GO:0010463

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Name mesenchymal cell proliferation
Categary Process
Go Slim No
Go Link GO:0010463
Unique Molecular Interactions 102
Total Molecular Interactions 127
Total Single Events 1164
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for mesenchymal cell proliferation. They are ordered first by their pain relevance and then by number of times they were reported for mesenchymal cell proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
2 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
3 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
4 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
5 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
6 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
7 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
8 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
9 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
10 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
11 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
12 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
13 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
14 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
15 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
16 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
17 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
18 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29
19 INT185076 Bpifa2 Positive_regulation of Hand2 1 0.16 0.36 0.28
20 INT278209 Ciita Regulation of Hand2 1 0.36 1.53 0.28
21 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
22 INT278216 Ciita Regulation of Gene_expression of Hand2 1 0.36 1.53 0.28
23 INT246442 Hand2 Positive_regulation of Gene_expression of Cd79a 1 0.03 0.78 0.27
24 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
25 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26
26 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21
27 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
28 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2
29 INT338767 Positive_regulation of Binding of Hand1 and Hand2 1 0.07 0.5 0.2
30 INT226510 BTPs Negative_regulation of Hand2 1 0.03 0.22 0.2
31 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2
32 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
33 INT228737 Rae1 Negative_regulation of Hand2 1 0.08 1.07 0.19
34 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18
35 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18
36 INT181457 Binding of CCL16 and Hand2 1 0.04 0.92 0.17
37 INT294766 Cerk Regulation of Gene_expression of Hand2 1 0.13 0.32 0.15
38 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14
39 INT347015 Hand2 Regulation of Cd86 1 0.06 0 0.14
40 INT294764 Binding of Hand2 and Cerk 1 0.17 0.31 0.14
41 INT235546 Stat6 Positive_regulation of Positive_regulation of Hand2 1 0.02 0.9 0.14
42 INT347018 Cd80 Regulation of Hand2 1 0.03 0.05 0.13
43 INT347007 Cd86 Regulation of Hand2 1 0.06 0.05 0.13
44 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
45 INT294760 Cerk Positive_regulation of Hand2 1 0.23 0.16 0.12
46 INT253077 Prok2 Regulation of Gene_expression of Hand2 1 0.10 0.11 0.12
47 INT294758 Regulation of Cerk Positive_regulation of Hand2 1 0.21 0.16 0.12
48 INT228746 Hspa9 Negative_regulation of Positive_regulation of Hand2 1 0.11 0.31 0.11
49 INT228760 Rae1 Negative_regulation of Positive_regulation of Hand2 1 0.08 0.31 0.11
50 INT199595 FGF7 Positive_regulation of Transcription of TNF 1 0.40 0.58 0.11
51 INT175463 Sftpd Negative_regulation of Gene_expression of Hand2 1 0.17 0.96 0.11
52 INT263495 Hand1 Regulation of Localization of Hand2 1 0.12 0.5 0.09
53 INT263496 Hand2 Regulation of Localization of Hand1 1 0.12 0.5 0.09
54 INT199594 FGF7 Positive_regulation of NFE2L2 1 0.01 0.52 0.09
55 INT201349 Binding of Hand2 and Il4 1 0.17 0.67 0.09
56 INT199604 Binding of FGF7 and Fgf1 1 0.03 0.21 0.08
57 INT199603 Positive_regulation of Binding of FGF7 and Fgf1 1 0.04 0.21 0.08
58 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
59 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
60 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07
61 INT286298 Binding of Hand2 and Negative_regulation of Gene_expression of Il12a 1 0.07 0.3 0.07
62 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
63 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
64 INT282552 POU5F1 Positive_regulation of FGF4 1 0.29 0.29 0.05
65 INT278454 CSF2 Regulation of Hand2 1 0.02 0.66 0.05
66 INT278208 Ciita Negative_regulation of Gene_expression of Hand2 1 0.34 0.7 0.05
67 INT347020 Hand2 Regulation of Gene_expression of Cd86 1 0.08 0.19 0.04
68 INT347009 Hand2 Regulation of Gene_expression of Il4 1 0.01 0.19 0.04
69 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
70 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
71 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
72 INT303559 Binding of Fgf7 and Dysf 1 0.01 0.44 0.03
73 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
74 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
75 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
76 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
77 INT305845 Polk Positive_regulation of Regulation of Hand2 1 0.08 0.34 0
78 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
79 INT306114 GOPC Regulation of Gene_expression of FGF7 1 0.05 0.45 0
80 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
81 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
82 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
83 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
84 INT184137 Binding of Socs5 and Regulation of Hand2 1 0.09 1.01 0
85 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
86 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
87 INT331700 Fgf4 Positive_regulation of Gene_expression of Mmp9 1 0.30 0.41 0
88 INT319042 Negative_regulation of Binding of Fgf7 and Fig4 1 0.07 0.2 0
89 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
90 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
91 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
92 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
93 INT319043 Binding of Fgf7 and Fig4 1 0.06 0.26 0
94 INT305847 Polk Positive_regulation of Hand2 1 0.09 0.34 0
95 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
96 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
97 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
98 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
99 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
100 INT331701 Fgf4 Positive_regulation of Gene_expression of Kdr 1 0.11 0.54 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for mesenchymal cell proliferation. They are ordered first by their pain relevance and then by number of times they were reported in mesenchymal cell proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
2 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
3 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
4 INT173505 Localization of Hand2 63 0.57 45.32 13.66
5 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
6 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
7 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
8 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
9 INT156131 Binding of Hand2 14 0.25 10.35 3.99
10 INT83374 Gene_expression of FGF7 83 0.78 44.18 2.6
11 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
12 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
13 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
14 INT101707 Gene_expression of FGF4 9 0.78 3.99 1.73
15 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
16 INT181032 Gene_expression of Fgf7 8 0.61 5.96 1.41
17 INT199601 Positive_regulation of FGF7 9 0.50 6.13 1.22
18 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
19 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
20 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
21 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
22 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
23 INT199598 Binding of FGF7 4 0.48 2.83 0.9
24 INT112014 Negative_regulation of Regulation of Hand2 3 0.34 2.07 0.86
25 INT99708 Gene_expression of Fgf7 7 0.76 7.42 0.7
26 INT271488 Negative_regulation of Negative_regulation of Hand2 3 0.18 2.36 0.67
27 INT132588 Positive_regulation of Negative_regulation of Hand2 1 0.03 0.47 0.58
28 INT124042 Localization of FGF7 10 0.80 4.13 0.57
29 INT199602 Positive_regulation of Gene_expression of FGF7 12 0.70 7.47 0.55
30 INT206484 Localization of Shh 2 0.75 1.14 0.46
31 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
32 INT325217 Regulation of Positive_regulation of Hand2 1 0.21 0.32 0.41
33 INT262902 Regulation of Binding of FGF7 1 0.02 0.88 0.4
34 INT228271 Localization of Fgf7 2 0.28 1.59 0.39
35 INT194745 Regulation of Regulation of Hand2 1 0.03 0.95 0.39
36 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
37 INT226424 Negative_regulation of Transcription of Hand2 1 0.08 0.66 0.37
38 INT228280 Regulation of Gene_expression of Fgf7 1 0.18 0.95 0.34
39 INT257954 Regulation of FGF7 2 0.45 0.52 0.32
40 INT114473 Regulation of Gene_expression of FGF4 1 0.45 0.81 0.32
41 INT226394 Regulation of Phosphorylation of Hand2 1 0.05 0.97 0.28
42 INT114474 Binding of FGF4 1 0.32 0.66 0.28
43 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
44 INT100671 Positive_regulation of Transcription of Hand2 2 0.36 0.81 0.23
45 INT226390 Phosphorylation of Hand2 1 0.14 0.85 0.22
46 INT263492 Positive_regulation of Regulation of Hand2 3 0.19 4.76 0.21
47 INT199599 Negative_regulation of Gene_expression of FGF7 3 0.48 0.78 0.19
48 INT284888 Regulation of Transcription of Hand2 1 0.16 0.32 0.18
49 INT295673 Regulation of FGF4 1 0.05 0.83 0.17
50 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
51 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
52 INT199600 Negative_regulation of Localization of FGF7 1 0.35 1.09 0.16
53 INT99709 Regulation of Gene_expression of Fgf7 3 0.44 0.19 0.14
54 INT285494 Positive_regulation of Gene_expression of Fgf7 2 0.40 1.48 0.13
55 INT253190 Localization of Shh 2 0.77 1.06 0.13
56 INT119194 Negative_regulation of FGF7 2 0.43 1.42 0.13
57 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
58 INT285509 Negative_regulation of Gene_expression of Fgf7 1 0.14 1.14 0.1
59 INT270442 Transcription of Shh 1 0.53 0.25 0.09
60 INT213515 Binding of Shh 8 0.37 1.92 0.08
61 INT270453 Regulation of Shh 1 0.27 0.83 0.08
62 INT99713 Positive_regulation of Gene_expression of Fgf7 3 0.45 0.92 0.07
63 INT256862 Regulation of Shh 1 0.25 0 0.07
64 INT200103 Regulation of Gene_expression of FGF7 3 0.62 3.41 0.06
65 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
66 INT178418 Binding of Fgf7 1 0.16 1.26 0.05
67 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
68 INT282588 Positive_regulation of Gene_expression of FGF4 1 0.30 0.25 0.04
69 INT178396 Positive_regulation of Fgf7 2 0.55 0.98 0.03
70 INT192401 Positive_regulation of Binding of Hand2 1 0.08 0 0.03
71 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
72 INT253181 Transcription of Shh 1 0.68 0.54 0.03
73 INT331697 Gene_expression of Fgf4 6 0.58 1.57 0
74 INT99714 Transcription of Fgf7 2 0.67 0.22 0
75 INT331699 Positive_regulation of Fgf4 2 0.45 0.69 0
76 INT319037 Positive_regulation of Regulation of Fgf7 1 0.49 0.08 0
77 INT319041 Regulation of Fgf7 1 0.44 0.08 0
78 INT306120 Regulation of Transcription of FGF7 1 0.62 1.47 0
79 INT319039 Negative_regulation of Fgf7 1 0.42 0.18 0
80 INT331696 Localization of Fgf4 1 0.68 1.38 0
81 INT335001 Positive_regulation of Gene_expression of Fgf4 1 0.13 0 0
82 INT306124 Transcription of FGF7 1 0.72 3.68 0
83 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
84 INT306126 Negative_regulation of Transcription of FGF7 1 0.43 0.56 0
85 INT319038 Negative_regulation of Gene_expression of Fgf7 1 0.42 0.18 0
86 INT290929 Binding of Shh 1 0.31 0.1 0
87 INT286717 Regulation of Fgf4 1 0.26 0 0
88 INT319040 Protein_catabolism of Fgf7 1 0.64 0.17 0
89 INT306121 Positive_regulation of Localization of FGF7 1 0.50 0.12 0
90 INT239107 Binding of Fgf7 1 0.16 0.35 0
91 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
92 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
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