GO:0010694

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Name positive regulation of alkaline phosphatase activity
Categary Process
Go Slim No
Go Link GO:0010694
Unique Molecular Interactions 36
Total Molecular Interactions 59
Total Single Events 252
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of alkaline phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of alkaline phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
2 INT171792 GPER Regulation of Gene_expression of Itga2 1 0.00 0.54 0.12
3 INT238628 Mef2c Regulation of Gene_expression of Arc 1 0.09 0.16 0.08
4 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
5 INT303970 Lep Positive_regulation of Gene_expression of Itga2 1 0.09 0.29 0.08
6 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
7 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
8 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
9 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
10 INT290437 Gene_expression of Mef2c Negative_regulation of Upf1 1 0.02 0.25 0.03
11 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
12 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
13 INT269937 Binding of Smad3 and Mgst1 1 0.09 0 0
14 INT331089 Binding of Cd3e and Itga2 1 0.09 0.2 0
15 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
16 INT350706 Binding of Mef2c and Mir223 1 0.02 0.11 0
17 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
18 INT290439 Negative_regulation of Mef2c Positive_regulation of Gene_expression of Ppargc1a 1 0.21 0 0
19 INT290441 Mef2c Regulation of Mef2b 1 0.09 0.11 0
20 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
21 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
22 INT331088 Binding of Itga2 and Klrb1c 1 0.11 0.2 0
23 INT297213 Myoz1 Regulation of Mef2c 1 0.02 0.09 0
24 INT290438 Mef2c Regulation of Mef2a 1 0.26 0.11 0
25 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0
26 INT269921 Binding of Smad3 and Scn4a 1 0.12 0 0
27 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
28 INT218665 Olr811 Negative_regulation of Phosphorylation of Smad3 1 0.01 0.33 0
29 INT269929 Binding of Cdkn2b and Smad3 1 0.18 0.89 0
30 INT269935 Binding of Smad3 and Scn5a 1 0.13 0 0
31 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
32 INT269946 Binding of Smad3 and Gopc 1 0.08 0 0
33 INT275972 Binding of Itga2 and Gp6 1 0.05 0 0
34 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0
35 INT331090 Binding of Ctsl and Itga2 1 0.10 0.2 0
36 INT277611 Binding of Mef2c and Hdac4 1 0.34 1.12 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of alkaline phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of alkaline phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
2 INT277586 Negative_regulation of Mef2c 36 0.59 11.03 0.86
3 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
4 INT202361 Gene_expression of Mef2c 28 0.78 5.53 0.67
5 INT118891 Transcription of Itga2 1 0.03 0 0.54
6 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
7 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
8 INT238560 Regulation of Mef2c 9 0.45 2.12 0.33
9 INT239861 Gene_expression of Itga2 5 0.65 1.32 0.32
10 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
11 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
12 INT140187 Positive_regulation of Itga2 1 0.18 0.34 0.3
13 INT239863 Negative_regulation of Gene_expression of Itga2 1 0.03 0.8 0.29
14 INT171788 Positive_regulation of Binding of Itga2 1 0.02 0.94 0.28
15 INT171790 Regulation of Binding of Itga2 1 0.01 0.93 0.28
16 INT171789 Binding of Itga2 1 0.02 0.92 0.27
17 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
18 INT202355 Transcription of Mef2c 3 0.69 0.6 0.21
19 INT248543 Positive_regulation of Mef2c 7 0.69 2.82 0.18
20 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17
21 INT277602 Binding of Mef2c 10 0.39 4.35 0.16
22 INT158903 Gene_expression of Smad3 2 0.56 0.54 0.13
23 INT158890 Negative_regulation of Gene_expression of Smad3 1 0.42 0.13 0.13
24 INT115521 Gene_expression of Itga2 1 0.04 0.62 0.12
25 INT115520 Regulation of Itga2 2 0.01 0.46 0.1
26 INT290404 Positive_regulation of Negative_regulation of Mef2c 1 0.50 0.72 0.08
27 INT277578 Regulation of Negative_regulation of Mef2c 2 0.45 1.17 0.07
28 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06
29 INT290417 Positive_regulation of Gene_expression of Mef2c 1 0.50 1.25 0.06
30 INT262799 Localization of Smad3 6 0.56 2.09 0.04
31 INT290407 Positive_regulation of Binding of Mef2c 1 0.44 0.93 0.04
32 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03
33 INT271419 Localization of SMAD3 2 0.11 0.13 0.03
34 INT290419 Regulation of Gene_expression of Mef2c 1 0.62 0.41 0.03
35 INT290399 Negative_regulation of Gene_expression of Mef2c 1 0.59 0.59 0.03
36 INT254812 Positive_regulation of Phosphorylation of Smad3 1 0.25 0.94 0.03
37 INT254805 Transcription of Smad3 1 0.28 0.76 0.03
38 INT265337 Binding of Smad3 2 0.35 1 0
39 INT269913 Positive_regulation of Binding of Smad3 1 0.34 0.3 0
40 INT218693 Negative_regulation of Phosphorylation of Smad3 1 0.19 0.32 0
41 INT329784 Gene_expression of SMAD3 1 0.31 0.41 0
42 INT290400 Regulation of Regulation of Mef2c 1 0.45 0.24 0
43 INT268384 Positive_regulation of Phosphorylation of SMAD3 1 0.29 1.22 0
44 INT331077 Binding of Itga2 1 0.19 0.2 0
45 INT290429 Negative_regulation of Negative_regulation of Mef2c 1 0.37 0.05 0
46 INT269873 Positive_regulation of Negative_regulation of Smad3 1 0.34 0.31 0
47 INT290425 Negative_regulation of Binding of Mef2c 1 0.37 0 0
48 INT268382 Phosphorylation of SMAD3 1 0.34 0.6 0
49 INT290409 Negative_regulation of Transcription of Mef2c 1 0.43 0.08 0
50 INT254809 Positive_regulation of Transcription of Smad3 1 0.25 0.24 0
51 INT277587 Localization of Mef2c 1 0.65 0.43 0
52 INT268363 Binding of SMAD3 1 0.20 0.56 0
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