GO:0009410

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Name response to xenobiotic stimulus
Categary Process
Go Slim No
Go Link GO:0009410
Unique Molecular Interactions 121
Total Molecular Interactions 162
Total Single Events 1509
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to xenobiotic stimulus. They are ordered first by their pain relevance and then by number of times they were reported for response to xenobiotic stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT158144 Binding of Gpx1 and Glyat 2 0.31 0 1.29
2 INT22726 Positive_regulation of Ahr Positive_regulation of Hrtrt1 1 0.22 0.18 0.95
3 INT22725 Ahr Positive_regulation of Hrtrt1 1 0.22 0.18 0.95
4 INT164607 Positive_regulation of GSR Positive_regulation of Gpx1 1 0.01 0.33 0.81
5 INT164606 GSR Positive_regulation of Gpx1 1 0.01 0.32 0.8
6 INT31776 Positive_regulation of Gclc Positive_regulation of G6pd 1 0.29 0.19 0.75
7 INT303691 KNG1 Positive_regulation of AHR 1 0.03 0.98 0.69
8 INT303689 Regulation of KNG1 Positive_regulation of AHR 1 0.03 0.99 0.69
9 INT208372 Il13 Positive_regulation of Ahr 1 0.21 1.22 0.59
10 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54
11 INT55445 Positive_regulation of Ahr Regulation of Mme 1 0.23 0 0.53
12 INT147576 Positive_regulation of Ahr Positive_regulation of Gene_expression of Scrg1 1 0.00 0.17 0.52
13 INT162500 AHR Regulation of CYP1A1 3 0.19 0.18 0.51
14 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
15 INT162499 Binding of AHR and NEUROD1 3 0.25 0.19 0.49
16 INT200325 Ahrr Regulation of Oprm1 1 0.00 0.09 0.49
17 INT115914 AHR Regulation of Gene_expression of PPIG 1 0.25 0.36 0.44
18 INT115916 AHR Regulation of Gene_expression of SLC45A2 1 0.64 0.36 0.44
19 INT115915 AHR Regulation of Gene_expression of CYP2B6 1 0.06 0.36 0.43
20 INT161654 Gsr Regulation of Gpx1 1 0.14 0.85 0.42
21 INT168435 Positive_regulation of Binding of GLRX and Gpx1 1 0.05 0.91 0.42
22 INT168434 Binding of GLRX and Gpx1 1 0.04 0.9 0.42
23 INT168461 Sult1a1 Positive_regulation of Gpx1 1 0.12 0.83 0.39
24 INT148465 Positive_regulation of Ccl4 Positive_regulation of Gclc 1 0.32 0.06 0.38
25 INT148467 Ccl4 Positive_regulation of Gclc 1 0.32 0.05 0.37
26 INT104932 AHR Positive_regulation of CYP1A1 1 0.43 0.83 0.31
27 INT279959 Tnfrsf1b Negative_regulation of Ahr 1 0.10 0.98 0.24
28 INT179186 Fcer2a Regulation of Positive_regulation of Ahr 1 0.05 1.23 0.23
29 INT304104 Il13 Positive_regulation of Positive_regulation of AHR 1 0.14 2.6 0.19
30 INT101812 Binding of KEAP1 and Positive_regulation of Gene_expression of GCLC 1 0.54 0.1 0.19
31 INT188921 Binding of Pc and Ahr 1 0.12 0 0.19
32 INT101808 Binding of NFE2L2 and Positive_regulation of Gene_expression of GCLC 1 0.54 0.1 0.19
33 INT188920 Pc Positive_regulation of Ahr 1 0.14 0 0.18
34 INT200331 Binding of Ahrr and Gtf3a 1 0.00 0.18 0.17
35 INT134196 Ahr Regulation of Transcription of Cyp1a1 1 0.11 0.14 0.16
36 INT134202 Ahr Regulation of AHR 1 0.18 0.13 0.16
37 INT153785 AHR Regulation of UGT1A3 1 0.69 0.07 0.14
38 INT36376 Binding of AHR and FUT4 1 0.01 0.9 0.14
39 INT304094 Binding of AHR and SNRNP70 1 0.00 2.64 0.14
40 INT252573 Rpe Negative_regulation of Gpx1 1 0.07 2.34 0.13
41 INT338419 Il13 Regulation of Positive_regulation of Ahr 1 0.04 0.54 0.13
42 INT143661 Abl1 Regulation of Gpx1 1 0.19 0.56 0.12
43 INT36373 Binding of AHR and INSL3 1 0.00 0.5 0.12
44 INT101809 Gene_expression of NFE2L2 Positive_regulation of Gene_expression of GCLC 1 0.75 0 0.12
45 INT101811 NFE2L2 Regulation of Gene_expression of GCLC 1 0.67 0.06 0.12
46 INT143662 Rere Regulation of Gpx1 1 0.69 0.56 0.12
47 INT336632 Ecm1 Regulation of Regulation of Ahr 1 0.03 0.61 0.11
48 INT325222 Il13 Regulation of Ahr 1 0.21 0.58 0.11
49 INT227061 Binding of Ahr and Alb 1 0.23 0.08 0.1
50 INT134201 Positive_regulation of Binding of AHR and Cyp1a1 1 0.21 0.07 0.1
51 INT134200 Binding of AHR and Cyp1a1 1 0.16 0.07 0.1
52 INT101807 Gene_expression of KEAP1 Negative_regulation of Positive_regulation of GCLC 1 0.46 0 0.08
53 INT36372 Binding of AHR and KLF1 1 0.00 0.45 0.07
54 INT89724 RYBP Positive_regulation of Gclc 1 0.01 0.21 0.07
55 INT302985 HIVEP1 Positive_regulation of Positive_regulation of AHR 1 0.06 0.5 0.06
56 INT302984 MBP Positive_regulation of AHR 1 0.31 0.3 0.06
57 INT208432 Sms Negative_regulation of Negative_regulation of Gpx1 1 0.14 0.61 0.05
58 INT218009 AHR Positive_regulation of CYP27B1 1 0.16 0.06 0.05
59 INT208433 Sms Positive_regulation of Gene_expression of Gpx1 1 0.25 0.53 0.05
60 INT285388 Ahr Positive_regulation of Gene_expression of Cyp27b1 1 0.01 0.14 0.04
61 INT218011 AHR Positive_regulation of Transcription of CYP27B1 1 0.16 0 0.04
62 INT347414 Tlr4 Negative_regulation of Gpx1 1 0.01 0.36 0.04
63 INT250151 Binding of GSS and MCM3 1 0.01 1.38 0.04
64 INT285386 Ahr Positive_regulation of Binding of Cyp27b1 1 0.01 0.14 0.04
65 INT252767 CAT Regulation of Gpx1 1 0.00 0.25 0.04
66 INT197296 Ahr Regulation of Bhlha15 1 0.48 0.47 0.03
67 INT219423 Binding of AHR and ARNT 4 0.24 0.46 0
68 INT286268 Binding of GSR and Gpx1 2 0.02 0 0
69 INT219418 ARNT Positive_regulation of Localization of AHR 1 0.25 0 0
70 INT340275 NFATC1 Positive_regulation of Binding of Ahr 1 0.10 0.51 0
71 INT155123 Binding of Gpx1 and Cat 1 0.04 0.05 0
72 INT219503 Binding of AHR and Ppib 1 0.27 0 0
73 INT219406 AHR Positive_regulation of CBL 1 0.03 0.65 0
74 INT155124 Positive_regulation of Binding of Gpx1 and Cat 1 0.05 0.05 0
75 INT189127 Mch Positive_regulation of Ahr 1 0.18 0.29 0
76 INT197304 Ahr Regulation of Hes1 1 0.06 0.17 0
77 INT197295 Positive_regulation of Binding of Ahr and Cyp1a1 1 0.20 0 0
78 INT332894 Binding of Ahrr and Hdac3 1 0.01 0.08 0
79 INT351596 Regulation of Binding of GSR and Gpx1 1 0.02 0 0
80 INT332898 Binding of Ahrr and Aadac 1 0.00 0.08 0
81 INT219504 AHR Regulation of Gene_expression of Ppib 1 0.21 1.12 0
82 INT206963 Lipg Regulation of Gpx1 1 0.00 0.5 0
83 INT186889 Binding of AHR and PC 1 0.05 1.06 0
84 INT353194 ARNTL Regulation of Localization of Ahr 1 0.27 0.32 0
85 INT219424 Binding of AHR and TSPO 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to xenobiotic stimulus. They are ordered first by their pain relevance and then by number of times they were reported in response to xenobiotic stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07
2 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77
3 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83
4 INT90603 Positive_regulation of Ahr 103 0.69 58.65 7.73
5 INT14166 Positive_regulation of Ahr 32 0.61 20.78 7.47
6 INT38251 Negative_regulation of Gclc 7 0.57 1.37 5.06
7 INT14165 Negative_regulation of Ahr 14 0.51 8.35 4.17
8 INT115921 Positive_regulation of AHR 22 0.49 12.03 3.53
9 INT53584 Regulation of Gpx1 19 0.62 14.38 3.48
10 INT147572 Gene_expression of Ahr 73 0.75 38.99 3.15
11 INT90289 Positive_regulation of Gene_expression of Gpx1 10 0.17 8.07 3.05
12 INT47207 Negative_regulation of Ahr 25 0.52 16.11 3.02
13 INT44661 Regulation of Ahr 15 0.45 12.69 2.79
14 INT96876 Gene_expression of AHR 20 0.77 10.43 2.39
15 INT100886 Gene_expression of GCLC 16 0.76 5.63 2.29
16 INT100897 Positive_regulation of Gene_expression of GCLC 9 0.68 1.84 1.99
17 INT96877 Transcription of AHR 7 0.62 3.25 1.77
18 INT134197 Regulation of AHR 11 0.44 4.82 1.76
19 INT14167 Negative_regulation of Positive_regulation of Ahr 5 0.51 1.54 1.71
20 INT94848 Negative_regulation of Gene_expression of Gpx1 11 0.30 4.91 1.7
21 INT41395 Positive_regulation of Gclc 9 0.61 1.34 1.66
22 INT67869 Transcription of Gpx1 3 0.68 0.67 1.56
23 INT36389 Binding of AHR 18 0.45 7.22 1.46
24 INT90604 Positive_regulation of Positive_regulation of Ahr 8 0.45 3.52 1.45
25 INT54805 Regulation of Ahr 7 0.22 4.14 1.41
26 INT3816 Gene_expression of Ahr 13 0.65 7.51 1.31
27 INT200266 Gene_expression of Ahrr 4 0.01 0.73 1.29
28 INT29693 Binding of Ahr 11 0.31 13.27 1.23
29 INT100892 Positive_regulation of GCLC 8 0.68 3.44 1.08
30 INT89887 Regulation of Gene_expression of Gpx1 3 0.32 0.8 1.02
31 INT45079 Binding of Ahr 21 0.44 10.07 1
32 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87
33 INT94194 Transcription of Gclc 1 0.58 0.53 0.87
34 INT31775 Positive_regulation of Gclc 3 0.38 0.52 0.84
35 INT168432 Negative_regulation of Positive_regulation of Gpx1 4 0.40 2.89 0.75
36 INT208367 Regulation of Localization of Ahr 1 0.30 1.6 0.67
37 INT61226 Binding of Gclc 1 0.14 0 0.67
38 INT208371 Localization of Ahr 2 0.50 1.9 0.66
39 INT41394 Regulation of Gclc 5 0.43 1.78 0.64
40 INT114942 Negative_regulation of Positive_regulation of Ahr 5 0.55 2.65 0.62
41 INT148230 Positive_regulation of Regulation of Gpx1 1 0.31 0.58 0.6
42 INT64096 Negative_regulation of AHR 5 0.37 1.2 0.58
43 INT147571 Regulation of Binding of Ahr 1 0.26 0.15 0.54
44 INT104935 Localization of AHR 6 0.74 2.54 0.53
45 INT186728 Negative_regulation of Positive_regulation of AHR 1 0.08 1.61 0.52
46 INT147960 Negative_regulation of GCLC 8 0.28 4.4 0.45
47 INT94035 Transcription of Ahr 1 0.53 0.53 0.43
48 INT200249 Binding of Ahrr 4 0.01 0.2 0.38
49 INT279958 Regulation of Regulation of Ahr 1 0.29 1.32 0.37
50 INT197286 Positive_regulation of Gene_expression of Ahr 10 0.67 9.78 0.36
51 INT96871 Regulation of Transcription of AHR 2 0.41 0.46 0.33
52 INT115922 Negative_regulation of Binding of AHR 1 0.40 0.12 0.32
53 INT137586 Binding of Gpx1 8 0.23 2.76 0.29
54 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28
55 INT116703 Negative_regulation of Negative_regulation of Gpx1 3 0.18 0.81 0.28
56 INT153731 Positive_regulation of Gene_expression of Ahr 2 0.32 2 0.28
57 INT55443 Positive_regulation of Positive_regulation of Ahr 1 0.40 0 0.26
58 INT96869 Positive_regulation of Gene_expression of AHR 1 0.45 0.43 0.23
59 INT101822 Negative_regulation of Positive_regulation of GCLC 1 0.57 0.07 0.23
60 INT197292 Positive_regulation of Ahrr 2 0.39 0.57 0.21
61 INT221777 Negative_regulation of Ahrr 1 0.01 0.58 0.21
62 INT199771 Localization of Ahr 8 0.70 4.86 0.2
63 INT274775 Regulation of Positive_regulation of Gpx1 1 0.04 0.76 0.2
64 INT96875 Regulation of Gene_expression of AHR 1 0.25 0.38 0.18
65 INT96951 Positive_regulation of Gene_expression of Gclc 5 0.34 1.45 0.16
66 INT177568 Localization of Gpx1 5 0.49 1.82 0.16
67 INT322766 Regulation of GSS 2 0.06 0.89 0.16
68 INT134193 Regulation of Regulation of Ahr 1 0.12 0.14 0.16
69 INT101819 Positive_regulation of Positive_regulation of GCLC 2 0.59 1.47 0.15
70 INT289312 Phosphorylation of Ahr 1 0.03 0.86 0.15
71 INT153787 Positive_regulation of Transcription of AHR 1 0.45 0.08 0.15
72 INT294583 Negative_regulation of Gene_expression of Ahr 2 0.38 1.01 0.14
73 INT143657 Phosphorylation of Gpx1 1 0.82 0.97 0.14
74 INT134194 Regulation of Gene_expression of Ahr 1 0.12 0.17 0.14
75 INT143658 Regulation of Phosphorylation of Gpx1 1 0.45 0.97 0.14
76 INT143659 Positive_regulation of Phosphorylation of Gpx1 1 0.50 0.98 0.14
77 INT314341 Positive_regulation of Localization of Gpx1 1 0.08 0.82 0.13
78 INT197287 Regulation of Gene_expression of Ahr 5 0.45 1 0.11
79 INT250157 Gene_expression of GSS 2 0.22 1.54 0.1
80 INT45501 Negative_regulation of GSS 1 0.43 0.36 0.1
81 INT252568 Negative_regulation of Regulation of Gpx1 1 0.08 1.11 0.09
82 INT289311 Negative_regulation of Gene_expression of Ahr 1 0.02 1 0.09
83 INT134198 Positive_regulation of Binding of AHR 1 0.40 0.07 0.09
84 INT339153 Negative_regulation of Localization of AHR 1 0.06 1.09 0.08
85 INT195858 Transcription of Ahr 2 0.69 1.33 0.07
86 INT195859 Positive_regulation of Transcription of Ahr 2 0.48 0.73 0.07
87 INT199780 Positive_regulation of Localization of Ahr 2 0.45 1.03 0.07
88 INT197288 Regulation of Positive_regulation of Ahr 1 0.59 0.45 0.07
89 INT261026 Localization of Gclc 3 0.36 0.88 0.06
90 INT319133 Localization of Ahrr 2 0.02 0.48 0.06
91 INT261017 Regulation of Gclc 2 0.22 0.88 0.06
92 INT340266 Negative_regulation of Binding of Ahr 1 0.16 1.33 0.06
93 INT294584 Negative_regulation of Negative_regulation of Ahr 1 0.38 0.56 0.04
94 INT186262 Transcription of GCLC 3 0.23 1.19 0
95 INT319631 Positive_regulation of Transcription of Gclc 1 0.17 0 0
96 INT177821 Negative_regulation of Gene_expression of AHR 1 0.30 0.54 0
97 INT261016 Regulation of Positive_regulation of Gclc 1 0.22 0.23 0
98 INT319621 Transcription of Gclc 1 0.20 0 0
99 INT261006 Positive_regulation of Positive_regulation of Gclc 1 0.24 0.23 0
100 INT239147 Regulation of Binding of Gpx1 1 0.28 0.53 0
101 INT313321 Negative_regulation of Transcription of GCLC 1 0.15 0 0
102 INT322936 Positive_regulation of GSS 1 0.15 0.37 0
103 INT250158 Binding of GSS 1 0.14 0.57 0
104 INT268724 Positive_regulation of Negative_regulation of Gpx1 1 0.04 0.13 0
105 INT246068 Regulation of GCLC 1 0.24 0.11 0
106 INT211502 Negative_regulation of Negative_regulation of AHR 1 0.15 0 0
107 INT197281 Transcription of Ahrr 1 0.38 0 0
108 INT335757 Positive_regulation of Positive_regulation of Gpx1 1 0.07 0.66 0
109 INT347402 Negative_regulation of Binding of Gpx1 1 0.05 0 0
110 INT261005 Regulation of Localization of Gclc 1 0.13 0.39 0
111 INT187311 Regulation of Positive_regulation of AHR 1 0.28 0 0
112 INT351593 Positive_regulation of Binding of Gpx1 1 0.08 0 0
113 INT261027 Binding of Gclc 1 0.18 0 0
114 INT261022 Regulation of Gene_expression of Gclc 1 0.22 0.23 0
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