GO:0007494

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Name midgut development
Categary Process
Go Slim No
Go Link GO:0007494
Unique Molecular Interactions 57
Total Molecular Interactions 67
Total Single Events 503
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for midgut development. They are ordered first by their pain relevance and then by number of times they were reported for midgut development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
2 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
3 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
4 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
5 INT265070 Reln Positive_regulation of Gene_expression of Fos 1 0.02 0.51 1.01
6 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
7 INT128859 Positive_regulation of RXRA Regulation of Gene_expression of OPRM1 1 0.05 0.26 0.9
8 INT114947 YY1 Positive_regulation of Gene_expression of RXRA 1 0.33 0.25 0.65
9 INT70161 Casp1 Regulation of Oprd1 1 0.03 0 0.65
10 INT70162 Casp1 Regulation of Penk 1 0.03 0 0.64
11 INT114951 PPARA Positive_regulation of Gene_expression of RXRA 1 0.34 0.25 0.64
12 INT114949 NCOA1 Positive_regulation of Gene_expression of RXRA 1 0.13 0.24 0.61
13 INT128811 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Casp1 1 0.06 0.35 0.61
14 INT66766 Casp1 Positive_regulation of Transcription of Pla2g10 1 0.06 0.19 0.6
15 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
16 INT128604 Casp1 Positive_regulation of Gene_expression of Fos 1 0.10 0.55 0.59
17 INT222284 Negative_regulation of Casp1 Negative_regulation of Il18 1 0.01 0.79 0.46
18 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46
19 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
20 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
21 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
22 INT333453 Binding of PPARA and RXRA 1 0.02 0 0.31
23 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
24 INT326739 IL8 Regulation of Gene_expression of ARG2 1 0.35 0.46 0.17
25 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
26 INT326733 Negative_regulation of IL8 Negative_regulation of Gene_expression of ARG2 1 0.24 0.33 0.14
27 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
28 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
29 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
30 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
31 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
32 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
33 INT166724 Binding of Vdr and Rxra 1 0.28 0.32 0.09
34 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
35 INT213418 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of VCAM1 1 0.29 0.15 0.08
36 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
37 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
38 INT213419 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of HGF 1 0.25 0.15 0.08
39 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04
40 INT270458 Binding of Gli1 and Smo 1 0.00 0.65 0.04
41 INT326736 AR Regulation of Gene_expression of ARG2 1 0.34 0.43 0.03
42 INT326749 IL8 Positive_regulation of Gene_expression of ARG2 1 0.39 1.96 0.03
43 INT206895 Binding of ESR1 and Aldh1a1 1 0.03 0 0
44 INT326745 IL8 Positive_regulation of ARG2 1 0.26 0.26 0
45 INT326744 ARG1 Regulation of ARG2 1 0.50 1.04 0
46 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
47 INT326740 Gene_expression of AR Negative_regulation of Gene_expression of ARG2 1 0.24 0.8 0
48 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0
49 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
50 INT205974 Smo Positive_regulation of GLI1 1 0.04 0.66 0
51 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0
52 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
53 INT146469 Otc Regulation of Cp 1 0.10 0.23 0
54 INT115239 Binding of Casp1 and EXOSC3 1 0.40 0.11 0
55 INT323279 Binding of Nos3 and Arg2 1 0.01 0.67 0
56 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
57 INT115240 Binding of Casp1 and TPPP3 1 0.52 0.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for midgut development. They are ordered first by their pain relevance and then by number of times they were reported in midgut development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT70848 Gene_expression of Casp1 24 0.77 10.97 8.52
2 INT81586 Negative_regulation of Casp1 11 0.57 6.55 6.45
3 INT71220 Positive_regulation of Casp1 15 0.38 10.23 5.84
4 INT28734 Gene_expression of Reln 7 0.74 5.76 4.33
5 INT28030 Binding of Otc 5 0.37 2.72 4.3
6 INT21869 Negative_regulation of Otc 16 0.58 8.43 3.67
7 INT45324 Positive_regulation of Otc 8 0.59 3.94 3.36
8 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
9 INT107433 Localization of Casp1 6 0.56 2.44 2.64
10 INT120515 Gene_expression of Otc 13 0.66 4.33 2.6
11 INT281928 Gene_expression of ARG2 3 0.77 63.17 2.14
12 INT265064 Binding of Reln 1 0.02 2.7 1.83
13 INT265066 Positive_regulation of Reln 1 0.02 1.59 1.72
14 INT28735 Localization of Reln 2 0.12 1.49 1.7
15 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
16 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
17 INT128865 Regulation of Positive_regulation of RXRA 1 0.08 0.64 1.48
18 INT128863 Positive_regulation of RXRA 1 0.12 0.63 1.47
19 INT159312 Regulation of Reln 4 0.43 1.79 1.4
20 INT73590 Positive_regulation of Positive_regulation of Casp1 2 0.19 1.94 1.28
21 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
22 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
23 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
24 INT120514 Negative_regulation of Gene_expression of Otc 4 0.41 1.19 1.08
25 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
26 INT69442 Regulation of Otc 3 0.24 0.98 1.04
27 INT115238 Positive_regulation of Gene_expression of Casp1 5 0.68 1.78 0.88
28 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
29 INT270447 Binding of Smo 2 0.07 2.61 0.78
30 INT163783 Transcription of Casp1 1 0.58 0.88 0.73
31 INT163785 Positive_regulation of Transcription of Casp1 1 0.42 0.89 0.73
32 INT70156 Regulation of Casp1 2 0.15 0.79 0.7
33 INT138237 Negative_regulation of Negative_regulation of Casp1 1 0.30 0.56 0.69
34 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
35 INT114959 Gene_expression of RXRA 2 0.50 1.06 0.63
36 INT114960 Positive_regulation of Gene_expression of RXRA 1 0.32 0.24 0.61
37 INT205957 Negative_regulation of Smo 4 0.08 2.57 0.6
38 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
39 INT71172 Negative_regulation of Gene_expression of Casp1 2 0.58 1.3 0.58
40 INT138236 Positive_regulation of Localization of Casp1 2 0.48 0.82 0.54
41 INT326769 Regulation of Gene_expression of ARG2 1 0.61 9.7 0.54
42 INT281922 Positive_regulation of Gene_expression of ARG2 2 0.69 10.45 0.5
43 INT86006 Gene_expression of Aldh1a1 5 0.53 3.22 0.43
44 INT107432 Negative_regulation of Localization of Casp1 1 0.03 0 0.42
45 INT48336 Negative_regulation of ARG2 4 0.58 3.82 0.36
46 INT285391 Binding of RXRA 2 0.03 0.08 0.36
47 INT356400 Transcription of Smo 1 0.02 0.05 0.3
48 INT277474 Positive_regulation of Gene_expression of SMO 1 0.11 0 0.29
49 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27
50 INT326773 Positive_regulation of ARG2 1 0.69 1.89 0.27
51 INT37570 Localization of Otc 2 0.61 0.97 0.25
52 INT140639 Gene_expression of FOXF1 3 0.52 0.89 0.22
53 INT28031 Negative_regulation of Binding of Otc 1 0.43 0.36 0.22
54 INT344918 Regulation of Aldh1a1 1 0.43 0.69 0.2
55 INT159314 Positive_regulation of Gene_expression of Reln 1 0.44 0.47 0.2
56 INT206946 Gene_expression of Rxra 4 0.60 2.2 0.17
57 INT68735 Binding of Arg2 2 0.05 0.22 0.17
58 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
59 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
60 INT249096 Regulation of FOXF1 1 0.19 0.28 0.14
61 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
62 INT162574 Gene_expression of Wnt5a 7 0.47 0.92 0.1
63 INT282594 Localization of WNT5A 2 0.18 0.89 0.1
64 INT213448 Localization of FOXF1 1 0.58 0.15 0.1
65 INT233483 Regulation of Gene_expression of Wnt5a 1 0.19 0.33 0.1
66 INT214072 Regulation of Gene_expression of RXRA 1 0.01 0.83 0.09
67 INT265068 Transcription of Reln 1 0.03 0.07 0.09
68 INT166719 Positive_regulation of Rxra 1 0.36 0.31 0.09
69 INT162576 Positive_regulation of Wnt5a 3 0.48 0.71 0.08
70 INT326762 Negative_regulation of Positive_regulation of ARG2 1 0.58 0.25 0.08
71 INT280709 Positive_regulation of Positive_regulation of Otc 1 0.37 0 0.08
72 INT213440 Negative_regulation of FOXF1 1 0.33 0.14 0.08
73 INT290078 Regulation of WNT5A 1 0.07 2.3 0.07
74 INT152243 Binding of ARG2 2 0.37 0.67 0.06
75 INT81873 Positive_regulation of Aldh1a1 1 0.15 0.13 0.06
76 INT345344 Regulation of SMO 1 0.23 1.07 0.06
77 INT152244 Negative_regulation of Binding of ARG2 1 0.00 0.11 0.06
78 INT123164 Positive_regulation of Arg2 2 0.04 0.34 0.05
79 INT123165 Positive_regulation of Positive_regulation of Arg2 1 0.01 0.34 0.05
80 INT262772 Binding of SMO 1 0.27 0.59 0.05
81 INT262777 Localization of SMO 1 0.59 0.6 0.04
82 INT326761 Localization of ARG2 1 0.74 0 0.03
83 INT326778 Negative_regulation of Gene_expression of ARG2 1 0.58 7.05 0.03
84 INT86007 Transcription of Aldh1a1 2 0.54 1.41 0
85 INT252242 Gene_expression of Smo 1 0.01 0.23 0
86 INT335880 Regulation of Wnt5a 1 0.32 0.07 0
87 INT326760 Regulation of ARG2 1 0.61 0.95 0
88 INT346487 Negative_regulation of Phosphorylation of RXRA 1 0.01 0.63 0
89 INT353117 Negative_regulation of Positive_regulation of Casp1 1 0.06 1.25 0
90 INT323259 Gene_expression of Arg2 1 0.03 0.59 0
91 INT86005 Positive_regulation of Transcription of Aldh1a1 1 0.39 0.86 0
92 INT346494 Phosphorylation of RXRA 1 0.01 0.63 0
93 INT205956 Localization of Smo 1 0.06 0.71 0
94 INT326771 Positive_regulation of Transcription of ARG2 1 0.69 1.29 0
95 INT162572 Positive_regulation of Gene_expression of Wnt5a 1 0.02 0.3 0
96 INT326781 Transcription of ARG2 1 0.71 3.93 0
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