GO:0008217

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Name regulation of blood pressure
Categary Process
Go Slim No
Go Link GO:0008217
Unique Molecular Interactions 3572
Total Molecular Interactions 5192
Total Single Events 65926
Pain Genes Associated 116

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of blood pressure. They are ordered first by their pain relevance and then by number of times they were reported for regulation of blood pressure. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
3 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49
4 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
5 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18
6 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
7 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46
8 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18
9 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
10 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
11 INT91538 Pomc Positive_regulation of P9Ehs1 6 0.11 1.47 6.23
12 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
13 INT92466 Pomc Positive_regulation of Binding of Crygs 8 0.06 0 5.56
14 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27
15 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
16 INT1310 Pomc Regulation of Localization of Prl 9 0.40 0.61 4.96
17 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
18 INT102122 Binding of Calca and RT1-M4 7 0.29 5.83 4.94
19 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
20 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
21 INT24742 Binding of Calca and Vip 1 0.37 0.18 4.68
22 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
23 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
24 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
25 INT1313 Pomc Positive_regulation of Prl 7 0.35 0 4.19
26 INT128998 Cxcl1 Positive_regulation of Localization of Calca 1 0.66 2.96 4.15
27 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
28 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
29 INT13969 Binding of Calca and Sst 3 0.32 0.6 4.02
30 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93
31 INT13966 Calca Positive_regulation of Localization of Sst 5 0.49 0.75 3.91
32 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
33 INT71069 Oprl1 Regulation of Gene_expression of Tac4 1 0.03 0.13 3.64
34 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
35 INT24710 Binding of Calca and SUB1P1 1 0.01 2.09 3.48
36 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
37 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
38 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
39 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
40 INT29657 Binding of Calca and Calcb 1 0.26 0 3.16
41 INT17456 Binding of CSF2 and POMC 3 0.32 4.06 3.15
42 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
43 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
44 INT106338 Positive_regulation of Tacr1 Positive_regulation of Localization of Abat 5 0.34 0 3.01
45 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
46 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
47 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
48 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
49 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
50 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
51 INT194409 Binding of CALCA and IGKV1D-8 1 0.15 0 2.84
52 INT32656 Pomc Positive_regulation of Rbm39 1 0.08 0.42 2.84
53 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
54 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
55 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
56 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
57 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
58 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
59 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
60 INT30345 Pomc Regulation of Localization of Penk 3 0.31 0 2.61
61 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
62 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
63 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
64 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
65 INT107812 Nppa Positive_regulation of Localization of Sst 1 0.48 0.54 2.51
66 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
67 INT130284 Ins1 Negative_regulation of Gene_expression of Npy 1 0.32 0.1 2.47
68 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
69 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
70 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
71 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39
72 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37
73 INT13967 Calca Positive_regulation of Sst 1 0.45 0 2.3
74 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
75 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
76 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
77 INT91860 Npy Regulation of Npy1r 2 0.28 1.13 2.24
78 INT51317 Binding of POMC and OR5D2P 1 0.00 0.6 2.23
79 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
80 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
81 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
82 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
83 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
84 INT135035 Binding of Hk1 and Tac1 1 0.35 0.18 2.14
85 INT240131 Binding of Crp and Nppb 7 0.07 11.53 2.12
86 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
87 INT79470 Mgat4a Regulation of Localization of Calca 1 0.08 1.72 2.1
88 INT89733 Binding of Calca and Nrm 1 0.31 0.71 2.09
89 INT28387 Pomc Positive_regulation of Localization of LH 2 0.40 0.28 2.07
90 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
91 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
92 INT63873 SRPX Positive_regulation of Localization of Calca 1 0.02 0.49 2.04
93 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
94 INT26221 Calca Regulation of Gt(pU21)50Imeg 1 0.01 0 2.02
95 INT117821 Binding of Tacr1 and Cd4 1 0.34 0.86 2.02
96 INT138962 Dbi Positive_regulation of Pomc 1 0.00 1.53 2
97 INT32585 H2-Ab1 Negative_regulation of Pomc 1 0.03 0.13 2
98 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
99 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
100 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99
101 INT26948 Pomc Positive_regulation of Localization of Gh1 2 0.22 0.15 1.99
102 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
103 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
104 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
105 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
106 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
107 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
108 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
109 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
110 INT31438 Penk Positive_regulation of Localization of Pomc 1 0.18 0 1.9
111 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
112 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
113 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 0.48 1.1 1.84
114 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
115 INT163514 Ngf Positive_regulation of Gene_expression of Calca 1 0.30 2.21 1.82
116 INT19496 Pomc Regulation of Localization of Ins1 1 0.55 0.33 1.82
117 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
118 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
119 INT14576 Tac4 Regulation of Penk 1 0.07 0 1.77
120 INT139640 Jun Regulation of Gene_expression of Npy 1 0.21 1.98 1.75
121 INT190981 Binding of Npy and Scn2a1 1 0.10 0 1.75
122 INT24934 Calca Regulation of Nka1 3 0.05 0.43 1.73
123 INT26676 Pomc Regulation of Localization of Trh 3 0.14 0 1.73
124 INT165183 Ifnb1 Positive_regulation of P2rx4 1 0.04 1.73 1.73
125 INT24817 Binding of POMC and VTN 8 0.42 0.39 1.71
126 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
127 INT148090 Binding of CALCA and NCOR2 1 0.00 0.65 1.71
128 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
129 INT94617 KNG1 Positive_regulation of Localization of Calca 1 0.00 0.75 1.7
130 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
131 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
132 INT160304 Npy Regulation of Gene_expression of Fos 3 0.67 1.43 1.68
133 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
134 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
135 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
136 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
137 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
138 INT94618 KNG1 Positive_regulation of Calca 1 0.00 0.75 1.66
139 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
140 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
141 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65
142 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
143 INT23889 Calca Positive_regulation of Localization of Tacr1 1 0.11 0.45 1.65
144 INT24157 Binding of CALCA and SFTPA1 2 0.07 0.96 1.64
145 INT169441 TAC1 Positive_regulation of Tac1 1 0.01 1.7 1.64
146 INT147258 Binding of Tac1 and Penk 1 0.35 0 1.64
147 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
148 INT32412 Penk Regulation of Pomc 3 0.21 0.36 1.62
149 INT86637 POMC Regulation of Gene_expression of KRT16 2 0.47 1.22 1.61
150 INT160578 Binding of CALCA and TAC1 1 0.07 0.91 1.61
151 INT94270 Pomc Regulation of Transcription of Crh 1 0.17 0.67 1.6
152 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
153 INT33757 Hmmr Positive_regulation of Npr1 1 0.01 0 1.59
154 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
155 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58
156 INT41652 Binding of Pomc and Oprl1 3 0.16 0 1.57
157 INT107815 Gene_expression of Sst Positive_regulation of Localization of Nppa 1 0.52 0.27 1.57
158 INT94271 Pomc Regulation of Avp 1 0.20 0.67 1.57
159 INT81710 POMC Regulation of Gene_expression of FCGR3B 1 0.50 0.34 1.57
160 INT81709 POMC Regulation of Gene_expression of ITGB2 1 0.40 0.34 1.57
161 INT81719 POMC Regulation of Gene_expression of ITGAL 1 0.35 0.34 1.57
162 INT7796 Akr1d1 Regulation of Npy 1 0.03 0 1.57
163 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
164 INT81712 POMC Regulation of FCGR3B 1 0.16 0.34 1.56
165 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
166 INT81715 POMC Regulation of ITGB2 1 0.40 0.34 1.55
167 INT81721 POMC Regulation of ITGAM 1 0.39 0.34 1.55
168 INT13968 Calca Negative_regulation of Positive_regulation of Sst 1 0.34 0 1.55
169 INT81714 POMC Regulation of ITGAL 1 0.15 0.34 1.54
170 INT73016 PDYN Regulation of TAC1 1 0.29 0.34 1.54
171 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54
172 INT32152 POMC Positive_regulation of Gene_expression of IFNA1 2 0.67 0 1.53
173 INT13970 Positive_regulation of Calca Positive_regulation of Sst 1 0.37 0 1.53
174 INT13965 Calca Positive_regulation of Positive_regulation of Sst 1 0.37 0 1.53
175 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
176 INT140017 Avp Positive_regulation of Gene_expression of Pomc 1 0.38 0.85 1.52
177 INT69709 NPL Positive_regulation of Localization of POMC 2 0.36 1.22 1.51
178 INT32657 Positive_regulation of Pomc Positive_regulation of Rbm39 1 0.08 0.22 1.51
179 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
180 INT140008 Avp Positive_regulation of Pomc 1 0.38 0.84 1.51
181 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
182 INT96784 Binding of CALCA and Calca 3 0.23 0.27 1.47
183 INT180791 Negative_regulation of Gdnf Regulation of Calca 1 0.17 0 1.47
184 INT40209 TNS3 Regulation of POMC 1 0.16 0.27 1.47
185 INT107813 Sst Negative_regulation of Localization of Nppa 1 0.44 0.2 1.46
186 INT12691 SST Negative_regulation of Localization of POMC 3 0.24 1.24 1.45
187 INT1314 Pomc Regulation of Localization of Gnrhr 2 0.16 0.14 1.45
188 INT21425 Binding of Pomc and Gtpbp4 1 0.01 0.1 1.45
189 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
190 INT180767 Bdnf Positive_regulation of Gene_expression of Calca 1 0.17 0 1.45
191 INT276681 Calca Regulation of Nav1 1 0.07 0.74 1.45
192 INT276686 Calca Regulation of Nav1 1 0.26 0.74 1.45
193 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
194 INT29127 Npy Positive_regulation of LH 1 0.47 0 1.45
195 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
196 INT84434 Calca Negative_regulation of Negative_regulation of Hrh1 1 0.06 0.19 1.44
197 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
198 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 0.05 1.65 1.42
199 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42
200 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of blood pressure. They are ordered first by their pain relevance and then by number of times they were reported in regulation of blood pressure. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 2008 0.81 518.3 1408.65
2 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84
3 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08
4 INT443 Localization of POMC 1020 0.81 284.52 443.17
5 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04
6 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
7 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38
8 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26
9 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
10 INT2649 Regulation of Calca 433 0.62 146.05 330.95
11 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
12 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98
13 INT738 Regulation of POMC 459 0.62 111.19 243.74
14 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45
15 INT626 Localization of CALCA 289 0.81 125.39 221.15
16 INT1308 Localization of Pomc 457 0.81 66.83 217.5
17 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92
18 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08
19 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24
20 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6
21 INT1652 Regulation of Pomc 387 0.62 61.01 186.51
22 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
23 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63
24 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
25 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
26 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37
27 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57
28 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21
29 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2
30 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47
31 INT2541 Binding of Calca 200 0.48 67.14 134.62
32 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87
33 INT695 Binding of POMC 304 0.48 56.66 126.85
34 INT5008 Localization of Calca 204 0.81 80.35 125.16
35 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46
36 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11
37 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
38 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75
39 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
40 INT1438 Localization of Pomc 360 0.81 101.26 116.47
41 INT5283 Positive_regulation of Npy 191 0.70 66.77 109.2
42 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58
43 INT4936 Localization of Tacr1 125 0.80 35.7 107.7
44 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66
45 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61
46 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97
47 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84
48 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
49 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03
50 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52
51 INT5617 Localization of Nppa 266 0.81 83.51 83.89
52 INT6107 Localization of Npy 180 0.81 26.76 81.67
53 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53
54 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
55 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26
56 INT462 Regulation of Pomc 157 0.62 41.67 67.27
57 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
58 INT46 Localization of Ren 233 0.81 46.15 62.44
59 INT6761 Binding of CALCA 100 0.48 26.71 62.05
60 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97
61 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
62 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5
63 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3
64 INT1307 Positive_regulation of Localization of Pomc 120 0.70 24.58 58.48
65 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07
66 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
67 INT1463 Binding of Pomc 129 0.48 15.89 56.27
68 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
69 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
70 INT4241 Regulation of CALCA 87 0.62 28.19 55.29
71 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3
72 INT4891 Transcription of Calca 81 0.72 35.27 53.75
73 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66
74 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15
75 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04
76 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
77 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67
78 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33
79 INT97674 Positive_regulation of Localization of Calca 70 0.69 27.71 51.79
80 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34
81 INT5338 Regulation of Npy 92 0.62 25.54 51.24
82 INT8690 Localization of Tac1 71 0.80 22.98 50.75
83 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67
84 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
85 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
86 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
87 INT654 Localization of REN 250 0.81 75.12 47.86
88 INT375 Positive_regulation of REN 293 0.70 152.46 47.55
89 INT5337 Negative_regulation of Npy 87 0.59 19.6 46.75
90 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
91 INT8713 Regulation of Tac1 56 0.60 25.29 45.94
92 INT4776 Localization of TAC1 82 0.78 16.89 45.21
93 INT14853 Negative_regulation of Tac1 80 0.59 30.87 45.06
94 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41
95 INT1295 Binding of Pomc 85 0.48 12.92 42.8
96 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8
97 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
98 INT4850 Binding of Tac1 57 0.47 14.25 42.17
99 INT28265 Positive_regulation of Calca 62 0.70 29.1 41.17
100 INT4887 Gene_expression of Tac4 70 0.77 11.66 40.97
101 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97
102 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
103 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
104 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
105 INT4925 Binding of Tacr1 57 0.48 17.39 38.38
106 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35
107 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
108 INT5620 Positive_regulation of Localization of Nppa 105 0.70 30.23 36.45
109 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12
110 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
111 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97
112 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
113 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4
114 INT4892 Positive_regulation of Gene_expression of Tacr1 56 0.69 25.64 34.69
115 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38
116 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
117 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49
118 INT8746 Negative_regulation of Calca 50 0.59 21.22 33.45
119 INT1116 Regulation of Ren 103 0.62 27.66 33.26
120 INT4727 Regulation of TAC1 60 0.47 6.74 32.83
121 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
122 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
123 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
124 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41
125 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
126 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09
127 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01
128 INT5505 Regulation of Localization of Pomc 54 0.61 6.96 30.77
129 INT70776 Positive_regulation of P2rx1 62 0.62 32.55 30.75
130 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46
131 INT1158 Regulation of Agt 106 0.61 29.4 30.29
132 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
133 INT6196 Regulation of Nppa 83 0.62 30.31 30.18
134 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
135 INT660 Negative_regulation of REN 194 0.59 82.06 29.46
136 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18
137 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95
138 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76
139 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58
140 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
141 INT22499 Regulation of Calca 42 0.62 17.32 28.02
142 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69
143 INT7565 Transcription of Pomc 69 0.72 14.46 27.41
144 INT8881 Regulation of Gene_expression of Tacr1 38 0.61 17.49 27.19
145 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
146 INT8205 Negative_regulation of Nppa 77 0.59 26.43 25.72
147 INT11773 Gene_expression of Tac1 56 0.77 10 25.72
148 INT86789 Gene_expression of P2rx4 46 0.77 30.66 25.68
149 INT8779 Binding of TAC1 50 0.47 11.19 25.57
150 INT17925 Transcription of Npy 53 0.72 15.75 25.56
151 INT61953 Transcription of Nos2 101 0.72 46.64 25.49
152 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31
153 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31
154 INT67610 Positive_regulation of Pparg 53 0.70 31.91 25.2
155 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
156 INT2140 Regulation of REN 104 0.62 28.24 24.49
157 INT12424 Binding of Npy 48 0.48 8.23 24.26
158 INT8380 Positive_regulation of Gene_expression of Npy 49 0.70 19.62 24.13
159 INT89854 Regulation of Nos2 49 0.61 42.58 24.1
160 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
161 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01
162 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
163 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36
164 INT9526 Negative_regulation of Localization of Pomc 41 0.58 6.93 23.3
165 INT5511 Negative_regulation of Gene_expression of Pomc 47 0.59 12.08 23.02
166 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
167 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29
168 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51
169 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42
170 INT112427 Positive_regulation of P2rx4 27 0.68 26.29 21.31
171 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
172 INT11979 Transcription of Tac4 42 0.52 4.48 20.95
173 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
174 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49
175 INT66281 Transcription of Nos2 81 0.71 39.49 20.37
176 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
177 INT7017 Regulation of Npr1 45 0.52 3.38 20.05
178 INT41494 Negative_regulation of Gene_expression of Tacr1 25 0.58 11.73 19.91
179 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
180 INT4260 Negative_regulation of Positive_regulation of Npr1 29 0.43 4.39 19.57
181 INT67608 Gene_expression of Pparg 41 0.78 25.09 19.53
182 INT5048 Binding of Edn1 55 0.47 18.86 19.16
183 INT11628 Regulation of Localization of Pomc 44 0.61 10.46 18.66
184 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08
185 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07
186 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03
187 INT12360 Regulation of Tac1 31 0.61 5.9 18
188 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
189 INT6461 Gene_expression of Npr1 35 0.75 10.38 17.58
190 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
191 INT5618 Regulation of Localization of Nppa 36 0.62 13.42 17.46
192 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38
193 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
194 INT11977 Positive_regulation of Tac4 26 0.69 3.91 17.15
195 INT35998 Positive_regulation of Gene_expression of Calca 31 0.70 16.16 16.98
196 INT9299 Positive_regulation of Positive_regulation of Npr1 32 0.53 6.65 16.72
197 INT61949 Regulation of Nos2 74 0.58 34.08 16.7
198 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7
199 INT15202 Regulation of Tacr1 26 0.60 9.65 16.48
200 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33
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