GO:0008234

Name cysteine-type peptidase activity Categary Function Go Slim No Go Link GO:0008234

Unique Molecular Interactions 403 Total Molecular Interactions 486 Total Single Events 6799 Pain Genes Associated 35

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cysteine-type peptidase activity. They are ordered first by their pain relevance and then by number of times they were reported for cysteine-type peptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT155891	Nps Negative_regulation of Positive_regulation of Casp3	1	0.27	0.17	3.48
2	INT7190	Syt17 Positive_regulation of Ctsb	1	0.16	0	3.23
3	INT7193	Abl2 Positive_regulation of Ctsb	1	0.21	0	3.21
4	INT106750	Pes1 Negative_regulation of Positive_regulation of Casp3	3	0.23	0	2.35
5	INT85252	Negative_regulation of Chi3l1 Positive_regulation of Casp3	1	0.01	0	2.26
6	INT7195	Negative_regulation of Syt17 Positive_regulation of Ctsb	1	0.10	0	2.25
7	INT85251	Chi3l1 Positive_regulation of Casp3	1	0.01	0	2.25
8	INT106753	Pes1 Negative_regulation of Gene_expression of Casp3	2	0.12	0	2.19
9	INT146587	Npff Negative_regulation of Positive_regulation of Casp3	1	0.05	0.18	1.92
10	INT146586	Npff Negative_regulation of Gene_expression of Casp3	1	0.06	0.18	1.92
11	INT106751	Pes1 Negative_regulation of Casp3	2	0.23	0	1.54
12	INT137657	Gorasp2 Regulation of Binding of Casp3	1	0.09	0	1.52
13	INT202910	Uchl1 Positive_regulation of Gene_expression of Tacr1	1	0.05	1.65	1.42
14	INT202912	Uchl1 Positive_regulation of Gene_expression of Ntrk2	1	0.08	1.64	1.42
15	INT83707	Acyp2-ps1 Regulation of Casp3	1	0.17	0	1.28
16	INT83705	Acyp2-ps1 Regulation of Positive_regulation of Casp3	1	0.17	0	1.28
17	INT145315	D2Mit212 Regulation of Casp3	1	0.00	0	1.24
18	INT145316	D2Mit212 Regulation of Positive_regulation of Casp3	1	0.00	0	1.24
19	INT145317	D2Mit212 Positive_regulation of Casp3	1	0.01	0	1.22
20	INT7186	Trib3 Negative_regulation of Positive_regulation of Ctsb	1	0.03	0	1.21
21	INT7184	Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb	1	0.03	0	1.21
22	INT93435	Binding of Casp3 and Cckbr	1	0.06	0.15	1.18
23	INT155892	Nps Negative_regulation of Casp3	1	0.27	0.06	1.16
24	INT155890	Nps Negative_regulation of Gene_expression of Casp3	1	0.27	0.05	1.15
25	INT112607	DNAJC15 Negative_regulation of Positive_regulation of Casp3	1	0.03	0.14	1.12
26	INT159235	H2-M3 Negative_regulation of Casp3	1	0.05	0	1.12
27	INT159236	H2-M3 Positive_regulation of Casp3	1	0.06	0	1.12
28	INT155894	Nps Regulation of Gene_expression of Casp3	1	0.33	0.07	1.09
29	INT74460	GTS Negative_regulation of Casp3	1	0.04	0.37	1.08
30	INT159237	Gpm6a Positive_regulation of Casp3	1	0.03	0	1.07
31	INT7191	Negative_regulation of Abl2 Positive_regulation of Ctsb	1	0.13	0	1.04
32	INT307047	Foxm1 Positive_regulation of Casp3	1	0.11	0.06	1.03
33	INT98555	Oprm1 Positive_regulation of Casp8	1	0.51	0.36	1.02
34	INT98556	Oprm1 Positive_regulation of Casp3	1	0.38	0.36	1.01
35	INT90385	EXTL3 Regulation of Ctsl	1	0.00	1.1	0.98
36	INT98180	Aap Positive_regulation of Positive_regulation of Casp3	1	0.00	1.08	0.97
37	INT219279	Ctss Positive_regulation of Gene_expression of Fam64a	1	0.06	1.39	0.96
38	INT219273	Fam64a Positive_regulation of Gene_expression of Ctss	1	0.06	1.39	0.96
39	INT155893	Nps Regulation of Casp3	1	0.24	0.08	0.95
40	INT220031	Casp3 Positive_regulation of Gene_expression of Nos3	1	0.04	0	0.92
41	INT148806	Diablo Positive_regulation of Positive_regulation of Casp3	1	0.03	1.02	0.89
42	INT147885	Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3	1	0.13	0	0.88
43	INT307045	Tmie Negative_regulation of Positive_regulation of Casp3	1	0.01	0.29	0.85
44	INT339293	Casp1 Regulation of Localization of Il1	1	0.07	1.87	0.83
45	INT335644	CTSB Positive_regulation of F2RL1	1	0.02	2.58	0.82
46	INT116250	Vta1 Positive_regulation of Casp3	1	0.01	0	0.82
47	INT56236	Casp3 Positive_regulation of Gene_expression of RT1-Cl	1	0.00	0.45	0.82
48	INT339291	Casp1 Positive_regulation of Il1	2	0.12	1.63	0.8
49	INT141605	Gene_expression of Ctsl Positive_regulation of Positive_regulation of MET	1	0.34	0	0.8
50	INT307044	Tmie Regulation of Casp3	1	0.01	0	0.75
51	INT114860	Negative_regulation of Insrr Positive_regulation of Casp3	1	0.02	0.71	0.73
52	INT220033	Casp3 Positive_regulation of Gene_expression of Nos1	1	0.05	0.52	0.72
53	INT129694	Binding of Casp3 and Casp9	1	0.35	0.86	0.65
54	INT351445	Binding of Vta1 and Positive_regulation of Casp3	1	0.01	0.39	0.64
55	INT106754	Pes1 Positive_regulation of Casp3	1	0.13	0	0.63
56	INT106752	Negative_regulation of Pes1 Positive_regulation of Casp3	1	0.12	0	0.63
57	INT333544	CTSB Regulation of Protein_catabolism of APP	1	0.01	0.53	0.62
58	INT333543	CTSB Regulation of APP	1	0.01	0.53	0.62
59	INT36320	PDYN Negative_regulation of Ctsb	1	0.00	0	0.61
60	INT83706	Acyp2-ps1 Positive_regulation of Casp3	1	0.11	0	0.61
61	INT114505	Negative_regulation of Hmmr Positive_regulation of Casp3	1	0.01	0.72	0.6
62	INT114506	Hmmr Positive_regulation of Casp3	1	0.01	0.72	0.6
63	INT133320	Penk Negative_regulation of Gene_expression of Casp3	1	0.11	0.91	0.6
64	INT163376	RYBP Positive_regulation of Gene_expression of Casp3	2	0.01	0.57	0.59
65	INT350699	Binding of Casp8 and Stat3	1	0.04	1.81	0.58
66	INT350716	Binding of CD58 and Casp8	1	0.03	1.81	0.58
67	INT339290	Casp1 Regulation of Gene_expression of Il1	1	0.11	1.38	0.55
68	INT297311	Casp1 Positive_regulation of Il18	1	0.09	1.02	0.55
69	INT112399	Olr897-ps Regulation of Gene_expression of Casp3	1	0.03	0	0.54
70	INT118082	APP Positive_regulation of Casp3	1	0.00	0.5	0.54
71	INT162720	PEG3 Negative_regulation of Positive_regulation of CASP8	1	0.00	0.71	0.52
72	INT74517	Binding of Casp3 and Cnrip1	1	0.31	0	0.51
73	INT118485	CST3 Regulation of CTSH	1	0.36	0	0.49
74	INT165078	Binding of CTSB and Notch1	1	0.00	1.08	0.48
75	INT351446	Gria2 Negative_regulation of Casp3	1	0.02	0.37	0.47
76	INT307048	Cnr1 Positive_regulation of Casp3	1	0.08	0	0.47
77	INT155085	CASP1 Negative_regulation of CASP8	1	0.29	1.25	0.44
78	INT121850	CASP8 Positive_regulation of Protein_catabolism of BID	2	0.21	1.81	0.43
79	INT90079	Ass1 Positive_regulation of Casp1	1	0.02	0.99	0.43
80	INT244421	Binding of DST and Ctss	1	0.02	0.42	0.41
81	INT121848	AKT1 Regulation of CASP8	1	0.18	0.52	0.41
82	INT139873	Negative_regulation of CTSB Negative_regulation of Gene_expression of App	1	0.00	0.8	0.41
83	INT57236	Casp3 Positive_regulation of Prl	1	0.09	0	0.41
84	INT335643	CTSB Positive_regulation of PAR4	1	0.01	1.3	0.41
85	INT121855	CASP8 Regulation of ROS1	1	0.05	0.52	0.41
86	INT139874	CTSB Negative_regulation of Gene_expression of App	1	0.00	0.8	0.41
87	INT121849	CASP8 Positive_regulation of CYCS	1	0.35	0.48	0.4
88	INT121852	CASP8 Positive_regulation of Localization of CYCS	1	0.32	0.48	0.4
89	INT57235	Casp3 Positive_regulation of Localization of Prl	1	0.15	0	0.4
90	INT122502	TNF Positive_regulation of Localization of CAPN2	1	0.24	0.18	0.38
91	INT52960	Casp3 Negative_regulation of Positive_regulation of Ltp	1	0.02	0	0.37
92	INT145908	Pdyn Regulation of Positive_regulation of Casp3	1	0.14	0.94	0.37
93	INT278389	Binding of Casp1 and Il1	2	0.09	0.82	0.36
94	INT205703	P2rx7 Regulation of Positive_regulation of Casp1	1	0.11	0.66	0.33
95	INT263978	Binding of ADRB2 and TNFAIP3	1	0.01	0.5	0.32
96	INT28688	Binding of Kng1 and Ctsl1	1	0.15	0	0.31
97	INT286708	Negative_regulation of Mapk1 Negative_regulation of Casp3	1	0.12	0	0.31
98	INT135095	Negative_regulation of CTSB Negative_regulation of APP	1	0.00	0.74	0.3
99	INT50107	Ei24 Positive_regulation of Localization of CTSB	3	0.00	0.6	0.29
100	INT166162	Ccr9 Negative_regulation of Positive_regulation of Casp3	1	0.18	1.49	0.28
101	INT258858	CTSB Positive_regulation of Gene_expression of IL8	1	0.00	0.64	0.28
102	INT180246	Binding of Tbca and Uchl1	1	0.00	0.47	0.27
103	INT180245	Binding of Plp1 and Uchl1	1	0.03	0.47	0.27
104	INT181998	TNFRSF11B Negative_regulation of Gene_expression of CTSK	1	0.07	1.98	0.27
105	INT148629	Binding of Cat and Casp3	1	0.08	0.09	0.26
106	INT139980	Negative_regulation of CTSB Negative_regulation of Gene_expression of APP	1	0.15	0.7	0.26
107	INT139981	CTSB Negative_regulation of Gene_expression of APP	1	0.11	0.7	0.26
108	INT149713	Binding of Casp3 and Fas	1	0.40	1.09	0.25
109	INT159991	Ctsk Positive_regulation of POMC	1	0.01	0.35	0.25
110	INT296464	Binding of Cacng2 and Tinagl1	1	0.06	0.25	0.23
111	INT296449	Binding of Gria1 and Tinagl1	1	0.08	0.25	0.23
112	INT69042	Negative_regulation of Casp1 Negative_regulation of Positive_regulation of IL1B	1	0.21	0.17	0.22
113	INT69041	Casp1 Negative_regulation of Gene_expression of IL1B	1	0.21	0.17	0.22
114	INT289998	CNTF Negative_regulation of Casp3	1	0.04	0.99	0.22
115	INT289981	Cntf Negative_regulation of Casp3	1	0.02	1.01	0.22
116	INT349344	Bdnf Negative_regulation of Casp3	1	0.13	0.96	0.22
117	INT69040	Casp1 Negative_regulation of Gene_expression of IFNA1	1	0.07	0.17	0.22
118	INT289999	Binding of CNTF and Casp3	1	0.04	0.99	0.22
119	INT69039	Negative_regulation of Casp1 Negative_regulation of Gene_expression of IFNA1	1	0.07	0.17	0.22
120	INT173558	CTSK Positive_regulation of Protein_catabolism of COL5A2	1	0.00	0.53	0.22
121	INT247112	Binding of MPZ and SENP8	1	0.00	2.47	0.21
122	INT181675	Positive_regulation of Casp9 Positive_regulation of Casp3	1	0.06	0.51	0.2
123	INT315384	Adcyap1 Negative_regulation of Positive_regulation of Casp3	1	0.02	0.53	0.2
124	INT175948	TNF Positive_regulation of Positive_regulation of CASP8	1	0.02	1.12	0.2
125	INT175947	TNFSF10 Positive_regulation of Positive_regulation of CASP8	1	0.01	1.12	0.2
126	INT181677	Casp9 Positive_regulation of Casp3	1	0.06	0.5	0.19
127	INT261387	Nsdhl Negative_regulation of Casp3	1	0.03	1.08	0.19
128	INT306067	Binding of ADH5 and CYLD	1	0.02	3.13	0.19
129	INT349538	Smcp Positive_regulation of Positive_regulation of Casp9	1	0.04	0.68	0.18
130	INT351442	Gria2 Regulation of Gene_expression of Casp3	1	0.01	0	0.18
131	INT275400	Casp3 Positive_regulation of NDRG1	1	0.00	1.36	0.18
132	INT245183	Binding of CTSB and TCF7L2	1	0.39	6.39	0.18
133	INT69038	Casp1 Regulation of Gene_expression of IFNA1	1	0.07	0.16	0.18
134	INT349539	Smcp Positive_regulation of Positive_regulation of Casp8	1	0.04	0.68	0.18
135	INT96417	CYC1 Positive_regulation of Casp9	1	0.02	0.96	0.17
136	INT96416	CYC1 Positive_regulation of Casp3	1	0.02	0.96	0.17
137	INT10291	Trh Regulation of CTSC	1	0.01	0	0.16
138	INT149095	PITX2 Positive_regulation of Casp3	1	0.00	1.51	0.15
139	INT199128	Ctsb Positive_regulation of Prss1	1	0.02	0.9	0.15
140	INT349540	Tnfsf10 Positive_regulation of Positive_regulation of Casp8	1	0.05	0.65	0.15
141	INT199129	Ctsb Positive_regulation of PRSS1	1	0.01	0.9	0.15
142	INT292748	Akt1 Negative_regulation of Positive_regulation of Casp3	1	0.01	1.81	0.15
143	INT181997	TNFRSF11B Negative_regulation of CTSK	1	0.05	0.58	0.14
144	INT130923	HMHA1 Positive_regulation of Protein_catabolism of CASP8	1	0.04	1.37	0.14
145	INT226205	Negative_regulation of Akt1 Positive_regulation of Casp3	1	0.04	0.71	0.14
146	INT130920	HMHA1 Positive_regulation of CASP8	1	0.04	1.36	0.14
147	INT301283	Nfatc1 Regulation of Ctsk	1	0.06	0.19	0.13
148	INT275397	Binding of ITIH4 and Casp3	1	0.02	0.64	0.13
149	INT252631	Binding of Casp3 and Tnfrsf1a	1	0.10	0.69	0.13
150	INT275389	Binding of Casp3 and Htatsf1	1	0.00	0.64	0.13
151	INT342309	Apaf1 Positive_regulation of Casp9	1	0.02	1.1	0.13
152	INT252632	Binding of Casp3 and Tradd	1	0.11	0.68	0.12
153	INT349345	Bdnf Negative_regulation of Positive_regulation of Casp3	1	0.13	1.02	0.12
154	INT321578	Binding of Plaur and Positive_regulation of Ctsb	1	0.15	0.92	0.12
155	INT201754	CASP8 Positive_regulation of Casp3	1	0.00	0.47	0.12
156	INT216945	Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1	1	0.14	0.18	0.12
157	INT315391	IFNA1 Positive_regulation of Casp3	1	0.00	0.1	0.12
158	INT315390	Positive_regulation of IFNA1 Positive_regulation of Casp3	1	0.00	0.1	0.12
159	INT142961	Binding of Nfkb1 and Casp3	1	0.00	1.02	0.11
160	INT234062	Nes Positive_regulation of Casp3	1	0.18	0.08	0.11
161	INT205709	CAMP Positive_regulation of Positive_regulation of Casp1	1	0.00	0.27	0.11
162	INT171645	Negative_regulation of CTSB Positive_regulation of PRSS1	1	0.44	0.36	0.1
163	INT171644	CTSB Positive_regulation of PRSS1	1	0.52	0.36	0.1
164	INT171648	Binding of CTSB and PRSS1	1	0.27	0.42	0.1
165	INT322019	CASP8 Regulation of Gene_expression of IL1B	1	0.02	0	0.1
166	INT285023	Casp3 Negative_regulation of Casp7	1	0.07	0.44	0.1
167	INT304000	Lep Negative_regulation of Positive_regulation of CASP8	1	0.04	0.25	0.1
168	INT258143	Binding of Hcrt and Atxn3	1	0.15	1.93	0.08
169	INT278376	Negative_regulation of Casp1 Negative_regulation of Hps5	1	0.05	0.05	0.08
170	INT240484	Ctsk Positive_regulation of Protein_catabolism of Col7a1	1	0.12	0.42	0.07
171	INT264300	CTSK Positive_regulation of CYP27A1	1	0.03	0.69	0.07
172	INT203849	Ass1 Positive_regulation of Casp3	1	0.00	0.71	0.07
173	INT313807	Binding of TYRP1 and YOD1	1	0.00	0.49	0.06
174	INT313804	Binding of VARS and YOD1	1	0.00	0.49	0.06
175	INT307223	CYLD Positive_regulation of Localization of BCL3	1	0.12	0.51	0.06
176	INT307226	CYLD Negative_regulation of Localization of BCL3	1	0.10	0.45	0.06
177	INT62030	Bche Regulation of Localization of CTSB	1	0.09	0.15	0.06
178	INT211347	Binding of Sigmar1 and Positive_regulation of Casp3	1	0.12	0.92	0.06
179	INT313806	Binding of TYR and YOD1	1	0.01	0.49	0.06
180	INT320402	Binding of Usp14 and Psmb10	1	0.00	0	0.05
181	INT65410	Penk Positive_regulation of Uchl1	1	0.05	0.19	0.05
182	INT65415	Penk Positive_regulation of Binding of Uchl1	1	0.05	0.19	0.05
183	INT65413	Tac1 Positive_regulation of Uchl1	1	0.02	0.19	0.05
184	INT302162	CASP8 Positive_regulation of CASP3	2	0.01	2.07	0.04
185	INT242411	Mch Positive_regulation of Casp3	1	0.09	0.15	0.04
186	INT331350	Mir483 Negative_regulation of BC051665	1	0.00	0	0.04
187	INT353665	Binding of CXCL10 and SENP8	1	0.02	0.34	0.04
188	INT302983	Fadd Positive_regulation of Casp3	1	0.15	1.13	0.04
189	INT320439	Binding of Uchl5 and Psmb10	1	0.00	0	0.04
190	INT242413	Regulation of Mch Positive_regulation of Casp3	1	0.05	0.16	0.04
191	INT353670	Binding of DCPS and SENP8	1	0.00	0.34	0.04
192	INT110967	REG1A Positive_regulation of Gene_expression of CTSB	1	0.01	0	0.04
193	INT267217	Gene_expression of Hspb8 Negative_regulation of Positive_regulation of Casp3	1	0.14	2.8	0.04
194	INT322358	Binding of Parp1 and Casp3	1	0.05	1.08	0.04
195	INT251565	Binding of Casp8 and Fadd	1	0.04	1.18	0.04
196	INT251570	Binding of Casp8 and Faf1	1	0.01	1.18	0.04
197	INT332438	CASP8 Positive_regulation of Gene_expression of BID	1	0.02	1.33	0.03
198	INT172897	Negative_regulation of Lox Positive_regulation of Positive_regulation of Casp3	1	0.04	1.19	0.03
199	INT172910	Lox Positive_regulation of Positive_regulation of Casp3	1	0.03	1.19	0.03
200	INT220445	Bcl2 Negative_regulation of Positive_regulation of Casp9	1	0.01	1.37	0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for cysteine-type peptidase activity. They are ordered first by their pain relevance and then by number of times they were reported in cysteine-type peptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT22548	Positive_regulation of Casp3	483	0.70	258.78	213.07
2	INT65600	Positive_regulation of Casp3	376	0.70	198.44	128.03
3	INT14151	Gene_expression of Casp3	311	0.78	140.26	120.68
4	INT31116	Gene_expression of Casp3	192	0.78	78.21	57.43
5	INT22546	Positive_regulation of Gene_expression of Casp3	97	0.70	47.89	51.92
6	INT49552	Negative_regulation of Positive_regulation of Casp3	76	0.55	36.04	44.78
7	INT27493	Negative_regulation of Casp3	114	0.56	56.89	44.63
8	INT65597	Negative_regulation of Casp3	69	0.59	39.19	29.32
9	INT65598	Negative_regulation of Positive_regulation of Casp3	45	0.59	18.36	28.59
10	INT90313	Negative_regulation of Gene_expression of Casp3	57	0.57	22.23	26.77
11	INT22549	Positive_regulation of Positive_regulation of Casp3	48	0.56	29.5	23.7
12	INT29704	Regulation of Casp3	51	0.56	22.13	22.79
13	INT78694	Positive_regulation of Gene_expression of Casp3	46	0.66	18.64	19.62
14	INT22547	Regulation of Gene_expression of Casp3	23	0.62	8.04	16.78
15	INT78697	Negative_regulation of Gene_expression of Casp3	33	0.57	11.22	16.16
16	INT3623	Negative_regulation of CTSB	49	0.55	27.39	13.52
17	INT101147	Gene_expression of Uchl1	31	0.76	14.73	13.22
18	INT81626	Positive_regulation of Positive_regulation of Casp3	34	0.69	16.75	12.18
19	INT148639	Gene_expression of Uchl1	30	0.59	16.76	11.54
20	INT69035	Positive_regulation of Casp1	43	0.69	25.18	10.67
21	INT78695	Regulation of Casp3	24	0.44	9.43	10.48
22	INT29705	Regulation of Positive_regulation of Casp3	13	0.48	5.37	10.45
23	INT98130	Positive_regulation of CASP8	79	0.67	65.29	10.08
24	INT47301	Gene_expression of Ctsl	27	0.76	7.72	9.32
25	INT105103	Regulation of Gene_expression of Casp3	11	0.39	3.15	9.22
26	INT3622	Regulation of CTSB	34	0.58	16.08	8.76
27	INT78696	Regulation of Positive_regulation of Casp3	9	0.39	2.93	8.2
28	INT88919	Positive_regulation of Casp9	39	0.70	28.64	8.18
29	INT98178	Localization of Casp3	32	0.65	21.01	7.77
30	INT7168	Positive_regulation of Ctsb	9	0.70	0.3	7.58
31	INT69033	Negative_regulation of Casp1	21	0.58	13.15	7.52
32	INT91527	Gene_expression of CTSK	38	0.78	22.21	7.42
33	INT153794	Gene_expression of Ctsk	51	0.77	24.99	7.28
34	INT90077	Gene_expression of Casp1	29	0.76	20.79	6.26
35	INT57232	Binding of Casp3	22	0.36	9.42	6.2
36	INT181017	Gene_expression of Ctss	6	0.65	9.82	6.19
37	INT15542	Negative_regulation of CASP8	20	0.41	17.3	5.63
38	INT50105	Localization of CTSB	29	0.78	10.98	5.21
39	INT7170	Positive_regulation of Positive_regulation of Ctsb	1	0.40	0	4.76
40	INT26787	Localization of Uchl1	10	0.60	5.9	4.48
41	INT47298	Localization of Ctsl	13	0.79	3.77	4.08
42	INT20265	Gene_expression of Ctsb	3	0.47	1.01	3.52
43	INT36115	Transcription of Uchl1	7	0.60	3.24	3.25
44	INT70596	Regulation of Uchl1	5	0.39	3.87	3.11
45	INT137656	Negative_regulation of Binding of Casp3	4	0.21	0.7	3.09
46	INT116143	Positive_regulation of Casp9	32	0.67	30.34	3.04
47	INT98554	Positive_regulation of Casp8	20	0.67	21.32	2.9
48	INT88852	Protein_catabolism of Casp3	28	0.65	23.57	2.74
49	INT110980	Gene_expression of CTSB	17	0.45	8.02	2.69
50	INT15543	Gene_expression of CASP8	32	0.75	25.6	2.61
51	INT156876	Positive_regulation of Gene_expression of Casp1	10	0.50	10.25	2.58
52	INT73028	Positive_regulation of Transcription of Ctsb	1	0.55	1.53	2.54
53	INT59135	Positive_regulation of CTSB	15	0.67	7.53	2.53
54	INT141183	Gene_expression of Casp9	9	0.75	11.96	2.46
55	INT131112	Phosphorylation of Casp3	7	0.63	4.1	2.46
56	INT205692	Positive_regulation of Positive_regulation of Casp1	5	0.46	3	2.44
57	INT37427	Positive_regulation of Gene_expression of Ctsb	2	0.37	1.02	2.33
58	INT31118	Localization of Casp3	17	0.73	11.55	2.3
59	INT7173	Regulation of Positive_regulation of Ctsb	1	0.49	0	2.29
60	INT159989	Positive_regulation of Ctsk	17	0.69	10.51	2.25
61	INT129280	Gene_expression of Casp9	9	0.68	5.48	2.25
62	INT224620	Positive_regulation of Gene_expression of Ctsk	13	0.68	8.35	2.21
63	INT109970	Negative_regulation of Casp8	5	0.52	9.34	2.19
64	INT159645	Negative_regulation of Uchl1	8	0.31	6.84	2.14
65	INT116194	Gene_expression of Casp8	14	0.75	14.61	2.13
66	INT98176	Positive_regulation of Localization of Casp3	7	0.33	6.85	2.12
67	INT146660	Negative_regulation of Ctsk	9	0.43	6.01	2.07
68	INT47303	Regulation of Ctsl	10	0.56	2.64	2.04
69	INT58208	Negative_regulation of Ctsl	8	0.53	3.49	1.91
70	INT153775	Positive_regulation of CTSK	9	0.52	5.44	1.9
71	INT47302	Regulation of Gene_expression of Ctsl	2	0.53	0.54	1.77
72	INT122503	Localization of CAPN2	1	0.35	1.43	1.76
73	INT121964	Positive_regulation of Positive_regulation of Casp9	8	0.32	5.52	1.73
74	INT50106	Positive_regulation of Localization of CTSB	9	0.33	3.15	1.69
75	INT163998	Gene_expression of CTSC	9	0.65	11.24	1.69
76	INT73027	Transcription of Ctsb	1	0.56	1.01	1.68
77	INT88916	Negative_regulation of Casp9	5	0.33	3.01	1.67
78	INT102532	Protein_catabolism of Casp3	24	0.64	16.78	1.64
79	INT15544	Regulation of CASP8	6	0.41	5.83	1.63
80	INT88920	Negative_regulation of Positive_regulation of Casp9	7	0.59	5.27	1.57
81	INT214123	Negative_regulation of Gene_expression of Uchl1	3	0.06	4.52	1.52
82	INT106749	Negative_regulation of Negative_regulation of Casp3	6	0.34	5.12	1.48
83	INT140843	Regulation of Phosphorylation of Casp3	1	0.25	0.37	1.44
84	INT32625	Positive_regulation of Uchl1	2	0.49	1.39	1.4
85	INT42335	Binding of CTSB	11	0.34	5.98	1.37
86	INT171690	Transcription of Casp3	8	0.55	2.62	1.36
87	INT69034	Regulation of Casp1	3	0.27	3.56	1.36
88	INT97943	Positive_regulation of Protein_catabolism of Casp3	7	0.28	7.4	1.35
89	INT181055	Positive_regulation of Ctss	5	0.67	2.84	1.35
90	INT26786	Positive_regulation of Uchl1	7	0.34	1.37	1.32
91	INT15541	Positive_regulation of Negative_regulation of CASP8	2	0.31	1.23	1.31
92	INT136574	Regulation of TNFAIP3	2	0.11	1.33	1.3
93	INT96073	Localization of Casp1	11	0.78	4.91	1.29
94	INT244415	Regulation of Ctss	1	0.26	1.57	1.17
95	INT173578	Negative_regulation of CTSK	8	0.44	6.29	1.15
96	INT141184	Negative_regulation of Casp9	5	0.42	5.48	1.15
97	INT141190	Negative_regulation of Transcription of Casp9	1	0.57	1.42	1.15
98	INT141178	Transcription of Casp9	1	0.69	1.42	1.14
99	INT47305	Positive_regulation of Gene_expression of Ctsl	5	0.59	2.06	1.12
100	INT20317	Localization of Ctsb	3	0.81	0.68	1.12
101	INT59136	Negative_regulation of Positive_regulation of CTSB	3	0.41	2.02	1.11
102	INT182005	Positive_regulation of Gene_expression of CTSK	7	0.52	4.01	1.08
103	INT267750	Binding of Casp1	4	0.35	1.53	1.02
104	INT141187	Positive_regulation of Gene_expression of Casp9	3	0.49	4.2	1
105	INT209423	Negative_regulation of Gene_expression of Ctsk	4	0.41	2.4	0.96
106	INT6534	Negative_regulation of Ctsl1	3	0.54	0.11	0.94
107	INT31117	Binding of Casp3	14	0.23	5.27	0.93
108	INT156976	Gene_expression of TNFAIP3	4	0.65	5.25	0.93
109	INT181177	Gene_expression of CYLD	5	0.69	24.96	0.89
110	INT96074	Negative_regulation of Gene_expression of Casp1	4	0.57	2.77	0.87
111	INT7175	Negative_regulation of Positive_regulation of Ctsb	1	0.34	0	0.86
112	INT347182	Negative_regulation of TNFAIP3	3	0.23	5.6	0.84
113	INT131105	Positive_regulation of Negative_regulation of Casp3	3	0.29	3.15	0.84
114	INT123124	Positive_regulation of Gene_expression of Uchl1	1	0.49	0.54	0.84
115	INT123125	Positive_regulation of Positive_regulation of Uchl1	1	0.49	0.54	0.84
116	INT101146	Positive_regulation of Transcription of Uchl1	1	0.13	1.22	0.84
117	INT101145	Transcription of Uchl1	1	0.18	1.17	0.82
118	INT159728	Localization of Uchl1	2	0.73	0.54	0.8
119	INT120046	Negative_regulation of Localization of Ctsl	2	0.40	0.31	0.8
120	INT205685	Regulation of Positive_regulation of Casp1	3	0.11	1.62	0.78
121	INT181667	Regulation of Regulation of Casp3	1	0.22	1.7	0.77
122	INT181040	Positive_regulation of Gene_expression of Ctss	2	0.45	1.51	0.75
123	INT137503	Positive_regulation of Positive_regulation of Casp9	6	0.67	4.66	0.74
124	INT159988	Localization of Ctsk	5	0.70	2.9	0.74
125	INT182049	Protein_catabolism of Casp1	3	0.20	1.64	0.73
126	INT79243	Negative_regulation of Localization of CTSB	2	0.57	1.35	0.73
127	INT129490	Negative_regulation of Protein_catabolism of Casp3	4	0.22	3.91	0.71
128	INT244413	Regulation of Transcription of Ctss	1	0.26	0.89	0.71
129	INT272206	Gene_expression of CAPN3	4	0.77	3.83	0.7
130	INT156875	Positive_regulation of Gene_expression of Casp8	2	0.49	2.49	0.7
131	INT20318	Regulation of Ctsb	1	0.54	0.19	0.69
132	INT244416	Transcription of Ctss	1	0.52	0.88	0.68
133	INT351454	Regulation of Transcription of Casp3	1	0.02	0.51	0.67
134	INT285006	Positive_regulation of Casp7	4	0.25	4.11	0.66
135	INT264003	Positive_regulation of Transcription of TNFAIP3	1	0.38	1.01	0.65
136	INT189960	Gene_expression of SENP8	9	0.54	17.54	0.64
137	INT263996	Transcription of TNFAIP3	1	0.39	0.99	0.64
138	INT126164	Positive_regulation of Ctsb	15	0.49	3.34	0.63
139	INT59137	Protein_catabolism of CTSB	5	0.96	3.92	0.62
140	INT153773	Regulation of Gene_expression of CTSK	2	0.34	1.36	0.62
141	INT243712	Positive_regulation of Gene_expression of Uchl1	4	0.21	2.68	0.61
142	INT242061	Positive_regulation of Negative_regulation of Casp3	3	0.09	1.7	0.58
143	INT125867	Protein_catabolism of CASP8	9	0.65	8.5	0.57
144	INT28687	Gene_expression of Ctsl1	4	0.61	0.48	0.57
145	INT181673	Negative_regulation of Transcription of Casp3	3	0.34	0.61	0.55
146	INT67297	Negative_regulation of CTSC	3	0.42	0.5	0.54
147	INT51843	Localization of Ctsl1	3	0.62	0.54	0.54
148	INT69142	Positive_regulation of Atxn3	3	0.50	1.52	0.53
149	INT90078	Negative_regulation of Positive_regulation of Casp1	2	0.42	1.38	0.53
150	INT162721	Negative_regulation of Positive_regulation of CASP8	3	0.12	3.17	0.52
151	INT126367	Positive_regulation of Gene_expression of CTSB	3	0.04	1.57	0.52
152	INT160148	Positive_regulation of Ctsl	2	0.43	0.74	0.52
153	INT193736	Regulation of Positive_regulation of CTSB	1	0.04	1.13	0.52
154	INT273195	Localization of Ctss	2	0.19	1.65	0.51
155	INT129281	Positive_regulation of Gene_expression of Casp9	1	0.31	0.84	0.48
156	INT36603	Positive_regulation of CTSH	1	0.01	0	0.46
157	INT293504	Regulation of Gene_expression of Uchl1	1	0.03	0.31	0.46
158	INT6533	Binding of Ctsl1	2	0.34	0	0.45
159	INT129144	Regulation of Localization of Casp3	1	0.26	0.84	0.44
160	INT259608	Protein_catabolism of Ctss	1	0.11	1.22	0.44
161	INT133316	Localization of CTSK	5	0.52	2.43	0.43
162	INT153436	Positive_regulation of Localization of Casp3	3	0.49	2.12	0.43
163	INT271483	Regulation of Regulation of Uchl1	1	0.01	0.58	0.41
164	INT197157	Gene_expression of CAPN7	19	0.51	11.33	0.4
165	INT155293	Positive_regulation of Protein_catabolism of Casp3	3	0.45	1.7	0.4
166	INT277727	Negative_regulation of Casp7	2	0.21	2.42	0.4
167	INT117939	Transcription of Casp1	1	0.27	0.89	0.4
168	INT202908	Binding of Uchl1	1	0.08	0.27	0.4
169	INT348083	Positive_regulation of Ctsl1	1	0.08	0.21	0.4
170	INT117938	Negative_regulation of Transcription of Casp1	1	0.22	0.89	0.4
171	INT142872	Regulation of Casp8	6	0.29	3.11	0.39
172	INT181179	Binding of CYLD	4	0.43	7.06	0.39
173	INT240482	Regulation of Ctsk	1	0.45	1.77	0.39
174	INT229855	Gene_expression of Casp7	3	0.28	2.3	0.38
175	INT165472	Localization of CTSC	2	0.68	0.38	0.38
176	INT122508	Positive_regulation of Localization of CAPN2	1	0.23	0.18	0.38
177	INT224637	Protein_catabolism of Ctsl	1	0.12	0.76	0.37
178	INT122509	Regulation of Localization of CAPN2	1	0.12	0.28	0.37
179	INT159990	Negative_regulation of Negative_regulation of Ctsk	1	0.13	0.41	0.37
180	INT122505	Regulation of CAPN2	1	0.20	0.28	0.37
181	INT316037	Positive_regulation of Localization of Ctss	1	0.12	1.07	0.37
182	INT135045	Gene_expression of Atxn3	34	0.78	11.59	0.36
183	INT185432	Negative_regulation of CYLD	4	0.52	3.19	0.35
184	INT342958	Positive_regulation of Gene_expression of CAPN3	1	0.69	0.66	0.35
185	INT165916	Negative_regulation of Localization of Casp3	2	0.41	2.41	0.34
186	INT122507	Negative_regulation of Localization of CAPN2	1	0.21	0.4	0.34
187	INT137502	Regulation of Positive_regulation of Casp9	1	0.32	0.52	0.32
188	INT168388	Negative_regulation of Positive_regulation of Casp9	1	0.20	1.43	0.3
189	INT6536	Negative_regulation of Binding of Ctsl1	1	0.39	0	0.3
190	INT153774	Regulation of CTSK	2	0.28	0.1	0.29
191	INT122506	Gene_expression of CAPN2	1	0.26	0.19	0.29
192	INT135546	Positive_regulation of Positive_regulation of CASP8	13	0.31	10.97	0.28
193	INT298971	Positive_regulation of Localization of Casp1	2	0.06	0.97	0.28
194	INT126366	Regulation of Binding of CTSB	1	0.01	0.31	0.28
195	INT176260	Binding of CASP8	5	0.36	2.73	0.27
196	INT123126	Protein_catabolism of Uchl1	1	0.64	0.2	0.27
197	INT159323	Negative_regulation of Protein_catabolism of CASP8	1	0.31	0.59	0.27
198	INT75299	Binding of Atxn3	8	0.43	5.3	0.26
199	INT167206	Positive_regulation of Positive_regulation of Casp8	4	0.49	2.11	0.26
200	INT285009	Negative_regulation of Gene_expression of Casp7	1	0.16	1	0.26