64 0.82
134 INT288201 Mapk14 Positive_regulation of Cish 1 0.03 0.06 0.82
135 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
136 INT140281 Binding of Adora2a and Grina 1 0.19 0.64 0.82
137 INT73032 Cck Negative_regulation of Localization of Oxt 1 0.44 0 0.82
138 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
139 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
140 INT12883 Binding of IL2 and POMC 1 0.01 0 0.81
141 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
142 INT83094 IL1B Positive_regulation of Positive_regulation of BDKRB1 1 0.45 0.2 0.81
143 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
144 INT53199 Positive_regulation of Cd4 Positive_regulation of Gene_expression of Il2 1 0.52 0.72 0.8
145 INT8411 IL2 Regulation of Gene_expression of Vip 1 0.00 0.27 0.8
146 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
147 INT101439 Cck Positive_regulation of Agtr2 1 0.24 0.33 0.8
148 INT131650 Cck Positive_regulation of Fosl1 1 0.17 0 0.8
149 INT21543 Binding of Oprd1 and Cish 2 0.09 0.15 0.78
150 INT72017 Binding of Adora2a and Ptprg 2 0.07 0 0.77
151 INT224403 Binding of CCK and GYPC 1 0.04 0.83 0.77
152 INT76498 Binding of Tacr1 and Adora2a 1 0.09 0 0.77
153 INT139409 Cck Negative_regulation of Abat 1 0.14 0.5 0.76
154 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
155 INT82040 Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.11 0 0.75
156 INT210979 Grm5 Positive_regulation of Cysltr1 1 0.00 0.76 0.75
157 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
158 INT209035 Il2 Positive_regulation of Ccr1 1 0.00 0.38 0.73
159 INT21535 Binding of Il2 and Il1f5 1 0.13 0 0.73
160 INT209052 Il2 Positive_regulation of Il17a 1 0.03 0.38 0.73
161 INT209053 Il2 Positive_regulation of Elf1 1 0.06 0.38 0.73
162 INT209036 Il2 Positive_regulation of Cxcl1 1 0.04 0.38 0.73
163 INT209051 Il2 Positive_regulation of Csf2 1 0.02 0.38 0.73
164 INT106992 F2 Positive_regulation of PARD3 3 0.05 1.83 0.72
165 INT266769 IL2 Positive_regulation of Localization of IL4 1 0.00 1.03 0.72
166 INT82041 Positive_regulation of Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.12 0 0.72
167 INT72318 Adarb1 Positive_regulation of Positive_regulation of Cck 1 0.04 0 0.72
168 INT266765 IL2 Positive_regulation of Localization of IL10 1 0.01 1.03 0.72
169 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
170 INT168911 Grm5 Regulation of Mapk3 1 0.17 0.78 0.71
171 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
172 INT27034 HERPUD1 Regulation of Gene_expression of IL2 1 0.38 0 0.71
173 INT338057 Positive_regulation of F2r Positive_regulation of Localization of Calca 1 0.05 0.28 0.71
174 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
175 INT12238 CCK Positive_regulation of CDH2 1 0.02 0 0.7
176 INT151681 Il2 Negative_regulation of Art2a-ps 1 0.00 1.23 0.7
177 INT151678 Il2 Negative_regulation of Oas1b 1 0.13 1.23 0.7
178 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
179 INT282141 Grm5 Regulation of Grip2 1 0.00 0.61 0.69
180 INT253831 Cck Positive_regulation of Gene_expression of Cartpt 1 0.48 0.23 0.69
181 INT253825 Cck Positive_regulation of Crh 1 0.74 0 0.69
182 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
183 INT95282 Binding of CALCA and GAP43 1 0.40 0 0.68
184 INT22922 Penk Negative_regulation of Negative_regulation of Cck 1 0.48 0 0.68
185 INT54502 Pomc Positive_regulation of Gene_expression of Il2 1 0.16 0 0.68
186 INT253830 Cck Positive_regulation of Crh 1 0.38 0 0.68
187 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
188 INT194857 Positive_regulation of Adora2a Positive_regulation of Gene_expression of Vegfa 1 0.23 0.74 0.67
189 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
190 INT11611 Cck Positive_regulation of Localization of Avp 1 0.09 0 0.67
191 INT84213 Cck Regulation of Cckbr 1 0.41 0 0.67
192 INT11612 Cck Positive_regulation of Avp 1 0.10 0 0.67
193 INT56308 POMC Negative_regulation of Gene_expression of Il2 1 0.01 0.1 0.67
194 INT150338 Binding of F2 and F2R 1 0.11 0.4 0.67
195 INT26231 Binding of GSR and HTR1B 1 0.12 0.15 0.66
196 INT82382 Penk Positive_regulation of Gene_expression of Il2 1 0.10 0 0.66
197 INT15322 Binding of Npy and Cck 1 0.26 0.45 0.66
198 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
199 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
200 INT72504 IgG Negative_regulation of Il2 1 0.37 0 0.65

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT287 Localization of Cck 518 0.81 86.84 364.04
2 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41
3 INT3948 Regulation of Cck 291 0.62 58.07 255.88
4 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92
5 INT943 Negative_regulation of Cck 205 0.59 38.42 174.78
6 INT2366 Binding of Cck 192 0.48 30.64 163.46
7 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69
8 INT2862 Positive_regulation of Localization of Cck 108 0.70 20.75 94.25
9 INT11807 Gene_expression of Il2 266 0.78 112 64.97
10 INT20266 Positive_regulation of Bdkrb1 60 0.69 63.64 56.59
11 INT8153 Regulation of Localization of Cck 52 0.62 11.22 54.83
12 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21
13 INT2463 Localization of CCK 101 0.81 37.54 47.59
14 INT6544 Negative_regulation of Localization of Cck 67 0.59 8.05 47.23
15 INT5025 Positive_regulation of Gene_expression of Cck 63 0.70 10.96 47.11
16 INT2406 Gene_expression of CCK 85 0.78 28.04 46.67
17 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
18 INT49643 Gene_expression of Bdkrb1 39 0.78 46.49 40.21
19 INT7824 Regulation of Cck 39 0.62 5.31 39.28
20 INT12159 Transcription of Cck 46 0.72 9.36 37.58
21 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67
22 INT7833 Positive_regulation of Cck 33 0.70 8.54 34.21
23 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
24 INT95789 Positive_regulation of Grm5 42 0.55 20.1 33.72
25 INT10763 Localization of IL2 157 0.80 81.11 33.21
26 INT9796 Gene_expression of Cck 63 0.78 11.44 32.09
27 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7
28 INT2884 Positive_regulation of CCK 66 0.69 25.25 30.6
29 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04
30 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96
31 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
32 INT51602 Gene_expression of Grm5 59 0.75 17.29 26.99
33 INT28834 Positive_regulation of Bdkrb1 38 0.69 30.48 26.89
34 INT2408 Regulation of CCK 37 0.61 10.01 26.66
35 INT7832 Localization of Cck 39 0.81 6.81 26.54
36 INT19986 Negative_regulation of Cck 31 0.59 4.32 24.99
37 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
38 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
39 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
40 INT7827 Binding of Cck 32 0.48 4.66 23.73
41 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94
42 INT78571 Positive_regulation of Grm5 35 0.69 11.81 22.45
43 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63
44 INT15796 Regulation of IL2 66 0.61 25.43 20.62
45 INT1156 Binding of CCK 27 0.48 8.71 20.58
46 INT9782 Binding of HTR1B 43 0.47 12.08 19.83
47 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
48 INT9128 Regulation of Gene_expression of Cck 27 0.62 6.55 19.45
49 INT5048 Binding of Edn1 55 0.47 18.86 19.16
50 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93
51 INT10286 Positive_regulation of Positive_regulation of Cck 20 0.70 4.05 18.46
52 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26
53 INT9358 Positive_regulation of HTR1B 26 0.67 11 17.51
54 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38
55 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96
56 INT30517 Negative_regulation of Bdkrb1 16 0.58 16.52 16.88
57 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2
58 INT3926 Regulation of Bdkrb1 22 0.61 16.72 16.1
59 INT59987 Gene_expression of BDKRB1 25 0.77 11.95 15.93
60 INT78827 Gene_expression of Bdkrb1 34 0.78 18.48 15.81
61 INT61301 Positive_regulation of Gene_expression of Bdkrb1 7 0.68 16.95 15.44
62 INT1154 Negative_regulation of CCK 24 0.59 9.3 15.32
63 INT94650 Gene_expression of Grm5 32 0.77 11.26 14.82
64 INT9191 Localization of EDN1 94 0.81 57.01 14.78
65 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
66 INT15042 Gene_expression of Adora2a 37 0.77 3.77 14.24
67 INT22098 Positive_regulation of Il2 27 0.69 14.77 14.1
68 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
69 INT6365 Localization of Edn1 56 0.81 18.84 13.83
70 INT6645 Positive_regulation of BDKRB1 14 0.66 12.17 13.79
71 INT108063 Gene_expression of Adora2a 29 0.78 13.11 13.78
72 INT20381 Localization of Il2 71 0.77 34.23 13.03
73 INT7852 Negative_regulation of Gene_expression of Cck 15 0.59 2.02 12.85
74 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75
75 INT51014 Transcription of IL2 42 0.71 21.56 12.7
76 INT32595 Positive_regulation of Gene_expression of Il2 30 0.70 6.55 12.56
77 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
78 INT21467 Negative_regulation of Binding of Cck 18 0.57 2.84 11.91
79 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
80 INT72784 Positive_regulation of Adora2a 26 0.70 16.52 11.47
81 INT107522 Regulation of Grm5 9 0.44 6.42 11.46
82 INT14334 Negative_regulation of Il2 31 0.58 18.63 11.08
83 INT12158 Regulation of Transcription of Cck 5 0.60 0.99 11.03
84 INT14780 Regulation of Binding of Cck 9 0.49 4.33 10.83
85 INT12344 Negative_regulation of Gene_expression of Il2 28 0.59 15.53 10.23
86 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
87 INT10041 Protein_catabolism of Cck 18 0.96 2.71 9.81
88 INT6361 Localization of Edn1 30 0.81 19.09 9.7
89 INT15722 Positive_regulation of PPAP2A 25 0.43 4.83 9.65
90 INT78570 Negative_regulation of Grm5 15 0.57 5.45 9.17
91 INT7104 Binding of Bdkrb1 6 0.37 6.54 9.02
92 INT2885 Positive_regulation of Localization of CCK 19 0.70 9.92 8.94
93 INT107657 Positive_regulation of Positive_regulation of Grm5 6 0.69 1.83 8.92
94 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
95 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
96 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71
97 INT22383 Binding of IL2 59 0.48 39.06 8.56
98 INT10237 Binding of EDN1 40 0.48 16 8.48
99 INT12861 Gene_expression of Cish 40 0.57 23.01 8.48
100 INT15592 Positive_regulation of F2r 17 0.67 8.66 8.36
101 INT23209 Binding of Adora2a 17 0.38 2.04 8.35
102 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19
103 INT106056 Gene_expression of Hcrt 77 0.76 35.35 8.16
104 INT81153 Gene_expression of Hcrt 31 0.77 6.04 8.16
105 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13
106 INT56580 Positive_regulation of Htr1b 16 0.67 2.95 7.97
107 INT13041 Binding of Htr1b 14 0.47 4.92 7.95
108 INT77804 Regulation of Ednra 9 0.39 2.71 7.94
109 INT113038 Positive_regulation of Gene_expression of Bdkrb1 12 0.69 7.11 7.93
110 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
111 INT32596 Regulation of Gene_expression of Il2 13 0.61 6.85 7.83
112 INT54755 Negative_regulation of Adora2a 17 0.58 2.7 7.75
113 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
114 INT62452 Regulation of Il2 14 0.61 12.11 7.64
115 INT67170 Gene_expression of Ednra 22 0.65 9.35 7.57
116 INT26707 Binding of PPAP2A 21 0.35 6.01 7.43
117 INT6892 Regulation of Htr1b 9 0.60 1.32 7.24
118 INT3928 Localization of Bdkrb1 15 0.75 4.06 7.23
119 INT70814 Negative_regulation of Il2 40 0.56 13.36 7.22
120 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
121 INT32903 Negative_regulation of PPAP2A 14 0.48 5.02 7.2
122 INT25772 Regulation of HTR1B 15 0.60 3.8 7.17
123 INT15553 Negative_regulation of Htr1b 13 0.41 2.61 7.16
124 INT147498 Gene_expression of GRM5 10 0.75 3.16 7.12
125 INT17969 Negative_regulation of Regulation of Cck 9 0.43 1.03 7.04
126 INT167049 Binding of Ednra 3 0.07 3.47 6.84
127 INT46276 Regulation of Positive_regulation of Cck 9 0.45 0.86 6.82
128 INT98260 Negative_regulation of Gene_expression of Bdkrb1 4 0.57 5.98 6.7
129 INT70139 Regulation of Bdkrb1 6 0.52 8.41 6.66
130 INT12239 Regulation of Localization of CCK 11 0.62 6.03 6.61
131 INT65772 Positive_regulation of Positive_regulation of Bdkrb1 6 0.49 8.34 6.54
132 INT25385 Positive_regulation of Localization of Il2 17 0.45 9.53 6.45
133 INT79822 Gene_expression of Htr1b 10 0.65 2.92 6.27
134 INT84779 Positive_regulation of Hcrt 9 0.70 1.27 6.21
135 INT7825 Positive_regulation of Localization of Cck 7 0.47 0.89 5.92
136 INT22630 Positive_regulation of Binding of Cck 4 0.48 2.27 5.92
137 INT52464 Negative_regulation of Bdkrb1 9 0.57 8.71 5.87
138 INT83313 Gene_expression of Htr1b 4 0.75 5.1 5.73
139 INT12066 Localization of Il2 16 0.75 3.06 5.7
140 INT6601 Gene_expression of PPAP2A 21 0.27 3.13 5.52
141 INT96510 Localization of Htr1b 6 0.78 2.31 5.51
142 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
143 INT119132 Regulation of Grm5 8 0.48 2.66 5.46
144 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
145 INT83014 Binding of Adora2a 13 0.48 5.57 5.33
146 INT11805 Regulation of Gene_expression of Il2 19 0.62 6.62 5.2
147 INT125396 Positive_regulation of Positive_regulation of Bdkrb1 5 0.69 5.14 5.2
148 INT66305 Negative_regulation of HTR1B 9 0.57 1.7 5.15
149 INT59983 Regulation of BDKRB1 12 0.45 10.69 5.11
150 INT89664 Negative_regulation of Adora2a 11 0.59 7.81 5.07
151 INT18857 Negative_regulation of Positive_regulation of Cck 8 0.59 2.62 5.06
152 INT107655 Positive_regulation of Gene_expression of Grm5 6 0.67 5.09 5.06
153 INT59320 Transcription of Il2 32 0.69 6.39 4.95
154 INT58459 Negative_regulation of Localization of IL2 13 0.41 6.46 4.88
155 INT51468 Regulation of Adora2a 8 0.48 1.5 4.84
156 INT6103 Positive_regulation of Negative_regulation of Cck 5 0.50 0.61 4.83
157 INT113037 Transcription of Bdkrb1 4 0.69 3.89 4.82
158 INT92858 Negative_regulation of Ednra 6 0.57 1.25 4.81
159 INT85403 Transcription of Cck 3 0.68 3.07 4.72
160 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
161 INT90852 Gene_expression of F2r 26 0.78 5.5 4.66
162 INT246315 Localization of Ednra 22 0.15 2.73 4.64
163 INT21953 Binding of Ednra 12 0.33 4.72 4.56
164 INT113039 Binding of Bdkrb1 9 0.48 5.71 4.51
165 INT107390 Negative_regulation of Grm5 11 0.45 6 4.42
166 INT78328 Positive_regulation of Gene_expression of CCK 5 0.70 3.84 4.38
167 INT103037 Transcription of Bdkrb1 8 0.70 4.76 4.33
168 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
169 INT46277 Positive_regulation of Regulation of Cck 5 0.70 1.35 4.31
170 INT7826 Positive_regulation of Positive_regulation of Cck 3 0.50 0.15 4.28
171 INT74815 Binding of Grm5 11 0.36 3.62 4.25
172 INT23480 Regulation of PPAP2A 13 0.39 3.51 4.13
173 INT95784 Positive_regulation of Positive_regulation of Grm5 8 0.11 3.48 4.01
174 INT50228 Positive_regulation of Positive_regulation of Adora2a 8 0.39 0.1 4
175 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
176 INT29138 Positive_regulation of Localization of IL2 25 0.50 10.06 3.89
177 INT15673 Positive_regulation of Transcription of Cck 4 0.69 1.62 3.84
178 INT70529 Positive_regulation of Cish 16 0.59 14.43 3.8
179 INT34476 Regulation of Regulation of Cck 3 0.34 0.71 3.78
180 INT133788 Negative_regulation of Gene_expression of Bdkrb1 7 0.58 3.49 3.75
181 INT116220 Localization of HTR1B 5 0.78 1.86 3.75
182 INT18630 Transcription of CCK 9 0.71 3 3.73
183 INT61300 Negative_regulation of Binding of Bdkrb1 3 0.42 3 3.69
184 INT76229 Binding of BDKRB1 5 0.33 1.46 3.66
185 INT101701 Regulation of Adora2a 8 0.45 2.3 3.63
186 INT49203 Regulation of Protein_catabolism of Cck 2 0.38 1.33 3.52
187 INT93463 Localization of Hcrt 13 0.78 1.58 3.51
188 INT106057 Negative_regulation of Hcrt 27 0.57 15.5 3.47
189 INT56864 Negative_regulation of Positive_regulation of Cck 4 0.43 1.03 3.47
190 INT59984 Regulation of Gene_expression of BDKRB1 2 0.45 2.08 3.47
191 INT86082 Localization of Htr1b 4 0.73 2.77 3.46
192 INT59986 Localization of BDKRB1 5 0.61 1.69 3.45
193 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
194 INT59706 Transcription of HTR1B 5 0.69 0.4 3.4
195 INT115203 Negative_regulation of Positive_regulation of Ednra 5 0.33 1.27 3.32
196 INT46754 Localization of F2r 7 0.78 2.36 3.24
197 INT88748 Binding of Hcrt 7 0.47 0 3.22
198 INT89337 Negative_regulation of Gene_expression of CCK 4 0.58 3.14 3.21
199 INT25906 Negative_regulation of Cish 6 0.29 5.41 3.17
200 INT154198 Binding of Pick1 9 0.48 6.91 3.16
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