GO:0009086

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Name methionine biosynthetic process
Categary Process
Go Slim No
Go Link GO:0009086
Unique Molecular Interactions 116
Total Molecular Interactions 145
Total Single Events 1411
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for methionine biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for methionine biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
2 INT213973 Binding of Pax3 and Mthfd1 1 0.00 0.16 1.99
3 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
4 INT254243 Binding of HOMER1 and MRI1 1 0.03 1.99 1.57
5 INT158762 Binding of Vwf and Mthfr 1 0.05 1.85 1.37
6 INT27425 Mtr Positive_regulation of Gene_expression of Il1f5 1 0.06 0 1.3
7 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
8 INT168185 Binding of PLXNA2 and MRI1 1 0.25 0.78 1.08
9 INT107563 Penk Regulation of Mtr 1 0.00 0.1 1.04
10 INT107565 Hps4 Regulation of Mtr 1 0.00 0.1 1.04
11 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88
12 INT213972 Calca Regulation of Mthfd1 1 0.05 0.19 0.8
13 INT54669 Mtr Regulation of Gene_expression of Il1 1 0.02 0.2 0.77
14 INT54668 Mtr Regulation of Gene_expression of Il1f5 1 0.00 0.2 0.76
15 INT46657 Mtr Regulation of Gnrh1 1 0.01 0 0.71
16 INT46656 Mtr Regulation of Prl 1 0.05 0 0.7
17 INT213971 Mthfd1 Positive_regulation of Gene_expression of Pax3 1 0.00 0.14 0.68
18 INT27426 Mtr Positive_regulation of Localization of Il1f5 1 0.06 0 0.63
19 INT127778 Mthfd1 Regulation of Positive_regulation of Mthfr 1 0.01 0.71 0.62
20 INT184243 Mthfd1 Negative_regulation of Gene_expression of Il4 1 0.02 0.88 0.56
21 INT184242 Mthfd1 Negative_regulation of Gene_expression of Csf2 1 0.03 0.87 0.56
22 INT184244 Mthfd1 Negative_regulation of Gene_expression of TNF 1 0.01 0.88 0.56
23 INT350169 Binding of DMD and MRI1 1 0.11 3.08 0.54
24 INT50935 Mtr Regulation of Gene_expression of Il6 1 0.00 0 0.53
25 INT176010 Binding of MTHFR and ZNF677 1 0.00 0.7 0.5
26 INT28863 Mtr Negative_regulation of Dhfr 1 0.04 0.87 0.45
27 INT326514 Sugt1 Negative_regulation of MTHFR 1 0.01 0.77 0.42
28 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39
29 INT252292 CCL21 Regulation of Binding of Mthfd1 1 0.03 0.41 0.33
30 INT350701 Mthfd1 Regulation of Gene_expression of Cd4 1 0.03 1.46 0.33
31 INT276605 Tlr4 Positive_regulation of Gene_expression of Mthfd1 1 0.06 0.37 0.31
32 INT188789 Binding of pad and Mthfr 1 0.06 4.6 0.31
33 INT276602 Paf Positive_regulation of Gene_expression of Mthfd1 1 0.13 0.37 0.31
34 INT323926 MRM1 Positive_regulation of MRI1 1 0.04 0.44 0.26
35 INT311989 Binding of Chuk and Mthfd1 1 0.05 0.56 0.24
36 INT252340 Binding of Cd70 and Mthfd1 1 0.03 1.05 0.24
37 INT343911 Mthfd1 Positive_regulation of Gene_expression of IL12A 1 0.00 0.41 0.23
38 INT35014 IFNA1 Positive_regulation of ADI1 1 0.03 0.17 0.23
39 INT223570 Binding of Mri1 and Uhrf2 1 0.02 0.56 0.22
40 INT223569 Binding of cy and Mri1 1 0.00 0.57 0.22
41 INT35013 IFNG Positive_regulation of ADI1 1 0.22 0.16 0.21
42 INT354519 Cacna1c Regulation of Mri1 1 0.00 1.15 0.21
43 INT188698 Hand1 Positive_regulation of Localization of Mthfd1 1 0.06 0.71 0.2
44 INT50934 Mtr Positive_regulation of Gene_expression of Il6 1 0.00 0 0.2
45 INT213974 Vip Positive_regulation of Localization of Mthfd1 1 0.08 0.41 0.17
46 INT204790 Binding of Lat2 and Mthfd1 1 0.05 0.85 0.16
47 INT305371 Binding of IL1RL1 and MRI1 1 0.09 0.95 0.15
48 INT293696 Mthfd1 Positive_regulation of Akt1 1 0.05 0.08 0.13
49 INT271478 Tacr1 Regulation of Binding of Mthfd1 1 0.09 0.48 0.13
50 INT332581 Binding of Nqo1 and MRI1 1 0.01 1.68 0.12
51 INT289407 Mthfd1 Negative_regulation of Cd55 1 0.01 0.6 0.12
52 INT188594 Binding of Mthfd1 and Radil 1 0.01 0.25 0.12
53 INT289404 Mthfd1 Positive_regulation of Hc 1 0.04 0.58 0.12
54 INT289405 Mthfd1 Positive_regulation of C3ar1 1 0.00 0.53 0.11
55 INT284552 Binding of Cd8a and Mthfd1 2 0.03 1.32 0.1
56 INT252344 Binding of Cd40 and Mthfd1 2 0.16 0.34 0.08
57 INT297317 Positive_regulation of Mthfd1 Positive_regulation of Gene_expression of Il18 1 0.07 0.79 0.08
58 INT297309 Positive_regulation of Mthfd1 Positive_regulation of Gene_expression of Ifng 1 0.07 0.79 0.08
59 INT311988 Il4 Positive_regulation of Mthfd1 1 0.08 0.28 0.08
60 INT311986 Csf2 Positive_regulation of Mthfd1 1 0.03 0.28 0.08
61 INT184113 Socs1 Negative_regulation of Mthfd1 1 0.08 0.5 0.08
62 INT245985 Binding of MTR and Mtrr 1 0.06 0.8 0.07
63 INT184121 Socs1 Regulation of Mthfd1 1 0.05 0.44 0.07
64 INT11237 PAEP Positive_regulation of MRI1 1 0.07 0.46 0.07
65 INT193564 Binding of STMN1 and MRI1 1 0.07 0.06 0.07
66 INT245986 MTR Regulation of Mthfr 1 0.07 0.18 0.05
67 INT284565 Gopc Positive_regulation of Mthfd1 1 0.11 0.22 0.05
68 INT245981 Negative_regulation of TCN1 Regulation of Mthfr 1 0.03 0.18 0.05
69 INT284564 Binding of Itgax and Mthfd1 1 0.08 0.09 0.05
70 INT245984 TCN1 Regulation of Mtrr 1 0.02 0.18 0.05
71 INT245982 TCN1 Regulation of Mthfr 1 0.04 0.18 0.05
72 INT245983 Negative_regulation of TCN1 Regulation of Mtrr 1 0.02 0.18 0.05
73 INT245974 Mtrr Regulation of Mthfr 1 0.07 0.18 0.05
74 INT314967 Binding of Cd4 and Mthfd1 1 0.09 0.11 0.04
75 INT245987 Binding of MTR and Mthfr 1 0.11 0.48 0.03
76 INT252346 Binding of Apcs and Mthfd1 1 0.02 0.13 0.03
77 INT324798 Hmgb1 Positive_regulation of Positive_regulation of Mthfd1 1 0.04 0.16 0.03
78 INT311870 Positive_regulation of Binding of Cd8a and Mthfd1 1 0.00 0.32 0.03
79 INT252339 Binding of Cd40 and Positive_regulation of Mthfd1 1 0.04 0.19 0
80 INT189108 Mthfd1 Positive_regulation of H2 1 0.00 0.17 0
81 INT143067 Mthfd1 Positive_regulation of Serpine1 1 0.00 0 0
82 INT189106 Mthfd1 Positive_regulation of Gene_expression of H2 1 0.00 0.17 0
83 INT259081 Binding of Hbb-ar and ENOPH1 1 0.00 1.36 0
84 INT252331 Binding of Cd40lg and Mthfd1 1 0.03 0.1 0
85 INT252842 ENOPH1 Positive_regulation of Gene_expression of Ddit3 1 0.06 2.42 0
86 INT143066 Mthfd1 Regulation of Gene_expression of Plau 1 0.00 0 0
87 INT189112 Tap1 Positive_regulation of Gene_expression of Mthfd1 1 0.07 0.3 0
88 INT315941 Binding of Tlr4 and Mthfd1 1 0.05 0 0
89 INT252337 Mthfd1 Positive_regulation of Gene_expression of Cd80 1 0.04 0.1 0
90 INT252805 ENOPH1 Positive_regulation of Gene_expression of ESR1 1 0.00 2.46 0
91 INT284556 Tspan7 Positive_regulation of Mthfd1 1 0.00 1.66 0
92 INT299373 Binding of DBT and ENOPH1 1 0.00 0.24 0
93 INT143065 Mthfd1 Positive_regulation of Gene_expression of Serpine1 1 0.00 0 0
94 INT286884 Binding of Gopc and Mthfd1 1 0.02 0 0
95 INT293694 Binding of Ccl21a and Mthfd1 1 0.01 0 0
96 INT314969 Binding of Lbr and Mthfd1 1 0.01 0 0
97 INT252333 Mthfd1 Positive_regulation of Gene_expression of Cd86 1 0.04 0.1 0
98 INT189114 Mtap1a Positive_regulation of Gene_expression of Mthfd1 1 0.01 0.3 0
99 INT252792 ENOPH1 Positive_regulation of Gene_expression of DDIT3 1 0.03 2.42 0
100 INT284566 Tlr3 Positive_regulation of Mthfd1 1 0.17 2.43 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for methionine biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in methionine biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98
2 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03
3 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68
4 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35
5 INT180497 Binding of MRI1 45 0.42 28.35 14.77
6 INT70265 Regulation of MRI1 42 0.39 30.95 14.18
7 INT1672 Gene_expression of Mtr 18 0.67 3.39 13.32
8 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29
9 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96
10 INT71763 Gene_expression of Mri1 33 0.58 12.56 8.6
11 INT156827 Localization of MRI1 25 0.65 16.06 8.33
12 INT9802 Positive_regulation of Mtr 9 0.60 3.69 7.43
13 INT211701 Positive_regulation of Mri1 20 0.34 20.64 6.69
14 INT46518 Localization of Mtr 12 0.65 1.31 6.55
15 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45
16 INT138833 Binding of MTHFR 12 0.46 16.08 6.4
17 INT71764 Positive_regulation of Mri1 24 0.44 12.31 5.67
18 INT10006 Regulation of Mtr 9 0.23 3.56 5.42
19 INT145888 Negative_regulation of Mthfd1 27 0.41 8.98 5.4
20 INT12250 Negative_regulation of Mtr 19 0.50 6.9 5.35
21 INT121954 Binding of Mthfr 17 0.44 13.47 4.66
22 INT188588 Localization of Mthfd1 20 0.49 9.19 4.37
23 INT9803 Positive_regulation of Gene_expression of Mtr 3 0.60 1.45 4.36
24 INT24751 Gene_expression of Mtr 8 0.36 1.34 3.34
25 INT109448 Negative_regulation of MTHFR 8 0.58 7.62 3.11
26 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91
27 INT138652 Negative_regulation of Mthfr 13 0.54 7.3 2.88
28 INT188590 Positive_regulation of Gene_expression of Mthfd1 23 0.49 16.56 2.84
29 INT124063 Gene_expression of MTHFR 9 0.65 6.22 2.67
30 INT124417 Gene_expression of Mthfr 8 0.60 8.65 2.53
31 INT44544 Gene_expression of ENOPH1 18 0.76 10.28 2.35
32 INT186094 Binding of Mri1 14 0.20 7.8 2.35
33 INT204175 Localization of Mri1 12 0.60 2.73 2.35
34 INT237252 Localization of Mri1 7 0.45 4.42 2.23
35 INT127777 Positive_regulation of Mthfr 4 0.38 3.8 2.09
36 INT142049 Regulation of Mthfr 6 0.41 4.73 2
37 INT89253 Regulation of Mthfd1 14 0.23 8.1 1.94
38 INT157816 Positive_regulation of Positive_regulation of Mthfd1 5 0.33 3.73 1.93
39 INT25582 Regulation of Mtr 2 0.03 0.4 1.76
40 INT215987 Regulation of Mri1 4 0.30 2.1 1.54
41 INT47446 Regulation of Localization of Mtr 1 0.05 0.07 1.42
42 INT204772 Negative_regulation of Gene_expression of Mthfd1 10 0.15 3.48 1.29
43 INT2595 Binding of Mtr 1 0.29 0 1.24
44 INT237247 Regulation of Mri1 6 0.27 4.64 1.2
45 INT204170 Binding of Mri1 5 0.22 4.45 1.11
46 INT47131 Negative_regulation of Localization of Mtr 1 0.41 0 1.06
47 INT211700 Negative_regulation of Mri1 5 0.29 2.06 1.04
48 INT24750 Negative_regulation of Mtr 1 0.22 0.06 1.04
49 INT123536 Positive_regulation of MTHFR 7 0.57 4.74 1
50 INT177587 Regulation of Gene_expression of MRI1 4 0.22 0.88 0.97
51 INT10373 Gene_expression of ADI1 8 0.25 5.97 0.92
52 INT265569 Negative_regulation of Binding of MRI1 1 0.16 0.79 0.87
53 INT96480 Negative_regulation of Positive_regulation of Mthfd1 5 0.30 0.99 0.83
54 INT355872 Negative_regulation of Positive_regulation of Mri1 1 0.07 2.31 0.75
55 INT188591 Positive_regulation of Binding of Mthfd1 3 0.26 0.9 0.69
56 INT155639 Regulation of Negative_regulation of Mthfr 1 0.56 0.76 0.66
57 INT127776 Regulation of Mthfd1 1 0.20 0.65 0.64
58 INT176013 Negative_regulation of Binding of MTHFR 2 0.42 1.18 0.63
59 INT153699 Regulation of MTHFR 2 0.45 1.54 0.63
60 INT237251 Positive_regulation of Gene_expression of Mri1 1 0.30 1.13 0.63
61 INT10007 Regulation of Gene_expression of Mtr 2 0.23 1.17 0.61
62 INT14109 Positive_regulation of Mtr 1 0.03 0.49 0.6
63 INT287810 Regulation of Gene_expression of Mthfd1 4 0.17 2.14 0.58
64 INT327120 Positive_regulation of Positive_regulation of MRI1 1 0.05 0 0.5
65 INT253325 Positive_regulation of Negative_regulation of MTHFR 2 0.44 1.22 0.49
66 INT213967 Positive_regulation of Localization of Mthfd1 4 0.30 2.52 0.46
67 INT245316 Negative_regulation of ADI1 1 0.01 0.77 0.45
68 INT245315 Negative_regulation of Gene_expression of ADI1 1 0.01 0.77 0.45
69 INT50548 Binding of ENOPH1 8 0.35 2.64 0.43
70 INT237243 Regulation of Localization of Mri1 1 0.27 1.41 0.43
71 INT342823 Positive_regulation of Localization of Mri1 1 0.11 0.65 0.4
72 INT209498 Negative_regulation of Negative_regulation of Mthfd1 1 0.09 0 0.4
73 INT188788 Negative_regulation of Gene_expression of Mthfr 2 0.33 1.3 0.39
74 INT342465 Protein_catabolism of MRI1 1 0.04 0.79 0.38
75 INT262351 Regulation of Localization of Mri1 1 0.02 0.82 0.37
76 INT54952 Binding of Mtr 1 0.03 0.58 0.37
77 INT282427 Negative_regulation of Gene_expression of Mri1 1 0.07 0.75 0.35
78 INT166893 Negative_regulation of Gene_expression of Mtr 1 0.03 0.57 0.33
79 INT237244 Positive_regulation of Transcription of Mri1 1 0.30 1.17 0.32
80 INT237254 Transcription of Mri1 1 0.41 1.12 0.32
81 INT237249 Negative_regulation of Transcription of Mri1 1 0.26 1.12 0.32
82 INT280121 Negative_regulation of Binding of Mthfd1 2 0.41 0.38 0.3
83 INT225138 Positive_regulation of ENOPH1 4 0.15 2 0.28
84 INT225139 Positive_regulation of Binding of ENOPH1 1 0.12 0.7 0.28
85 INT282213 Negative_regulation of Regulation of Mtr 1 0.01 0.82 0.27
86 INT264998 Regulation of Binding of MRI1 1 0.31 1.34 0.27
87 INT176012 Localization of MTHFR 1 0.74 0.38 0.24
88 INT266791 Positive_regulation of Gene_expression of ENOPH1 1 0.04 0.85 0.22
89 INT35015 Positive_regulation of ADI1 2 0.15 2.75 0.21
90 INT138653 Positive_regulation of Negative_regulation of Mthfr 1 0.45 0.53 0.2
91 INT293693 Phosphorylation of Mthfd1 1 0.34 0.18 0.18
92 INT345376 Positive_regulation of Localization of Mri1 1 0.19 0.51 0.16
93 INT268246 Positive_regulation of Regulation of Mri1 1 0.05 0.9 0.16
94 INT50551 Negative_regulation of Binding of ENOPH1 1 0.42 1.05 0.15
95 INT10372 Binding of ADI1 3 0.10 1.67 0.12
96 INT259060 Negative_regulation of ENOPH1 2 0.04 2.64 0.12
97 INT289385 Negative_regulation of Localization of Mthfd1 1 0.03 0.6 0.12
98 INT50552 Transcription of ENOPH1 2 0.67 0.45 0.1
99 INT50549 Localization of ENOPH1 2 0.64 0.45 0.09
100 INT253327 Negative_regulation of Positive_regulation of MTHFR 1 0.41 1.17 0.09
101 INT12251 Regulation of Negative_regulation of Mtr 1 0.19 0 0.09
102 INT215985 Positive_regulation of Gene_expression of Mri1 1 0.25 0.18 0.08
103 INT245968 Gene_expression of Mtrr 1 0.27 0.27 0.07
104 INT245969 Binding of Mtrr 1 0.19 0.8 0.07
105 INT200068 Phosphorylation of ENOPH1 1 0.17 0.11 0.06
106 INT245972 Regulation of Mtrr 1 0.21 1.1 0.06
107 INT288754 Negative_regulation of Positive_regulation of Mtr 1 0.11 0.1 0.05
108 INT143346 Localization of Mthfr 2 0.54 0.4 0.04
109 INT96481 Regulation of Positive_regulation of Mthfd1 2 0.02 1.3 0.04
110 INT245971 Localization of Mtrr 1 0.34 0.16 0.04
111 INT288765 Positive_regulation of Negative_regulation of Mtr 1 0.12 0.09 0.04
112 INT336885 Regulation of Binding of Mri1 1 0.03 0.14 0.04
113 INT188589 Transcription of Mthfd1 1 0.35 0.07 0.03
114 INT175217 Regulation of ENOPH1 5 0.06 0.44 0
115 INT234117 Positive_regulation of Binding of MRI1 2 0.44 0.19 0
116 INT234406 Localization of ADI1 2 0.06 4.52 0
117 INT234401 Positive_regulation of Positive_regulation of ADI1 1 0.03 1.46 0
118 INT142048 Transcription of Mthfr 1 0.51 0.18 0
119 INT68931 Negative_regulation of Localization of ENOPH1 1 0.04 0 0
120 INT234429 Positive_regulation of Localization of ADI1 1 0.03 1.92 0
121 INT349972 Negative_regulation of Mri1 1 0.04 0.61 0
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