GO:0008385

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Name IkappaB kinase complex
Categary Component
Go Slim No
Go Link GO:0008385
Unique Molecular Interactions 95
Total Molecular Interactions 159
Total Single Events 776
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for IkappaB kinase complex. They are ordered first by their pain relevance and then by number of times they were reported for IkappaB kinase complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT289173 PYCARD Regulation of MFGE8 1 0.05 0 0.96
2 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
3 INT136795 Spp1 Positive_regulation of Chuk 1 0.11 1.54 0.77
4 INT278812 PYCARD Positive_regulation of VTA1 1 0.09 0.11 0.71
5 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
6 INT150391 Binding of MEFV and PYCARD 4 0.14 3 0.48
7 INT338086 PYCARD Positive_regulation of TCEA1 1 0.10 0 0.47
8 INT338083 Binding of LEFTY1 and PYCARD 1 0.02 0 0.46
9 INT228323 PYCARD Positive_regulation of FIG4 1 0.17 0 0.42
10 INT338085 Binding of PYCARD and GOPC 1 0.05 0 0.39
11 INT278813 Binding of NOVA2 and PYCARD 1 0.13 0 0.38
12 INT349664 PYCARD Negative_regulation of Localization of AR 1 0.05 0 0.32
13 INT349662 Binding of PYCARD and Negative_regulation of Localization of AR 1 0.05 0 0.32
14 INT289178 Regulation of PYCARD Regulation of MFGE8 1 0.05 0 0.32
15 INT289175 PYCARD Regulation of behavior 1 0.03 0 0.31
16 INT289179 PYCARD Regulation of TW 1 0.02 0 0.3
17 INT143722 Binding of Ikbkg and Nfkb1 1 0.02 0.79 0.29
18 INT254206 Il10 Negative_regulation of Chuk 1 0.05 0.59 0.29
19 INT143724 Binding of Ikbkg and Nfkbia 1 0.02 0.79 0.29
20 INT143721 Positive_regulation of Binding of Ikbkg and Nfkb1 1 0.03 0.8 0.29
21 INT351770 Binding of Il6 and Ikbkb 1 0.10 1.06 0.29
22 INT143723 Positive_regulation of Binding of Ikbkg and Nfkbia 1 0.02 0.8 0.29
23 INT254208 Il10 Negative_regulation of Regulation of Chuk 1 0.05 0.59 0.29
24 INT324801 Positive_regulation of Binding of Chuk and Irak1 1 0.03 0.86 0.28
25 INT324825 Binding of Chuk and Myd88 1 0.03 0.86 0.28
26 INT324810 Binding of Chuk and Irak1 1 0.02 0.85 0.28
27 INT324806 Positive_regulation of Binding of Chuk and Myd88 1 0.04 0.86 0.28
28 INT143725 Chuk Negative_regulation of Phosphorylation of Nfkb1 1 0.17 0.71 0.26
29 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25
30 INT311989 Binding of Chuk and Mthfd1 1 0.05 0.56 0.24
31 INT274584 Binding of PSTPIP1 and PYCARD 1 0.13 1.34 0.22
32 INT289174 PYCARD Positive_regulation of MFGE8 1 0.05 0 0.21
33 INT258456 PYCARD Negative_regulation of Localization of Tms 1 0.02 0.05 0.21
34 INT258455 Tms Negative_regulation of Localization of PYCARD 1 0.02 0.05 0.21
35 INT349668 Binding of HRH1 and PYCARD 1 0.00 0.37 0.21
36 INT289176 PYCARD Regulation of Localization of MFGE8 1 0.05 0 0.18
37 INT289177 PYCARD Regulation of Gene_expression of TW 1 0.03 0 0.18
38 INT65744 Map3k7 Negative_regulation of Gene_expression of Il2 1 0.10 0.74 0.18
39 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17
40 INT137647 PYCARD Positive_regulation of NLN 1 0.02 0.08 0.15
41 INT137646 Negative_regulation of PYCARD Positive_regulation of NLN 1 0.02 0.08 0.15
42 INT222874 NDUFA6 Regulation of Chuk 1 0.01 1.57 0.15
43 INT97517 Binding of PYCARD and Mefv 1 0.07 0.78 0.14
44 INT222876 Binding of NDUFA6 and Chuk 1 0.02 2.02 0.13
45 INT222875 Binding of NDUFA6 and Positive_regulation of Chuk 1 0.01 0.74 0.13
46 INT139787 Negative_regulation of TNFAIP8 Positive_regulation of IKBKG 1 0.10 0.89 0.11
47 INT139783 TNFAIP8 Positive_regulation of IKBKG 1 0.12 0.88 0.11
48 INT139786 TNFAIP8 Positive_regulation of Phosphorylation of IKBKG 1 0.12 0.89 0.11
49 INT139792 TNFAIP8 Positive_regulation of Protein_catabolism of IKBKG 1 0.12 0.89 0.11
50 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09
51 INT222873 NDUFA6 Negative_regulation of Phosphorylation of Chuk 1 0.01 0.24 0.08
52 INT88752 Map3k7 Negative_regulation of Ednra 1 0.05 0 0.08
53 INT163619 Ikbkb Regulation of Rela 1 0.18 0.23 0.08
54 INT163618 Chuk Regulation of Rela 1 0.16 0.23 0.08
55 INT312645 Binding of DNAJA3 and Musk 1 0.08 0.96 0.07
56 INT250153 Binding of PRNP and IKBKG 1 0.09 2.83 0.06
57 INT250150 Binding of IKBKG and SACM1L 1 0.00 2.78 0.06
58 INT222878 NDUFA6 Negative_regulation of Chuk 1 0.01 2.06 0.05
59 INT349663 Binding of TFPI and PYCARD 1 0.04 0 0.04
60 INT348024 Binding of Chuk and Traf3 1 0.13 0.65 0.04
61 INT349661 PYCARD Positive_regulation of AR 1 0.08 0 0.03
62 INT274573 Positive_regulation of Binding of MEFV and PYCARD 1 0.09 0.06 0.03
63 INT283348 Binding of Tmie and Erc1 1 0.00 0 0
64 INT268186 Positive_regulation of Binding of Gpi1 and Erc1 1 0.01 0.17 0
65 INT336288 PYCARD Positive_regulation of SMN1 1 0.13 0 0
66 INT348018 Map3k7 Positive_regulation of Chuk 1 0.19 0.06 0
67 INT222868 Binding of Chuk and Pkn1 1 0.00 0 0
68 INT283358 Binding of Srr and Erc1 1 0.00 0.07 0
69 INT283349 Srr Positive_regulation of Gene_expression of Erc1 1 0.26 0 0
70 INT312642 DNAJA3 Positive_regulation of Musk 1 0.08 0.37 0
71 INT349666 Binding of AR and PYCARD 1 0.06 0 0
72 INT283342 Binding of Bsn and Erc1 1 0.00 0 0
73 INT222871 Binding of Chuk and Ikbkg 1 0.02 0 0
74 INT268198 Prnp Positive_regulation of Erc1 1 0.04 0.26 0
75 INT268194 Erc1 Positive_regulation of Gene_expression of Prnp 1 0.05 0.2 0
76 INT268182 Positive_regulation of Binding of Prnp and Erc1 1 0.06 0.1 0
77 INT348035 Map3k7 Positive_regulation of Binding of Chuk 1 0.20 0.06 0
78 INT222870 Traf2 Positive_regulation of Chuk 1 0.03 0.37 0
79 INT348529 TNF Positive_regulation of Gene_expression of IKBKG 1 0.01 0.23 0
80 INT283355 Srr Positive_regulation of Erc1 1 0.11 0 0
81 INT268189 Binding of Gpi1 and Erc1 1 0.01 0.17 0
82 INT268188 Binding of Prnp and Erc1 1 0.04 0.27 0
83 INT268181 Binding of Trf and Erc1 1 0.02 0.07 0
84 INT268179 Negative_regulation of Binding of Trf and Erc1 1 0.03 0.07 0
85 INT268176 Positive_regulation of Erc1 Positive_regulation of Gene_expression of Prnp 1 0.06 0.2 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for IkappaB kinase complex. They are ordered first by their pain relevance and then by number of times they were reported in IkappaB kinase complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27
2 INT97516 Binding of PYCARD 46 0.36 7.06 7.85
3 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02
4 INT1766 Negative_regulation of PYCARD 25 0.37 6.54 6.76
5 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17
6 INT113700 Positive_regulation of Chuk 30 0.41 21.17 5.69
7 INT166765 Localization of PYCARD 21 0.70 3.89 5.66
8 INT133231 Regulation of PYCARD 18 0.39 5.02 4.44
9 INT12772 Positive_regulation of Positive_regulation of IKBKG 9 0.69 0.84 4.12
10 INT117075 Negative_regulation of Ikbkb 3 0.26 9.51 3.91
11 INT12770 Negative_regulation of Positive_regulation of IKBKG 7 0.56 0.34 3.02
12 INT174958 Negative_regulation of Chuk 21 0.25 8.73 2.96
13 INT53443 Gene_expression of IKBKG 15 0.65 7.5 2.71
14 INT222845 Gene_expression of Chuk 27 0.52 25.15 2.67
15 INT12769 Localization of IKBKG 6 0.15 1.66 2.43
16 INT132893 Binding of CHUK 1 0.00 0.63 2.25
17 INT132892 Positive_regulation of CHUK 3 0.08 1.62 2.01
18 INT21565 Binding of Ikbkb 4 0.17 1.89 1.64
19 INT132890 Positive_regulation of Binding of CHUK 1 0.00 0.44 1.6
20 INT132891 Gene_expression of CHUK 1 0.01 0.47 1.58
21 INT34912 Regulation of IKBKG 5 0.08 2.41 1.42
22 INT68774 Positive_regulation of Ikbkb 2 0.21 0.99 1.39
23 INT143716 Phosphorylation of Chuk 16 0.41 5.25 1.35
24 INT217438 Binding of Chuk 24 0.25 7.29 1.29
25 INT228328 Positive_regulation of Gene_expression of PYCARD 7 0.34 0.27 1.23
26 INT267652 Negative_regulation of Gene_expression of PYCARD 6 0.37 2.35 1.22
27 INT119348 Binding of IKBKG 7 0.15 4.03 1.14
28 INT135615 Positive_regulation of IKBKB 3 0.59 6.16 1.1
29 INT71370 Regulation of Ikbkb 3 0.12 1.69 1.08
30 INT307280 Regulation of Gene_expression of PYCARD 2 0.39 0.27 1.02
31 INT117435 Negative_regulation of IKBKB 3 0.37 2.67 0.97
32 INT40520 Gene_expression of Ikbkb 3 0.30 1.51 0.86
33 INT228326 Positive_regulation of Localization of PYCARD 3 0.41 0 0.8
34 INT111059 Regulation of Ikbkb 1 0.26 0.56 0.71
35 INT91330 Regulation of Localization of IKBKG 1 0.01 0.76 0.61
36 INT91328 Regulation of Gene_expression of IKBKG 1 0.01 0.75 0.61
37 INT143713 Positive_regulation of Phosphorylation of Chuk 4 0.25 1.38 0.58
38 INT272887 Negative_regulation of Ikbkb 2 0.29 2.18 0.55
39 INT232453 Negative_regulation of DNAJA3 1 0.41 0 0.54
40 INT116553 Phosphorylation of Ikbkb 3 0.37 1.35 0.5
41 INT135620 Regulation of IKBKB 1 0.39 1.23 0.48
42 INT12768 Negative_regulation of Localization of IKBKG 1 0.07 0 0.48
43 INT117436 Binding of IKBKB 2 0.26 1.44 0.47
44 INT202494 Regulation of Chuk 5 0.20 2.17 0.46
45 INT222850 Positive_regulation of Gene_expression of Chuk 7 0.34 4.91 0.44
46 INT222840 Gene_expression of Ikbkg 2 0.52 3.15 0.42
47 INT37187 Positive_regulation of Localization of IKBKG 1 0.10 0.35 0.4
48 INT73684 Gene_expression of Erc1 2 0.65 0.39 0.39
49 INT141493 Negative_regulation of CHUK 2 0.07 1.15 0.38
50 INT278150 Positive_regulation of Negative_regulation of Ikbkb 1 0.22 0.81 0.37
51 INT349671 Phosphorylation of PYCARD 1 0.33 0 0.35
52 INT278148 Negative_regulation of Gene_expression of Ikbkb 1 0.19 0.64 0.34
53 INT228331 Positive_regulation of Negative_regulation of PYCARD 1 0.34 0 0.32
54 INT222838 Negative_regulation of Gene_expression of Chuk 5 0.25 3.43 0.31
55 INT140380 Phosphorylation of Ikbkb 2 0.31 1.5 0.29
56 INT140381 Positive_regulation of Phosphorylation of Ikbkb 1 0.12 1.21 0.29
57 INT143715 Positive_regulation of Ikbkg 1 0.03 0.8 0.29
58 INT278145 Positive_regulation of Positive_regulation of Chuk 2 0.29 1.45 0.28
59 INT278153 Regulation of Negative_regulation of Ikbkb 1 0.20 0.65 0.27
60 INT222844 Positive_regulation of Binding of Chuk 1 0.13 0.58 0.26
61 INT65739 Gene_expression of Map3k7 1 0.54 1.41 0.25
62 INT307281 Regulation of Regulation of PYCARD 1 0.30 0 0.24
63 INT308984 Positive_regulation of Negative_regulation of Ikbkb 1 0.35 1.44 0.24
64 INT338089 Negative_regulation of Regulation of PYCARD 1 0.35 0 0.24
65 INT30059 Regulation of Positive_regulation of IKBKG 1 0.08 0 0.24
66 INT206047 Negative_regulation of Positive_regulation of Chuk 2 0.11 0.6 0.23
67 INT119347 Regulation of Binding of IKBKG 1 0.18 0.28 0.22
68 INT278149 Localization of Ikbkb 1 0.33 0.97 0.22
69 INT117434 Negative_regulation of Binding of IKBKB 1 0.30 1.39 0.2
70 INT222836 Negative_regulation of Phosphorylation of Chuk 5 0.16 0.98 0.19
71 INT145832 Gene_expression of IKBKB 1 0.02 1.23 0.19
72 INT222837 Regulation of Binding of Chuk 1 0.12 1.18 0.18
73 INT296766 Transcription of IKBKG 1 0.04 1.02 0.17
74 INT227586 Negative_regulation of Gene_expression of IKBKG 1 0.21 0 0.16
75 INT302181 Positive_regulation of Negative_regulation of Chuk 1 0.04 0.54 0.16
76 INT245861 Gene_expression of Erc1 7 0.65 1.18 0.15
77 INT139795 Negative_regulation of IKBKG 2 0.21 1.14 0.15
78 INT243679 Protein_catabolism of Chuk 1 0.02 0 0.14
79 INT139796 Positive_regulation of Phosphorylation of IKBKG 1 0.25 0.89 0.11
80 INT139800 Positive_regulation of Protein_catabolism of IKBKG 1 0.25 0.89 0.11
81 INT139794 Negative_regulation of Phosphorylation of IKBKG 1 0.21 0.89 0.11
82 INT278151 Negative_regulation of Negative_regulation of Ikbkb 1 0.19 0.61 0.11
83 INT139802 Phosphorylation of IKBKG 1 0.41 0.88 0.11
84 INT139793 Protein_catabolism of IKBKG 1 0.50 0.88 0.11
85 INT139797 Negative_regulation of Protein_catabolism of IKBKG 1 0.29 0.89 0.11
86 INT245855 Binding of Erc1 2 0.06 0.54 0.09
87 INT53444 Positive_regulation of Gene_expression of IKBKG 1 0.42 0.56 0.09
88 INT202489 Localization of Chuk 3 0.53 1.63 0.08
89 INT347977 Negative_regulation of Gene_expression of Ikbkg 1 0.33 1.28 0.08
90 INT312616 Binding of DNAJA3 1 0.07 0.58 0.07
91 INT349674 Regulation of Positive_regulation of PYCARD 2 0.11 0.34 0.05
92 INT354591 Negative_regulation of Positive_regulation of PYCARD 1 0.05 0.34 0.05
93 INT222835 Localization of Ikbkg 2 0.18 0.56 0.04
94 INT307913 Negative_regulation of Binding of PYCARD 1 0.37 0 0.04
95 INT350468 Regulation of Ikbkg 1 0.11 0.61 0.04
96 INT350469 Positive_regulation of Localization of Ikbkg 1 0.12 0.57 0.04
97 INT283331 Localization of Erc1 1 0.73 0 0.03
98 INT274594 Positive_regulation of Binding of PYCARD 1 0.09 0.07 0.03
99 INT298990 Localization of Ikbkb 1 0.05 0.2 0.03
100 INT298981 Positive_regulation of Localization of Ikbkb 1 0.04 0.2 0.03
101 INT245853 Positive_regulation of Erc1 2 0.07 0.2 0
102 INT245857 Localization of Erc1 2 0.10 0.52 0
103 INT268158 Positive_regulation of Positive_regulation of Erc1 1 0.05 0.2 0
104 INT266482 Phosphorylation of Map3k7 1 0.18 0.26 0
105 INT222834 Binding of Ikbkg 1 0.06 0.05 0
106 INT296998 Regulation of Erc1 1 0.44 0.52 0
107 INT202479 Positive_regulation of Localization of Chuk 1 0.35 0.33 0
108 INT268169 Negative_regulation of Erc1 1 0.04 0.07 0
109 INT244144 Transcription of PYCARD 1 0.49 0.49 0
110 INT120906 Positive_regulation of Phosphorylation of Ikbkb 1 0.11 0.46 0
111 INT268166 Positive_regulation of Gene_expression of Erc1 1 0.05 0.36 0
112 INT350472 Negative_regulation of Ikbkg 1 0.17 0.17 0
113 INT351769 Transcription of Ikbkb 1 0.28 0 0
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