GO:0008637

Name apoptotic mitochondrial changes Categary Process Go Slim No Go Link GO:0008637

Unique Molecular Interactions 717 Total Molecular Interactions 1004 Total Single Events 7148 Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for apoptotic mitochondrial changes. They are ordered first by their pain relevance and then by number of times they were reported for apoptotic mitochondrial changes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT132225	Negative_regulation of Binding of Akt1 and Sh2d6	1	0.10	3.92	7.2
2	INT338167	Binding of CDKN2A and MC1R	1	0.42	6.14	5.76
3	INT132231	Negative_regulation of Binding of Akt1 and Pik3cg	1	0.34	1.96	3.6
4	INT317522	Akt1 Positive_regulation of Phosphorylation of Nos1	1	0.43	0.4	3.13
5	INT168758	Hist1h1t Positive_regulation of Phosphorylation of Akt1	2	0.02	0.44	2.79
6	INT317551	Binding of Akt1 and Oprm1	1	0.19	0.21	2.74
7	INT121726	Ngf Positive_regulation of Phosphorylation of Akt1	1	0.37	1.4	2.34
8	INT114432	Oprl1 Positive_regulation of Akt1	1	0.18	0.08	2.2
9	INT132229	Binding of Akt1 and Sh2d6	1	0.09	0.98	1.8
10	INT169464	Akt1 Positive_regulation of Egfr	1	0.28	1.63	1.7
11	INT322412	PPBP Negative_regulation of Phosphorylation of Akt1	1	0.01	0	1.65
12	INT156008	Bcl2 Regulation of Localization of Aifm1	1	0.17	1.92	1.47
13	INT214372	Ptprq Positive_regulation of Akt1	1	0.04	0.88	1.43
14	INT214369	Pik3cb Positive_regulation of Akt1	1	0.56	0.87	1.41
15	INT73597	Positive_regulation of BAX Positive_regulation of Casp1	1	0.06	0.69	1.28
16	INT73598	BAX Positive_regulation of Casp1	1	0.06	0.63	1.27
17	INT162163	CDKN2A Positive_regulation of PLD2	1	0.24	0	1.24
18	INT317548	Positive_regulation of Akt1 Positive_regulation of Prkca	1	0.15	0	1.11
19	INT317516	Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1	1	0.17	0.1	1.11
20	INT323175	PRKCA Positive_regulation of Akt1	1	0.02	0	1.1
21	INT151218	Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1	1	0.00	0.26	1.03
22	INT317554	Akt1 Regulation of Negative_regulation of Oprm1	1	0.21	0.07	1
23	INT317567	Binding of Akt1 and Nos1	1	0.22	0	0.96
24	INT62109	SLC25A4 Negative_regulation of Localization of Gh	1	0.06	0	0.94
25	INT137923	VEGFA Positive_regulation of Phosphorylation of Akt1	1	0.05	0	0.93
26	INT114883	Akt1 Regulation of Pik3r1	2	0.16	0.65	0.92
27	INT317541	Oprd1 Negative_regulation of Akt1	1	0.06	0	0.91
28	INT249012	Binding of Akt1 and Gabrg1	1	0.01	0	0.9
29	INT132226	Binding of Akt1 and Pik3cg	1	0.30	0.49	0.9
30	INT62111	SLC25A4 Negative_regulation of Regulation of Ghrh	1	0.41	0	0.9
31	INT199109	Binding of Akt1 and Arhgdia	1	0.02	2.73	0.87
32	INT34740	BID Regulation of Gene_expression of PLOD1	1	0.01	0	0.83
33	INT317556	Phosphorylation of Gopc Positive_regulation of Akt1	1	0.10	0.08	0.82
34	INT317514	Akt1 Regulation of Localization of Oprm1	1	0.21	0.07	0.82
35	INT228255	Binding of Akt1 and Pten	2	0.43	1.78	0.8
36	INT111888	Akt1 Regulation of Regulation of Oprm1	1	0.04	0	0.77
37	INT134043	Jak2 Positive_regulation of Akt1	1	0.31	0.22	0.76
38	INT335592	Ltp Positive_regulation of Positive_regulation of Akt1	1	0.01	0.19	0.74
39	INT106527	Akt1 Positive_regulation of Jun	1	0.05	0.53	0.74
40	INT276213	Pten Regulation of Phosphorylation of Akt1	1	0.51	0.61	0.72
41	INT16048	MAX Positive_regulation of SLC25A4	1	0.50	0	0.71
42	INT298728	Akt1 Positive_regulation of Rela	1	0.01	1.03	0.67
43	INT151559	Atp2a1 Negative_regulation of Positive_regulation of CASP3	1	0.06	0.68	0.66
44	INT289357	Ngfr Positive_regulation of Akt1	1	0.03	3.1	0.66
45	INT308668	Akt1 Positive_regulation of Nos3	3	0.05	4.61	0.65
46	INT296793	Akt1 Positive_regulation of Gene_expression of Bax	1	0.11	0.75	0.65
47	INT296790	Tlr9 Regulation of Bax	1	0.14	0.76	0.65
48	INT296791	Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax	1	0.11	0.8	0.65
49	INT134047	Fitm1 Positive_regulation of Phosphorylation of Akt1	1	0.05	0.21	0.63
50	INT134044	Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1	1	0.05	0.21	0.63
51	INT112701	Bid Regulation of RFFL	1	0.00	0.52	0.62
52	INT200808	Binding of Akt1 and Insrr	2	0.00	0.98	0.61
53	INT282286	Akt1 Positive_regulation of Pak1	1	0.15	0.24	0.61
54	INT112699	Bid Regulation of Bax	1	0.25	0.51	0.61
55	INT139901	Ins1 Positive_regulation of Akt1	9	0.31	4.58	0.6
56	INT248994	Binding of Akt1 and Ptar1	1	0.00	0	0.58
57	INT323176	PRKCA Positive_regulation of Phosphorylation of Akt1	1	0.02	0	0.56
58	INT302832	Tnfsf10 Positive_regulation of Akt1	1	0.04	1.63	0.56
59	INT114064	Agtr2 Positive_regulation of Phosphorylation of Akt1	1	0.24	0.41	0.54
60	INT282284	Cpox Positive_regulation of Akt1	1	0.02	0.47	0.54
61	INT343913	Binding of FOS and Smad3	1	0.19	0.92	0.54
62	INT282282	Ptger2 Positive_regulation of Akt1	1	0.03	0.47	0.54
63	INT162994	Binding of Akt1 and Trib3	1	0.04	0.09	0.54
64	INT127320	Gpx3 Regulation of Akt1	2	0.00	3.11	0.53
65	INT317523	Oprm1 Positive_regulation of Gene_expression of Akt1	1	0.32	0.05	0.53
66	INT151558	ERLEC1 Regulation of Atp2a1	1	0.00	0.64	0.53
67	INT109307	Pik3r1 Positive_regulation of Phosphorylation of Akt1	1	0.29	0.4	0.53
68	INT151557	NARG2 Regulation of Atp2a1	1	0.01	0.64	0.53
69	INT317574	Oprm1 Positive_regulation of Akt1	1	0.22	0.05	0.52
70	INT151221	Negative_regulation of SIGMAR1 Negative_regulation of Akt1	1	0.00	0.13	0.51
71	INT102844	Pdc Regulation of Akt1	1	0.03	0	0.49
72	INT134042	Jak2 Regulation of Akt1	1	0.18	0.13	0.47
73	INT309126	Edc4 Positive_regulation of Akt1	1	0.02	0.99	0.47
74	INT309144	Dlat Positive_regulation of Akt1	1	0.03	0.99	0.47
75	INT276207	Binding of Akt1 and Myo1f	1	0.11	0.05	0.47
76	INT114065	Akt1 Regulation of Gene_expression of Insr	1	0.13	0.28	0.46
77	INT95404	Map3k1 Positive_regulation of Phosphorylation of Ephb1	1	0.12	0.16	0.46
78	INT276218	Binding of Akt1 and Pten	1	0.26	0.08	0.46
79	INT95408	Map3k1 Positive_regulation of Ephb1	1	0.12	0.16	0.46
80	INT238638	Gopc Negative_regulation of Gene_expression of Bax	1	0.04	0.85	0.45
81	INT139900	Kcne2 Positive_regulation of Akt1	1	0.06	2.95	0.44
82	INT121850	CASP8 Positive_regulation of Protein_catabolism of BID	2	0.21	1.81	0.43
83	INT116613	Lnpep Negative_regulation of Gene_expression of BAX	1	0.42	0.62	0.43
84	INT116612	Lnpep Negative_regulation of BAX	1	0.42	0.62	0.42
85	INT348785	Ins1 Positive_regulation of Phosphorylation of Akt1	1	0.17	3.5	0.42
86	INT322396	Hist1h1t Positive_regulation of Akt1	1	0.01	0	0.42
87	INT322395	Akt1 Regulation of Pik3cb	1	0.08	0	0.42
88	INT122749	Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1	1	0.07	0.24	0.41
89	INT354704	Binding of MAP3K1 and Pick1	1	0.00	0.76	0.41
90	INT121856	BID Regulation of ROS1	1	0.05	0.52	0.41
91	INT121854	AKT1 Regulation of BID	1	0.17	0.52	0.41
92	INT276216	Binding of Akt1 and Ins1	2	0.03	2.61	0.4
93	INT231842	Pcdh8 Positive_regulation of Akt1	1	0.00	1.59	0.4
94	INT158032	Binding of CDKN2A and KRT20	1	0.28	0.59	0.4
95	INT322409	Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1	1	0.04	0	0.4
96	INT324802	Binding of Cd24a and Siglecg	1	0.03	1.34	0.4
97	INT166155	Ccr9 Positive_regulation of Akt1	1	0.58	2.14	0.39
98	INT62110	SLC25A4 Negative_regulation of Regulation of Gh	1	0.06	0	0.39
99	INT146611	Ins1 Positive_regulation of Phosphorylation of Akt1	9	0.23	4.34	0.37
100	INT172213	Binding of BAX and BCL2L1	3	0.22	4.02	0.35
101	INT148243	Binding of Akt1 and Kit	1	0.03	0.44	0.35
102	INT122758	Positive_regulation of Helt Positive_regulation of Akt1	1	0.00	0.2	0.35
103	INT288208	Binding of Mapk14 and Positive_regulation of Akt1	1	0.01	0.42	0.35
104	INT122756	Helt Positive_regulation of Akt1	1	0.00	0.2	0.35
105	INT309118	Dlat Positive_regulation of Positive_regulation of Akt1	1	0.03	0.32	0.34
106	INT204071	HP Positive_regulation of Gene_expression of CDKN2A	1	0.00	3.48	0.34
107	INT155061	Stat3 Negative_regulation of Bax	1	0.22	3.71	0.34
108	INT249019	Gabrg1 Positive_regulation of Akt1	1	0.02	0	0.34
109	INT130803	MC1R Regulation of Positive_regulation of Cdkn2a	1	0.17	0.82	0.34
110	INT196820	Negative_regulation of Ppp1cc Positive_regulation of Akt1	1	0.00	0	0.34
111	INT214377	Akt1 Regulation of Amph	1	0.15	0	0.33
112	INT165580	Binding of Akt1 and Grin2b	1	0.02	0.2	0.32
113	INT255934	Tauph Positive_regulation of Map3k1	1	0.00	0.1	0.32
114	INT255946	MAPK14 Positive_regulation of Map3k1	1	0.04	0.1	0.32
115	INT255740	Pik3r1 Positive_regulation of Akt1	5	0.24	2.42	0.31
116	INT303063	Akt1 Negative_regulation of Gene_expression of Syn1	1	0.09	0.45	0.31
117	INT165921	Tlr4 Positive_regulation of Akt1	1	0.16	0.75	0.31
118	INT165920	Negative_regulation of Tlr4 Positive_regulation of Akt1	1	0.13	0.75	0.31
119	INT163762	MDM2 Positive_regulation of Gene_expression of BAX	1	0.27	0.86	0.3
120	INT122575	Akt1 Positive_regulation of Phosphorylation of Nos3	4	0.37	3.89	0.29
121	INT132367	Lgals1 Positive_regulation of Akt1	1	0.22	0.13	0.28
122	INT317533	Akt1 Positive_regulation of Nos1	1	0.43	0	0.28
123	INT274932	Binding of Insrr and Map3k1	1	0.00	0	0.28
124	INT149322	Amph Positive_regulation of Akt1	1	0.39	0	0.27
125	INT274947	Binding of Map3k1 and Grip1	1	0.00	0	0.27
126	INT237927	BCL2 Positive_regulation of BAX	2	0.24	2.22	0.26
127	INT107189	Atp2a2 Negative_regulation of Atp2a1	1	0.27	0	0.26
128	INT237919	BAX Positive_regulation of Protein_catabolism of PARP1	1	0.03	1.41	0.26
129	INT223930	Binding of Akt1 and Pik3cb	1	0.07	0.35	0.26
130	INT147593	Binding of CDK4 and CDKN2A	1	0.42	0.23	0.26
131	INT147592	Positive_regulation of Binding of CDK4 and CDKN2A	1	0.44	0.23	0.26
132	INT223929	Negative_regulation of Binding of Akt1 and Pik3cb	1	0.08	0.36	0.26
133	INT303082	Akt1 Negative_regulation of Gene_expression of Mafk	1	0.20	0.37	0.26
134	INT308661	Akt1 Positive_regulation of Chuk	1	0.02	0.6	0.25
135	INT314047	THL Negative_regulation of Phosphorylation of Akt1	1	0.14	0.71	0.25
136	INT326094	Akt1 Positive_regulation of Gene_expression of Gopc	1	0.03	0.49	0.24
137	INT326092	Gene_expression of Akt1 Negative_regulation of Gopc	1	0.03	0.55	0.24
138	INT326093	Akt1 Positive_regulation of Gopc	1	0.03	0.43	0.23
139	INT323173	THRA Positive_regulation of Phosphorylation of Akt1	1	0.00	0	0.22
140	INT260844	NRP2 Positive_regulation of Akt1	1	0.00	0.73	0.22
141	INT116467	Vegfa Positive_regulation of Akt1	1	0.33	1.41	0.21
142	INT323174	DBT Positive_regulation of Phosphorylation of Akt1	1	0.01	0	0.21
143	INT116468	VEGFA Positive_regulation of Akt1	1	0.04	1.39	0.21
144	INT289356	Binding of Akt1 and Fgf2	1	0.03	0.82	0.21
145	INT309661	C5 Positive_regulation of Phosphorylation of Akt1	1	0.51	0.45	0.21
146	INT324824	Positive_regulation of Binding of Cd24a and Siglecg	1	0.03	0.68	0.2
147	INT221237	Prkca Regulation of Phosphorylation of Akt1	1	0.01	0.28	0.2
148	INT64964	Binding of Alb and Cd24	1	0.02	0.2	0.2
149	INT224688	Pten Regulation of Akt1	1	0.04	1.12	0.19
150	INT324822	Binding of Cd24a and Hsp90aa1	1	0.10	0.71	0.19
151	INT324797	Binding of Cd24a and Hmgb1	1	0.19	0.66	0.19
152	INT279965	STAT3 Regulation of Transcription of BCL2L1	1	0.10	2.31	0.19
153	INT334631	Igf1r Positive_regulation of Phosphorylation of Akt1	1	0.19	0.5	0.18
154	INT303058	Akt1 Negative_regulation of Gene_expression of Syt1	1	0.21	0.43	0.18
155	INT221231	Pdpk1 Positive_regulation of Akt1	1	0.09	0.13	0.18
156	INT221244	Pdpk1 Positive_regulation of Phosphorylation of Akt1	1	0.09	0.13	0.18
157	INT155063	Csf2 Negative_regulation of Gene_expression of Bax	1	0.27	1.46	0.18
158	INT253129	Ins1 Regulation of Phosphorylation of Akt1	3	0.11	1.66	0.17
159	INT179841	Il11 Regulation of Positive_regulation of Akt1	1	0.08	0.07	0.17
160	INT155066	Csf2 Negative_regulation of Bax	1	0.12	1.89	0.17
161	INT349475	Regulation of Bax Regulation of Bcl2	1	0.07	1.35	0.17
162	INT282858	Bpifa2 Negative_regulation of Akt1	1	0.05	0.91	0.17
163	INT226209	Pik3cb Positive_regulation of Phosphorylation of Akt1	1	0.10	1.16	0.17
164	INT282861	Bpifa2 Negative_regulation of Phosphorylation of Akt1	1	0.05	0.91	0.17
165	INT155232	TXNIP Regulation of BAX	1	0.23	0.15	0.17
166	INT218937	Akt1 Positive_regulation of Parn	1	0.01	0.65	0.16
167	INT316484	Akt1 Positive_regulation of Positive_regulation of Stat3	1	0.01	0.87	0.16
168	INT343475	Epo Regulation of Akt1	1	0.18	0.41	0.16
169	INT343478	Epo Regulation of Gene_expression of Akt1	1	0.40	0.41	0.16
170	INT218930	Akt1 Positive_regulation of Xiap	1	0.06	0.64	0.16
171	INT336891	Epo Negative_regulation of Transcription of Bax	1	0.10	0.68	0.16
172	INT224697	TNF Positive_regulation of Akt1	1	0.01	0	0.15
173	INT136855	Arf5 Positive_regulation of Cdkn2a	1	0.07	1.8	0.15
174	INT293698	Positive_regulation of Binding of Akt1 and Plek	1	0.05	0.12	0.15
175	INT292750	Akt1 Positive_regulation of Bcl2	1	0.01	1.67	0.15
176	INT349476	Bax Regulation of Bcl2	1	0.07	1.33	0.15
177	INT293695	Binding of Akt1 and Plek	1	0.03	0.12	0.15
178	INT292749	Akt1 Positive_regulation of Ctnnd2	1	0.09	1.73	0.15
179	INT231844	Pcdh8 Negative_regulation of Positive_regulation of Akt1	1	0.00	0.63	0.15
180	INT224694	Il1 Positive_regulation of Akt1	1	0.01	0	0.15
181	INT293699	Regulation of Binding of Akt1 and Plek	1	0.04	0.12	0.15
182	INT292748	Akt1 Negative_regulation of Positive_regulation of Casp3	1	0.01	1.81	0.15
183	INT213005	Hdl1 Positive_regulation of Akt1	3	0.19	3.81	0.14
184	INT253122	Ins1 Positive_regulation of Akt1	2	0.15	1.81	0.14
185	INT314856	Binding of Cdc7 and Cdkn2a	1	0.28	1.34	0.14
186	INT302146	CDKN2A Regulation of CDKN1B	1	0.11	0.51	0.14
187	INT130918	HMHA1 Positive_regulation of BAX	1	0.04	1.37	0.14
188	INT231274	Nrg1 Regulation of Gene_expression of Akt1	1	0.19	0	0.14
189	INT302144	CDKN2A Regulation of CDKN1A	1	0.11	0.51	0.14
190	INT226205	Negative_regulation of Akt1 Positive_regulation of Casp3	1	0.04	0.71	0.14
191	INT177916	PRKG1 Positive_regulation of Positive_regulation of MAP3K1	1	0.05	1.07	0.14
192	INT355226	VEGFA Positive_regulation of Akt1	1	0.04	0.27	0.14
193	INT314852	Binding of Cdkn2a and Tgfbr3	1	0.28	1.15	0.14
194	INT273040	Vip Regulation of Bax	1	0.23	1.69	0.13
195	INT293697	Dock2 Positive_regulation of Akt1	1	0.14	0.08	0.13
196	INT252336	Il2 Positive_regulation of Akt1	1	0.01	0	0.13
197	INT263321	Akt1 Regulation of Bad	1	0.00	0.74	0.13
198	INT282862	Bpifa2 Negative_regulation of Positive_regulation of Akt1	1	0.05	0.75	0.13
199	INT182478	Binding of Akt1 and Cx3cr1	1	0.11	0.12	0.13
200	INT320765	Dsg2 Positive_regulation of Akt1	1	0.48	0.74	0.13

Single Events

The table below shows the top 100 pain related interactions that have been reported for apoptotic mitochondrial changes. They are ordered first by their pain relevance and then by number of times they were reported in apoptotic mitochondrial changes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT103924	Positive_regulation of Akt1	359	0.69	158.94	60.34
2	INT117713	Phosphorylation of Akt1	275	0.82	95.82	54.34
3	INT40777	Positive_regulation of Akt1	163	0.69	59.41	49.43
4	INT106525	Phosphorylation of Akt1	436	0.82	183.81	47.82
5	INT114881	Gene_expression of Akt1	227	0.78	102.49	31.81
6	INT112707	Negative_regulation of Akt1	89	0.59	28.85	27.76
7	INT122570	Negative_regulation of Akt1	173	0.59	91.44	25.53
8	INT100423	Gene_expression of Bax	141	0.75	98.43	24.48
9	INT40776	Gene_expression of Akt1	99	0.77	34.91	24.39
10	INT117718	Positive_regulation of Phosphorylation of Akt1	112	0.69	39.26	24.09
11	INT73593	Gene_expression of BAX	173	0.76	147.81	20.94
12	INT109511	Gene_expression of Bax	133	0.78	113.22	14.36
13	INT94774	Regulation of CDKN2A	43	0.60	44.41	13.99
14	INT78472	Gene_expression of CDKN2A	223	0.78	173.76	13.61
15	INT109304	Positive_regulation of Phosphorylation of Akt1	113	0.69	40.92	13.49
16	INT26534	Regulation of Akt1	34	0.61	14.47	11.86
17	INT75137	Regulation of Akt1	74	0.48	37.89	9.7
18	INT102110	Positive_regulation of Gene_expression of Bax	42	0.67	35.77	9.51
19	INT102106	Positive_regulation of Bax	48	0.67	30.62	9.28
20	INT73596	Positive_regulation of Gene_expression of BAX	43	0.67	40.97	9.22
21	INT120967	Negative_regulation of Phosphorylation of Akt1	47	0.57	23.67	8.98
22	INT104396	Positive_regulation of Positive_regulation of Akt1	44	0.55	14.78	8.69
23	INT106522	Negative_regulation of Phosphorylation of Akt1	65	0.58	34.44	7.83
24	INT73595	Positive_regulation of BAX	61	0.61	56.97	7.82
25	INT92138	Binding of CDKN2A	28	0.37	25.64	7.47
26	INT103925	Negative_regulation of Positive_regulation of Akt1	32	0.58	15.19	7.39
27	INT102107	Negative_regulation of Gene_expression of Bax	30	0.57	29.48	7.33
28	INT126748	Positive_regulation of Positive_regulation of Akt1	26	0.55	11.15	7.08
29	INT98837	Positive_regulation of Bax	72	0.61	63.14	6.41
30	INT123787	Gene_expression of Bid	25	0.66	16	6.35
31	INT117721	Positive_regulation of Gene_expression of Akt1	22	0.69	6.26	6.08
32	INT114882	Positive_regulation of Gene_expression of Akt1	45	0.69	21.29	6.06
33	INT125467	Positive_regulation of Gene_expression of CDKN2A	35	0.63	39.07	5.56
34	INT13295	Positive_regulation of Cdkn2a	18	0.68	13.02	5.47
35	INT89794	Positive_regulation of CDKN2A	58	0.67	50.18	5.38
36	INT145929	Regulation of Bax	20	0.60	18.12	5.35
37	INT87420	Gene_expression of BCL2L1	56	0.75	48.84	5.32
38	INT109513	Positive_regulation of Gene_expression of Bax	37	0.67	29.52	5.06
39	INT134657	Localization of Akt1	37	0.68	11.58	4.62
40	INT122569	Negative_regulation of Gene_expression of Akt1	34	0.54	17.15	4.44
41	INT99504	Negative_regulation of Bax	19	0.56	8.89	4.44
42	INT101858	Negative_regulation of BAX	25	0.57	23.77	4.16
43	INT75136	Binding of Akt1	27	0.27	8.81	4.15
44	INT84686	Regulation of BAX	26	0.49	28.54	4.13
45	INT139898	Negative_regulation of Positive_regulation of Akt1	15	0.42	4.66	4.06
46	INT123752	Regulation of Bax	19	0.60	16.45	4
47	INT112692	Localization of Bax	31	0.80	20.97	3.98
48	INT101857	Negative_regulation of BCL2L1	22	0.57	23.56	3.95
49	INT132223	Negative_regulation of Negative_regulation of Akt1	6	0.42	2.75	3.66
50	INT136692	Localization of Akt1	12	0.78	2.14	3.65
51	INT137634	Localization of Aifm1	17	0.80	11.8	3.45
52	INT124579	Localization of BAX	35	0.78	30.31	3.43
53	INT104928	Positive_regulation of BID	10	0.67	6.9	3.41
54	INT111482	Gene_expression of Cd24a	23	0.72	13.74	3.37
55	INT78471	Regulation of Gene_expression of CDKN2A	13	0.45	12.52	3.28
56	INT157687	Regulation of Gene_expression of Akt1	9	0.62	4.96	3.27
57	INT104930	Protein_catabolism of BID	12	0.86	10.82	3.15
58	INT117720	Negative_regulation of Gene_expression of Akt1	11	0.37	2.33	3.08
59	INT78248	Negative_regulation of Cdkn2a	17	0.59	15.15	2.8
60	INT117715	Regulation of Phosphorylation of Akt1	15	0.51	3.23	2.78
61	INT156016	Binding of BCL2L1	10	0.36	7.42	2.64
62	INT108555	Positive_regulation of HK2	5	0.29	4.91	2.62
63	INT159121	Positive_regulation of Map3k1	10	0.45	8.79	2.6
64	INT214355	Binding of Akt1	13	0.36	3.72	2.59
65	INT92141	Negative_regulation of CDKN2A	53	0.57	44.23	2.48
66	INT338170	Regulation of Regulation of CDKN2A	1	0.44	0.96	2.46
67	INT149975	Negative_regulation of Ppif	1	0.41	0.44	2.36
68	INT102146	Phosphorylation of Bax	4	0.66	3.48	2.35
69	INT151574	Gene_expression of Aifm1	5	0.62	3.63	2.34
70	INT97748	Positive_regulation of BCL2L1	12	0.67	9.83	2.26
71	INT91836	Negative_regulation of Gene_expression of BCL2L1	9	0.49	8.59	2.25
72	INT138286	Regulation of Positive_regulation of Akt1	13	0.45	4.93	2.22
73	INT102752	Positive_regulation of Gene_expression of BCL2L1	14	0.67	13.8	2.19
74	INT103966	Negative_regulation of Gene_expression of BAX	9	0.56	7.95	2.14
75	INT77627	Regulation of Gene_expression of BAX	14	0.44	15.09	2.12
76	INT154970	Localization of Bax	15	0.74	11.12	2.11
77	INT94772	Gene_expression of Cdkn2a	14	0.75	8.25	2.04
78	INT112698	Gene_expression of Bid	8	0.64	6.52	1.97
79	INT98836	Transcription of Bax	6	0.69	5.04	1.96
80	INT95400	Negative_regulation of Map3k1	3	0.15	0.78	1.92
81	INT134442	Transcription of Bax	14	0.67	7.6	1.9
82	INT135540	Negative_regulation of Bax	16	0.48	11.8	1.89
83	INT134443	Binding of Bax	10	0.47	5.62	1.84
84	INT152629	Positive_regulation of Bid	6	0.46	6.74	1.78
85	INT142236	Regulation of Phosphorylation of Akt1	13	0.61	5.02	1.75
86	INT156005	Positive_regulation of Gene_expression of Aifm1	1	0.36	1.56	1.75
87	INT104883	Positive_regulation of Positive_regulation of Bax	4	0.45	4.05	1.74
88	INT165332	Negative_regulation of Negative_regulation of Akt1	5	0.42	3.27	1.7
89	INT71788	Gene_expression of MAP3K1	13	0.70	4.9	1.66
90	INT97749	Regulation of BCL2L1	10	0.41	9.72	1.65
91	INT117714	Regulation of Positive_regulation of Akt1	3	0.61	0.44	1.61
92	INT17094	Negative_regulation of SLC25A4	3	0.41	3.82	1.52
93	INT162463	Localization of BID	6	0.73	7.47	1.5
94	INT146785	Positive_regulation of Localization of Bax	7	0.69	6.16	1.47
95	INT121859	Negative_regulation of Protein_catabolism of BID	3	0.42	2.1	1.46
96	INT109512	Negative_regulation of Gene_expression of Bax	12	0.42	8.04	1.44
97	INT78470	Negative_regulation of Gene_expression of CDKN2A	14	0.59	14.44	1.38
98	INT141037	Positive_regulation of Aifm1	3	0.45	3.32	1.38
99	INT50785	Gene_expression of Map3k1	6	0.44	4.22	1.32
100	INT112695	Negative_regulation of Protein_catabolism of Bax	3	0.36	1.72	1.3
101	INT154969	Positive_regulation of Localization of Bax	4	0.64	3.42	1.27
102	INT104926	Positive_regulation of Protein_catabolism of BID	2	0.49	2.12	1.22
103	INT112693	Protein_catabolism of Bax	5	0.74	3.17	1.2
104	INT121861	Regulation of BID	4	0.31	2.73	1.15
105	INT141189	Negative_regulation of Transcription of Bax	1	0.41	1.42	1.14
106	INT184720	Negative_regulation of Smad3	8	0.55	5.23	1.1
107	INT207203	Transcription of Akt1	6	0.67	3.73	1.1
108	INT141036	Negative_regulation of Aifm1	1	0.00	1.26	1.07
109	INT42104	Regulation of Cdkn2a	4	0.44	5.67	1.06
110	INT191050	Positive_regulation of Negative_regulation of Akt1	6	0.31	1.82	1.03
111	INT152809	Negative_regulation of Hk2	2	0.57	1.95	0.98
112	INT175507	Regulation of Gene_expression of Bax	13	0.50	10.91	0.95
113	INT134660	Positive_regulation of Localization of Akt1	10	0.32	6.33	0.94
114	INT338168	Positive_regulation of Binding of CDKN2A	1	0.49	0.52	0.94
115	INT98134	Binding of BAX	17	0.39	11.45	0.93
116	INT156015	Negative_regulation of Protein_catabolism of BCL2L1	1	0.42	1.23	0.93
117	INT156014	Protein_catabolism of BCL2L1	1	0.64	1.23	0.93
118	INT163508	Regulation of Gene_expression of Akt1	3	0.45	1.65	0.92
119	INT156017	Positive_regulation of Binding of BCL2L1	1	0.49	1.21	0.91
120	INT214709	Gene_expression of Hk2	5	0.76	9.11	0.86
121	INT137512	Positive_regulation of Positive_regulation of BAX	5	0.49	4.91	0.85
122	INT142025	Localization of Bid	13	0.69	8.24	0.84
123	INT80671	Gene_expression of HK2	6	0.70	3.23	0.84
124	INT80665	Negative_regulation of Gene_expression of HK2	4	0.39	2.41	0.84
125	INT140794	Gene_expression of Smad3	22	0.64	9.41	0.83
126	INT71784	Positive_regulation of Gene_expression of MAP3K1	4	0.34	4.8	0.82
127	INT144697	Regulation of Gene_expression of Bax	8	0.37	9.5	0.81
128	INT82896	Transcription of BAX	3	0.67	4.61	0.8
129	INT50784	Positive_regulation of Gene_expression of Map3k1	2	0.06	0.94	0.8
130	INT340843	Binding of Cd24a	1	0.02	0.24	0.8
131	INT55560	Binding of SLC25A4	8	0.36	1.94	0.79
132	INT144429	Positive_regulation of Cdkn2a	7	0.58	4.05	0.78
133	INT148984	Positive_regulation of Localization of BAX	6	0.48	5.29	0.77
134	INT129115	Negative_regulation of Cdkn2a	16	0.50	17.03	0.76
135	INT177933	Positive_regulation of MAP3K1	6	0.42	4.13	0.76
136	INT151170	Regulation of Regulation of Akt1	2	0.45	3.28	0.73
137	INT112419	Negative_regulation of Positive_regulation of HK2	1	0.00	0.41	0.69
138	INT146711	Positive_regulation of Hk2	2	0.18	1.27	0.68
139	INT123784	Positive_regulation of Gene_expression of Bid	4	0.40	2.41	0.66
140	INT207204	Regulation of Transcription of Akt1	3	0.35	1.41	0.66
141	INT281466	Negative_regulation of Regulation of Akt1	1	0.33	0.31	0.63
142	INT172204	Gene_expression of SLC25A4	8	0.70	4.11	0.62
143	INT251026	Negative_regulation of Phosphorylation of CDKN2A	5	0.42	5.02	0.62
144	INT177886	Positive_regulation of Gene_expression of Cdkn2a	3	0.67	3.42	0.62
145	INT147598	Negative_regulation of Positive_regulation of CDKN2A	3	0.41	1.47	0.59
146	INT111602	Negative_regulation of Gene_expression of MAP3K1	1	0.06	0.58	0.58
147	INT133765	Regulation of Gene_expression of Bid	1	0.29	0.45	0.58
148	INT19047	Localization of SLC25A4	5	0.73	2.73	0.57
149	INT242011	Localization of Cdkn2a	4	0.73	2.49	0.54
150	INT144701	Gene_expression of Cdkn2a	15	0.75	8.42	0.53
151	INT218900	Regulation of Negative_regulation of Akt1	3	0.15	1.73	0.53
152	INT340842	Regulation of Gene_expression of Cd24a	1	0.42	0.08	0.53
153	INT176242	Binding of Bax	10	0.42	10.18	0.52
154	INT107187	Gene_expression of Atp2a1	1	0.43	0	0.52
155	INT144431	Positive_regulation of Transcription of Cdkn2a	1	0.41	1.11	0.51
156	INT144426	Transcription of Cdkn2a	1	0.42	1.11	0.51
157	INT64961	Binding of Cd24	4	0.15	0.64	0.5
158	INT276189	Regulation of Localization of Akt1	1	0.43	0.2	0.5
159	INT102108	Protein_catabolism of Bax	8	0.64	5.69	0.48
160	INT326696	Regulation of Cd24a	2	0.44	0	0.48
161	INT134446	Positive_regulation of Binding of Bax	1	0.49	0.72	0.48
162	INT148985	Positive_regulation of Positive_regulation of BID	1	0.53	0.84	0.48
163	INT229243	Negative_regulation of Phosphorylation of BAX	1	0.18	2.32	0.47
164	INT95401	Phosphorylation of Map3k1	1	0.21	0.16	0.46
165	INT204293	Protein_catabolism of Bid	9	0.65	6.07	0.45
166	INT220088	Positive_regulation of Positive_regulation of CDKN2A	4	0.49	4.04	0.44
167	INT252657	Positive_regulation of Phosphorylation of CDKN2A	2	0.45	3.09	0.42
168	INT42105	Regulation of Positive_regulation of Cdkn2a	1	0.44	0.33	0.42
169	INT152059	Regulation of Transcription of Bax	1	0.26	0.07	0.42
170	INT105888	Phosphorylation of BAX	9	0.80	4.78	0.4
171	INT45887	Positive_regulation of SLC25A4	2	0.45	0.9	0.4
172	INT135802	Positive_regulation of Negative_regulation of Bax	2	0.41	0.57	0.4
173	INT137640	Negative_regulation of Localization of Aifm1	2	0.58	0.39	0.39
174	INT121860	Negative_regulation of BID	2	0.29	1.92	0.38
175	INT121862	Negative_regulation of Negative_regulation of BID	1	0.29	0.54	0.38
176	INT229233	Positive_regulation of Phosphorylation of BAX	1	0.21	1.94	0.38
177	INT218691	Phosphorylation of Smad3	1	0.28	3	0.38
178	INT157804	Phosphorylation of Smad3	18	0.77	8.15	0.35
179	INT204069	Negative_regulation of Positive_regulation of Bax	5	0.31	3.08	0.34
180	INT279985	Transcription of BCL2L1	5	0.69	3.76	0.34
181	INT169538	Negative_regulation of Localization of Bax	3	0.49	1.41	0.34
182	INT123783	Transcription of Bid	2	0.08	0.68	0.34
183	INT184482	Positive_regulation of Positive_regulation of Bax	5	0.41	4.7	0.33
184	INT221191	Negative_regulation of Localization of Bax	4	0.38	2.85	0.33
185	INT196323	Localization of Cdkn2a	8	0.73	9.1	0.32
186	INT116196	Protein_catabolism of Bid	7	0.66	6.24	0.32
187	INT251025	Phosphorylation of CDKN2A	4	0.61	3.19	0.32
188	INT321348	Positive_regulation of Localization of Akt1	1	0.30	0.08	0.32
189	INT164827	Negative_regulation of Atp2a1	1	0.43	0.15	0.32
190	INT62108	Positive_regulation of Localization of SLC25A4	1	0.49	0	0.31
191	INT109530	Negative_regulation of Positive_regulation of BAX	3	0.42	3.01	0.3
192	INT140795	Positive_regulation of Gene_expression of Smad3	3	0.48	3.16	0.3
193	INT102721	Negative_regulation of MAP3K1	2	0.53	8.03	0.3
194	INT82900	Positive_regulation of Transcription of BAX	2	0.49	1.86	0.29
195	INT228477	Positive_regulation of Gene_expression of Cdkn2a	2	0.11	1.3	0.29
196	INT102111	Positive_regulation of Protein_catabolism of Bax	2	0.45	1.14	0.27
197	INT239955	Gene_expression of Atp2a1	7	0.29	0.78	0.26
198	INT184624	Localization of CDKN2A	8	0.74	7.87	0.25
199	INT239464	Regulation of Negative_regulation of Akt1	3	0.31	0.37	0.25
200	INT262797	Regulation of Gene_expression of Smad3	2	0.34	2.27	0.25